Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNJ632)

Drug Name

AR-534 Drug Info

Synonyms

CHEMBL2177159

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Glycogen synthase kinase-3 alpha (GSK-3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[2]
LY2090314	DMTBFE4	Acute myeloid leukaemia	2A60	Phase 2	[3]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[4]
KENPAULLONE	DMAGVXW	Discovery agent	N.A.	Patented	[3]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[3]
TDZD-8	DMG6Q45	Malignant glioma	2A00.0	Patented	[3]
AR-A014418	DMUPN01	Ovarian cancer	2C73	Patented	[3]
PMID27828716-Compound-21	DMO1NAR	N. A.	N. A.	Patented	[3]
Thiadiazolidindione derivative 2	DM5AUL0	N. A.	N. A.	Patented	[3]
PMID27828716-Compound-18	DMNR6KL	N. A.	N. A.	Patented	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycogen synthase kinase-3 alpha (GSK-3A)	TTRZQE3	GSK3A_HUMAN	Inhibitor	[1]

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References

1	A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest. 2009 May;119(5):1382-95.
2	Challenges and new opportunities in the investigation of new drug therapies to treat frontotemporal dementia. Expert Opin Ther Targets. 2008 Nov;12(11):1367-76.
3	Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015).Expert Opin Ther Pat. 2017 Jun;27(6):657-666.
4	The GSK3 kinase inhibitor lithium produces unexpected hyperphosphorylation of -catenin, a GSK3 substrate, in human glioblastoma cells. Biol Open. 2018 Jan 26;7(1):bio030874.