Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOB2K5)

• Drug Name: UTIBAPRIL Drug Info
• Synonyms: FPL-63547; Utibapril < Rec INN; (S)-2-tert-Butyl-4-[(S)-N-[(S)-1-carboxy-3-phenylpropyl]alanyl]-DELTA2-1,3,4-thiadiazoline-5-carboxylic acid 4-ethyl ester; 5-tert-Butyl-3-[N-[1(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-2,3-dihydro-1,3,4-thiadiazole-2(S)-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Discontinued in Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 9803778
  CAS Number: CAS 109683-61-6
  TTD Drug ID: DMOB2K5

Molecule-Related Drug Atlas

Drug(s) Targeting Angiotensin-converting enzyme (ACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[3]
Spirapril	DM5XLTY	Hypertension	BA00-BA04	Approved	[4]
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[5]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[6]
Moexipril	DM26E4B	Hypertension	BA00-BA04	Approved	[7]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[8]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[9]
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[10]
Fosinopril	DM9NJ52	Chronic heart failure	BD1Z	Approved	[11]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[12]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Angiotensin-converting enzyme (ACE)	TTL69WB	ACE_HUMAN	Inhibitor	[2]

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000394)
• [2] Differential inhibition of plasma versus tissue ACE by utibapril: biochemical and functional evidence for inhibition of vascular ACE activity. J Cardiovasc Pharmacol. 1997 May;29(5):684-91.
• [3] Determination of bezafibrate, methotrexate, cyclophosphamide, orlistat and enalapril in waste and surface waters using on-line solid-phase extracti... J Environ Monit. 2009 Apr;11(4):830-8.
• [4] Central angiotensin II controls alcohol consumption via its AT1 receptor. FASEB J. 2005 Sep;19(11):1474-81.
• [5] Using ACE inhibitors appropriately. Am Fam Physician. 2002 Aug 1;66(3):461-8.
• [6] Efficacy of benazepril hydrochloride to delay the progression of occult dilated cardiomyopathy in Doberman Pinschers. J Vet Intern Med. 2009 Sep-Oct;23(5):977-83.
• [7] Moexipril for treatment of primary biliary cirrhosis in patients with an incomplete response to ursodeoxycholic acid. Dig Dis Sci. 2010 Feb;55(2):476-83.
• [8] Knockouts model the 100 best-selling drugs--will they model the next 100 Nat Rev Drug Discov. 2003 Jan;2(1):38-51.
• [9] Fixed combination perindopril-amlodipine (Coveram) in the treatment of hypertension and coronary heart disease. Rev Med Liege. 2009 Apr;64(4):223-7.
• [10] Selective reduction of central pulse pressure under angiotensin blockage in SHR: role of the fibronectin-alpha5beta1 integrin complex. Am J Hypertens. 2009 Jul;22(7):711-7.
• [11] Angiotensin-converting enzyme inhibition and novel cardiovascular risk biomarkers: results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study. Am Heart J. 2009 Feb;157(2):334.e1-8.
• [12] Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient m... J Atheroscler Thromb. 2009 Jun;16(3):164-71.