Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOCEPA)

• Drug Name: 5,8-Dihydroxy-1,4-naphthoquinone Drug Info
• Synonyms: Naphthazarin; 475-38-7; Naphthazarine; 5,8-dihydroxynaphthalene-1,4-dione; Naphthazarone; 5,8-Dihydroxynaphthoquinone; 5,8-Dihydroxy-1,4-naphthalenedione; NAPHTHAZALIN; 5,8-Dihydroxynaphthalene-1,4(4aH,8aH)-dione; 5,8-Dihydroxy-1,4-naphthosemiquinone; CCRIS 6670; Dihydroxynaphthoquinone; EINECS 207-495-4; NSC 26647; UNII-S9IX5I5C0K; S9IX5I5C0K; CHEMBL274056; CHEBI:28849; 1,4-NAPHTHOQUINONE, 5,8-DIHYDROXY-; NSC26647; 5,8-Dihydroxy-[1,4]naphthoquinone; NSC344555

Indication

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 10141
  ChEBI ID: CHEBI:28849
  CAS Number: CAS 475-38-7
  TTD Drug ID: DMOCEPA

Molecule-Related Drug Atlas

Drug(s) Targeting Arachidonate 5-lipoxygenase (5-LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[4]
Diethylcarbamazine	DM1TJ8F	Elephantiasis		Approved	[5]
Silymarin	DMXBYQR	N. A.	N. A.	Phase 4	[6]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[7]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[2]
ABT-761	DM3FIC2	Asthma	CA23	Phase 3	[8]
Tenidap	DMHQRYE	Rheumatoid arthritis	FA20	Phase 3	[9]
FPL-62064	DMGF8MZ	Inflammation	1A00-CA43.1	Phase 3	[10]
Flobufen	DMPSG4D	Rheumatoid arthritis	FA20	Phase 3	[11]
Darbufelone	DMYVKM5	Asthma	CA23	Phase 2/3	[12]

Drug(s) Targeting Cytoplasmic thioredoxin reductase (TXNRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fotemustine	DMV62ED	Solid tumour/cancer	2A00-2F9Z	Approved	[13]
Spermidine	DMVJNFI	Plaque psoriasis	EA90.0	Phase 3	[13]
Golden phosphorous acetyletic compound 2	DMYJ15A	N. A.	N. A.	Patented	[14]
Terpyridineplatinum(II) complexe 3	DM54EFD	N. A.	N. A.	Patented	[14]
Terpyridineplatinum(II) complexe 4	DMOV86T	N. A.	N. A.	Patented	[14]
Golden phosphorous acetyletic compound 1	DMVAKUI	N. A.	N. A.	Patented	[14]
Acyl oxymethyl acrylamide ester derivative 1	DMXTUE1	N. A.	N. A.	Patented	[14]
PMID27977313-Compound-18	DMIA3GH	N. A.	N. A.	Patented	[14]
Triazole gold complexe 1	DMCWES7	N. A.	N. A.	Patented	[14]
4-aryl quinol derivative 2	DM7TW5Z	N. A.	N. A.	Patented	[14]

Drug(s) Affected By Dihydroorotate dehydrogenase (DHODH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[15]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[18]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[21]
Atovaquone	DMY4UMW	Fungal infection	1F29-1F2F	Approved	[3]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[22]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[3]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[2]
Cytoplasmic thioredoxin reductase (TXNRD1)	TTR7UJ3	TRXR1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Dihydroorotate dehydrogenase (DHODH)	OTAKFN78	PYRD_HUMAN	Gene/Protein Processing	[3]

References

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• [14] Thioredoxin reductase inhibitors: a patent review.Expert Opin Ther Pat. 2017 May;27(5):547-556.
• [15] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
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• [17] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [18] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [19] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [20] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [21] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [22] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.