Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMOTANY)

• Drug Name: RS-130830 Drug Info
• Synonyms: CTS-1027; 193022-04-7; RS-130830; UNII-2QD3F58224; CHEMBL440498; 2QD3F58224; 4-[4-(4-CHLORO-PHENOXY)-BENZENESULFONYLMETHYL]-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HYDROXYAMIDE; 4-[[[4-(4-Chlorophenoxy)phenyl]sulfonyl]methyl]tetrahydro-N-hydroxy-2H-pyran-4-carboxamide; 4-(4-(4-Chloro-phenoxy)-benzenesulfonylmethyl)-tetrahydro-pyran-4-carboxylic acid hydroxyamide; Ro-1130830; AC1MOE9A; SCHEMBL2381112; BDBM11863; DTXSID90172907; 830c; CTS 1027; ZINC1488366; BCP13018; 3563AH; alpha-tetrahydropyran beta-sulfone 1B; AKOS030526690

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Discontinued in Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 3342298
  CAS Number: CAS 193022-04-7
  TTD Drug ID: DMOTANY

Molecule-Related Drug Atlas

Drug(s) Targeting Matrix metalloproteinase-13 (MMP-13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[3]
Apratastat	DM8W4N9	Rheumatoid arthritis	FA20	Phase 2	[4]
PMID17935984C1	DMO1IHL	Pain	MG30-MG3Z	Clinical trial	[5]
PMID29130358-Compound-Figure18(14a)	DMHIBTZ	N. A.	N. A.	Patented	[6]
PMID29130358-Compound-Figure16(9b)	DMPAQLZ	N. A.	N. A.	Patented	[6]
PMID29130358-Compound-Figure16(9a)	DMKX5R8	N. A.	N. A.	Patented	[6]
PMID29130358-Compound-Figure18(14)	DM7WXJ9	N. A.	N. A.	Patented	[6]
PMID29130358-Compound-Figure16(9c)	DM0ZRI9	N. A.	N. A.	Patented	[6]
GM6001	DM7V9CT	Corneal ulcer	9A76	Discontinued in Phase 2	[7]
MMI270	DM38N2K	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Matrix metalloproteinase-1 (MMP-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prinomastat	DM9HOKG	Lung cancer	2C25.0	Approved	[9]
Marimastat	DM6V34C	Pancreatic cancer	2C10	Phase 3	[10]
CIPEMASTAT	DM803GL	Rheumatoid arthritis	FA20	Phase 3	[11]
Apratastat	DM8W4N9	Rheumatoid arthritis	FA20	Phase 2	[4]
PMID29130358-Compound-Figure18(14a)	DMHIBTZ	N. A.	N. A.	Patented	[6]
PMID29130358-Compound-Figure10(2a)	DMFWXPS	N. A.	N. A.	Patented	[6]
BMS 275291	DMKSFPE	Kaposi sarcoma	2B57	Discontinued in Phase 3	[12]
GM6001	DM7V9CT	Corneal ulcer	9A76	Discontinued in Phase 2	[13]
XL784	DMICR39	Diabetic nephropathy	GB61.Z	Discontinued in Phase 2	[14]
SC-44463	DMBPNKT	N. A.	N. A.	Terminated	[15]

Drug(s) Targeting Matrix metalloproteinase-9 (MMP-9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[16]
DP-b99	DM97S10	Stroke	8B20	Phase 3	[17]
GS-5745	DMP8MDW	Gastric adenocarcinoma	2B72	Phase 3	[18]
Andecaliximab	DMLDB1X	Gastric adenocarcinoma	2B72	Phase 3	[19]
BLZ-100	DMFKA4G	Glioma	2A00.0	Phase 1/2	[20]
Neovastat	DMXTYWJ	Non-small-cell lung cancer	2C25.Y	Phase 1	[21]
PMID29130358-Compound-Figure18(14a)	DMHIBTZ	N. A.	N. A.	Patented	[6]
PMID29130358-Compound-Figure17(12)	DMML4PA	N. A.	N. A.	Patented	[6]
PMID29130358-Compound-Figure17(10)	DMVA15O	N. A.	N. A.	Patented	[6]
PMID29130358-Compound-SB-3CT	DMC64XQ	N. A.	N. A.	Patented	[6]

Drug(s) Targeting Matrix metalloproteinase-2 (MMP-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prinomastat	DM9HOKG	Lung cancer	2C25.0	Approved	[9]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[22]
Marimastat	DM6V34C	Pancreatic cancer	2C10	Phase 3	[10]
Neovastat	DMXTYWJ	Non-small-cell lung cancer	2C25.Y	Phase 1	[21]
Metastat	DMTQ4PN	Acne vulgaris	ED80	Phase 1	[23]
PMID29130358-Compound-Figure18(14a)	DMHIBTZ	N. A.	N. A.	Patented	[6]
PMID29130358-Compound-Figure10(2a)	DMFWXPS	N. A.	N. A.	Patented	[6]
PMID29130358-Compound-Figure16(9b)	DMPAQLZ	N. A.	N. A.	Patented	[6]
PMID29130358-Compound-SB-3CT	DMC64XQ	N. A.	N. A.	Patented	[6]
PMID29130358-Compound-Figure16(9a)	DMKX5R8	N. A.	N. A.	Patented	[6]

Drug(s) Targeting Matrix metalloproteinase-3 (MMP-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID29130358-Compound-Figure10(2a)	DMFWXPS	N. A.	N. A.	Patented	[6]
GM6001	DM7V9CT	Corneal ulcer	9A76	Discontinued in Phase 2	[13]
PG-530742	DMELXBQ	Myocardial infarction	BA41-BA43	Discontinued in Phase 2	[24]
Batimastat	DM92VRP	Idiopathic pulmonary fibrosis	CB03.4	Preclinical	[25]
SC-44463	DMBPNKT	N. A.	N. A.	Terminated	[26]
BB-1101	DM7GH5Z	Multiple sclerosis	8A40	Terminated	[27]
L-696418	DMV785R	N. A.	N. A.	Terminated	[28]
RO-319790	DML3NEU	Rheumatoid arthritis	FA20	Terminated	[29]
MMI270	DM38N2K	Discovery agent	N.A.	Investigative	[23]
IK-862	DMJA4UE	Discovery agent	N.A.	Investigative	[30]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Matrix metalloproteinase-1 (MMP-1)	TTMX39J	MMP1_HUMAN	Inhibitor	[2]
Matrix metalloproteinase-13 (MMP-13)	TTHY57M	MMP13_HUMAN	Inhibitor	[2]
Matrix metalloproteinase-2 (MMP-2)	TTLM12X	MMP2_HUMAN	Inhibitor	[2]
Matrix metalloproteinase-3 (MMP-3)	TTUZ2L5	MMP3_HUMAN	Inhibitor	[2]
Matrix metalloproteinase-9 (MMP-9)	TT6X50U	MMP9_HUMAN	Inhibitor	[2]

References

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