General Information of Drug (ID: DMPKE6G)

Drug Name
4-(2,4-dichloro-phenoxy)-2'-methyl-biphenyl-3-ol Drug Info
Synonyms 4-(2,4-Dichlorophenoxy)-2'-Methylbiphenyl-3-Ol; Triclosan derivative, 15; CHEMBL261708; BDBM25414; 2-(2,4-dichlorophenoxy)-5-(2-methylphenyl)phenol
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
15942656
TTD Drug ID
DMPKE6G

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [2]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [3]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [4]
Beta-D-Glucose DM5IHYP Discovery agent N.A. Investigative [4]
MORIN DM2OGZ5 Discovery agent N.A. Investigative [5]
3,7,3',4'-TETRAHYDROXYFLAVONE DMES906 Discovery agent N.A. Investigative [5]
(-)-CATECHINGALLATE DMZOGSK Discovery agent N.A. Investigative [5]
Thiolactomycin DMBAWDG Malaria 1F40-1F45 Investigative [2]
GALLOCATECHIN GALLATE DMX2084 Discovery agent N.A. Investigative [5]
Diazaborines DM5UFZX Discovery agent N.A. Investigative [6]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Plasmodium Enoyl-ACP reductase (Malaria fabI) TTNX2CS Q965D5_PLAFA Inhibitor [1]

References

1 X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalar... J Biol Chem. 2007 Aug 31;282(35):25436-44.
2 Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.
3 Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75.
4 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5 Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
6 Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97.