General Information of Drug Therapeutic Target (DTT) (ID: TTNX2CS)

DTT Name Plasmodium Enoyl-ACP reductase (Malaria fabI)
Synonyms fabI; NADH-dependent enoyl-ACP reductase; Enoyl-acyl-carrier protein reductase; Enoyl-acyl carrier reductase; Enoyl-acyl carrier protein reductase; Enoyl-ACP reductase FabI
Gene Name Malaria fabI
DTT Type
Successful target
[1]
BioChemical Class
CH-CH donor oxidoreductase
UniProt ID
Q965D5_PLAFA
TTD ID
T53748
EC Number
EC 1.3.1.9
Sequence
MNKISQRLLFLFLHFYTTVCFIQNNTQKTFHNVLQNEQIRGKEKAFYRKEKRENIFIGNK
MKHVHNMNNTHNNNHYMEKEEQDASNINKIKEENKNEDICFIAGIGDTNGYGWGIAKELS
KRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEE
TKNNKRYNMLQNYPIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSK
SSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLG
RNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNSHDVHNIMNNSGEKEEKKN
SASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIM
FLPDDIYRNENE
Function
Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.

Molecular Interaction Atlas (MIA) of This DTT

Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This DTT
1 Approved Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [1]
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1 Clinical Trial Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [2]
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36 Investigative Drug(s) Targeting This DTT
Drug Name Drug ID Indication ICD 11 Highest Status REF
(-)-CATECHINGALLATE DMZOGSK Discovery agent N.A. Investigative [3]
2-(2,4-dichlorophenoxy)-5-(2-methylbutyl)phenol DM4XL8Z Discovery agent N.A. Investigative [4]
2-(2,4-dichlorophenoxy)-5-(3-phenylpropyl)phenol DME3FUD Discovery agent N.A. Investigative [5]
2-(2,4-dichlorophenoxy)-5-ethylphenol DMPSR1O Discovery agent N.A. Investigative [5]
2-(2,4-dichlorophenoxy)-5-isobutylphenol DMKOFRE Discovery agent N.A. Investigative [4]
2-(2,4-dichlorophenoxy)-5-isopentylphenol DME0LZ2 Discovery agent N.A. Investigative [4]
2-(2,4-dichlorophenoxy)-5-methylphenol DM1L3US Discovery agent N.A. Investigative [5]
2-(2,4-dichlorophenoxy)-5-phenethylphenol DM6ZNR3 Discovery agent N.A. Investigative [4]
2-(2,4-dichlorophenoxy)-5-propylphenol DMKP974 Discovery agent N.A. Investigative [5]
2-(2-((benzylamino)methyl)phenoxy)-5-chlorophenol DMGZKCT Discovery agent N.A. Investigative [6]
2-(4-amino-2-chlorophenoxy)-5-chlorophenol DMUANX1 Discovery agent N.A. Investigative [7]
2-(4-chloro-2-hydroxyphenoxy)benzenaminium DMBHFIM Discovery agent N.A. Investigative [4]
3,7,3',4'-TETRAHYDROXYFLAVONE DMES906 Discovery agent N.A. Investigative [3]
3,7-dihydroxy-flavone DMH04P7 Discovery agent N.A. Investigative [3]
3-chloro-4-(4-chloro-2-hydroxyphenoxy)benzamide DMZ5JFG Discovery agent N.A. Investigative [7]
4-(2,4-dichloro-phenoxy)-2'-methyl-biphenyl-3-ol DMPKE6G Discovery agent N.A. Investigative [5]
4-(2,4-dichloro-phenoxy)-4'-fluoro-biphenyl-3-ol DMAK789 Discovery agent N.A. Investigative [5]
4-(2,4-dichloro-phenoxy)-biphenyl-3-ol DMB96SY Discovery agent N.A. Investigative [5]
4-(2,4-dichlorophenoxy)-3'-methylbiphenyl-3-ol DMY6GWF Discovery agent N.A. Investigative [4]
4-(2,4-dichlorophenoxy)-3-hydroxybenzonitrile DMS7POY Discovery agent N.A. Investigative [5]
4-(2,4-dichlorophenoxy)-4'-methylbiphenyl-3-ol DMRPVO3 Discovery agent N.A. Investigative [4]
4-(2-Thienyl)-1-(4-Methylbenzyl)-1h-Imidazole DMX681M Discovery agent N.A. Investigative [8]
5-benzyl-2-(2,4-dichlorophenoxy)phenol DM5MJ3I Discovery agent N.A. Investigative [4]
5-butyl-2-(2,4-dichlorophenoxy)phenol DMCNU6I Discovery agent N.A. Investigative [4]
5-chloro-2-(2-chloro-4-hydroxyphenoxy)phenol DMDZ8NA Discovery agent N.A. Investigative [7]
5-chloro-2-(2-chloro-4-nitrophenoxy)phenol DMAJ8BS Discovery agent N.A. Investigative [7]
Beta-D-Glucose DM5IHYP Discovery agent N.A. Investigative [8]
BUTEIN DM8E54P Discovery agent N.A. Investigative [2]
Diazaborines DM5UFZX Discovery agent N.A. Investigative [9]
GALLOCATECHIN GALLATE DMX2084 Discovery agent N.A. Investigative [3]
Indole Naphthyridinone DMB4ZNW Discovery agent N.A. Investigative [8]
ISORHAMNETIN DMQ4Z6E Discovery agent N.A. Investigative [3]
MORIN DM2OGZ5 Discovery agent N.A. Investigative [3]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [8]
OROIDIN DMA2DQT Discovery agent N.A. Investigative [10]
Thiolactomycin DMBAWDG Malaria 1F40-1F45 Investigative [1]
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⏷ Show the Full List of 36 Investigative Drug(s)

References

1 Novel molecular targets for antimalarial drug development. Chem Biol Drug Des. 2008 Apr;71(4):287-97.
2 Green tea catechins potentiate triclosan binding to enoyl-ACP reductase from Plasmodium falciparum (PfENR). J Med Chem. 2007 Feb 22;50(4):765-75.
3 Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
4 Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier pr... Eur J Med Chem. 2009 Jul;44(7):3009-19.
5 X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalar... J Biol Chem. 2007 Aug 31;282(35):25436-44.
6 Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan der... Bioorg Med Chem Lett. 2006 Apr 15;16(8):2163-9.
7 Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. ... Bioorg Med Chem Lett. 2005 Dec 1;15(23):5247-52.
8 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
9 Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res. 2001 Nov;40(6):467-97.
10 Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tubercul... Bioorg Med Chem. 2007 Nov 1;15(21):6834-45.