Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQFD42)

Drug Name
Leriglitazone Drug Info
Synonyms
Hydroxypioglitazone; 146062-44-4; Leriglitazone; Hydroxy Pioglitazone (M-IV); MIN-102; Leriglitazone [USAN]; K824X25AYA; CHEBI:82937; UNII-K824X25AYA; 2,4-Thiazolidinedione, 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-; 5-[[4-[2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione; WHO 10868; Hydroxy Pioglitazone-D5 (Major) (M-IV); 2,4-Thiazolidinedione, 5-((4-(2-(5-(1-hydroxyethyl)-2-pyridinyl)ethoxy)phenyl)methyl)-; 5-(4-(2-(5-(1-hydroxyethyl)pyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione; 1-Hydroxypioglitazone; Pioglitazone, hydroxy; LERIGLITAZONE [INN]; Leriglitazone (USAN/INN); CHEMBL1267; SCHEMBL4098326; DTXSID30399914; OXVFDZYQLGRLCD-UHFFFAOYSA-N; BDBM50530214; ZINC01482947; AKOS015856344; DB15021; 5-[[4-[2-[5-(1-Hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione; HY-117727; CS-0067030; FT-0643388; D11603; A1-01710; J-008187; Q27156475; 5-(4-{2-[5-(1-hydroxyethyl)pyridin-2-yl]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione; 5-[4-[2-[5-(1-hydroxyethyl)-2-pyridyl]ethoxy]benzyl]-2,4-thiazolidinedione; ALL-AMBO-5-((4-(2-(5-(1-HYDROXYETHYL)PYRIDIN-2-YL)ETHOXY)PHENYL)METHYL)-1,3-THIAZOLE-2,4(3H,5H)-DIONE
Indication
Disease Entry ICD 11 Status REF
Cerebral X-linked adrenoleukodystrophy 5C57.1 Phase 3 [1]
Cross-matching ID
PubChem CID
4147757
TTD Drug ID
DMQFD42

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Peroxisome proliferator-activated receptor gamma (PPAR-gamma)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [3]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [4]
Lobeglitazone DMHY3IP Type-2 diabetes 5A11 Approved [5]
Rosiglitazone XR DMT45MU Type-2 diabetes 5A11 Approved [6]
Thiazolidinedione DMC1NBW Alzheimer disease 8A20 Approved [4]
Glitazone DMDN4A1 N. A. N. A. Phase 4 [7]
MURAGLITAZAR DMG3NFZ N. A. N. A. Phase 3 [8]
Rivoglitazone DMBY31K Ocular inflammation 9C61.24 Phase 3 [9]
Balaglitazone DMXBHR6 Type-1 diabetes 5A10 Phase 3 [10]
Ragaglitazar DMFSHEM Type-1 diabetes 5A10 Phase 3 [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Peroxisome proliferator-activated receptor gamma (PPAR-gamma) TTZMAO3 PPARG_HUMAN Agonist [2]

References

1 ClinicalTrials.gov (NCT05819866) A Clinical Study to Assess the Efficacy and Safety of Leriglitazone in Adult Male Subjects With Cerebral Adrenoleukodystrophy. U.S.National Institutes of Health.
2 Clinical pipeline report, company report or official report of Minoryx Therapeutics
3 Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists. Int J Cancer. 2003 May 1;104(5):597-602.
4 Functional PPAR-gamma receptor is a novel therapeutic target for ACTH-secreting pituitary adenomas. Nat Med. 2002 Nov;8(11):1281-7.
5 Tolerability and pharmacokinetics of lobeglitazone, a novel peroxisome proliferator-activated receptor-gamma agonist, after a single oral administration in healthy female subjects. Clin Drug Investig. 2014 Jul;34(7):467-74.
6 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
7 Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem. 2000 Jun 2;275(22):16638-42.
8 Muraglitazar, a dual (alpha/gamma) PPAR activator: a randomized, double-blind, placebo-controlled, 24-week monotherapy trial in adult patients with... Clin Ther. 2005 Aug;27(8):1181-95.
9 A randomized-controlled trial to investigate the effects of rivoglitazone, a novel PPAR gamma agonist on glucose-lipid control in type 2 diabetes. Diabetes Obes Metab. 2011 Sep;13(9):806-13.
10 Balaglitazone: a second generation peroxisome proliferator-activated receptor (PPAR) gamma () agonist.Mini Rev Med Chem.2012 Feb;12(2):87-97.
11 Ragaglitazar: the pharmacokinetics, pharmacodynamics, and tolerability of a novel dual PPAR alpha and gamma agonist in healthy subjects and patients with type 2 diabetes. J Clin Pharmacol. 2003 Nov;43(11):1244-56.