Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR3P98)

Drug Name

ORG 34517/34850 Drug Info

Synonyms

Sardomozide; 4-Aiah; SAM 486A; Cgp 48664; UNII-CEB05S0B9I; SAM486A; 149400-88-4; CEB05S0B9I; 4-amidinoindan-1-one 2'-amidinohydrazone; (E)-2-(4-carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazinecarboximidamide; Urea azine with 1-oxo-4-indancarboxamidine; Sardomozide chloride; Hydrazinecarboximidamide, 2-(4-(aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene)-; 4-AMIDINOINDAN-1-ONE-2'-AMIDINOHYDRAZONE; 1443105-76-7; C11H14N6; Cgp 48664A; CHEMBL1202793; Sardomozide [INN]

Indication

Disease Entry	ICD 11	Status	REF
Mood disorder	6A60-6E23	Phase 2	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[2]

Cross-matching ID

PubChem CID: 9576789
CAS Number: CAS 149400-88-4
TTD Drug ID: DMR3P98

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[4]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[5]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[6]
Fluticasone	DMGCSVF	Allergic rhinitis	CA08.0	Approved	[7]
Betamethasone Valerate	DMMIAXO	Dermatological disease	DA24.Y	Approved	[5]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[5]
Deflazacort	DMV0RNS	Duchenne dystrophy	8C70	Approved	[5]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[8]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[9]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[10]
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Drug(s) Targeting S-adenosylmethionine decarboxylase proenzyme (AMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tromethamine	DMOBLGK	Acidosis	5C73	Approved	[11]
Putrescine	DMWE6V1	Burn and burn infection	ND90-NE2Z	Discontinued in Phase 2	[11]
MGBG	DM9GOT6	Head and neck cancer	2D42	Terminated	[3]
CGP-40215A	DM69YWS	Pneumocystis pneumonia	CA40.20	Terminated	[12]
5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine	DM6HGUL	Discovery agent	N.A.	Investigative	[13]
5'-Deoxy-5'-(N,N-dimethylamino)adenosine	DMF7JPO	Discovery agent	N.A.	Investigative	[14]
Hydroxyalanine	DM5HWZY	Discovery agent	N.A.	Investigative	[15]
5'-Deoxy-5'-dimethylsulfonioadenosine chloride	DM1NAMK	Discovery agent	N.A.	Investigative	[14]
[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine	DM3WDOY	Discovery agent	N.A.	Investigative	[14]
5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine	DMT6D5V	Discovery agent	N.A.	Investigative	[13]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucocorticoid receptor (NR3C1)	TTYRL6O	GCR_HUMAN	Antagonist	[1]
S-adenosylmethionine decarboxylase proenzyme (AMD1)	TTBFROQ	DCAM_HUMAN	Inhibitor	[3]

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References

1	Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology. 2008 Aug;33(9):2080-92.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5268).
3	A phase I study of a new polyamine biosynthesis inhibitor, SAM486A, in cancer patients with solid tumours. Br J Cancer. 2000 Sep;83(5):594-601.
4	Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells. Exp Hematol. 2009 May;37(5):559-72.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6	Aldosterone (mineralocorticoid) equivalent to prednisolone (glucocorticoid) in reversing hearing loss in MRL/MpJ-Fas1pr autoimmune mice. Laryngoscope. 2000 Nov;110(11):1902-6.
7	Fluticasone furoate nasal spray in allergic rhinitis. Drugs Today (Barc). 2008 Apr;44(4):251-60.
8	Cytochromes P450 (CYP) in the Poeciliopsis lucida hepatocellular carcinoma cell line (PLHC-1): dose- and time-dependent glucocorticoid potentiation of CYP1A induction without induction of CYP3A. ArchBiochem Biophys. 1996 May 1;329(1):113-22.
9	PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide. Eur J Pharm Sci. 2009 Mar 2;36(4-5):565-71.
10	The glucocorticoid agonist activities of mifepristone (RU486) and progesterone are dependent on glucocorticoid receptor levels but not on EC50 values. Steroids. 2007 Jun;72(6-7):600-8.
11	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
12	Antileishmanial effect of a potent S-adenosylmethionine decarboxylase inhibitor: CGP 40215A. Pharmacol Res. 1996 Jan;33(1):67-70.
13	S-adenosylmethionine decarboxylase as an enzyme target for therapy. Pharmacol Ther. 1992 Dec;56(3):359-77.
14	New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues ... J Med Chem. 2009 Mar 12;52(5):1388-407.
15	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.