Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRDUC0)

Drug Name

Elagolix sodium Drug Info

Synonyms

Elagolix sodium salt; UNII-5948VUI423; Elagolix sodium [USAN]; 5948VUI423; Elagolix sodium (USAN); SCHEMBL1641994; NBI 56418NA; NBI-56418-NA; MolPort-003-984-965; NBI-56418 NA; DQYGXRQUFSRDCH-UQIIZPHYSA-M; AKOS030524154; VA12044; KS-0000063K; KB-76766; HY-14369; AC-29671; CS-0003317; D09336

Indication

Disease Entry	ICD 11	Status	REF
Endometriosis	GA10	Approved	[1]

Cross-matching ID

PubChem CID: 24785956
CAS Number: CAS 832720-36-2
TTD Drug ID: DMRDUC0
ACDINA Drug ID: D01034

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Gonadotropin-releasing hormone receptor (GNRHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gonadorelin	DMAQ469	Amenorrhea	GA20.0	Approved	[2]
Relugolix	DMK7IWL	Prostate cancer	2C82.0	Approved	[3]
Ganirelix	DMGMB30	Ovulation dysfunction	5A80	Approved	[4]
Abarelix	DM5WFNP	Prostate cancer	2C82.0	Approved	[5]
Triptorelin	DMTK4LS	Infertility	GB04	Approved	[6]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[7]
Nafarelin	DMAHEFY	Endometriosis	GA10	Approved	[8]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[9]
Degarelix	DM3O8QY	Prostate cancer	2C82.0	Approved	[10]
AEZS-108	DMAYO46	Acute lymphoblastic leukaemia	2A85	Phase 3	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gonadotropin-releasing hormone receptor (GNRHR)	TT8R70G	GNRHR_HUMAN	Antagonist	[1]

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References

1	2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
2	Use of cognitive behavior therapy for functional hypothalamic amenorrhea. Ann N Y Acad Sci. 2006 Dec;1092:114-29.
3	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
4	Age attenuates testosterone secretion driven by amplitude-varying pulses of recombinant human luteinizing hormone during acute gonadotrope inhibiti... J Clin Endocrinol Metab. 2007 Sep;92(9):3626-32.
5	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6	Regulation of GnRH I receptor gene expression by the GnRH agonist triptorelin, estradiol, and progesterone in the gonadotroph-derived cell line alphaT3-1. Endocrine. 2006 Aug;30(1):139-44.
7	Clinical pipeline report, company report or official report of Takeda (2009).
8	Reversible downregulation of endocrine and germinative testicular function (hormonal castration) in the dog with the GnRH-agonist azagly-nafarelin ... Theriogenology. 2009 Apr 15;71(7):1037-45.
9	Gonadotropin releasing hormone analogs induce apoptosis by extrinsic pathway involving p53 phosphorylation in primary cell cultures of human prostatic adenocarcinomas. Prostate. 2009 Jul 1;69(10):1025-33.
10	Iterative approach to the discovery of novel degarelix analogues: substitutions at positions 3, 7, and 8. Part II. J Med Chem. 2005 Jul 28;48(15):4851-60.
11	Stability of cytotoxic luteinizing hormone-releasing hormone conjugate (AN-152) containing doxorubicin 14-O-hemiglutarate in mouse and human serum in vitro: implications for the design of preclinicalstudies. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):829-34.