Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMSHIQA)

Drug Name
CID755673 Drug Info
Synonyms
CID755673; 521937-07-5; CID 755673; cid-755673; MLS000043346; 7-Hydroxy-2,3,4,5-tetrahydro-1H-benzofuro[2,3-c]azepin-1-one; 7-hydroxy-2,3,4,5-tetrahydro-1H-[1]benzofuro[2,3-c]azepin-1-one; SMR000019965; 7-hydroxy-2,3,4,5-tetrahydro-[1]benzofuro[2,3-c]azepin-1-one; 2,3,4,5-Tetrahydro-7-hydroxy-1H-benzofuro[2,3-c]azepin-1-one; 3-Hydroxy-5,6,7,8-tetrahydro-10-oxa-8-aza-benzo[a]azulen-9-one; AC1LFLHI; SCHEMBL9904268; cid_755673; REGID_for_CID_755673; CHEMBL1450770; BDBM32334; CTK4J5567; CHEBI:92059; KS-00001CWT; EX-A393
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Cross-matching ID
PubChem CID
755673
ChEBI ID
CHEBI:92059
CAS Number
CAS 521937-07-5
TTD Drug ID
DMSHIQA

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Investigative Drug(s)
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Protein kinase D (PRKD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
G6976 DMEZO4M Solid tumour/cancer 2A00-2F9Z Investigative [1]
K252a DMT68RG Solid tumour/cancer 2A00-2F9Z Investigative [1]
CRT0066101 DMX09KI Solid tumour/cancer 2A00-2F9Z Investigative [1]
BPKDi DM5OHIY Solid tumour/cancer 2A00-2F9Z Investigative [1]
INDUS-815B DMBOQ6M Kidney disease GC2Z Investigative [3]
Drug(s) Affected By Copper-transporting ATPase 2 (ATP7B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [4]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [5]
Quercetin DM3NC4M Obesity 5B81 Approved [6]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [7]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [8]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [9]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [10]
Folic Acid DMEMBJC Colorectal carcinoma Approved [11]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [12]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [13]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Protein kinase D (PRKD1) TTSLUMT KPCD1_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Copper-transporting ATPase 2 (ATP7B) OTPWLNCO ATP7B_HUMAN Post-Translational Modifications [2]

References

1 Protein kinase D as a potential new target for cancer therapy. Biochim Biophys Acta. 2010 Dec;1806(2):183-92.
2 Involvement of protein kinase D in expression and trafficking of ATP7B (copper ATPase). J Biol Chem. 2011 Mar 4;286(9):7389-96. doi: 10.1074/jbc.M110.171454. Epub 2010 Dec 27.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1489).
4 Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance. Cancer Res. 2000 Mar 1;60(5):1312-6.
5 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
6 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
7 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
8 The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation. Biochemistry. 2009 Jun 23;48(24):5573-81. doi: 10.1021/bi900325k.
9 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
10 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
11 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
12 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
13 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.