Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTH52F)

• Drug Name: 21-AMINOEPOTHILONE B Drug Info
• Synonyms: BMS-310705; (4S,7R,8S,9S,13R,14S,16S)-13,14-Epoxy-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[1-methyl-2(E)-[2-(aminomethyl)thiazol-4-yl]vinyl]-1-oxacyclohexadecane-2,6-dione

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Terminated	[1]

• Cross-matching ID:
  PubChem CID: 9828138
  CAS Number: CAS 280578-49-6
  TTD Drug ID: DMTH52F

Molecule-Related Drug Atlas

Drug(s) Targeting Tubulin (TUB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[4]
Vinorelbine	DMVXFYE	Advanced cancer	2A00-2F9Z	Approved	[5]
Cabazitaxel	DMPAZHC	Breast cancer	2C60-2C65	Approved	[6]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[7]
Ixabepilone	DM2OZ3G	Breast cancer	2C60-2C65	Approved	[6]
Eribulin	DM1DX4Q	Breast cancer	2C60-2C65	Approved	[6]
Epothilon	DMITJRU	Ovarian cancer	2C73	Phase 3	[8]
DOLASTATIN-10	DMDUV1S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[9]
BMS-188797	DML1CK2	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
Indibulin	DM6OFJ8	Advanced sarcoma	2A60-2C35	Phase 2	[11]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[13]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[14]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[15]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[16]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[19]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[20]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[21]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[22]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[25]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[28]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[29]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[30]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[31]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tubulin (TUB)	TTML2WA	NOUNIPROTAC	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[3]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Gene/Protein Processing	[3]

References

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