Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUPWQT)

• Drug Name: PGF1alpha Drug Info
• Synonyms: U 18714; prostaglandin F1alpha

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5280939
  ChEBI ID: CHEBI:28852
  CAS Number: CAS 745-62-0
  TTD Drug ID: DMUPWQT
  VARIDT Drug ID: DR01480

Molecule-Related Drug Atlas

Drug(s) Targeting Cation channel sperm-associated protein 3 (CatSper3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NNC55-0396	DMID3F7	Discovery agent	N.A.	Investigative	[4]

Drug(s) Targeting Cation channel sperm-associated protein 1 (CatSper1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NNC55-0396	DMID3F7	Discovery agent	N.A.	Investigative	[4]
HC-056456	DMOG1Q4	Discovery agent	N.A.	Investigative	[5]

Drug(s) Targeting Cation channel sperm-associated protein (CatSper)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NNC55-0396	DMID3F7	Discovery agent	N.A.	Investigative	[4]

Drug(s) Targeting Cation channel sperm-associated protein 2 (CatSper2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NNC55-0396	DMID3F7	Discovery agent	N.A.	Investigative	[4]

Drug(s) Affected By Prostaglandin reductase 1 (PTGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[10]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[13]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[14]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cation channel sperm-associated protein (CatSper)	TTWOCZI	NOUNIPROTAC	Activator	[2]
Cation channel sperm-associated protein 1 (CatSper1)	TT5CISB	CTSR1_HUMAN	Activator	[2]
Cation channel sperm-associated protein 2 (CatSper2)	TTOEGC4	CTSR2_HUMAN	Activator	[2]
Cation channel sperm-associated protein 3 (CatSper3)	TTP52ZV	CTSR3_HUMAN	Activator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Prostaglandin reductase 1 (PTGR1)	OTMAR351	PTGR1_HUMAN	Regulation of Drug Effects	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5412).
• [2] Progesterone activates the principal Ca2+ channel of human sperm. Nature. 2011 Mar 17;471(7338):387-91.
• [3] Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis. Chem Biol Interact. 2015 Jun 5;234:105-13.
• [4] The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm. Nature. 2011 Mar 17;471(7338):382-6.
• [5] Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation. PLoS One. 2009 Aug 31;4(8):e6844.
• [6] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [7] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [8] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [9] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [10] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [11] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [12] Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
• [13] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [14] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.