Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUVZAO)

• Drug Name: GSK642444 Drug Info
• Synonyms: threo isoleucyl thiazolidide, 1; BDBM17299

Indication

Disease Entry	ICD 11	Status	REF
Chronic obstructive pulmonary disease	CA22	Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 23647689
  TTD Drug ID: DMUVZAO

Molecule-Related Drug Atlas

Drug(s) Targeting Adrenergic receptor beta-2 (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indacaterol	DMQJHR7	Chronic obstructive pulmonary disease	CA22	Approved	[1]
Formoterol	DMSOURV	Allergic asthma	CA23.0	Approved	[3]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[4]
Arformoterol	DMYM974	Chronic obstructive pulmonary disease	CA22	Approved	[5]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[6]
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[7]
Clenbuterol	DMCKYZ5	Chronic breathing disorder	7A4Z	Approved	[8]
Ritodrine	DM4V6RL	Premature labour	JB00	Approved	[9]
Olodaterol	DM62B78	Chronic obstructive pulmonary disease	CA22	Approved	[10]
Fenoterol	DMIP3ZV	Asthma	CA23	Approved	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-2 (ADRB2)	TT2CJVK	ADRB2_HUMAN	Agonist	[2]

References

• [1] Emerging drugs in chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2009 Mar;14(1):181-94.
• [2] Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
• [3] Long-acting beta2-agonists for chronic obstructive pulmonary disease patients with poorly reversible airflow limitation. Cochrane Database Syst Rev. 2002;(3):CD001104.
• [4] Potential of beta2-adrenoceptor agonists as add-on therapy for multiple sclerosis: focus on salbutamol (albuterol). CNS Drugs. 2002;16(1):1-8.
• [5] Arformoterol tartrate in the treatment of bronchoconstriction in patients with chronic obstructive pulmonary disease. Drugs Today (Barc). 2009 Jan;45(1):3-9.
• [6] Current therapeutic uses and potential of beta-adrenoceptor agonists and antagonists. Eur J Clin Pharmacol. 1998 Feb;53(6):389-404.
• [7] Pharmacogenetic tests in asthma therapy. Clin Lab Med. 2008 Dec;28(4):645-65.
• [8] Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor. Anesth Analg. 2009 Jan;108(1):280-7.
• [9] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [10] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
• [11] Functional alpha1- and beta2-adrenergic receptors in human osteoblasts. J Cell Physiol. 2009 Jul;220(1):267-75.