Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUWTPX)

Drug Name

4-tert-butyl-N-hydroxybenzamide Drug Info

Synonyms

4-tert-butyl-N-hydroxybenzamide; 62034-73-5; CHEMBL249284; Benzamide, 4-(1,1-dimethylethyl)-N-hydroxy-; p-tert-butyl benzohydroxamic acid; Oprea1_740446; SCHEMBL5696343; 4-tert-Butylbenzhydroxamic Acid; 4-tert-Butylbenzohydroxamic acid; CTK2C8432; DTXSID80613051; BDBM50215019; 4-(tert-butyl )-benzhydroxamic acid; ZINC19478595; AKOS000181279

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 21397854
CAS Number: CAS 62034-73-5
TTD Drug ID: DMUWTPX

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Histone deacetylase 1 (HDAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[2]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[3]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[2]
HBI-8000	DMDWYUN	Non-small-cell lung cancer	2C25.Y	Registered	[4]
ITF2357	DMFZBNE	Duchenne dystrophy	8C70	Phase 3	[5]
NVP-LAQ824	DM8JWNA	Mood disorder	6A60-6E23	Phase 3	[6]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[7]
Phenylbutyrate	DMBHPDW	Urea cycle disorder	5C50.A	Phase 2	[8]
MGCD-0103	DM726HX	Non-small-cell lung cancer	2C25.Y	Phase 2	[2]
Resminostat	DMNE1FR	Hepatocellular carcinoma	2C12.02	Phase 2	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histone deacetylase 1 (HDAC1)	TT6R7JZ	HDAC1_HUMAN	Inhibitor	[1]

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References

1	Design of novel histone deacetylase inhibitors. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4619-24.
2	Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov. 2009 Sep;8(9):724-32.
3	Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
4	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
5	Emerging drugs for the therapy of primary and post essential thrombocythemia, post polycythemia vera myelofibrosis. Expert Opin Emerg Drugs. 2009 Sep;14(3):471-9.
6	NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood. 2003 Oct 1;102(7):2615-22.
7	Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
8	Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
9	2011 Pipeline of 4SC AG.