Details of the Drug

General Information of Drug (ID: DM58WKG)

• Drug Name: Panobinostat
• Synonyms: Faridak; LBH 589; LBH589; LBH-589; LBH-589B; NVP-LBH589; NVP-LBH-589; Panobinostat, NVP-LBH589, LBH589; (E)-N-HYDROXY-3-(4-{[2-(2-METHYL-1H-INDOL-3-YL)-ETHYLAMINO]-METHYL}-PHENYL)-ACRYLAMIDE; (E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide

Indication

Disease Entry	ICD 11	Status	REF
Chronic graft versus host disease	N.A.	Approved	[1]
Lung cancer	2C25.0	Approved	[1]
Multiple myeloma	2A83	Approved	[2]
Non-small-cell lung cancer	2C25.Y	Approved	[1]
Plasma cell myeloma	2A83.1	Approved	[1]
Primary cutaneous T-cell lymphoma	N.A.	Approved	[1]
Type-2 diabetes	5A11	Phase 3	[3]
Primary myelofibrosis	2A20.2	Phase 2	[3]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 349.4
  Logarithm of the Partition Coefficient (xlogp); 3
  Rotatable Bond Count (rotbonds); 7
  Hydrogen Bond Donor Count (hbonddonor); 4
  Hydrogen Bond Acceptor Count (hbondacc); 3
• ADMET Property:
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 2 h []
  Clearance: The drug present in the plasma can be removed from the body at the rate of 10.2 mL/min/kg [4]
  Half-life: The concentration or amount of drug in body reduced by one-half in 30 hours [4]
  Unbound Fraction: The unbound fraction of drug in plasma is 0.1% [4]

Adverse Drug Reaction (ADR)

ADR Term	Variation	Related DOT	DOT ID	REF
Cerebrovascular disorder	Not Available	NAA15	OT53SIZG	[5]
Platelet aggregation	Not Available	CBS	OT46FSKD	[5]
Platelet aggregation	Not Available	MTHFR	OTUBJSR7	[5]

• Chemical Identifiers:
  Formula: C21H23N3O2
  IUPAC Name: (E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide
  Canonical SMILES: CC1=C(C2=CC=CC=C2N1)CCNCC3=CC=C(C=C3)/C=C/C(=O)NO
  InChI: InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
  InChIKey: FPOHNWQLNRZRFC-ZHACJKMWSA-N
• Cross-matching ID:
  PubChem CID: 6918837
  ChEBI ID: CHEBI:85990
  CAS Number: 404950-80-7
  DrugBank ID: DB06603
  TTD ID: D0E3SH
  VARIDT ID: DR00181
  INTEDE ID: DR1234
  ACDINA ID: D00507
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histone deacetylase 1 (HDAC1)	TT6R7JZ	HDAC1_HUMAN	Inhibitor	[6]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[7]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[8]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1)	OTJISZOX	PLCE1_HUMAN	Gene/Protein Processing	[9]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[9]
2-hydroxyacylsphingosine 1-beta-galactosyltransferase	OT17ST61	CGT_HUMAN	Gene/Protein Processing	[9]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Gene/Protein Processing	[9]
3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic (HMGCLL1)	OT9SQ5PU	HMGC2_HUMAN	Gene/Protein Processing	[9]
4-aminobutyrate aminotransferase, mitochondrial (ABAT)	OTXAGR7J	GABT_HUMAN	Gene/Protein Processing	[9]
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9 (FUT9)	OTLIJBQY	FUT9_HUMAN	Gene/Protein Processing	[9]
4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL)	OTW7D1SV	HPDL_HUMAN	Gene/Protein Processing	[9]
A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAMTS15)	OTYB6JS3	ATS15_HUMAN	Gene/Protein Processing	[9]
A disintegrin and metalloproteinase with thrombospondin motifs 19 (ADAMTS19)	OTEG5Q2G	ATS19_HUMAN	Gene/Protein Processing	[9]

Molecular Expression Atlas of This Drug

• The Studied Disease: Chronic graft versus host disease

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histone deacetylase 1 (HDAC1)	DTT	HDAC1	6.73E-02	0.24	0.59
P-glycoprotein 1 (ABCB1)	DTP	P-GP	2.55E-01	4.83E-01	5.66E-01
Cytochrome P450 3A4 (CYP3A4)	DME	CYP3A4	1.10E-01	-1.23E-01	-2.88E-01

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Panobinostat (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Metreleptin	DM1NOEK	Moderate	Increased metabolism of Panobinostat caused by Metreleptin mediated induction of CYP450 enzyme.	Acute diabete complication [5A2Y]	[10]
Ivosidenib	DM8S6T7	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Ivosidenib.	Acute myeloid leukaemia [2A60]	[10]
Arn-509	DMT81LZ	Major	Increased metabolism of Panobinostat caused by Arn-509 mediated induction of CYP450 enzyme.	Acute myeloid leukaemia [2A60]	[10]
Gilteritinib	DMTI0ZO	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Gilteritinib.	Acute myeloid leukaemia [2A60]	[10]
Oliceridine	DM6MDCF	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Oliceridine.	Acute pain [MG31]	[10]
Ivabradine	DM0L594	Major	Increased risk of ventricular arrhythmias by the combination of Panobinostat and Ivabradine.	Angina pectoris [BA40]	[11]
Bedaquiline	DM3906J	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Bedaquiline.	Antimicrobial drug resistance [MG50-MG52]	[10]
Levalbuterol	DM5YBO1	Moderate	Increased risk of ventricular arrhythmias by the combination of Panobinostat and Levalbuterol.	Asthma [CA23]	[12]
Pexidartinib	DMS2J0Z	Major	Increased risk of hepatotoxicity by the combination of Panobinostat and Pexidartinib.	Bone/articular cartilage neoplasm [2F7B]	[13]
Eribulin	DM1DX4Q	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Eribulin.	Breast cancer [2C60-2C6Y]	[10]
Tucatinib	DMBESUA	Major	Decreased metabolism of Panobinostat caused by Tucatinib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[14]
Palbociclib	DMD7L94	Moderate	Decreased metabolism of Panobinostat caused by Palbociclib mediated inhibition of CYP450 enzyme.	Breast cancer [2C60-2C6Y]	[14]
Bosutinib	DMTI8YE	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Bosutinib.	Breast cancer [2C60-2C6Y]	[10]
PF-04449913	DMSB068	Major	Increased risk of prolong QT interval by the combination of Panobinostat and PF-04449913.	Chronic myelomonocytic leukaemia [2A40]	[10]
Olodaterol	DM62B78	Moderate	Increased risk of prolong QT interval by the combination of Panobinostat and Olodaterol.	Chronic obstructive pulmonary disease [CA22]	[15]
Vilanterol	DMF5EK1	Moderate	Increased risk of ventricular arrhythmias by the combination of Panobinostat and Vilanterol.	Chronic obstructive pulmonary disease [CA22]	[12]
Regorafenib	DMHSY1I	Major	Increased risk of bleeding by the combination of Panobinostat and Regorafenib.	Colorectal cancer [2B91]	[16]
Ardeparin	DMYRX8B	Major	Increased risk of bleeding by the combination of Panobinostat and Ardeparin.	Coronary thrombosis [BA43]	[16]
Pasireotide	DMHM7JS	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Pasireotide.	Cushing syndrome [5A70]	[10]
Osilodrostat	DMIJC9X	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Osilodrostat.	Cushing syndrome [5A70]	[10]
Ivacaftor	DMZC1HS	Moderate	Decreased metabolism of Panobinostat caused by Ivacaftor mediated inhibition of CYP450 enzyme.	Cystic fibrosis [CA25]	[14]
MK-8228	DMOB58Q	Moderate	Decreased metabolism of Panobinostat caused by MK-8228 mediated inhibition of CYP450 enzyme.	Cytomegaloviral disease [1D82]	[14]
Danaparoid	DM6CLBN	Major	Increased risk of bleeding by the combination of Panobinostat and Danaparoid.	Deep vein thrombosis [BD71]	[16]
Vortioxetine	DM6F1PU	Major	Increased risk of bleeding by the combination of Panobinostat and Vortioxetine.	Depression [6A70-6A7Z]	[17]
OPC-34712	DMHG57U	Major	Decreased metabolism of Panobinostat caused by OPC-34712 mediated inhibition of CYP450 enzyme.	Depression [6A70-6A7Z]	[18]
Deutetrabenazine	DMUPFLI	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Deutetrabenazine.	Dystonic disorder [8A02]	[10]
Ingrezza	DMVPLNC	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Ingrezza.	Dystonic disorder [8A02]	[10]
Stiripentol	DMMSDOY	Moderate	Decreased metabolism of Panobinostat caused by Stiripentol mediated inhibition of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[14]
Eslicarbazepine	DMZREFQ	Moderate	Increased metabolism of Panobinostat caused by Eslicarbazepine mediated induction of CYP450 enzyme.	Epilepsy/seizure [8A61-8A6Z]	[10]
Cannabidiol	DM0659E	Moderate	Increased risk of hepatotoxicity by the combination of Panobinostat and Cannabidiol.	Epileptic encephalopathy [8A62]	[11]
Tazemetostat	DMWP1BH	Moderate	Increased metabolism of Panobinostat caused by Tazemetostat mediated induction of CYP450 enzyme.	Follicular lymphoma [2A80]	[10]
Avapritinib	DMK2GZX	Major	Increased risk of bleeding by the combination of Panobinostat and Avapritinib.	Gastrointestinal stromal tumour [2B5B]	[16]
Boceprevir	DMBSHMF	Major	Decreased metabolism of Panobinostat caused by Boceprevir mediated inhibition of CYP450 enzyme.	Hepatitis virus infection [1E50-1E51]	[14]
Fostemsavir	DM50ILT	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Fostemsavir.	Human immunodeficiency virus disease [1C60-1C62]	[10]
Cobicistat	DM6L4H2	Major	Decreased metabolism of Panobinostat caused by Cobicistat mediated inhibition of CYP450 enzyme.	Human immunodeficiency virus disease [1C60-1C62]	[14]
Rilpivirine	DMJ0QOW	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Rilpivirine.	Human immunodeficiency virus disease [1C60-1C62]	[10]
Teriflunomide	DMQ2FKJ	Major	Additive myelosuppressive effects by the combination of Panobinostat and Teriflunomide.	Hyper-lipoproteinaemia [5C80]	[19]
BMS-201038	DMQTAGO	Major	Increased risk of hepatotoxicity by the combination of Panobinostat and BMS-201038.	Hyper-lipoproteinaemia [5C80]	[20]
Berotralstat	DMWA2DZ	Moderate	Decreased metabolism of Panobinostat caused by Berotralstat mediated inhibition of CYP450 enzyme.	Innate/adaptive immunodeficiency [4A00]	[14]
Suvorexant	DM0E6S3	Moderate	Decreased metabolism of Panobinostat caused by Suvorexant mediated inhibition of CYP450 enzyme.	Insomnia [7A00-7A0Z]	[14]
Polyethylene glycol	DM4I1JP	Major	Increased risk of ventricular arrhythmias by the combination of Panobinostat and Polyethylene glycol.	Irritable bowel syndrome [DD91]	[21]
Denosumab	DMNI0KO	Moderate	Additive myelosuppressive effects by the combination of Panobinostat and Denosumab.	Low bone mass disorder [FB83]	[22]
Crizotinib	DM4F29C	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Crizotinib.	Lung cancer [2C25]	[10]
Ceritinib	DMB920Z	Major	Decreased metabolism of Panobinostat caused by Ceritinib mediated inhibition of CYP450 enzyme.	Lung cancer [2C25]	[14]
PF-06463922	DMKM7EW	Moderate	Increased metabolism of Panobinostat caused by PF-06463922 mediated induction of CYP450 enzyme.	Lung cancer [2C25]	[10]
Osimertinib	DMRJLAT	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Osimertinib.	Lung cancer [2C25]	[10]
Lumefantrine	DM29GAD	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Lumefantrine.	Malaria [1F40-1F45]	[16]
Calaspargase pegol	DMQZBXI	Moderate	Increased risk of hepatotoxicity by the combination of Panobinostat and Calaspargase pegol.	Malignant haematopoietic neoplasm [2B33]	[23]
Idelalisib	DM602WT	Moderate	Increased risk of hepatotoxicity by the combination of Panobinostat and Idelalisib.	Mature B-cell leukaemia [2A82]	[24]
IPI-145	DMWA24P	Moderate	Decreased metabolism of Panobinostat caused by IPI-145 mediated inhibition of CYP450 enzyme.	Mature B-cell leukaemia [2A82]	[14]
Acalabrutinib	DM7GCVW	Major	Increased risk of bleeding by the combination of Panobinostat and Acalabrutinib.	Mature B-cell lymphoma [2A85]	[16]
Ibrutinib	DMHZCPO	Major	Increased risk of bleeding by the combination of Panobinostat and Ibrutinib.	Mature B-cell lymphoma [2A85]	[16]
Arry-162	DM1P6FR	Major	Increased risk of bleeding by the combination of Panobinostat and Arry-162.	Melanoma [2C30]	[16]
Vemurafenib	DM62UG5	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Vemurafenib.	Melanoma [2C30]	[25]
LGX818	DMNQXV8	Major	Increased risk of prolong QT interval by the combination of Panobinostat and LGX818.	Melanoma [2C30]	[10]
Dabrafenib	DMX6OE3	Moderate	Increased metabolism of Panobinostat caused by Dabrafenib mediated induction of CYP450 enzyme.	Melanoma [2C30]	[10]
Tecfidera	DM2OVDT	Moderate	Additive immunosuppressive effects by the combination of Panobinostat and Tecfidera.	Multiple sclerosis [8A40]	[26]
Siponimod	DM2R86O	Major	Increased risk of ventricular arrhythmias by the combination of Panobinostat and Siponimod.	Multiple sclerosis [8A40]	[16]
Fingolimod	DM5JVAN	Major	Additive immunosuppressive effects by the combination of Panobinostat and Fingolimod.	Multiple sclerosis [8A40]	[27]
Ocrelizumab	DMEZ2KH	Moderate	Additive immunosuppressive effects by the combination of Panobinostat and Ocrelizumab.	Multiple sclerosis [8A40]	[28]
Ozanimod	DMT6AM2	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Ozanimod.	Multiple sclerosis [8A40]	[10]
Fedratinib	DM4ZBK6	Major	Increased risk of bleeding by the combination of Panobinostat and Fedratinib.	Myeloproliferative neoplasm [2A20]	[16]
Ruxolitinib	DM7Q98D	Major	Increased risk of bleeding by the combination of Panobinostat and Ruxolitinib.	Myeloproliferative neoplasm [2A20]	[16]
Entrectinib	DMMPTLH	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Entrectinib.	Non-small cell lung cancer [2C25]	[10]
Nepafenac	DMYK490	Moderate	Increased risk of bleeding by the combination of Panobinostat and Nepafenac.	Osteoarthritis [FA00-FA05]	[29]
Rucaparib	DM9PVX8	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Rucaparib.	Ovarian cancer [2C73]	[10]
Triclabendazole	DMPWGBR	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Triclabendazole.	Parasitic worm infestation [1F90]	[10]
Abametapir	DM2RX0I	Moderate	Decreased metabolism of Panobinostat caused by Abametapir mediated inhibition of CYP450 enzyme.	Pediculosis [1G00]	[30]
Macimorelin	DMQYJIR	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Macimorelin.	Pituitary gland disorder [5A60-5A61]	[31]
Lefamulin	DME6G97	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Lefamulin.	Pneumonia [CA40]	[10]
Degarelix	DM3O8QY	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Degarelix.	Prostate cancer [2C82]	[10]
Enzalutamide	DMGL19D	Major	Increased metabolism of Panobinostat caused by Enzalutamide mediated induction of CYP450 enzyme.	Prostate cancer [2C82]	[10]
Relugolix	DMK7IWL	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Relugolix.	Prostate cancer [2C82]	[10]
Golimumab	DMHZV7X	Major	Additive immunosuppressive effects by the combination of Panobinostat and Golimumab.	Rheumatoid arthritis [FA20]	[32]
Anthrax vaccine	DM9GSWY	Moderate	Antagonize the effect of Panobinostat when combined with Anthrax vaccine.	Sepsis [1G40-1G41]	[33]
Voxelotor	DMCS6M5	Moderate	Decreased metabolism of Panobinostat caused by Voxelotor mediated inhibition of CYP450 enzyme.	Sickle-cell disorder [3A51]	[14]
Telotristat ethyl	DMDIYFZ	Moderate	Increased metabolism of Panobinostat caused by Telotristat ethyl mediated induction of CYP450 enzyme.	Small intestine developmental anomaly [DA90]	[11]
Larotrectinib	DM26CQR	Moderate	Decreased metabolism of Panobinostat caused by Larotrectinib mediated inhibition of CYP450 enzyme.	Solid tumour/cancer [2A00-2F9Z]	[14]
LEE011	DMMX75K	Major	Increased risk of prolong QT interval by the combination of Panobinostat and LEE011.	Solid tumour/cancer [2A00-2F9Z]	[10]
Triptorelin	DMTK4LS	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Triptorelin.	Solid tumour/cancer [2A00-2F9Z]	[10]
Pitolisant	DM8RFNJ	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Pitolisant.	Somnolence [MG42]	[10]
Plicamycin	DM7C8YV	Major	Increased risk of bleeding by the combination of Panobinostat and Plicamycin.	Testicular cancer [2C80]	[16]
Fostamatinib	DM6AUHV	Moderate	Decreased metabolism of Panobinostat caused by Fostamatinib mediated inhibition of CYP450 enzyme.	Thrombocytopenia [3B64]	[34]
Apixaban	DM89JLN	Major	Increased risk of bleeding by the combination of Panobinostat and Apixaban.	Thrombosis [DB61-GB90]	[16]
Brilinta	DMBR01X	Moderate	Decreased metabolism of Panobinostat caused by Brilinta mediated inhibition of CYP450 enzyme.	Thrombosis [DB61-GB90]	[14]
Lenvatinib	DMB1IU4	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Lenvatinib.	Thyroid cancer [2D10]	[10]
Cabozantinib	DMIYDT4	Major	Increased risk of prolong QT interval by the combination of Panobinostat and Cabozantinib.	Thyroid cancer [2D10]	[10]
Elagolix	DMB2C0E	Moderate	Increased metabolism of Panobinostat caused by Elagolix mediated induction of CYP450 enzyme.	Uterine fibroid [2E86]	[10]
Betrixaban	DM2C4RF	Major	Increased risk of bleeding by the combination of Panobinostat and Betrixaban.	Venous thromboembolism [BD72]	[16]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
FD&C blue no. 1	E00263	19700	Colorant
Mannitol	E00103	6251	Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Gelatin	E00630	Not Available	Other agent
Magnesium stearate	E00208	11177	lubricant
Titanium dioxide	E00322	26042	Coating agent; Colorant; Opacifying agent
Colcothar yellow	E00436	518696	Colorant
Haematite red	E00236	14833	Colorant
Cellulose microcrystalline	E00698	Not Available	Adsorbent; Suspending agent; Diluent
Pregelatinized starch	E00674	Not Available	Binding agent; Diluent; Disintegrant

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Panobinostat 10 mg capsule	10 mg	Oral Capsule	Oral
Panobinostat 15 mg capsule	15 mg	Oral Capsule	Oral
Panobinostat 20 mg capsule	20 mg	Oral Capsule	Oral
Panobinostat Lactate eq 10mg base capsule	eq 10mg base	Capsule	Oral
Panobinostat Lactate eq 15mg base capsule	eq 15mg base	Capsule	Oral
Panobinostat Lactate eq 20mg base capsule	eq 20mg base	Capsule	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

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