Details of the Drug-Related molecule(s) Interaction Atlas

P-nitrobenzoic acid Drug Info

Benzoic acid, 4-nitro-; Benzoic acid, p-nitro-; Kyselina p-nitrobenzoova; Kyselina p-nitrobenzoova [Czech]; Nitrodracylic acid; OTLNPYWUJOZPPA-UHFFFAOYSA-N; p-Nitrobenzenecarboxylic acid; p-Nitrobenzoic acid; p-Nitrodracylic acid; p-nitro benzoic acid; p-nitrobenzoicacid; para-nitrobenzoic acid; 1-Carboxy-4-nitrobenzene; 4-NITROBENZOIC ACID; 4-Nitro-benzoic acid; 4-Nitrodracylic acid; 62-23-7; AI3-00149; CCRIS 1185; CHEBI:262350; CHEMBL101263; EINECS 200-526-2; G83NWR61OW; HSDB 2140; MFCD00007352; NSC 7707; UNII-G83NWR61OW

Cross-matching ID

PubChem CID

6108

ChEBI ID

CHEBI:262350

CAS Number

CAS 62-23-7

TTD Drug ID

DMVJUOZ

INTEDE Drug ID

DR2208

General Information of Drug (ID: DMVJUOZ)

Molecule-Related Drug Atlas

Molecule Type:

DME

Drug Status:

Approved Drug(s)

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Drug(s) Metabolized By Nitroreductase (NTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrofurantoin	DM7PQIK	Urinary tract infection	GC08	Approved	[1]
Nitrazepam	DMEGIQ6	Epilepsy	8A60-8A68	Approved	[2]
Nitrofurantoin	DM7PQIK	Urinary tract infection	GC08	Approved	[1]
Metronidazole	DMTIVEN	Abscess		Approved	[3]
Nitrofurantoin	DM7PQIK	Urinary tract infection	GC08	Approved	[1]
Nitrofurantoin	DM7PQIK	Urinary tract infection	GC08	Approved	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Nitroreductase (NTR)	DEP7ECA	B1R7B9_CLOPF	Substrate	[1]
Nitroreductase (NTR)	DEAVXGM	A0A412R9E4_9FIRM	Substrate	[1]
Nitroreductase (NTR)	DE7XBKW	A0A174SJF2_9CLOT	Substrate	[1]
Nitroreductase (NTR)	DEH3ABM	A0A351QTB1_CLOSP	Substrate	[1]

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References

1	Isolation of nitrofurantoin-resistant mutants of nitroreductase-producing Clostridium sp. strains from the human intestinal tract. Antimicrob Agents Chemother. 1998 May;42(5):1121-6.
2	Reduction of nitrazepam by Clostridium leptum, a nitroreductase-producing bacterium isolated from the human intestinal tract. Clin Infect Dis. 1997 Sep;25 Suppl 2:S121-2.
3	Acetamide--a metabolite of metronidazole formed by the intestinal flora. Biochem Pharmacol. 1979 Dec 15;28(24):3611-5.