Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMX8M26)

Drug Name

Hyaluronate sodium Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Joint lubricant	FA30-FA38	Approved	[1]
Enthesopathy	FB53-FB55	Phase 3	[2]
Pancytopenia	3A70.Z	Investigative	[3]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

DME

Drug Status:

Discontinued Drug(s)

Approved Drug(s)

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Drug(s) Targeting Hyaluronic acid receptor (LYVE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RG-7356	DMUR6OV	Haematological malignancy	2B33.Y	Discontinued in Phase 1	[8]
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Drug(s) Metabolized By Hyaluronate lyase (hyaL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chondroitin sulfate	DM0N19Y	N. A.	N. A.	Phase 4	[5] , [9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hyaluronic acid receptor (LYVE1)	TTG8DNU	LYVE1_HUMAN	Modulator	[4]

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Drug-Metabolizing Enzyme (DME)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Clinical pipeline report, company report or official report of Genentech.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4954).
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4954).
5	A bacterial ABC transporter enables import of mammalian host glycosaminoglycans. Sci Rep. 2017 Apr 21;7(1):1069.
6	A novel hyaluronidase produced by Bacillus sp. A50. PLoS One. 2014 Apr 15;9(4):e94156.
7	Intracellular oxidative damage due to antibiotics on gut bacteria reduced by glutathione oxidoreductase-derived antioxidant molecule GM15. Arch Microbiol. 2020 Feb 14.
8	Preclinical evaluation of 89Zr-labeled anti-CD44 monoclonal antibody RG7356 in mice and cynomolgus monkeys: Prelude to Phase 1 clinical studies. MAbs. 2014 Mar-Apr;6(2):567-75.
9	A case of Streptobacillus moniliformis infection with cutaneous leukocytoclastic vasculitis. Acta Med Okayama. 2016 Oct;70(5):377-381. Case Reports