Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXWOCP)

• Drug Name: Ethotoin Drug Info
• Synonyms: Accenon; Ethotoine; Ethotoinum; Etotoina; Peganone; Pegoanone; Abbott brand of ethotoin; Accenon (TN); Ethotoine [INN-French]; Ethotoinum [INN-Latin]; Etotoina [INN-Spanish]; Peganone (TN); Ethotoin [INN:BAN:JAN]; Ethotoin (JAN/USP/INN); (+-)-3-Ethyl-5-phenylhydantoin; 1-Ethyl-2,5-dioxo-4-phenylimidazolidine; 3-Ethyl-5-phenyl-2,4-imidazolidinedione; 3-Ethyl-5-phenylhydantoin; 3-Ethyl-5-phenylimidazolidin-2,4-dione; 3-ethyl-5-phenylimidazolidine-2,4-dione

Indication

Disease Entry	ICD 11	Status	REF
Complex partial seizure	8A68.0	Approved	[1]
Epilepsy with generalized tonic-clonic seizures		Approved	[2]

• Therapeutic Class: Anticonvulsants
• Cross-matching ID:
  PubChem CID: 3292
  ChEBI ID: CHEBI:4888
  CAS Number: CAS 86-35-1
  TTD Drug ID: DMXWOCP
  ACDINA Drug ID: D00255

Molecule-Related Drug Atlas

Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.5 (SCN5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mephenytoin	DM5UGDK	Epilepsy	8A60-8A68	Approved	[4]
Mexiletine	DMCTE9R	Ventricular tachycardia	BC71	Approved	[5]
Fosphenytoin	DMOX3LB	Epilepsy	8A60-8A68	Approved	[4]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[5]
LOMERIZINE	DME0TC8	Migraine	8A80	Approved	[6]
Tetrodotoxin	DMWMPRG	Bacterial infection	1A00-1C4Z	Approved	[7]
Dyclonine	DMU6OFP	Pain	MG30-MG3Z	Approved	[8]
Moricizine	DMOMBJW	Arrhythmia	BC9Z	Approved	[9]
Prilocaine	DMI7DZ2	Pain	MG30-MG3Z	Approved	[8]
Hexylcaine	DMEADRK	Anaesthesia	9A78.6	Approved	[3]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated sodium channel alpha Nav1.5 (SCN5A)	TTZOVE0	SCN5A_HUMAN	Blocker	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7183).
• [2] Ethotoin FDA Label
• [3] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [4] Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs. 2009;23(7):555-68.
• [5] Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000 Dec;11(12):1320-9.
• [6] Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37.
• [7] Halothane attenuates the cerebroprotective action of several Na+ and Ca2+ channel blockers via reversal of their ion channel blockade. Eur J Pharmacol. 2002 Oct 4;452(2):175-81.
• [8] Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12.
• [9] From first class to third class: recent upheaval in antiarrhythmic therapy--lessons from clinical trials. Am J Cardiol. 1996 Aug 29;78(4A):28-33.