Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMY6QOR)

Drug Name

KC-12291 Drug Info

Synonyms

KC-12291; CHEMBL452043; SCHEMBL6577701; kc12291; ZINC1545352; NCGC00370808-01

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Voltage-gated sodium channel alpha Nav1.5 (SCN5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mephenytoin	DM5UGDK	Epilepsy	8A60-8A68	Approved	[2]
Mexiletine	DMCTE9R	Ventricular tachycardia	BC71	Approved	[3]
Fosphenytoin	DMOX3LB	Epilepsy	8A60-8A68	Approved	[2]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[3]
LOMERIZINE	DME0TC8	Migraine	8A80	Approved	[4]
Tetrodotoxin	DMWMPRG	Bacterial infection	1A00-1C4Z	Approved	[5]
Dyclonine	DMU6OFP	Pain	MG30-MG3Z	Approved	[6]
Moricizine	DMOMBJW	Arrhythmia	BC9Z	Approved	[7]
Ethotoin	DMXWOCP	Complex partial seizure	8A68.0	Approved	[8]
Prilocaine	DMI7DZ2	Pain	MG30-MG3Z	Approved	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Voltage-gated sodium channel alpha Nav1.5 (SCN5A)	TTZOVE0	SCN5A_HUMAN	Inhibitor	[1]

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References

1	Sodium late current blockers in ischemia reperfusion: is the bullet magic J Med Chem. 2008 Jul 10;51(13):3856-66.
2	Lacosamide: a new approach to target voltage-gated sodium currents in epileptic disorders. CNS Drugs. 2009;23(7):555-68.
3	Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000 Dec;11(12):1320-9.
4	Medicinal chemistry of neuronal voltage-gated sodium channel blockers. J Med Chem. 2001 Jan 18;44(2):115-37.
5	Halothane attenuates the cerebroprotective action of several Na+ and Ca2+ channel blockers via reversal of their ion channel blockade. Eur J Pharmacol. 2002 Oct 4;452(2):175-81.
6	Monoamine transporter and sodium channel mechanisms in the rapid pressor response to cocaine. Pharmacol Biochem Behav. 1998 Feb;59(2):305-12.
7	From first class to third class: recent upheaval in antiarrhythmic therapy--lessons from clinical trials. Am J Cardiol. 1996 Aug 29;78(4A):28-33.
8	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.