General Information of Drug (ID: DMY8IOP)

Drug Name
3,6,9,12,15-Pentaoxaheptadecane Drug Info
Synonyms
3,6,9,12,15-Pentaoxaheptadecane; Diethoxytetraethylene glycol; Tetraethylene glycol diethyl ether; 4353-28-0; Glycol, diethoxytetraethylene; Ether, bis(2-(2-ethoxyethoxy)ethyl); Diethylether tetraethylenglykolu; EINECS 224-423-7; Diethylether tetraethylenglykolu [Czech]; BRN 1767873; bis(2-(2-ethoxyethoxy)ethyl) ether; P3G; 1-ethoxy-2-[2-[2-(2-ethoxyethoxy)ethoxy]ethoxy]ethane; AC1Q58NT; AC1L2UE6; SCHEMBL216926; tetraethyleneglycol diethyl ether; DTXSID0052099; CTK3I9254; CHEBI:44751; HYDWALOBQJFOMS-UHFFFAOYSA-N; ZINC5650744
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
78057
ChEBI ID
CHEBI:44751
CAS Number
CAS 4353-28-0
TTD Drug ID
DMY8IOP

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Drug(s) Targeting Acetylcholinesterase (AChE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [2]
Donepezil DMIYG7Z Advanced cancer 2A00-2F9Z Approved [3]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [4]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [5]
Huperzine A DMMAWLU Alzheimer disease 8A20 Approved [6]
Neostigmine DM6T2J3 Myasthenia gravis 8C6Y Approved [7]
YM443 DMNZCI1 Functional dyspepsia DD90.3 Approved [8]
Ambenonium DMOP0BL Myasthenia gravis 8C6Y Approved [9]
Demecarium bromide DMAYEU1 Open-angle glaucoma 9C61 Approved [10]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [11]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Kynureninase (KYNU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-Amino-4-[3-hydroxyphenyl]-4-hydroxybutanoic acid DM1R3VC Breast cancer 2C60-2C65 Preclinical [12]
S-(2-Aminophenyl)-L-cysteine S,S-dioxide DM9Y05C Bacterial infection 1A00-1C4Z Preclinical [13]
3-methoxydesaminokynurenine DMHVIK3 Discovery agent N.A. Investigative [14]
3-Hydroxyhippuric acid DM2LBFW Discovery agent N.A. Investigative [1]
3-hydroxydesaminokynurenine DM5T6AM Discovery agent N.A. Investigative [14]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetylcholinesterase (AChE) TT1RS9F ACES_HUMAN Inhibitor [1]
Kynureninase (KYNU) TTWQM3J KYNU_HUMAN Inhibitor [1]

References

1 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2 Evidence that the clinical effects of cholinesterase inhibitors are related to potency and targeting of action. Int J Clin Pract Suppl. 2002 Jun;(127):6-19.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465).
4 Acetylcholinesterase activity in Corbicula fluminea Mull., as a biomarker of organophosphate pesticide pollution in Pinacanauan River, Philippines. Environ Monit Assess. 2010 Jun;165(1-4):331-40.
5 [From symptomatic to disease modifying therapy Recent developments in the pharmacotherapy of Alzheimer's disease]. Fortschr Neurol Psychiatr. 2009 Jun;77(6):326-33.
6 Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia. Brain Res. 2002 Sep 13;949(1-2):162-70.
7 Screening of acetylcholinesterase inhibitors by CE after enzymatic reaction at capillary inlet. J Sep Sci. 2009 May;32(10):1748-56.
8 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
9 Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens. Neuropsychopharmacology. 2008 Aug;33(9):2158-66.
10 The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs. Vet Ophthalmol. 2003 Mar;6(1):23-5.
11 Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators. Chem Biol. 2003 Jun;10(6):491-502.
12 2-Amino-4-[3'-hydroxyphenyl]-4-hydroxybutanoic acid; a potent inhibitor of rat and recombinant human kynureninase. Bioorg Med Chem Lett. 2002 Feb 11;12(3):361-3.
13 Structure, mechanism, and substrate specificity of kynureninase. Biochim Biophys Acta. 2011 Nov;1814(11):1481-8.
14 Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase. BMC Biochem. 2003 Sep 24;4:13.