Details of the Drug

General Information of Drug (ID: DMBSK7X)

Drug Name
Isoflurophate
Synonyms
DFP; DIFP; Diflupyl; Diflurophate; Diisopropylfluorfosfat; Diisopropylfluorophosphate; Diisopropylfluorphosphorsaeureester; Diisopropylphosphofluoridate; Diisopropylphosphorofluoridate; Dyflos; Floropryl; Fluoropryl; Fluorostigmine; Fluostigmine; Fluropryl; Isofluorophate; Isofluorphate; Isoflurophosphate; Neoglaucit; Di isopropylphosphorofluoridate; Diisopropoxyphosphoryl fluoride; Diisopropyl fluoridophosphate; Diisopropyl fluorophosphate; Diisopropyl fluorophosphonate; Diisopropyl phosphofluoridate; Diisopropyl phosphorofluoridate; Diisopropylfluorfosfat [Czech]; Diisopropylfluorophosphoric acid ester; Diisopropylfluorphosphorsaeureester [German]; Disiopropyl fluorophosphonate; Fluorodiisopropyl phosphate; Isoflurophate [USP]; Isopropyl fluophosphate; Isopropyl phosphorofluoridate; Merck Brand of Isoflurophate; Phosphoric acid diisopropyl ester fluoride; EA 1152; TL 466; DIISOPROPYL-FLUOROPHOSPHATE; Di-isopropylphosphorofluoridate; Floropryl (TN); Fluophosphoric acid, diisopropyl ester; Fluorophosphoric acid, diisopropyl ester; Isoflurophate (USP); PF-3; Phosphorofluoridic acid, diisopropyl ester; T-1703; Bis(1-methylethyl) Phosphorofluoridate; Dipropan-2-yl phosphorofluoridoate; O,O-Diisopropyl fluorophosphate; Bis(propan-2-yl) fluorophosphate; O,O'-Diisopropyl phosphoryl fluoride; Phosphorofluoridic acid, bis(1-methylethyl) ester; 2-[fluoro(propan-2-yloxy)phosphoryl]oxypropane
Indication
Disease Entry ICD 11 Status REF
Glaucoma/ocular hypertension 9C61 Approved [1]
Therapeutic Class
Antiglaucomic Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 184.15
Topological Polar Surface Area (xlogp) 1.2
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 0
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C6H14FO3P
IUPAC Name
2-[fluoro(propan-2-yloxy)phosphoryl]oxypropane
Canonical SMILES
CC(C)OP(=O)(OC(C)C)F
InChI
InChI=1S/C6H14FO3P/c1-5(2)9-11(7,8)10-6(3)4/h5-6H,1-4H3
InChIKey
MUCZHBLJLSDCSD-UHFFFAOYSA-N
Cross-matching ID
PubChem CID
5936
ChEBI ID
CHEBI:17941
CAS Number
55-91-4
DrugBank ID
DB00677
TTD ID
D0B2OT

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Acetylcholinesterase (AChE) TT1RS9F ACES_HUMAN Inhibitor [2]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Glaucoma/ocular hypertension
ICD Disease Classification 9C61
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Acetylcholinesterase (AChE) DTT ACHE 6.39E-02 -1.07 -1.15
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Isoflurophate (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Scopolamine DMOM8AL Moderate Antagonize the effect of Isoflurophate when combined with Scopolamine. Addictive disorder [6C50-6C5Z] [13]
Mepyramine DMB4SFH Moderate Antagonize the effect of Isoflurophate when combined with Mepyramine. Allergic/hypersensitivity disorder [4A80-4A8Z] [13]
Phenyltoloxamine DMKAEQW Moderate Antagonize the effect of Isoflurophate when combined with Phenyltoloxamine. Allergic/hypersensitivity disorder [4A80-4A8Z] [13]
Desipramine DMT2FDC Moderate Antagonize the effect of Isoflurophate when combined with Desipramine. Attention deficit hyperactivity disorder [6A05] [13]
Umeclidinium DM4E8O9 Moderate Antagonize the effect of Isoflurophate when combined with Umeclidinium. Chronic obstructive pulmonary disease [CA22] [13]
Tiotropium DMFDC0Q Moderate Antagonize the effect of Isoflurophate when combined with Tiotropium. Chronic obstructive pulmonary disease [CA22] [13]
Revefenacin DMMP5SI Moderate Antagonize the effect of Isoflurophate when combined with Revefenacin. Chronic obstructive pulmonary disease [CA22] [13]
Trimipramine DM1SC8M Moderate Antagonize the effect of Isoflurophate when combined with Trimipramine. Depression [6A70-6A7Z] [13]
Cyclobenzaprine DM1YBRM Moderate Antagonize the effect of Isoflurophate when combined with Cyclobenzaprine. Depression [6A70-6A7Z] [13]
OPC-34712 DMHG57U Moderate Antagonize the effect of Isoflurophate when combined with OPC-34712. Depression [6A70-6A7Z] [13]
Clomipramine DMINRKW Moderate Antagonize the effect of Isoflurophate when combined with Clomipramine. Depression [6A70-6A7Z] [13]
Doxepin DMPI98T Moderate Antagonize the effect of Isoflurophate when combined with Doxepin. Depression [6A70-6A7Z] [13]
Mepenzolate DM8YU2F Moderate Antagonize the effect of Isoflurophate when combined with Mepenzolate. Digestive system disease [DE2Z] [13]
Oxybutynine DMJPBAX Moderate Antagonize the effect of Isoflurophate when combined with Oxybutynine. Discovery agent [N.A.] [13]
Meclizine DMS7T13 Moderate Antagonize the effect of Isoflurophate when combined with Meclizine. Dizziness and giddiness [MB48] [13]
Diphenhydramine DMKQTBA Moderate Antagonize the effect of Isoflurophate when combined with Diphenhydramine. Episodic vestibular syndrome [AB31] [13]
Tropicamide DM1D90W Moderate Antagonize the effect of Isoflurophate when combined with Tropicamide. Eye anterior segment structural developmental anomaly [LA11] [13]
Solifenacin DMG592Q Moderate Antagonize the effect of Isoflurophate when combined with Solifenacin. Functional bladder disorder [GC50] [13]
Tolterodine DMSHPW8 Moderate Antagonize the effect of Isoflurophate when combined with Tolterodine. Functional bladder disorder [GC50] [13]
Propantheline DM2EN6G Moderate Antagonize the effect of Isoflurophate when combined with Propantheline. Gastric ulcer [DA60] [13]
Cyclopentolate DMA8LM5 Moderate Antagonize the effect of Isoflurophate when combined with Cyclopentolate. General examination [QA00] [13]
Belladonna DM2RBWK Moderate Antagonize the effect of Isoflurophate when combined with Belladonna. Infectious gastroenteritis/colitis [1A40] [13]
ITI-007 DMUQ1DO Moderate Antagonize the effect of Isoflurophate when combined with ITI-007. Insomnia [7A00-7A0Z] [13]
Clidinium DMUMQZ0 Moderate Antagonize the effect of Isoflurophate when combined with Clidinium. Irritable bowel syndrome [DD91] [13]
Dicyclomine DMZSDGX Moderate Antagonize the effect of Isoflurophate when combined with Dicyclomine. Irritable bowel syndrome [DD91] [13]
Thalidomide DM70BU5 Moderate Increased risk of ventricular arrhythmias by the combination of Isoflurophate and Thalidomide. Multiple myeloma [2A83] [14]
Siponimod DM2R86O Major Increased risk of bradycardia by the combination of Isoflurophate and Siponimod. Multiple sclerosis [8A40] [14]
Fingolimod DM5JVAN Moderate Increased risk of atrioventricular block by the combination of Isoflurophate and Fingolimod. Multiple sclerosis [8A40] [15]
Ozanimod DMT6AM2 Moderate Increased risk of atrioventricular block by the combination of Isoflurophate and Ozanimod. Multiple sclerosis [8A40] [16]
Dimenhydrinate DM264B3 Moderate Antagonize the effect of Isoflurophate when combined with Dimenhydrinate. Nausea/vomiting [MD90] [13]
Promethazine DM6I5GR Moderate Antagonize the effect of Isoflurophate when combined with Promethazine. Nausea/vomiting [MD90] [13]
Flavoxate DMKV4NL Moderate Antagonize the effect of Isoflurophate when combined with Flavoxate. Pain [MG30-MG3Z] [13]
Biperiden DME78OA Moderate Antagonize the effect of Isoflurophate when combined with Biperiden. Parkinsonism [8A00] [13]
Orphenadrine DMW542E Moderate Antagonize the effect of Isoflurophate when combined with Orphenadrine. Parkinsonism [8A00] [13]
Methylscopolamine DM5VWOB Moderate Antagonize the effect of Isoflurophate when combined with Methylscopolamine. Peptic ulcer [DA61] [13]
Quetiapine DM1N62C Moderate Antagonize the effect of Isoflurophate when combined with Quetiapine. Schizophrenia [6A20] [13]
Mesoridazine DM2ZGAN Moderate Antagonize the effect of Isoflurophate when combined with Mesoridazine. Schizophrenia [6A20] [13]
Thioridazine DM35M8J Moderate Antagonize the effect of Isoflurophate when combined with Thioridazine. Schizophrenia [6A20] [13]
Aripiprazole DM3NUMH Moderate Antagonize the effect of Isoflurophate when combined with Aripiprazole. Schizophrenia [6A20] [13]
Perphenazine DMA4MRX Moderate Antagonize the effect of Isoflurophate when combined with Perphenazine. Schizophrenia [6A20] [13]
Molindone DMAH70G Moderate Antagonize the effect of Isoflurophate when combined with Molindone. Schizophrenia [6A20] [13]
Thiothixene DMDINC4 Moderate Antagonize the effect of Isoflurophate when combined with Thiothixene. Schizophrenia [6A20] [13]
Trifluoperazine DMKBYWI Moderate Antagonize the effect of Isoflurophate when combined with Trifluoperazine. Schizophrenia [6A20] [13]
Risperidone DMN6DXL Moderate Antagonize the effect of Isoflurophate when combined with Risperidone. Schizophrenia [6A20] [13]
Pimozide DMW83TP Moderate Antagonize the effect of Isoflurophate when combined with Pimozide. Schizophrenia [6A20] [13]
Chlorpheniramine DM5URA2 Moderate Antagonize the effect of Isoflurophate when combined with Chlorpheniramine. Vasomotor/allergic rhinitis [CA08] [13]
Carbinoxamine DMCT31R Moderate Antagonize the effect of Isoflurophate when combined with Carbinoxamine. Vasomotor/allergic rhinitis [CA08] [13]
Brompheniramine DMFOVSD Moderate Antagonize the effect of Isoflurophate when combined with Brompheniramine. Vasomotor/allergic rhinitis [CA08] [13]
Acrivastine DMTIGA0 Moderate Antagonize the effect of Isoflurophate when combined with Acrivastine. Vasomotor/allergic rhinitis [CA08] [13]
Procainamide DMNMXR8 Moderate Antagonize the effect of Isoflurophate when combined with Procainamide. Ventricular tachyarrhythmia [BC71] [13]
⏷ Show the Full List of 50 DDI Information of This Drug

References

1 Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006;12(28):3665-79.
2 Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators. Chem Biol. 2003 Jun;10(6):491-502.
3 Evidence that the clinical effects of cholinesterase inhibitors are related to potency and targeting of action. Int J Clin Pract Suppl. 2002 Jun;(127):6-19.
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2465).
5 Acetylcholinesterase activity in Corbicula fluminea Mull., as a biomarker of organophosphate pesticide pollution in Pinacanauan River, Philippines. Environ Monit Assess. 2010 Jun;165(1-4):331-40.
6 [From symptomatic to disease modifying therapy Recent developments in the pharmacotherapy of Alzheimer's disease]. Fortschr Neurol Psychiatr. 2009 Jun;77(6):326-33.
7 Huperzine A attenuates cognitive deficits and brain injury in neonatal rats after hypoxia-ischemia. Brain Res. 2002 Sep 13;949(1-2):162-70.
8 Screening of acetylcholinesterase inhibitors by CE after enzymatic reaction at capillary inlet. J Sep Sci. 2009 May;32(10):1748-56.
9 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
10 Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens. Neuropsychopharmacology. 2008 Aug;33(9):2158-66.
11 The effects of topical ocular application of 0.25% demecarium bromide on serum acetylcholinesterase levels in normal dogs. Vet Ophthalmol. 2003 Mar;6(1):23-5.
12 Neuromuscular blockade, reversal agent use, and operating room time: retrospective analysis of US inpatient surgeries. Curr Med Res Opin. 2009 Apr;25(4):943-50.
13 Multum Information Services, Inc. Expert Review Panel.
14 Cerner Multum, Inc. "Australian Product Information.".
15 Product Information. Gilenya (fingolimod). Novartis Pharmaceuticals, East Hanover, NJ.
16 Product Information. Zeposia (ozanimod). Celgene Corporation, Summit, NJ.