General Information of Drug (ID: DMY9FDT)

Drug Name
2'-Deoxyguanosine-5'-Monophosphate Drug Info
Synonyms
Deoxyguanylic acid; Deoxy-GMP; 2'-Deoxyguanylic acid; Deoxyguanylate; Deoxyguanosine 5'-monophosphate; dGMP; 2'-Deoxy-GMP; 2'-dGMP; Deoxyguanosine monophosphate; Deoxyguanosine 5'-phosphate; 2'-Deoxyguanosine 5'-phosphate; 2'-Deoxy-5'-guanylic acid; 2'-deoxyguanosine 5'-monophosphate; 5'-DGMP; 5'-Deoxyguanylic acid; Deoxy GMP; 2'-Deoxyguanosine 5'MP; 902-04-5; deoxyguanosine-phosphate; 5'-Guanylic acid, 2'-deoxy-; 2'-dG-5'-MP; 2'-Deoxy-5'-GMP; UNII-7EAM4TG712; 2'-Deoxyguanosine 5'-phosphoric; 5'-dGMP
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
135398597
ChEBI ID
CHEBI:16192
CAS Number
CAS 902-04-5
TTD Drug ID
DMY9FDT

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [3]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [4]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [5]
Trifluridine DMG2YBD Herpetic keratitis 1F00.10 Approved [6]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [7]
Raltitrexed DMT9K8G Rectal adenocarcinoma 2B92 Approved [8]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [9]
Flucytosine DM13VTW Cryptococcal meningitis Approved [10]
Nolatrexed DMOF0CA Solid tumour/cancer 2A00-2F9Z Phase 3 [11]
Plevitrexed (R)-isomer DMTL39C Gastric adenocarcinoma 2B72 Phase 2 [12]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Candida Thymidylate synthase (Candi TMP1) TTU6BFZ TYSY_CANAL Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5122).
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 The efficacy of the combination therapy of 5-fluorouracil, cisplatin and leucovorin for hepatocellular carcinoma and its predictable factors. Cancer Chemother Pharmacol. 2004 Apr;53(4):296-304.
4 Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. Int J Cancer. 2003 Feb 20;103(5):587-99.
5 Updated clinical information on multitargeted antifolates in lung cancer. Clin Lung Cancer. 2009 Mar;10 Suppl 1:S35-40.
6 Trifluorothymidine induces cell death independently of p53. Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):699-703.
7 UGT1A7 and UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan. Clin Cancer Res. 2005 Feb 1;11(3):1226-36.
8 DNA damage and homologous recombination signaling induced by thymidylate deprivation. Biochem Pharmacol. 2008 Oct 15;76(8):987-96.
9 Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells. Br J Pharmacol. 1999 Aug;127(8):1777-86.
10 Antifungal agents: mode of action in yeast cells. Rev Esp Quimioter. 2006 Jun;19(2):130-9.
11 A phase I study of the lipophilic thymidylate synthase inhibitor Thymitaq (nolatrexed dihydrochloride) given by 10-day oral administration. Br J Cancer. 1999 Feb;79(5-6):915-20.
12 Cooperative inhibition of human thymidylate synthase by mixtures of active site binding and allosteric inhibitors. Biochemistry. 2007 Mar 13;46(10):2823-30.