Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZM5KE)

Drug Name

arachidonylcyclopropylamide Drug Info

Synonyms

arachidonyl cyclopropylamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 5311007
CAS Number: CAS 229021-64-1
TTD Drug ID: DMZM5KE

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting N-arachidonyl glycine receptor (GPR18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
N-arachidonoylglycine	DM85RJ1	Discovery agent	N.A.	Investigative	[4]
O-1602	DM9VISB	Discovery agent	N.A.	Investigative	[3]
abnormal cannabidiol	DMV6DAO	Discovery agent	N.A.	Investigative	[3]
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Drug(s) Targeting Cannabinoid receptor 1 (CB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[5]
NABILONE	DMVRYT2	Insomnia	7A00-7A0Z	Approved	[6]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[7]
SR141716A	DMCO5JZ	Obesity	5B81	Approved	[8]
Tebipenem	DMVSX6O	Urinary tract infection	GC08	Phase 3	[9]
Conatumumab	DM2UOSN	Colorectal cancer	2B91.Z	Phase 2	[10]
GW-42004	DMY3KSU	Lipid metabolism disorder	5C52.Z	Phase 2	[11]
SR-147778	DMNAECP	Obesity	5B81	Phase 2	[12]
Nimacimab	DM21Z68	Diabetic nephropathy	GB61.Z	Phase 2	[13]
AEF0117	DMQ1GH4	Marijuana use disorder	6C41	Phase 2	[14]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cannabinoid receptor 1 (CB1)	TT6OEDT	CNR1_HUMAN	Agonist	[2]
N-arachidonyl glycine receptor (GPR18)	TTSLJAR	GPR18_HUMAN	Agonist	[3]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 739).
2	Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1). J Pharmacol Exp Ther. 1999 Jun;289(3):1427-33.
3	Delta(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells. Br J Pharmacol. 2012 Apr;165(8):2414-24.
4	Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18. Biochem Biophys Res Commun. 2006 Sep 1;347(3):827-32.
5	Emerging strategies for exploiting cannabinoid receptor agonists as medicines. Br J Pharmacol. 2009 Feb;156(3):397-411.
6	Novel 1',1'-chain substituted hexahydrocannabinols: 9-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid r... J Med Chem. 2010 Oct 14;53(19):6996-7010.
7	Tetrahydrolipstatin analogues as modulators of endocannabinoid 2-arachidonoylglycerol metabolism. J Med Chem. 2008 Nov 13;51(21):6970-9.
8	Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50.
9	Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60.
10	Clinical pipeline report, company report or official report of AstraZeneca (2009).
11	Company report (Gwpharm)
12	Surinabant, a selective cannabinoid receptor type 1 antagonist, inhibits 9-tetrahydrocannabinol-induced central nervous system and heart rate effects in humans.Br J Clin Pharmacol.2013 Jul;76(1):65-77.
13	Clinical pipeline report, company report or official report of Bird Rock Bio.
14	Clinical pipeline report, company report or official report of Affimed Therapeutics.