Details of the Drug Reposition

General Information of This Drug (ID: DM4YDAJ)

• Drug Name: Sildenafil (DM4YDAJ)
• Synonyms: sildenafil; 139755-83-2; VIAGRA; Sildenafil [INN:BAN]; UK-92480; UNII-3M7OB98Y7H; UK-92,480-10; C22H30N6O4S; HSDB 7305; CHEMBL192; UK 92480-10; CHEBI:9139; 3M7OB98Y7H; BNRNXUUZRGQAQC-UHFFFAOYSA-N; Sildenafil
• Therapeutic Class: Antiviral Agents
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

2 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Alveolar capillary dysplasia with misalignment of pulmonary veins	DIS6CNDL	N.A.	Approved	[1]
Erectile dysfunction	DISD8MTH	HA01.1	Approved	[2]

1 Phase 3 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Coronavirus Disease 2019 (COVID-19)	DISM7GNX	1D6Y	Phase 3	[3]

4 Discontinued in Phase 3 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Coronary vasospasm	DISSHV10	N.A.	Discontinued in Phase 3	[4]
Persistent fetal circulation syndrome	DISSDYEX	N.A.	Discontinued in Phase 3	[5]
Pulmonary arterial hypertension	DISP8ZX5	BB01.0	Discontinued in Phase 3	[6]
Pre-eclampsia	DISY7Q29	JA24	Discontinued in Phase 3	[7]

1 Investigative Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Respiratory failure	DISVMYJO	CB41	Investigative	[1]

References

• [1] Sildenafil FDA Label
• [2] FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 206401.
• [3] ClinicalTrials.gov (NCT04304313) A Pilot Study of Sildenafil in COVID-19. U.S. National Institutes of Health.
• [4] Efficacy of Pentoxifylline on Rapidly Progressive Glomerulonephritis
• [5] Quetiapine Extended Release (XR) Treatment of Major Depressive Disorder With Comorbid Generalized Anxiety Disorder
• [6] Plasma Exchange for Renal Vasculitis
• [7] Trametinib in Treating Patients With Recurrent or Progressive Low-Grade Ovarian Cancer or Peritoneal Cavity Cancer