Details of Disease

General Information of Disease (ID: DISVMYJO)

Disease Name Respiratory failure
Synonyms
acute and chronic respiratory failure; acute-on-chronic respiratory failure; chronic respiratory failure; acute respiratory failure; respiratory failure; failure, respiratory; respiratory insufficiency/failure
Disease Class CB41: Respiratory failure
Definition
The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function.
Disease Hierarchy
DIS1LT8E: Lung disease
DISVMYJO: Respiratory failure
ICD Code
ICD-11
ICD-11: CB41
ICD-10
ICD-10: J96
ICD-9
ICD-9: 518.81
Expand ICD-11
'CB41
Expand ICD-10
'J96
Expand ICD-9
518.81
Disease Identifiers
MONDO ID
MONDO_0021113
MESH ID
D012131
UMLS CUI
C1145670
MedGen ID
257837
HPO ID
HP:0002878
SNOMED CT ID
409622000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Dexmedetomidine DM93L4X Approved Small molecular drug [1]
Nitric Oxide DM1RBYG Approved Small molecular drug [2]
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This Disease is Treated as An Indication in 1 Drugs in Phase 3 Trial
Drug Name Drug ID Highest Status Drug Type REF
Sildenafil DM4YDAJ Phase 3 Trial Small molecular drug [3]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
PS948115 DM7DZS6 Discontinued in Phase 1 NA [4]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 24 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CHAT TTKYFSB Limited Genetic Variation [5]
FLNA TTSTRZY Limited Biomarker [6]
FUS TTKGYZ9 Limited Genetic Variation [7]
SCN4A TT84DRB Limited Genetic Variation [8]
SMN1 TT8QL6X Limited Biomarker [9]
BCHE TT3MSAO moderate Biomarker [10]
LAMC2 TTNS7H3 moderate Genetic Variation [11]
MECP2 TTTAU9R moderate Biomarker [12]
MGAM TTXWASR moderate Genetic Variation [13]
TARDBP TT9RZ03 moderate Genetic Variation [14]
CACNA1S TT94HRF Strong Biomarker [15]
CRYAB TT7RUHB Strong Genetic Variation [16]
EML4 TT92GY4 Strong Altered Expression [17]
GAA TTLPC70 Strong Biomarker [18]
IGF1R TTQFBMY Strong Biomarker [19]
MAPT TTS87KH Strong Biomarker [20]
OPRM1 TTKWM86 Strong Biomarker [21]
PLAT TTXAGYU Strong Therapeutic [22]
POLB TTA0XPV Strong Genetic Variation [23]
SHCBP1 TTZ9WGL Strong Biomarker [24]
SLC23A1 TT6XAGK Strong Biomarker [25]
TRH TT2Z39D Strong Therapeutic [26]
TRPM4 TTJ2HKA Strong Biomarker [27]
SLC18A3 TTV8KWS Definitive Biomarker [28]
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⏷ Show the Full List of 24 DTT(s)
This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCA3 DT2T6VQ Limited Biomarker [29]
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This Disease Is Related to 1 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
SI DE5EO4Y moderate Genetic Variation [13]
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This Disease Is Related to 53 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CEBPG OTGNAX3H Limited Biomarker [30]
MEGF10 OTILSPJ6 Limited Biomarker [31]
SCO2 OTJQQDRS Limited Genetic Variation [32]
SMN2 OT54RLO1 Limited Biomarker [9]
TTN OT0LZ058 Limited Genetic Variation [33]
HPS4 OTBTW01J Disputed Biomarker [34]
SELENON OTSGKO5M Disputed Genetic Variation [35]
ACTA1 OTOVGLPG moderate Genetic Variation [36]
COLQ OT4BHUGQ moderate Genetic Variation [37]
DCTN1 OT5B51FJ moderate Genetic Variation [38]
GLE1 OT0K44H1 moderate Genetic Variation [39]
LAMA2 OTFROQWE moderate Genetic Variation [40]
MYOT OTCEW5XW moderate Genetic Variation [41]
NABP2 OTQU8081 moderate Biomarker [42]
SPSB1 OTGY26U4 moderate Biomarker [42]
TBCD OTS4JKNQ moderate Biomarker [43]
TK2 OTS1V4XB moderate Genetic Variation [44]
ACADVL OT50L4XB Strong Genetic Variation [45]
ARSL OTF1VTCR Strong Biomarker [46]
ATOH1 OTBZYG2R Strong Biomarker [47]
CAPN3 OTCHG3YK Strong Genetic Variation [48]
DEPP1 OTB36PHJ Strong Biomarker [49]
EXOSC9 OTFKB37F Strong Genetic Variation [50]
FBLN5 OTLVNZ8U Strong Biomarker [51]
FEV OTYEC4IR Strong Genetic Variation [52]
FLNC OT3F8J6Y Strong Genetic Variation [16]
FOXF1 OT2CJZ5K Strong Genetic Variation [53]
IFIH1 OTZA2AHA Strong Biomarker [54]
IFT80 OTMH0MBI Strong Biomarker [55]
IGFALS OTTWCZYM Strong Biomarker [56]
IGHMBP2 OTAZFPF5 Strong Genetic Variation [57]
LRIT1 OTNEQPMZ Strong Biomarker [24]
MARCHF10 OTAYGHDM Strong Biomarker [58]
MGME1 OTC5LPXX Strong Genetic Variation [59]
MYOG OTPLJKFA Strong Genetic Variation [60]
MYRF OTKF6AEB Strong Genetic Variation [61]
NAXE OTRZPISQ Strong Genetic Variation [62]
NDST1 OT9E10W2 Strong Biomarker [63]
NKX2-1 OTCMEJTA Strong Genetic Variation [64]
PDYN OTEJ6430 Strong Therapeutic [65]
PHF14 OTZT3GV1 Strong Biomarker [66]
PIEZO2 OTQ7AT38 Strong Genetic Variation [67]
PPP6R2 OTERHESI Strong Genetic Variation [68]
SARS1 OTFKXQ1O Strong Genetic Variation [69]
SARS2 OTU4T99W Strong Genetic Variation [69]
SFTPB OTOHS07E Strong Biomarker [70]
SNRPN OTQB1ID1 Strong Biomarker [71]
SNX27 OTVPS7S0 Strong Genetic Variation [72]
TBX4 OTW58FG4 Strong Genetic Variation [73]
TNRC6B OTGVT0SH Strong Biomarker [74]
TPM2 OTA1L0P8 Strong Genetic Variation [75]
TTF1 OT4K90WD Strong Genetic Variation [64]
SFTPC OTIZJD09 Definitive Biomarker [76]
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⏷ Show the Full List of 53 DOT(s)

References

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