Details of the Drug Reposition

General Information of This Drug (ID: DMDNJHG)

• Drug Name: Aztreonam (DMDNJHG)
• Synonyms: Azactam; Primbactam; Azactam (TN); SQ-26776; Monobactam, SQ 26776, Squibb 26776, Aztreonam; [2S-[2alpha,3beta(Z)]]-2-[[[1-(2-Amino-4-thiazolyl)-2-[(2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino]-2-oxoethylidene]amino]oxy]-2-methylpropanoic acid; 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-{[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino}-2-oxoethylidene]amino}oxy)-2-methylpropanoic acid; 2-[(Z)-[1-(2-amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid
• Therapeutic Class: Antibiotics
• Drug Type: Small molecular drug

Information on Drug Reposition of This Drug

5 Approved Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Pseudomonas aeruginosa infectious disease	DISC07AQ	N.A.	Approved	[1]
Peritonitis	DISMCMLQ	N.A.	Approved	[1]
Endometritis	DISHGJ6G	N.A.	Approved	[1]
Bacterial infection	DIS5QJ9S	1A00-1C4Z	Approved	[2]
Urinary tract infection	DISMT6UV	GC08	Approved	[1]

3 Discontinued in Phase 2 Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Rhinoscleroma	DISNSWVK	N.A.	Discontinued in Phase 2	[3]
Bacterial urinary tract infection	DISNNJTF	N.A.	Discontinued in Phase 2	[4]
Escherichia coli infection	DISPP65M	1A03	Discontinued in Phase 2	[5]

1 Investigative Indication(s)

Indication Name	Indication ID	ICD-11	Status	REF
Pelvic inflammatory disease	DISWQR4J	GA05	Investigative	[1]

References

• [1] Aztreonam FDA Label
• [2] Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
• [3] Trial for Microarray Analysis of Colon Cancer Outcome-A (MACCO-A)
• [4] Effects of Inhaled Treprostinil Sodium for the Treatment of Pulmonary Hypertension Associated With Idiopathic Pulmonary Fibrosis
• [5] Gemcitabine, Cisplatin, Plus Lenalidomide as First-line Therapy for Patients With Metastatic Urothelial Carcinoma