Details of Disease

General Information of Disease (ID: DISWQR4J)

• Disease Name: Pelvic inflammatory disease
• Synonyms: pelvic inflammatory disease, (PID); pelvic infection; inflammatory disease (PID), pelvic; disease (PID), pelvic inflammatory; PID, pelvic inflammatory disease; pelvic inflammatory disease; PID
• Disease Class: GA05: Female pelvic inflammatory disease
• Definition: Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity. It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. PID may be either symptomatic or asymptomatic. It may cause infertility and it may raise the risk of ectopic pregnancy. PID is a disease associated with HIV infection.
• Disease Hierarchy:
  DISWD40R: Disease
  DISXEPZF: Gynecological disease
  DIS184KT: Skin inflammation
  DISWQR4J: Pelvic inflammatory disease
• ICD Code: ICD-11: ICD-11: GA05
• Disease Identifiers:
  MONDO ID: MONDO_0000922
  MESH ID: D000292
  UMLS CUI: C0242172
  MedGen ID: 66845
  SNOMED CT ID: 198130006

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 15 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amphotericin B	DMTAJQE	Approved	Small molecular drug	[1]
Ampicillin	DMHWE7P	Approved	Small molecular drug	[2]
Aztreonam	DMDNJHG	Approved	Small molecular drug	[3]
Cefotetan	DM07TX3	Approved	Small molecular drug	[4]
Cefoxitin	DMY8NC4	Approved	NA	[5]
Ceftazidime	DM41GRA	Approved	Small molecular drug	[6]
Ceftriaxone	DMCEW64	Approved	Small molecular drug	[7]
Cilastatin	DME2H5T	Approved	Small molecular drug	[8]
Clindamycin	DM15HL8	Approved	Small molecular drug	[9]
Imipenem	DMI9FBP	Approved	Small molecular drug	[8]
Piperacillin	DMTBKF3	Approved	Small molecular drug	[10]
SprayGel	DMNGQL2	Approved	NA	[11]
Tazobactam	DM3XNUI	Approved	Small molecular drug	[12]
Tetracycline	DMZA017	Approved	Small molecular drug	[13]
Ticarcillin	DM4ME02	Approved	Small molecular drug	[14]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 9 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CD19	TTW640A	moderate	Biomarker	[15]
CTSA	TT5NILS	Strong	Altered Expression	[16]
IL4	TTLGTKB	Strong	Therapeutic	[17]
MAP3K14	TT4LIAC	Strong	Genetic Variation	[18]
P2RY14	TT72OKI	Strong	Altered Expression	[19]
STK4	TTCPLVN	Strong	Genetic Variation	[20]
TIRAP	TTKU0LS	Strong	Biomarker	[21]
TNFRSF13B	TTL9OD4	Strong	Genetic Variation	[22]
WAS	TTE8T73	Strong	Genetic Variation	[23]

This Disease Is Related to 8 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MTA2	OTCCYIQJ	moderate	Genetic Variation	[24]
CARD11	OTRCTLYC	Strong	Biomarker	[25]
DOCK8	OTNQLL21	Strong	Genetic Variation	[26]
IL2RG	OTRZ3OMY	Strong	Genetic Variation	[27]
LRBA	OTOUZN9G	Strong	Biomarker	[28]
MAN1B1	OTI780UB	Strong	Altered Expression	[16]
RASGRP1	OTX9WN2E	Strong	Biomarker	[29]
ROM1	OTE7H0YV	Strong	Biomarker	[30]

References

• [1] Amphotericin B FDA Label
• [2] Ampicillin FDA Label
• [3] Aztreonam FDA Label
• [4] Cefotetan FDA Label
• [5] Cefoxitin FDA Label
• [6] Ceftazidime FDA Label
• [7] Ceftriaxone FDA Label
• [8] Cilastatin FDA Label
• [9] Clindamycin FDA Label
• [10] Piperacillin FDA Label
• [11] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [12] Tazobactam FDA Label
• [13] Tetracycline FDA Label
• [14] Ticarcillin FDA Label
• [15] Managing costs in primary immunodeficiency: minimal immunophenotyping and three national references.APMIS. 2019 Apr;127(4):228-235. doi: 10.1111/apm.12932.
• [16] Increased activity of lysosomal enzymes in the peritoneal fluid of patients with gynecologic cancers and pelvic inflammatory disease.J Cancer Res Clin Oncol. 2005 Jun;131(6):371-6. doi: 10.1007/s00432-004-0649-5. Epub 2005 Mar 23.
• [17] [Effect of Smilax china bioactive fraction on tumor necrosis factor- and interleukin-4 contents in uterine tissue of rats with chronic pelvic inflammatory disease].Nan Fang Yi Ke Da Xue Xue Bao. 2014 Feb;34(2):236-40.
• [18] Exome Sequencing Identifies a Novel MAP3K14 Mutation in Recessive Atypical Combined Immunodeficiency.Front Immunol. 2017 Nov 27;8:1624. doi: 10.3389/fimmu.2017.01624. eCollection 2017.
• [19] The UDP-glucose receptor P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8.J Immunol. 2009 Jun 1;182(11):7074-84. doi: 10.4049/jimmunol.0900001.
• [20] EBV Negative Lymphoma and Autoimmune Lymphoproliferative Syndrome Like Phenotype Extend the Clinical Spectrum of Primary Immunodeficiency Caused by STK4 Deficiency.Front Immunol. 2018 Oct 16;9:2400. doi: 10.3389/fimmu.2018.02400. eCollection 2018.
• [21] Racial variation in toll-like receptor variants among women with pelvic inflammatory disease.J Infect Dis. 2013 Mar 15;207(6):940-6. doi: 10.1093/infdis/jis922. Epub 2012 Dec 18.
• [22] Rare TACI Mutation in a 3-Year-Old Boy With CVID Phenotype.Front Pediatr. 2019 Oct 15;7:418. doi: 10.3389/fped.2019.00418. eCollection 2019.
• [23] The role of WASp in T cells and B cells.Cell Immunol. 2019 Jul;341:103919. doi: 10.1016/j.cellimm.2019.04.007. Epub 2019 Apr 17.
• [24] Convergent and Discriminant Validity of Personality Inventory for DSM-5-BF in a Primary Care Sample.J Pers Disord. 2019 Dec;33(6):846-856. doi: 10.1521/pedi_2018_32_372. Epub 2018 Oct 24.
• [25] Hyper-IgE in the allergy clinic--when is it primary immunodeficiency?.Allergy. 2018 Nov;73(11):2122-2136. doi: 10.1111/all.13578. Epub 2018 Oct 2.
• [26] DOCK8 mutation diagnosed using whole-exome sequencing of the dried blood spot-derived DNA: a case report of an Iraqi girl diagnosed in Japan.BMC Med Genet. 2019 Jun 26;20(1):114. doi: 10.1186/s12881-019-0837-4.
• [27] Novel RAG1 mutation and the occurrence of mycobacterial and Chromobacterium violaceum infections in a case of leaky SCID.Microb Pathog. 2017 Aug;109:114-119. doi: 10.1016/j.micpath.2017.05.033. Epub 2017 May 25.
• [28] Monogenic polyautoimmunity in primary immunodeficiency diseases.Autoimmun Rev. 2018 Oct;17(10):1028-1039. doi: 10.1016/j.autrev.2018.05.001. Epub 2018 Aug 11.
• [29] Novel Mutations in RASGRP1 are Associated with Immunodeficiency, Immune Dysregulation, and EBV-Induced Lymphoma.J Clin Immunol. 2018 Aug;38(6):699-710. doi: 10.1007/s10875-018-0533-8. Epub 2018 Jul 20.
• [30] Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study.J Neuroinflammation. 2008 Nov 21;5:52. doi: 10.1186/1742-2094-5-52.