Details of Disease

Disease Name

Endometritis

uterine infection; inflammation of endometrium; endometrium inflammation

Definition

An acute or chronic, usually bacterial infectious process affecting the endometrium. It may extend to the myometrium and parametrial tissues. Symptoms include lower abdominal pain, vaginal discharge, and vaginal bleeding.

Disease Hierarchy

DISWD40R: Disease

DIS0837X: Endometrial disorder

DIS3FXDI: Mucositis

DISHGJ6G: Endometritis

Disease Identifiers

MONDO ID

MONDO_0000918

MESH ID

D004716

UMLS CUI

C0014179

MedGen ID

41789

HPO ID

HP:0025636

SNOMED CT ID

78623009

General Information of Disease (ID: DISHGJ6G)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 9 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Aztreonam	DMDNJHG	Approved	Small molecular drug	[1]
Cefotetan	DM07TX3	Approved	Small molecular drug	[2]
Cefoxitin	DMY8NC4	Approved	NA	[3]
Ceftazidime	DM41GRA	Approved	Small molecular drug	[4]
Ceftriaxone	DMCEW64	Approved	Small molecular drug	[5]
Cilastatin	DME2H5T	Approved	Small molecular drug	[6]
Ertapenem	DM4S3O8	Approved	Small molecular drug	[7]
Imipenem	DMI9FBP	Approved	Small molecular drug	[6]
Metronidazole	DMTIVEN	Approved	Small molecular drug	[8]
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⏷ Show the Full List of 9 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CASP6	TTKW4ML	Strong	Therapeutic	[9]
CASP7	TTM7Y45	Strong	Therapeutic	[9]
CASP9	TTB6T7O	Strong	Therapeutic	[9]
IL1A	TTPM6HI	Strong	Biomarker	[10]
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This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC26A2	DTFSLX5	Strong	Biomarker	[11]
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This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DDAH2	OT8Q40G2	Strong	Biomarker	[12]
FGF12	OTBM9QIO	Strong	Biomarker	[11]
GPAT3	OTJUGPK0	Strong	Biomarker	[11]
NLRP5	OTLU1YML	Strong	Biomarker	[13]
SPINK5	OT61IIAO	Strong	Biomarker	[11]
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References

1	Aztreonam FDA Label
2	Cefotetan FDA Label
3	Cefoxitin FDA Label
4	Ceftazidime FDA Label
5	Ceftriaxone FDA Label
6	Cilastatin FDA Label
7	Ertapenem FDA Label
8	Metronidazole FDA Label
9	Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats.Biol Trace Elem Res. 2016 Oct;173(2):345-53. doi: 10.1007/s12011-016-0659-6. Epub 2016 Feb 26.
10	Uterine cytokine profile in a rat model of endometritis.Am J Reprod Immunol. 2015 Mar;73(3):214-20. doi: 10.1111/aji.12330. Epub 2014 Oct 20.
11	Genomic breeding values, SNP effects and gene identification for disease traits in cow training sets.Anim Genet. 2018 Jun;49(3):178-192. doi: 10.1111/age.12661. Epub 2018 Apr 6.
12	Elevated Levels of ADMA Are Associated with Lower DDAH2 and Higher PRMT1 in LPS-Induced Endometritis Rats.Inflammation. 2018 Feb;41(1):299-306. doi: 10.1007/s10753-017-0687-1.
13	The "RESEAU MATER": An efficient infection control for endometritis, but not for urinary tract infection after vaginal delivery.J Infect Public Health. 2017 Jul-Aug;10(4):457-469. doi: 10.1016/j.jiph.2016.08.002. Epub 2016 Sep 1.