Details of the Drug

General Information of Drug (ID: DMJMVKI)

• Drug Name: Metipranolol
• Synonyms: Disorat; Methypranol; Metipranololum; Trimepranol; Turoptin; BM-01004; Betanol (TN); Disorat (TN); Metipranololum [INN-Latin]; OptiPranolol (TN); Trimepranol (TN); VUAB-6453; VUFB-6453; Metipranolol (USAN/INN); Metipranolol [USAN:BAN:INN]; [4-[2-hydroxy-3-(propan-2-ylamino)propoxy]-2,3,6-trimethylphenyl] acetate; Phenol, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2,3,6-trimethyl-, 1-acetate; Phenol, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2,3,6-trimethyl-, 1-acetate (9CI); Phenol,4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2,3,6-trimethyl-, (+-)-, 1-acetate; (+-)-1-(4-Hydroxy-2,3,5-trimethylphenoxy)-3-(isopropylamino)-2-propanol 4-acetate; (RS)-4-(2-Hydroxy-3-isopropylaminopropoxy)-2,3,6-trimethylphenyl acetat; 1-(4-Acetoxy-2,3,5-Trimethylphenoxy)-3-Isopropylamino-2-Propanol; 1-(4-Hydroxy-2,3,5-trimethylphenoxy)-3-(isopropylamino)-2-propanol 4-acetate; 2-Propanol, 1-(4-hydroxy-2,3,5-trimethylphenoxy)-3-(isopropylamino)-, 4-acetate; 4-(2-Hydroxy-3-((1-methylethyl)-amino)propoxy)-2,3,6-trimethylphenol 1-acetate; 4-[2-hydroxy-3-(isopropylamino)propoxy]-2,3,6-trimethylphenyl acetate; 62164P

Indication

Disease Entry	ICD 11	Status	REF
Open-angle glaucoma	9C61	Approved	[1], [2], [3]

• Therapeutic Class: Antihypertensive Agents
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 309.4
  Topological Polar Surface Area (xlogp); 2.7
  Rotatable Bond Count (rotbonds); 8
  Hydrogen Bond Donor Count (hbonddonor); 2
  Hydrogen Bond Acceptor Count (hbondacc); 5
• Chemical Identifiers:
  Formula: C17H27NO4
  IUPAC Name: [4-[2-hydroxy-3-(propan-2-ylamino)propoxy]-2,3,6-trimethylphenyl] acetate
  Canonical SMILES: CC1=CC(=C(C(=C1OC(=O)C)C)C)OCC(CNC(C)C)O
  InChI: InChI=1S/C17H27NO4/c1-10(2)18-8-15(20)9-21-16-7-11(3)17(22-14(6)19)13(5)12(16)4/h7,10,15,18,20H,8-9H2,1-6H3
  InChIKey: BQIPXWYNLPYNHW-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 31477
  ChEBI ID: CHEBI:6897
  CAS Number: 22664-55-7
  DrugBank ID: DB01214
  TTD ID: D0L5FY
  INTEDE ID: DR1066

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-1 (ADRB1)	TTR6W5O	ADRB1_HUMAN	Antagonist	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2D6 (CYP2D6) Main DME	DECB0K3	CP2D6_HUMAN	Substrate	[5]

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Metipranolol (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Bepridil	DM0RKS4	Moderate	Increased risk of cardiac depression by the combination of Metipranolol and Bepridil.	Angina pectoris [BA40]	[24]
Dronedarone	DMA8FS5	Moderate	Increased risk of atrioventricular block by the combination of Metipranolol and Dronedarone.	Angina pectoris [BA40]	[25]
Atracurium	DM42HXN	Moderate	Additive neuromuscular blocking effects by the combination of Metipranolol and Atracurium.	Corneal disease [9A76-9A78]	[26]
Mivacurium	DM473VD	Moderate	Additive neuromuscular blocking effects by the combination of Metipranolol and Mivacurium.	Corneal disease [9A76-9A78]	[26]
Pancuronium	DMB0VY8	Moderate	Additive neuromuscular blocking effects by the combination of Metipranolol and Pancuronium.	Corneal disease [9A76-9A78]	[26]
Pasireotide	DMHM7JS	Moderate	Increased risk of bradycardia by the combination of Metipranolol and Pasireotide.	Cushing syndrome [5A70]	[27]
Levamlodipine	DM92S6N	Moderate	Increased risk of cardiac depression by the combination of Metipranolol and Levamlodipine.	Hypertension [BA00-BA04]	[24]
Clevidipine butyrate	DMW4M97	Moderate	Increased risk of cardiac depression by the combination of Metipranolol and Clevidipine butyrate.	Hypertension [BA00-BA04]	[24]
Siponimod	DM2R86O	Major	Increased risk of atrioventricular block by the combination of Metipranolol and Siponimod.	Multiple sclerosis [8A40]	[28]
Fingolimod	DM5JVAN	Moderate	Increased risk of bradycardia by the combination of Metipranolol and Fingolimod.	Multiple sclerosis [8A40]	[29]
Ozanimod	DMT6AM2	Moderate	Increased risk of bradycardia by the combination of Metipranolol and Ozanimod.	Multiple sclerosis [8A40]	[30]
Polythiazide	DMCH80F	Moderate	Increased risk of hypertriglyceridemia by the combination of Metipranolol and Polythiazide.	Oedema [MG29]	[31]
Silodosin	DMJSBT6	Moderate	Additive hypotensive effects by the combination of Metipranolol and Silodosin.	Prostate hyperplasia [GA90]	[32]
Pipecuronium	DM5F84A	Moderate	Additive neuromuscular blocking effects by the combination of Metipranolol and Pipecuronium.	Tonus and reflex abnormality [MB47]	[26]
Vecuronium	DMP0UK2	Moderate	Additive neuromuscular blocking effects by the combination of Metipranolol and Vecuronium.	Tonus and reflex abnormality [MB47]	[26]

References

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