Details of the Drug

General Information of Drug (ID: DMQEC6Z)

• Drug Name: Melanoma vaccine
• Synonyms: NA17.A2 peptides, Institut Curie; Vaccine (melanoma), Institut Curie; Melanoma vaccine (NA17.A2/tyrosinase/MART-1, gp100); Melanoma vaccine (NA17.A2/tyrosinase/MART-1, gp100), Institut Curie

Indication

Disease Entry	ICD 11	Status	REF
Melanoma	2C30	Phase 3	[1]

• Drug Type: Vaccine
• Cross-matching ID: TTD ID: D0U9MJ

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
MART-1 melanoma antigen (MLANA)	TT362RB	MAR1_HUMAN	Not Available	[2]
Melanocytes lineage-specific antigen GP100 (PMEL)	TT8MK59	PMEL_HUMAN	Not Available	[2]
Tyrosinase (TYR)	TTULVH8	TYRO_HUMAN	Not Available	[2]

Molecular Expression Atlas of This Drug

• ICD Disease Classification: 02 Neoplasm
• Disease Class: ICD-11: 2C82 Prostate cancer
• The Studied Tissue: Skin
• The Studied Disease: Melanoma [ICD-11:2C82]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Tyrosinase (TYR)	DTT	TYR	6.68E-04	2.54	1.15
Melanocytes lineage-specific antigen GP100 (PMEL)	DTT	PMEL	1.08E-03	1.89	1.06
MART-1 melanoma antigen (MLANA)	DTT	MLANA	3.29E-02	1.64	0.76

References

• [1] ClinicalTrials.gov (NCT00036816) Vaccine Therapy in Treating Patients With Melanoma of the Eye. U.S. National Institutes of Health.
• [2] National Cancer Institute Drug Dictionary (drug id 685201).