Details of Disease

General Information of Disease (ID: DISTVL0C)

• Disease Name: Anemia
• Synonyms: anemia (disease); anemia; anaemia (disease)
• Disease Class: 3A00-3A9Z: Anemia
• Definition: A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability.
• Disease Hierarchy:
  DIS9XD9A: Hematologic disease
  DISTVL0C: Anemia
• ICD Code:
  ICD-11: ICD-11: 3A00-3A9Z
  ICD-10: ICD-10: D50-D64
• Disease Identifiers:
  MONDO ID: MONDO_0002280
  MESH ID: D000740
  UMLS CUI: C0002871
  MedGen ID: 1526
  HPO ID: HP:0001903
  SNOMED CT ID: 271737000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 9 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Calcium levofolinate	DMVG98V	Approved	Small molecular drug	[1]
Cyanocobalamin	DMYY0AJ	Approved	NA	[1]
Darbepoetin alfa	DMMJTYW	Approved	NA	[2]
Epoetin alfa	DMKWB73	Approved	NA	[3]
Hemoglobin glutamer	DMPKAWJ	Approved	NA	[1]
Iron proteinsuccinylate	DMYDNZ3	Approved	NA	[1]
Levoleucovorin	DMH5LME	Approved	Small molecular drug	[1]
Mecobalamin	DM0C63F	Approved	NA	[4]
Siltuximab	DMGEATB	Approved	Antibody	[5]

This Disease is Treated as An Indication in 25 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ACE-536	DMRI15Q	Phase 3	NA	[6]
Epoetin zeta	DM9QPOU	Phase 3	NA	[7]
ErepoXen	DM9YI2C	Phase 3	NA	[8]
Hematide	DMUE843	Phase 3	NA	[9]
Hemoglobin raffimer	DMMTL7V	Phase 2/3	NA	[10]
Roledumab	DMWZ6DK	Phase 2/3	Antibody	[11]
5-hydroxymethyl-2-furfural	DMPFVJB	Phase 2	Small molecular drug	[12]
BAY-85-3934	DM7NHLC	Phase 2	Small molecular drug	[13]
Erythropoietin gene therapy	DMG5BDT	Phase 2	NA	[14]
INCB00928	DMFG8TI	Phase 2	Small molecular drug	[15]
MK-2578	DM1M57I	Phase 2	NA	[16]
NOX-H94	DM5HPZU	Phase 2	NA	[17]
Soluble FePPi	DMRORBG	Phase 2	NA	[18]
SPD602	DMKJ9LU	Phase 2	NA	[19]
Erythropoietin-transfected autologous cell therapy	DMNZ6VA	Phase 1/2	NA	[20]
PBI-1402	DMC8K91	Phase 1/2	NA	[21]
ACE-011	DMJ36YH	Phase 1	Small molecular drug	[22]
DA-3880	DM5O1LU	Phase 1	NA	[23]
DS-1093	DM42KZW	Phase 1	NA	[24]
Ferroportin mab	DM13YK0	Phase 1	Antibody	[25]
GC-1113	DMK96CE	Phase 1	NA	[26]
Hepcidin mab	DMBFYSR	Phase 1	Antibody	[27]
Long-acting erythropoietin conjugate	DM9OA35	Phase 1	NA	[28]
LY2787106	DM9NYHT	Phase 1	Antibody	[29]
Retroviral MGMT-transduced hematopoietic cells	DMJTW0A	Phase 1	NA	[30]

This Disease is Treated as An Indication in 6 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Inactine	DM1DGAE	Discontinued in Phase 3	NA	[31]
ETRX-101	DMRB23N	Discontinued in Phase 2	NA	[32]
Rozrolimupab	DMNBUS7	Discontinued in Phase 2	Antibody	[33]
FC EPO	DMEX12T	Discontinued in Phase 1	NA	[34]
Albupoietin	DMXK4CI	Terminated	NA	[35]
RHb1.1	DM7CY0T	Terminated	NA	[36]

This Disease is Treated as An Indication in 23 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AFT-EPO	DMED3YX	Investigative	NA	[37]
ALN-HPN	DMJDLAF	Investigative	NA	[37]
BBT-009	DM2YTXL	Investigative	NA	[38]
BBT-021	DMLIT84	Investigative	NA	[38]
BR-05001	DM6CQDR	Investigative	NA	[37]
CKD-406	DMIGMFD	Investigative	NA	[37]
EPO peptide mimetics	DMP2QF0	Investigative	NA	[38]
Erythropoietin	DM3R8YL	Investigative	NA	[39]
FG-6874	DMN07VU	Investigative	NA	[37]
GX-E2	DMW40HT	Investigative	NA	[37]
Hemoxin	DM9SHZF	Investigative	NA	[37]
Human serum albumin	DMWDH1Q	Investigative	NA	[37]
JNJ-42041935	DM08YTN	Investigative	Small molecular drug	[37]
MOD-7023	DMVITGF	Investigative	NA	[37]
Nova-EPO	DM82DNL	Investigative	NA	[38]
P-1116	DMQ6TZE	Investigative	NA	[38]
PanCyte	DMBIVKT	Investigative	NA	[37]
PEG-EPO	DM5GVZJ	Investigative	NA	[38]
PEGylated recombinant EPO	DMNVPVN	Investigative	NA	[37]
PT-401	DM736T8	Investigative	NA	[38]
TBI-304	DM5MHGP	Investigative	NA	[37]
YPEG-EPO	DMTSZYU	Investigative	NA	[37]
ZP-EPO	DMEWYLE	Investigative	NA	[37]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 105 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ABCA1	TTJW1GN	Limited	Genetic Variation	[40]
ACVRL1	TTGYPTC	Limited	Biomarker	[41]
CACNA2D3	TTN7T29	Limited	Genetic Variation	[42]
CD59	TTBGTEJ	Limited	Altered Expression	[43]
F2	TT6L509	Limited	Genetic Variation	[44]
FABP3	TT3TGLR	Limited	Biomarker	[45]
HLA-B	TTGS10J	Limited	Biomarker	[46]
LCAT	TTGZ91P	Limited	Genetic Variation	[47]
PDGFRA	TT8FYO9	Limited	Biomarker	[48]
PRL	TTJ2TSA	Limited	Altered Expression	[49]
SLC17A5	TTFSUIA	Limited	Biomarker	[50]
SLC29A1	TTLXAKE	Limited	Genetic Variation	[51]
THRA	TTTSEPU	Limited	Biomarker	[52]
ACR	TTAHE2N	moderate	Genetic Variation	[53]
ANK1	TTKFPMH	moderate	Genetic Variation	[54]
CALCR	TTLWS2O	moderate	Biomarker	[55]
IFNA2	TTSIUJ9	moderate	Genetic Variation	[56]
MTHFR	TTQWOU1	moderate	Genetic Variation	[57]
PTH	TT6F7GZ	moderate	Altered Expression	[58]
SLC40A1	TT6Y1PG	moderate	Altered Expression	[59]
SLC6A8	TTYUHB5	moderate	Biomarker	[55]
TYMS	TTP1UKZ	moderate	Genetic Variation	[60]
ACHE	TT1RS9F	Strong	Biomarker	[61]
AGT	TT5C0UB	Strong	Biomarker	[62]
ALAD	TTJHKYD	Strong	Biomarker	[63]
APOA1	TT5S8DR	Strong	Biomarker	[64]
APOH	TT2OUI9	Strong	Biomarker	[65]
ATG7	TTLVB9Z	Strong	Biomarker	[66]
BACH1	TT2ME4S	Strong	Altered Expression	[67]
BMP6	TT07RIB	Strong	Biomarker	[68]
BRIP1	TTZV7LJ	Strong	Biomarker	[69]
CA5A	TT75WPO	Strong	Biomarker	[70]
CAD	TT2YT1K	Strong	Genetic Variation	[71]
CASR	TTBUYHA	Strong	Genetic Variation	[72]
CCL21	TTLZK1U	Strong	Altered Expression	[73]
CDK6	TTO0FDJ	Strong	Biomarker	[74]
CEACAM5	TTY6DTE	Strong	Biomarker	[75]
CSF3	TT5TQ2W	Strong	Biomarker	[76]
CSNK1A1	TTFQEMX	Strong	Biomarker	[77]
CUBN	TT9YLCR	Strong	Genetic Variation	[78]
DYRK3	TTV4EX0	Strong	Altered Expression	[79]
E2F2	TT5FYX0	Strong	Genetic Variation	[80]
EGLN1	TT9ISBX	Strong	Biomarker	[81]
EPHB6	TTZEMUY	Strong	Biomarker	[82]
EPOR	TTAUX24	Strong	Biomarker	[83]
F10	TTCIHJA	Strong	Biomarker	[84]
F11	TTDM4ZU	Strong	Biomarker	[85]
FABP1	TTIV96N	Strong	Altered Expression	[86]
FABP2	TTS4YLO	Strong	Altered Expression	[86]
FANCA	TTV5HJS	Strong	Genetic Variation	[87]
FCGR2A	TTXT21W	Strong	Biomarker	[88]
FECH	TTQ6VF4	Strong	Genetic Variation	[89]
FGF23	TT2IZ4K	Strong	Biomarker	[90]
FUT3	TTUPAD7	Strong	Biomarker	[91]
G6PD	TTKN8W0	Strong	Genetic Variation	[92]
GBA	TT1B5PU	Strong	Altered Expression	[93]
GPX1	TTYAHBP	Strong	Therapeutic	[94]
GSR	TTEP6RV	Strong	Biomarker	[95]
HBB	TTM6HK1	Strong	Biomarker	[96]
HP	TTLC8E1	Strong	Biomarker	[97]
IFNAR1	TTSYFMA	Strong	Biomarker	[98]
IFNAR2	TTMQB37	Strong	Biomarker	[98]
IGF2	TTE8WGO	Strong	Therapeutic	[99]
IL12B	TTGW72V	Strong	Genetic Variation	[100]
IL2	TTF89GD	Strong	Altered Expression	[101]
JAK1	TT6DM01	Strong	Biomarker	[102]
KIT	TTX41N9	Strong	Altered Expression	[103]
KLK4	TT4319X	Strong	Biomarker	[104]
LAIR1	TTSI7A8	Strong	Biomarker	[105]
LCK	TT860QF	Strong	Biomarker	[106]
LTF	TTSZDQU	Strong	Altered Expression	[107]
MAOB	TTGP7BY	Strong	Biomarker	[108]
MPL	TTIHYA4	Strong	Genetic Variation	[109]
MUC1	TTBHFYQ	Strong	Altered Expression	[110]
NCOA4	TT8OY02	Strong	Biomarker	[111]
NEK1	TTO5QT2	Strong	Genetic Variation	[112]
PI4KA	TTCUS9F	Strong	Altered Expression	[113]
PKLR	TT31N4S	Strong	Genetic Variation	[114]
PNP	TTMCF1Y	Strong	Altered Expression	[115]
PPOX	TTNFMS9	Strong	Genetic Variation	[116]
PRCP	TTTJZ4M	Strong	Biomarker	[117]
PRKAR1A	TTNAHEX	Strong	Genetic Variation	[72]
RHD	TTLCKI8	Strong	Genetic Variation	[118]
SF3B1	TTL2WUI	Strong	Genetic Variation	[119]
SLC11A2	TT2IS7P	Strong	Genetic Variation	[120]
SLC15A1	TT5LF3C	Strong	Altered Expression	[121]
SLC19A2	TT2A1DZ	Strong	Genetic Variation	[122]
SLC28A2	TTVP9IQ	Strong	Biomarker	[123]
SLC9A3	TTFZVPO	Strong	Biomarker	[124]
SLCO1B3	TTU86P0	Strong	Genetic Variation	[125]
TCL1A	TTUKRDV	Strong	Altered Expression	[126]
TEC	TT1ZV49	Strong	Biomarker	[127]
TF	TT8WXAV	Strong	Biomarker	[128]
TFRC	TT8MG4S	Strong	Biomarker	[129]
TGM2	TT2F4OL	Strong	Biomarker	[130]
THPO	TTCG5PE	Strong	Altered Expression	[131]
TNFRSF10A	TT5WLRX	Strong	Biomarker	[132]
UGCG	TTPHEX3	Strong	Biomarker	[133]
CD55	TT5Z9WY	Definitive	Altered Expression	[43]
CSF2	TTNYZG2	Definitive	Biomarker	[134]
EPAS1	TTWPA54	Definitive	Genetic Variation	[111]
JMJD1C	TTBISK4	Definitive	Genetic Variation	[135]
REN	TTB2MXP	Definitive	Biomarker	[62]
SLC46A1	TTY8Z2E	Definitive	Biomarker	[136]
TMPRSS6	TTL9KE7	Definitive	Altered Expression	[137]

This Disease Is Related to 7 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC28A3	DT4YL5R	Limited	Biomarker	[123]
ATP7A	DT0LT17	Strong	Biomarker	[138]
SLC20A1	DTMULXV	Strong	Biomarker	[139]
SLC25A37	DTLBGTZ	Strong	Biomarker	[140]
SLC25A5	DTL1TRY	Strong	Biomarker	[141]
SLC39A8	DTLPQGT	Strong	Biomarker	[142]
SLC4A1	DTB0Q3P	Strong	Genetic Variation	[143]

This Disease Is Related to 9 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
MARS1	DE0K52I	Limited	Genetic Variation	[144]
ALAS2	DE437BY	Disputed	Biomarker	[145]
ABO	DESIA7R	Strong	Biomarker	[146]
AKR1C4	DEAJN47	Strong	Genetic Variation	[53]
CYP2C8	DES5XRU	Strong	Genetic Variation	[147]
GPT	DER5HFI	Strong	Genetic Variation	[148]
PGPEP1	DEVDR46	Strong	Biomarker	[117]
TPMT	DEFQ8VO	Strong	Biomarker	[149]
UBASH3B	DE10BJ5	Strong	Genetic Variation	[150]

This Disease Is Related to 147 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ARID2	OTIRJXWM	Limited	Biomarker	[151]
ASPG	OT5E2EKR	Limited	Biomarker	[152]
CNOT3	OT4D5Z9L	Limited	Biomarker	[153]
COQ2	OTDAKEY4	Limited	Genetic Variation	[154]
COX10	OTCYIS0L	Limited	Altered Expression	[155]
FANCB	OTMZTXB5	Limited	Biomarker	[156]
FIP1L1	OTF91GTL	Limited	Biomarker	[48]
H2BC11	OTGM083T	Limited	Genetic Variation	[42]
HBG2	OT4J48JJ	Limited	Biomarker	[157]
KLF1	OT1FK08U	Limited	Genetic Variation	[158]
LRPAP1	OT6DVD2Q	Limited	Biomarker	[159]
MECOM	OTP983W8	Limited	Biomarker	[160]
MPIG6B	OTVNKQWA	Limited	Genetic Variation	[161]
SEC61A1	OTLBE3CB	Limited	Genetic Variation	[162]
SMAD4	OTWQWCKG	Limited	Genetic Variation	[163]
STAT5B	OTZVPEBT	Limited	Genetic Variation	[164]
TET2	OTKKT03T	Limited	Genetic Variation	[165]
TSPAN33	OTH6C0WU	Limited	Biomarker	[166]
ARL6IP5	OTYZ6BEQ	Disputed	Genetic Variation	[167]
ACAD8	OT3JI5GB	moderate	Biomarker	[168]
AMMECR1	OTWMQ67T	moderate	Genetic Variation	[169]
CHMP2B	OTZA7RJB	moderate	Genetic Variation	[120]
CP	OTM8JE4Y	moderate	Altered Expression	[170]
DMRT1	OT5PU9U1	moderate	Genetic Variation	[120]
FUT2	OTLXM6WI	moderate	Genetic Variation	[171]
GLRX5	OTE3L48D	moderate	Genetic Variation	[172]
HBG1	OTVL4NSU	moderate	Biomarker	[157]
IL3	OT0CQ35N	moderate	Therapeutic	[99]
MTX1	OTLSDNZO	moderate	Biomarker	[173]
RARS1	OTHPZ6JN	moderate	Biomarker	[174]
RBM38	OTPO8EXU	moderate	Genetic Variation	[175]
TRNT1	OTD57ILL	moderate	Altered Expression	[176]
ACO1	OT2VUR7L	Strong	Genetic Variation	[177]
ADD2	OTRCPCD2	Strong	Biomarker	[178]
ADGRE1	OTQQ9Q7G	Strong	Genetic Variation	[179]
ADRM1	OTOU4EY6	Strong	Biomarker	[104]
AHSP	OTTHBSUS	Strong	Biomarker	[180]
AK3	OTM59ZGG	Strong	Biomarker	[85]
ALKBH3	OTS1CD9Z	Strong	Biomarker	[181]
APOA5	OTEVKLVA	Strong	Genetic Variation	[57]
ARHGEF12	OTM2D3LT	Strong	Biomarker	[182]
ASF1A	OT4S44GP	Strong	Biomarker	[183]
ATAD1	OTJ02XFL	Strong	Biomarker	[184]
ATG5	OT4T5SMS	Strong	Biomarker	[66]
ATOH8	OT7SY3BN	Strong	Altered Expression	[185]
ATP11C	OTKMV2K5	Strong	Altered Expression	[186]
ATP5F1E	OTMPLAIS	Strong	Genetic Variation	[89]
ATP5IF1	OTQFD73H	Strong	Genetic Variation	[89]
B3GLCT	OTXH6KOQ	Strong	Biomarker	[187]
BMPER	OTBYON4H	Strong	Genetic Variation	[188]
BOC	OTXBCY9W	Strong	Genetic Variation	[189]
CAV2	OT1FGRQX	Strong	Biomarker	[70]
CD5L	OTPY4WQR	Strong	Genetic Variation	[190]
CLEC11A	OT9KBH7C	Strong	Biomarker	[191]
COX4I2	OTB98B21	Strong	Genetic Variation	[192]
CRPPA	OTC85K8Q	Strong	Genetic Variation	[193]
CRYGD	OTW29JC4	Strong	Biomarker	[194]
CUL4A	OTTBV70J	Strong	Biomarker	[195]
CYGB	OTX153DQ	Strong	Biomarker	[196]
DBI	OT884QY9	Strong	Biomarker	[197]
DHX40	OTOL02QN	Strong	Biomarker	[198]
DIRAS1	OT07F6PE	Strong	Genetic Variation	[199]
DMTN	OTDTKPBW	Strong	Biomarker	[200]
DNASE2	OT6RC1BL	Strong	Biomarker	[201]
DNLZ	OT48CG1W	Strong	Biomarker	[82]
DUOXA1	OTNG3HH4	Strong	Genetic Variation	[193]
EBAG9	OTTQLQCP	Strong	Biomarker	[202]
EMB	OT67E3Q1	Strong	Biomarker	[203]
ERFE	OTSES1HA	Strong	Biomarker	[82]
ERVW-1	OTWV8DXJ	Strong	Biomarker	[204]
ESAM	OTF518AI	Strong	Genetic Variation	[205]
FCGR2C	OTNLMNYB	Strong	Genetic Variation	[206]
FLOT2	OTZ0QR5L	Strong	Biomarker	[207]
FTMT	OTIUX6XG	Strong	Biomarker	[208]
GATA1	OTX1R7O1	Strong	Biomarker	[209]
GATA2	OTBP2QQ2	Strong	Altered Expression	[210]
GDF11	OTOSNMND	Strong	Biomarker	[211]
GIPC1	OTXLVCPJ	Strong	Genetic Variation	[193]
GNLY	OTZJKA8C	Strong	Biomarker	[212]
HEPH	OTZ2F15Z	Strong	Genetic Variation	[213]
HOXD13	OTWSC8TF	Strong	Biomarker	[214]
IFIH1	OTZA2AHA	Strong	CausalMutation	[215]
IFNA1	OTPMKY0L	Strong	Biomarker	[216]
IFNA8	OTW0PCKU	Strong	Genetic Variation	[56]
IL12RB1	OTM1IJO2	Strong	Genetic Variation	[217]
INHA	OT7HWCO3	Strong	Biomarker	[218]
INSRR	OT3F75WA	Strong	Genetic Variation	[219]
IREB2	OT747D24	Strong	Biomarker	[177]
ISL1	OTVNVKAX	Strong	Altered Expression	[220]
IVNS1ABP	OTYHL4I7	Strong	Biomarker	[221]
KCNE2	OTUO214Y	Strong	Biomarker	[222]
LHX2	OTK61NP8	Strong	Biomarker	[220]
LPIN2	OTRRTMXX	Strong	Altered Expression	[223]
LUC7L	OT77JDB7	Strong	Genetic Variation	[224]
MMD	OTB5I4OC	Strong	Altered Expression	[225]
MOCOS	OT0TL3Q5	Strong	Biomarker	[226]
MPG	OTAHW80B	Strong	Biomarker	[227]
MT1E	OTXJKU4Y	Strong	Biomarker	[228]
NCOA5	OTOGWTWB	Strong	Biomarker	[183]
NFE2	OTLM94BI	Strong	Altered Expression	[229]
NR1D2	OT9CVF41	Strong	Biomarker	[230]
NUP98	OTNT12G2	Strong	Biomarker	[214]
OAS1	OT8ZLOCY	Strong	Genetic Variation	[231]
OR10A4	OTYYB8SY	Strong	Genetic Variation	[232]
PAEP	OTQA0NV4	Strong	Biomarker	[233]
PDC	OT1UUVYY	Strong	Biomarker	[234]
PFN2	OT5SSSA7	Strong	Biomarker	[235]
PGAM1	OTZ5DB06	Strong	Biomarker	[236]
PGK1	OT6V1ICH	Strong	Genetic Variation	[237]
PIK3C2A	OTFBU4GD	Strong	Genetic Variation	[238]
PMCH	OT3D9SA4	Strong	Biomarker	[239]
POU1F1	OTXT8A5C	Strong	Biomarker	[139]
PRB1	OTV0SYMD	Strong	Biomarker	[240]
PRKAG2	OTHTAM54	Strong	Genetic Variation	[241]
PROCR	OTRHED17	Strong	Biomarker	[242]
PRSS27	OTC4G4UF	Strong	Genetic Variation	[243]
RHOC	OTOLE1FT	Strong	Biomarker	[106]
RPL10A	OTDLCJ53	Strong	Biomarker	[244]
RPS14	OTB90KV5	Strong	Biomarker	[245]
RPS15	OT0WYZYG	Strong	Genetic Variation	[199]
RPS19	OTBKGP48	Strong	Genetic Variation	[209]
RPS7	OTIK25WI	Strong	Genetic Variation	[246]
RTN3	OTGZ51QF	Strong	Genetic Variation	[179]
RUNX1T1	OT30DED5	Strong	Genetic Variation	[53]
SAMD14	OTLDQW51	Strong	Biomarker	[247]
SAMHD1	OTBCIBC7	Strong	Genetic Variation	[248]
SEC23B	OT2NFSIQ	Strong	Genetic Variation	[249]
SFTPA1	OT87XL1U	Strong	Biomarker	[250]
SHMT2	OT5NCAZN	Strong	Biomarker	[251]
SIGLEC1	OTNWSQA9	Strong	Biomarker	[252]
SIPA1	OTXY5RXC	Strong	Biomarker	[250]
SMARCA5	OT5GR4Z2	Strong	Biomarker	[253]
SMCP	OTXKY794	Strong	Biomarker	[226]
SMIM10L2B	OT04IG2N	Strong	Biomarker	[254]
SPTA1	OT1YMP65	Strong	Genetic Variation	[255]
ST13	OTNML6UP	Strong	Biomarker	[256]
STK40	OT4R325X	Strong	Genetic Variation	[257]
TBX1	OTQLBPRA	Strong	Biomarker	[258]
TCL1B	OT4CSO39	Strong	Altered Expression	[126]
THOC5	OTHY50SK	Strong	Biomarker	[259]
TMED3	OTNOPHHC	Strong	Biomarker	[260]
TREX1	OTQG7K12	Strong	Genetic Variation	[261]
TRIT1	OTCU9FS5	Strong	Genetic Variation	[262]
TTC7A	OTDHLPQM	Strong	Genetic Variation	[263]
IL17RD	OTKD9XST	Definitive	Genetic Variation	[264]
IL17RE	OTMFTNLS	Definitive	Genetic Variation	[264]
RASA3	OT9C54MN	Definitive	Genetic Variation	[265]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Emerging treatments for traumatic brain injury. Expert Opin Emerg Drugs. 2009 Mar;14(1):67-84.
• [3] FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (BLA) 103951.
• [4] Clinical pipeline report, company report or official report of Eisai.
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7396).
• [6] ClinicalTrials.gov (NCT02268409) ACE-536 Extension Study - Beta Thalassemia. U.S. National Institutes of Health.
• [7] Comparison of the therapeutic effects of epoetin zeta to epoetin alfa in the maintenance phase of renal anaemia treatment. Curr Med Res Opin. 2008 Mar;24(3):625-37.
• [8] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033828)
• [9] Clinical pipeline report, company report or official report of Takeda.
• [10] ClinicalTrials.gov (NCT00038454) Phase II Study To Evaluate The Safety and Efficacy of Hemoglobin Raffimer in Patients Undergoing First Time CABG Surgery. U.S. National Institutes of Health.
• [11] ClinicalTrials.gov (NCT02287896) Pharmacokinetics and Safety of Roledumab, in RhD-negative Pregnant Women Carrying an RhD-positive Foetus. U.S. National Institutes of Health.
• [12] ClinicalTrials.gov (NCT01987908) Evaluation of Different Dose Regimens of Aes-103 Given for 28 Days to Subjects With Stable Sickle Cell Disease. U.S. National Institutes of Health.
• [13] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8456).
• [14] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026354)
• [15] ClinicalTrials.gov (NCT04582539) To Assess the Safety and Tolerability of INCB000928 in Participants With Myelodysplastic Syndromes or Multiple Myeloma.. U.S. National Institutes of Health.
• [16] ClinicalTrials.gov (NCT00968617) A Study of MK2578 in Patients With Chronic Kidney Disease Who Are Not on Dialysis (2578-002). U.S. National Institutes of Health.
• [17] The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys. Blood. 2013 Mar 21;121(12):2311-5.
• [18] Clinical pipeline report, company report or official report of Rockwell Medical Inc.
• [19] ClinicalTrials.gov (NCT01671111) Study for Transfusionally Iron Overloaded Children, Adolescents and Adults Using FBS0701 (SSP-004184). U.S. National Institutes of Health.
• [20] ClinicalTrials.gov (NCT00542568) Safety and Efficacy of Sustained Erythropoietin Therapy. U.S. National Institutes of Health.
• [21] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016000)
• [22] Clinical pipeline report, company report or official report of Acceleron Pharma (2011).
• [23] ClinicalTrials.gov (NCT02241200) A Study in Healthy Volunteers to Compare the Profiles of DA-3880 and EU Sourced ARANESP (Amgen). U.S. National Institutes of Health.
• [24] ClinicalTrials.gov (NCT02299661) Pilot PK/PD Study of DS-1093a in Patients With Chronic Kidney Disease. U.S. National Institutes of Health.
• [25] ClinicalTrials.gov (NCT01991483) A Study of LY2928057 in Hemodialysis Participants. U.S. National Institutes of Health.
• [26] ClinicalTrials.gov (NCT01363934) To Evaluate the Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Erythropoietin. U.S. National Institutes of Health.
• [27] ClinicalTrials.gov (NCT01340976) A Phase 1 Study of LY2787106 in Cancer and Anemia. U.S. National Institutes of Health.
• [28] ClinicalTrials.gov (NCT01030315) A Study of HM10760A (Long-acting Erythropoietin) in Healthy Adult Caucasian and Japanese Subjects. U.S. National Institutes of Health.
• [29] ClinicalTrials.gov (NCT01340976) A Phase 1 Study of LY2787106 in Cancer and Anemia. U.S. National Institutes of Health.
• [30] In vivo selection for human and murine hematopoietic cells transduced with a therapeutic MGMT lentiviral vector that inhibits HIV replication. Mol Ther. 2004 Feb;9(2):160-72.
• [31] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800011182)
• [32] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013086)
• [33] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025976)
• [34] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027346)
• [35] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017518)
• [36] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008362)
• [37] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [38] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1718).
• [39] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4921).
• [40] Genetic variability in drug transport, metabolism or DNA repair affecting toxicity of chemotherapy in ovarian cancer.BMC Pharmacol Toxicol. 2015 Feb 27;16:2. doi: 10.1186/s40360-015-0001-5.
• [41] Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models.J Clin Invest. 2020 Feb 3;130(2):942-957. doi: 10.1172/JCI127425.
• [42] Genetic contribution to iron status: SNPs related to iron deficiency anaemia and fine mapping of CACNA2D3 calcium channel subunit.Blood Cells Mol Dis. 2015 Dec;55(4):273-80. doi: 10.1016/j.bcmd.2015.07.008. Epub 2015 Jul 16.
• [43] Expression pattern of CD55 and CD59 on red blood cells in sickle cell disease.Hematology. 2017 Mar;22(2):105-113. doi: 10.1080/10245332.2016.1231988. Epub 2016 Sep 25.
• [44] Outcomes during anticoagulation in patients with symptomatic vs. incidental splanchnic vein thrombosis.Thromb Res. 2018 Apr;164:69-74. doi: 10.1016/j.thromres.2018.02.143. Epub 2018 Mar 2.
• [45] Gender differences in the impact of anemia on subclinical myocardial damage and cardiovascular mortality in the general population: The Yamagata (Takahata) study.Int J Cardiol. 2018 Feb 1;252:207-212. doi: 10.1016/j.ijcard.2017.11.019. Epub 2017 Nov 10.
• [46] HLA-B*15:02 is associated with anemia in patients with chronic hepatitis C treated with pegylated interferon- and ribavirin.Tissue Antigens. 2012 Nov;80(5):424-30. doi: 10.1111/j.1399-0039.2012.01956.x. Epub 2012 Aug 30.
• [47] Identification and functional analysis of missense mutations in the lecithin cholesterol acyltransferase gene in a Chilean patient with hypoalphalipoproteinemia.Lipids Health Dis. 2019 Jun 5;18(1):132. doi: 10.1186/s12944-019-1045-0.
• [48] Response to imatinib mesylate in patients with hypereosinophilic syndrome.Int J Hematol. 2012 Sep;96(3):320-6. doi: 10.1007/s12185-012-1141-7. Epub 2012 Jul 18.
• [49] Prolactinomas in males: any differences?.Pituitary. 2020 Feb;23(1):52-57. doi: 10.1007/s11102-019-01009-y.
• [50] Clinical and Laboratory Associations with Persistent Hyperferritinemia in 373 Black Hemochromatosis and Iron Overload Screening Study Participants.Ann Hepatol. 2017 Sep-Oct;16(5):802-811. doi: 10.5604/01.3001.0010.2815.
• [51] Sustained viral response and treatment-induced cytopenia correlate with SLCs and KLF12 genotypes in interferon/ribavirin-treated Chinese chronic hepatitis C patients.J Gastroenterol Hepatol. 2016 Aug;31(8):1489-97. doi: 10.1111/jgh.13290.
• [52] Anemia in Patients With Resistance to Thyroid Hormone : A Role for Thyroid Hormone Receptor in Human Erythropoiesis.J Clin Endocrinol Metab. 2017 Sep 1;102(9):3517-3525. doi: 10.1210/jc.2017-00840.
• [53] Utility of the low-accelerating-dose regimen in 182 liver recipients with recurrent hepatitis C virus.World J Gastroenterol. 2015 May 28;21(20):6236-45. doi: 10.3748/wjg.v21.i20.6236.
• [54] Mutational characteristics of ANK1 and SPTB genes in hereditary spherocytosis. Clin Genet. 2016 Jul;90(1):69-78. doi: 10.1111/cge.12749. Epub 2016 Mar 15.
• [55] Baseline hemoglobin <11.0 g/dL has stronger prognostic value than anemia status in nasopharynx cancers treated with chemoradiotherapy.Int J Biol Markers. 2019 Jun;34(2):139-147. doi: 10.1177/1724600818821688. Epub 2019 Mar 13.
• [56] Reduced interferon (IFN)- conditioned by IFNA2 (-173) and IFNA8 (-884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.Hum Genet. 2012 Aug;131(8):1375-91. doi: 10.1007/s00439-012-1175-1. Epub 2012 May 9.
• [57] The Methylenetetrahydrofolate Reductase C677T (rs1801133) and Apolipoprotein A5-1131T>C (rs662799) Polymorphisms, and Anemia Are Independent Risk Factors for Ischemic Stroke.J Stroke Cerebrovasc Dis. 2018 May;27(5):1357-1362. doi: 10.1016/j.jstrokecerebrovasdis.2017.12.025. Epub 2018 Feb 3.
• [58] The True Story on Deficiencies After Sleeve Gastrectomy: Results of a Double-Blind RCT.Obes Surg. 2020 Apr;30(4):1280-1290. doi: 10.1007/s11695-019-04252-1.
• [59] Change in iron transporter expression in human term placenta with different maternal iron status.Eur J Obstet Gynecol Reprod Biol. 2008 Sep;140(1):48-54. doi: 10.1016/j.ejogrb.2008.02.012. Epub 2008 Jun 30.
• [60] Phase II trial of carboplatin and pemetrexed as first-line chemotherapy for non-squamous non-small cell lung cancer, and correlation between the efficacy/toxicity and genetic polymorphisms associated with pemetrexed metabolism: Hokkaido Lung Cancer Clinical Study Group Trial (HOT) 0902.Cancer Chemother Pharmacol. 2014 Dec;74(6):1149-57. doi: 10.1007/s00280-014-2589-3. Epub 2014 Oct 8.
• [61] Differentiation of erythroblast requires the dimeric form of acetylcholinesterase: Interference with erythropoietin receptor.Chem Biol Interact. 2019 Aug 1;308:317-322. doi: 10.1016/j.cbi.2019.06.006. Epub 2019 Jun 4.
• [62] Inhibition of the renin-angiotensin system in the cardiorenal syndrome with anaemia: a double-edged sword.J Hypertens. 2019 Nov;37(11):2145-2153. doi: 10.1097/HJH.0000000000002111.
• [63] Delta-aminolevulinate dehydratase activity in red blood cells of rats infected with Trypanosoma evansi.Parasitology. 2011 Sep;138(10):1272-7. doi: 10.1017/S0031182011000989.
• [64] Apolipoprotein A-I Is a Prognosticator of Nasopharyngeal Carcinoma in the Era of Intensity-modulated Radiotherapy.J Cancer. 2018 Jan 11;9(4):702-710. doi: 10.7150/jca.22836. eCollection 2018.
• [65] Impact of IL28B, APOH and ITPA Polymorphisms on Efficacy and Safety of TVR- or BOC-Based Triple Therapy in Treatment-Experienced HCV-1 Patients with Compensated Cirrhosis from the ANRS CO20-CUPIC Study.PLoS One. 2015 Dec 15;10(12):e0145105. doi: 10.1371/journal.pone.0145105. eCollection 2015.
• [66] Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia.Cell Death Discov. 2015 Aug 17;1:15008-. doi: 10.1038/cddiscovery.2015.8.
• [67] Nuclear factor erythroid 2-related factors 1 and 2 are able to define the worst prognosis group among high-risk diffuse large B cell lymphomas treated with R-CHOEP.J Clin Pathol. 2019 Apr;72(4):316-321. doi: 10.1136/jclinpath-2018-205584. Epub 2019 Feb 12.
• [68] Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo.Haematologica. 2011 Dec;96(12):1761-9. doi: 10.3324/haematol.2011.048926. Epub 2011 Aug 22.
• [69] FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability.Mol Cell Biol. 2008 Jun;28(12):4116-28. doi: 10.1128/MCB.02210-07. Epub 2008 Apr 21.
• [70] Severe neurologic disease and chick mortality in crested screamers (Chauna torquata) infected with a novel Gyrovirus.Virology. 2018 Jul;520:111-115. doi: 10.1016/j.virol.2018.05.014. Epub 2018 May 28.
• [71] Multi-gene panel testing improves diagnosis and management of patients with hereditary anemias.Am J Hematol. 2018 May;93(5):672-682. doi: 10.1002/ajh.25058. Epub 2018 Feb 24.
• [72] Early and late hematologic toxicity following CD19 CAR-T cells.Bone Marrow Transplant. 2019 Oct;54(10):1643-1650. doi: 10.1038/s41409-019-0487-3. Epub 2019 Feb 26.
• [73] Splenomegaly induced by anemia impairs T cell movement in the spleen partially via EPO.Mol Immunol. 2019 Aug;112:399-405. doi: 10.1016/j.molimm.2019.06.021. Epub 2019 Jul 9.
• [74] Cdk6 contributes to cytoskeletal stability in erythroid cells.Haematologica. 2017 Jun;102(6):995-1005. doi: 10.3324/haematol.2016.159947. Epub 2017 Mar 2.
• [75] Clinical features and treatment of patients with lung adenocarcinoma with bone marrow metastasis.Tumori. 2019 Oct;105(5):388-393. doi: 10.1177/0300891619839864. Epub 2019 Apr 1.
• [76] Efficacy of granulocyte colony stimulating factor in combination with erythropoiesis stimulating agents for treatment of anemia in patients with lower risk myelodysplastic syndromes: A systematic review.Crit Rev Oncol Hematol. 2019 Apr;136:37-47. doi: 10.1016/j.critrevonc.2019.01.021. Epub 2019 Feb 15.
• [77] Molecular pathogenesis of myelodysplastic syndromes with deletion 5q.Eur J Haematol. 2019 Mar;102(3):203-209. doi: 10.1111/ejh.13207. Epub 2019 Jan 16.
• [78] Amnionless-mediated glycosylation is crucial for cell surface targeting of cubilin in renal and intestinal cells.Sci Rep. 2018 Feb 5;8(1):2351. doi: 10.1038/s41598-018-20731-4.
• [79] Crystal Structure of Human Dual-Specificity Tyrosine-Regulated Kinase 3 Reveals New Structural Features and Insights into its Auto-phosphorylation.J Mol Biol. 2018 May 11;430(10):1521-1530. doi: 10.1016/j.jmb.2018.04.001. Epub 2018 Apr 7.
• [80] E2F-2 Promotes Nuclear Condensation and Enucleation of Terminally Differentiated Erythroblasts.Mol Cell Biol. 2016 Dec 19;37(1):e00274-16. doi: 10.1128/MCB.00274-16. Print 2017 Jan 1.
• [81] Application of in-vitro screening methods on hypoxia inducible factor prolyl hydroxylase inhibitors.Bioorg Med Chem. 2017 Aug 1;25(15):3891-3899. doi: 10.1016/j.bmc.2017.05.026. Epub 2017 May 13.
• [82] Hepcidin-25/erythroferrone ratio predicts improvement of anaemia in haemodialysis patients treated with ferric citrate hydrate.Nephrology (Carlton). 2019 Aug;24(8):819-826. doi: 10.1111/nep.13495. Epub 2019 Apr 29.
• [83] Model-based approach for methoxy polyethylene glycol-epoetin beta drug development in paediatric patients with anaemia of chronic kidney disease.Br J Clin Pharmacol. 2020 Apr;86(4):801-811. doi: 10.1111/bcp.14186. Epub 2020 Jan 21.
• [84] Venous thromboprophylaxis after total hip arthroplasty: aspirin, warfarin, enoxaparin, or factor Xa inhibitors?.Hip Int. 2020 Sep;30(5):564-571. doi: 10.1177/1120700019841600. Epub 2019 Apr 16.
• [85] Clinical manifestations and management of labor and delivery in women with factor IX deficiency.Haemophilia. 2004 Sep;10(5):483-90. doi: 10.1111/j.1365-2516.2004.00946.x.
• [86] Severe Anemia Is Associated with Intestinal Injury in Preterm Neonates.Am J Perinatol. 2020 May;37(6):603-606. doi: 10.1055/s-0039-1683982. Epub 2019 Apr 4.
• [87] HSP90 Shapes the Consequences of Human Genetic Variation.Cell. 2017 Feb 23;168(5):856-866.e12. doi: 10.1016/j.cell.2017.01.023. Epub 2017 Feb 16.
• [88] Functional haplotypes of Fc gamma (Fc) receptor (FcRIIA and FcRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children.Hum Genet. 2012 Feb;131(2):289-99. doi: 10.1007/s00439-011-1076-8. Epub 2011 Aug 5.
• [89] Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts.Nature. 2012 Nov 22;491(7425):608-12. doi: 10.1038/nature11536. Epub 2012 Nov 7.
• [90] FGF23 at the crossroads of phosphate, iron economy and erythropoiesis.Nat Rev Nephrol. 2020 Jan;16(1):7-19. doi: 10.1038/s41581-019-0189-5. Epub 2019 Sep 13.
• [91] Lower Esophageal Sphincter-preserving Anastomosis Is an Acceptable Reconstruction Method Following Laparoscopy-assisted Proximal Gastrectomy.Anticancer Res. 2019 Jan;39(1):425-430. doi: 10.21873/anticanres.13129.
• [92] Glucose-6-phosphate dehydrogenase deficiency and risk of cardiovascular disease: A propensity score-matched study.Atherosclerosis. 2019 Mar;282:148-153. doi: 10.1016/j.atherosclerosis.2019.01.027. Epub 2019 Jan 28.
• [93] Thrombocytopenia and GBA gene mutation in a patient with adult type 1 Gaucher disease.Platelets. 2017 Dec;28(8):829-831. doi: 10.1080/09537104.2017.1306044. Epub 2017 Jun 5.
• [94] Haematological and biochemical toxicity induced by methanol in rats: ameliorative effects of Opuntia vulgaris fruit extract.Hum Exp Toxicol. 2011 Dec;30(12):1963-71. doi: 10.1177/0960327111403175. Epub 2011 Mar 21.
• [95] [Cytogenetic and cytologic findings in enzymopenic panmyelopathies and pancytopenias. Familial myelopathy of Fanconi, glutathione-reductase deficiency anemia and megaloblastic B12 deficiency anemia].Humangenetik. 1966;2(3):287-316. doi: 10.1007/BF00395947.
• [96] Beta-thalassemia: renal complications and mechanisms: a narrative review.Hematology. 2019 Dec;24(1):426-438. doi: 10.1080/16078454.2019.1599096.
• [97] Effect of percutaneous paravalvular leak closure on hemolysis.Catheter Cardiovasc Interv. 2019 Mar 1;93(4):713-719. doi: 10.1002/ccd.27917. Epub 2018 Oct 2.
• [98] Deficiency in interferon type 1 receptor improves definitive erythropoiesis in Klf1 null mice.Cell Death Differ. 2018 Mar;25(3):589-599. doi: 10.1038/s41418-017-0003-5. Epub 2017 Dec 11.
• [99] Antagonism between interleukin 3 and erythropoietin in mice with azidothymidine-induced anemia and in bone marrow endothelial cells.Cytokine. 2002 Apr 7;18(1):51-60. doi: 10.1006/cyto.2002.1029.
• [100] Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria.BMC Genet. 2011 Aug 6;12:69. doi: 10.1186/1471-2156-12-69.
• [101] Role of Intracystic Cytokines and Nitric Oxide in Ovarian Neoplasms.Scand J Immunol. 2017 Dec;86(6):462-470. doi: 10.1111/sji.12617. Epub 2017 Oct 22.
• [102] Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents.Blood. 2017 Mar 30;129(13):1823-1830. doi: 10.1182/blood-2016-09-740092. Epub 2017 Feb 10.
• [103] The fraction of CD117/c-KIT-expressing erythroid precursors predicts ESA response in low-risk myelodysplastic syndromes.Cytometry B Clin Cytom. 2019 May;96(3):215-222. doi: 10.1002/cyto.b.21781. Epub 2019 Apr 9.
• [104] Maternal Characteristics Affect Fetal Growth Response in the Women First Preconception Nutrition Trial.Nutrients. 2019 Oct 21;11(10):2534. doi: 10.3390/nu11102534.
• [105] Molecular basis of reduced LAIR1 expression in childhood severe malarial anaemia: Implications for leukocyte inhibitory signalling.EBioMedicine. 2019 Jul;45:278-289. doi: 10.1016/j.ebiom.2019.06.040. Epub 2019 Jun 27.
• [106] Gene expression profiles associated with anaemia and ITPA genotypes in patients with chronic hepatitis C (CH-C).J Viral Hepat. 2012 Jun;19(6):414-22. doi: 10.1111/j.1365-2893.2011.01564.x. Epub 2011 Dec 7.
• [107] Steady-state plasma lactoferrin levels in relation to infections and complications of sickle cell disease.Hematol J. 2004;5(4):371-2. doi: 10.1038/sj.thj.6200372.
• [108] Fermented Goat Milk Consumption Enhances Brain Molecular Functions during Iron Deficiency Anemia Recovery.Nutrients. 2019 Oct 7;11(10):2394. doi: 10.3390/nu11102394.
• [109] Congenital amegakaryocytic thrombocytopenia iPS cells exhibit defective MPL-mediated signaling.J Clin Invest. 2013 Sep;123(9):3802-14. doi: 10.1172/JCI64721. Epub 2013 Aug 1.
• [110] CA 15-3 predicting breast cancer relapse: beware of vitamin B12 deficiency.Per Med. 2018 May 1;15(3):163-165. doi: 10.2217/pme-2017-0067. Epub 2018 May 10.
• [111] NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms.Haematologica. 2019 Jul;104(7):1342-1354. doi: 10.3324/haematol.2018.204123. Epub 2019 Jan 10.
• [112] NIMA-related kinase 1 (NEK1) regulates meiosis I spindle assembly by altering the balance between -Adducin and Myosin X.PLoS One. 2017 Oct 5;12(10):e0185780. doi: 10.1371/journal.pone.0185780. eCollection 2017.
• [113] A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis.Cell Rep. 2018 Jan 30;22(5):1211-1224. doi: 10.1016/j.celrep.2018.01.017.
• [114] Dyserythropoiesis in a child with pyruvate kinase deficiency and coexistent unilateral multicystic dysplastic kidney.Pediatr Blood Cancer. 2014 Aug;61(8):1463-5. doi: 10.1002/pbc.24953. Epub 2014 Jan 30.
• [115] Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity.Lancet. 1975 May 3;1(7914):1010-3. doi: 10.1016/s0140-6736(75)91950-9.
• [116] High-content screening in zebrafish embryos identifies butafenacil as a potent inducer of anemia.PLoS One. 2014 Aug 4;9(8):e104190. doi: 10.1371/journal.pone.0104190. eCollection 2014.
• [117] A Model to Predict In-Hospital Mortality in HIV/AIDS Patients with Pneumocystis Pneumonia in China: The Clinical Practice in Real World.Biomed Res Int. 2019 Feb 17;2019:6057028. doi: 10.1155/2019/6057028. eCollection 2019.
• [118] Management of red cell alloimmunisation in pregnancy: the non-invasive monitoring of the disease.Prenat Diagn. 2010 Jul;30(7):668-73. doi: 10.1002/pd.2551.
• [119] Activin Receptor II Ligand Traps: New Treatment Paradigm for Low-Risk MDS.Curr Hematol Malig Rep. 2019 Aug;14(4):346-351. doi: 10.1007/s11899-019-00517-9.
• [120] The DMT1 IVS4+44C>A polymorphism and the risk of iron deficiency anemia in children with celiac disease.PLoS One. 2017 Oct 12;12(10):e0185822. doi: 10.1371/journal.pone.0185822. eCollection 2017.
• [121] Fermented goat milk consumption during anaemia recovery: ergogenic effect and improvement of skeletal muscle homeostasis.Eur J Nutr. 2017 Oct;56(7):2277-2287. doi: 10.1007/s00394-016-1268-z. Epub 2016 Jul 13.
• [122] Genetic defects of thiamine transport and metabolism: A review of clinical phenotypes, genetics, and functional studies.J Inherit Metab Dis. 2019 Jul;42(4):581-597. doi: 10.1002/jimd.12125. Epub 2019 Jun 24.
• [123] Role of ITPA and SLC28A2 genes in the prediction of anaemia associated with protease inhibitor plus ribavirin and peginterferon in hepatitis C treatment. J Clin Virol. 2015 Jul;68:56-60.
• [124] Intestinal brush-border Na+/H+ exchanger-3 drives H+-coupled iron absorption in the mouse.Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G423-30. doi: 10.1152/ajpgi.00167.2016. Epub 2016 Jul 7.
• [125] Pharmacogenetic analysis of advanced non-small-cell lung cancer patients treated with first-line paclitaxel and carboplatin chemotherapy. Pharmacogenet Genomics. 2016 Mar;26(3):116-25.
• [126] TCL1 expression predicts overall survival in patients with mantle cell lymphoma.Eur J Haematol. 2015 Dec;95(6):583-94. doi: 10.1111/ejh.12539. Epub 2015 Mar 16.
• [127] Transient erythroblastopenia of childhood associated with human herpesvirus type 6, variant B.Am J Clin Pathol. 1997 Aug;108(2):127-32. doi: 10.1093/ajcp/108.2.127.
• [128] Identification of protein changes in the blood plasma of lung cancer patients subjected to chemotherapy using a 2D-DIGE approach.PLoS One. 2019 Oct 17;14(10):e0223840. doi: 10.1371/journal.pone.0223840. eCollection 2019.
• [129] Evaluation of reticulocyte hemoglobin for assessment of anemia in rheumatological disorders.Int J Rheum Dis. 2019 May;22(5):815-825. doi: 10.1111/1756-185X.13567. Epub 2019 Apr 9.
• [130] HLA-DQ2/DQ8 frequency in adult patients with celiac disease, their first-degree relatives, and normal population in Turkey.Turk J Gastroenterol. 2019 Apr;30(4):321-325. doi: 10.5152/tjg.2019.18255.
• [131] Anemia and thrombocytosis induced by ribavirin monotherapy in patients with chronic hepatitis C.J Gastroenterol. 2012 Nov;47(11):1228-37. doi: 10.1007/s00535-012-0579-y. Epub 2012 Mar 30.
• [132] Mapatumumab, an antibody targeting TRAIL-R1, in combination with paclitaxel and carboplatin in patients with advanced solid malignancies: results of a phase I and pharmacokinetic study.J Clin Oncol. 2009 Sep 10;27(26):4413-21. doi: 10.1200/JCO.2008.21.7422. Epub 2009 Aug 3.
• [133] Risk factors associated with in-hospital mortality in elderly patients admitted to a regional trauma center after sustaining a fall.Aging Clin Exp Res. 2017 Jun;29(3):427-433. doi: 10.1007/s40520-016-0579-5. Epub 2016 May 3.
• [134] Full-dose CHOP chemotherapy combined with granulocyte colony-stimulating factor for aggressive non-Hodgkin's lymphoma in elderly patients: a prospective study.Ann Hematol. 2001 Oct;80(10):602-6. doi: 10.1007/s002770100358.
• [135] Interaction of iron status with single nucleotide polymorphisms on incidence of type 2 diabetes.PLoS One. 2017 Apr 13;12(4):e0175681. doi: 10.1371/journal.pone.0175681. eCollection 2017.
• [136] A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency.Blood. 2011 May 5;117(18):4895-904. doi: 10.1182/blood-2010-04-279653. Epub 2011 Feb 23.
• [137] RNAi-mediated reduction of hepatic Tmprss6 diminishes anemia and secondary iron overload in a splenectomized mouse model of -thalassemia intermedia.Am J Hematol. 2018 Jun;93(6):745-750. doi: 10.1002/ajh.25079. Epub 2018 Mar 23.
• [138] Investigation of iron metabolism in mice expressing a mutant Menke's copper transporting ATPase (Atp7a) protein with diminished activity (Brindled; Mo (Br) (/y) ).PLoS One. 2013 Jun 11;8(6):e66010. doi: 10.1371/journal.pone.0066010. Print 2013.
• [139] Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B cell development.Exp Hematol. 2013 May;41(5):432-43.e7. doi: 10.1016/j.exphem.2013.01.004. Epub 2013 Jan 30.
• [140] Reduction of mitoferrin results in abnormal development and extended lifespan in Caenorhabditis elegans.PLoS One. 2012;7(1):e29666. doi: 10.1371/journal.pone.0029666. Epub 2012 Jan 11.
• [141] Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.Cell Death Differ. 2015 Sep;22(9):1437-50. doi: 10.1038/cdd.2014.230. Epub 2015 Jan 23.
• [142] In utero gene expression in the Slc39a8(neo/neo) knockdown mouse.Sci Rep. 2018 Jul 16;8(1):10703. doi: 10.1038/s41598-018-29109-y.
• [143] Promoter polymorphism of the anion-exchange protein 1 associated with severe malarial anemia and fatality.J Infect Dis. 2006 Oct 1;194(7):949-57. doi: 10.1086/507430. Epub 2006 Aug 30.
• [144] Mutations in methionyl-tRNA synthetase gene in a Chinese family with interstitial lung and liver disease, postnatal growth failure and anemia.J Hum Genet. 2017 Jun;62(6):647-651. doi: 10.1038/jhg.2017.10. Epub 2017 Feb 2.
• [145] A toxicogenomic approach for identifying biomarkers for myelosuppressive anemia in rats.Toxicology. 2011 Apr 11;282(3):139-45. doi: 10.1016/j.tox.2011.01.027. Epub 2011 Feb 4.
• [146] Increased susceptibility of blood type O individuals to develop anemia in Plasmodium vivax infection.Infect Genet Evol. 2017 Jun;50:87-92. doi: 10.1016/j.meegid.2017.03.001. Epub 2017 Mar 6.
• [147] SNPs and taxane toxicity in breast cancer patients.Pharmacogenomics. 2014;15(15):1845-58. doi: 10.2217/pgs.14.127.
• [148] Pralatrexate in Chinese Patients with Relapsed or Refractory Peripheral T-cell Lymphoma: A Single-arm, Multicenter Study.Target Oncol. 2019 Apr;14(2):149-158. doi: 10.1007/s11523-019-00630-y.
• [149] Expressing thiopurine S-methyltransferase activity as units per litre of whole-blood overcomes misleading high results in patients with anaemia.Ann Clin Biochem. 2010 Sep;47(Pt 5):408-14. doi: 10.1258/acb.2010.010058. Epub 2010 Jul 1.
• [150] Propensity score matching analysis of a phase II study on simultaneous modulated accelerated radiation therapy using helical tomotherapy for nasopharyngeal carcinomas.BMC Cancer. 2017 Aug 29;17(1):582. doi: 10.1186/s12885-017-3581-1.
• [151] The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis.J Hematol Oncol. 2018 Feb 26;11(1):27. doi: 10.1186/s13045-018-0567-7.
• [152] The sonographic appearance of cyclophosphamide-induced acute haemorrhagic cystitis.Clin Radiol. 1990 Apr;41(4):289-90. doi: 10.1016/s0009-9260(05)81670-8.
• [153] Insufficient liver maturation affects murine early postnatal hair cycle.Biochem Biophys Res Commun. 2020 Jan 1;521(1):172-177. doi: 10.1016/j.bbrc.2019.10.099. Epub 2019 Oct 18.
• [154] Merozoite surface antigen 1 and 2 genotypes and rosetting of Plasmodium falciparum in severe and mild malaria in Lambarn, Gabon.Trans R Soc Trop Med Hyg. 1998 Jan-Feb;92(1):110-4. doi: 10.1016/s0035-9203(98)90979-8.
• [155] Mutations in COX10 result in a defect in mitochondrial heme A biosynthesis and account for multiple, early-onset clinical phenotypes associated with isolated COX deficiency.Hum Mol Genet. 2003 Oct 15;12(20):2693-702. doi: 10.1093/hmg/ddg284. Epub 2003 Aug 19.
• [156] Fas ligand expression in the bone marrow in myelodysplastic syndromes correlates with FAB subtype and anemia, and predicts survival.Leukemia. 1999 Jan;13(1):44-53. doi: 10.1038/sj.leu.2401233.
• [157] Lentiviral Transfer of -Globin with Fusion Gene NUP98-HOXA10HD Expands Hematopoietic Stem Cells and Ameliorates Murine -Thalassemia.Mol Ther. 2017 Mar 1;25(3):593-605. doi: 10.1016/j.ymthe.2017.01.019. Epub 2017 Feb 9.
• [158] Novel mutations in KLF1 encoding the In(Lu) phenotype reflect a diversity of clinical presentations.Transfusion. 2018 Jan;58(1):196-199. doi: 10.1111/trf.14378. Epub 2017 Oct 19.
• [159] Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine -thalassemia.Blood. 2014 Jun 19;123(25):3864-72. doi: 10.1182/blood-2013-06-511238. Epub 2014 May 2.
• [160] EVI1 Impairs myelopoiesis by deregulation of PU.1 function.Cancer Res. 2009 Feb 15;69(4):1633-42. doi: 10.1158/0008-5472.CAN-08-2562. Epub 2009 Feb 10.
• [161] Novel G6B gene variant causes familial autosomal recessive thrombocytopenia and anemia.Eur J Haematol. 2017 Mar;98(3):218-227. doi: 10.1111/ejh.12819. Epub 2017 Jan 3.
• [162] Heterozygous Loss-of-Function SEC61A1 Mutations Cause Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney Disease with Anemia.Am J Hum Genet. 2016 Jul 7;99(1):174-87. doi: 10.1016/j.ajhg.2016.05.028.
• [163] Juvenile polyposis, hereditary hemorrhagic telangiectasia, and early onset colorectal cancer in patients with SMAD4 mutation.J Gastroenterol. 2012 Jul;47(7):795-804. doi: 10.1007/s00535-012-0545-8. Epub 2012 Feb 14.
• [164] Integrative view on how erythropoietin signaling controls transcription patterns in erythroid cells.Curr Opin Hematol. 2018 May;25(3):189-195. doi: 10.1097/MOH.0000000000000415.
• [165] A zebrafish model of myelodysplastic syndrome produced through tet2 genomic editing.Mol Cell Biol. 2015 Mar;35(5):789-804. doi: 10.1128/MCB.00971-14. Epub 2014 Dec 15.
• [166] Penumbra encodes a novel tetraspanin that is highly expressed in erythroid progenitors and promotes effective erythropoiesis.Blood. 2007 Apr 15;109(8):3244-52. doi: 10.1182/blood-2006-09-046672. Epub 2006 Dec 7.
• [167] Haptoglobin genotype, anaemia and malaria in Gambian children.Trop Med Int Health. 2008 Jan;13(1):76-82. doi: 10.1111/j.1365-3156.2007.01976.x.
• [168] Inflammation, but Not the Underlying Disease or Its Location, Predicts Oral Iron Absorption Capacity in Patients With Inflammatory Bowel Disease.J Crohns Colitis. 2020 Mar 13;14(3):316-322. doi: 10.1093/ecco-jcc/jjz149.
• [169] X-linked elliptocytosis with impaired growth is related to mutated AMMECR1.Gene. 2017 Mar 30;606:47-52. doi: 10.1016/j.gene.2017.01.001. Epub 2017 Jan 9.
• [170] Clinical relevance of heterozygosis for aceruloplasminemia.Am J Med Genet B Neuropsychiatr Genet. 2019 Jun;180(4):266-271. doi: 10.1002/ajmg.b.32723. Epub 2019 Mar 22.
• [171] Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant.Biochimie. 2013 May;95(5):995-1001. doi: 10.1016/j.biochi.2013.01.022. Epub 2013 Feb 8.
• [172] The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload. Blood. 2007 Aug 15;110(4):1353-8. doi: 10.1182/blood-2007-02-072520. Epub 2007 May 7.
• [173] Cytopenias among patients with rheumatic diseases using methotrexate: a meta-analysis of randomized controlled clinical trials.Rheumatology (Oxford). 2020 Apr 1;59(4):709-717. doi: 10.1093/rheumatology/kez343.
• [174] The role of JAK2 mutations in RARS and other MDS.Hematology Am Soc Hematol Educ Program. 2008:52-9. doi: 10.1182/asheducation-2008.1.52.
• [175] RNA Binding Protein RBM38 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19, Which Facilitates Viral DNA Replication.J Virol. 2018 Mar 28;92(8):e02050-17. doi: 10.1128/JVI.02050-17. Print 2018 Apr 15.
• [176] Hypomorphic mutations in TRNT1 cause retinitis pigmentosa with erythrocytic microcytosis. Hum Mol Genet. 2016 Jan 1;25(1):44-56. doi: 10.1093/hmg/ddv446. Epub 2015 Oct 22.
• [177] Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure.Eur Heart J. 2017 Feb 1;38(5):362-372. doi: 10.1093/eurheartj/ehw333.
• [178] Haematological phenotypes in relation to the C1797T beta-adducin polymorphism in a Caucasian population.Clin Sci (Lond). 2003 Apr;104(4):369-76.
• [179] Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case-control study.Malar J. 2014 Jun 16;13:236. doi: 10.1186/1475-2875-13-236.
• [180] Transgenic human alpha-hemoglobin stabilizing protein could partially relieve betaIVS-2-654-thalassemia syndrome in model mice.Hum Gene Ther. 2010 Feb;21(2):149-56. doi: 10.1089/hum.2009.132.
• [181] Plasma advanced oxidative protein products are associated with anti-oxidative stress pathway genes and malaria in a longitudinal cohort.Malar J. 2014 Apr 3;13:134. doi: 10.1186/1475-2875-13-134.
• [182] ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients.Haematologica. 2020 Apr;105(4):925-936. doi: 10.3324/haematol.2018.210286. Epub 2019 Aug 29.
• [183] Synergetic pathogenicity of Newcastle disease vaccines LaSota strain and contaminated chicken infectious anemia virus.Poult Sci. 2019 May 1;98(5):1985-1992. doi: 10.3382/ps/pey555.
• [184] Genetic linkage of autologous T cell epitopes in a chimeric recombinant construct improves anti-parasite and anti-disease protective effect of a malaria vaccine candidate.Vaccine. 2010 Mar 19;28(14):2580-92. doi: 10.1016/j.vaccine.2010.01.019. Epub 2010 Jan 22.
• [185] Hepcidin suppression in -thalassemia is associated with the down-regulation of atonal homolog 8.Int J Hematol. 2017 Aug;106(2):196-205. doi: 10.1007/s12185-017-2231-3. Epub 2017 Apr 12.
• [186] Identification and functional analyses of disease-associated P4-ATPase phospholipid flippase variants in red blood cells.J Biol Chem. 2019 Apr 26;294(17):6809-6821. doi: 10.1074/jbc.RA118.007270. Epub 2019 Mar 8.
• [187] Molecular predictors for anaemia after kidney transplantation.Nephrol Dial Transplant. 2009 Mar;24(3):1015-23. doi: 10.1093/ndt/gfn683. Epub 2008 Dec 18.
• [188] Inosine triphosphatase genetic variants are protective against anemia during antiviral therapy for HCV2/3 but do not decrease dose reductions of RBV or increase SVR.Hepatology. 2011 Feb;53(2):389-95. doi: 10.1002/hep.24068. Epub 2011 Jan 10.
• [189] Overall safety profile of boceprevir plus peginterferon alfa-2b and ribavirin in patients with chronic hepatitis C genotype 1: a combined analysis of 3 phase 2/3 clinical trials.Liver Int. 2014 May;34(5):707-19. doi: 10.1111/liv.12300. Epub 2013 Oct 9.
• [190] Association of Anemia and Iron Parameters With Mortality Among Patients Undergoing Prevalent Hemodialysis in Taiwan: The AIM - HD Study.J Am Heart Assoc. 2018 Aug 7;7(15):e009206. doi: 10.1161/JAHA.118.009206.
• [191] A novel functional variant in the stem cell growth factor promoter protects against severe malarial anemia.Infect Immun. 2010 Jan;78(1):453-60. doi: 10.1128/IAI.00895-09. Epub 2009 Nov 2.
• [192] Exocrine pancreatic insufficiency, dyserythropoeitic anemia, and calvarial hyperostosis are caused by a mutation in the COX4I2 gene.Am J Hum Genet. 2009 Mar;84(3):412-7. doi: 10.1016/j.ajhg.2009.02.006. Epub 2009 Mar 5.
• [193] Efficacy and safety of Everolimus and Exemestane in hormone-receptor positive (HR+) human-epidermal-growth-factor negative (HER2-) advanced breast cancer patients: New insights beyond clinical trials. The EVA study.Breast. 2017 Oct;35:115-121. doi: 10.1016/j.breast.2017.06.043. Epub 2017 Jul 13.
• [194] Anti-cyclic citrullinated peptide antibody is highly associated with rheumatoid factor and radiological defects in rheumatoid arthritis patients.Medicine (Baltimore). 2019 Mar;98(12):e14945. doi: 10.1097/MD.0000000000014945.
• [195] Cul4a promotes zebrafish primitive erythropoiesis via upregulating scl and gata1 expression.Cell Death Dis. 2019 May 17;10(6):388. doi: 10.1038/s41419-019-1629-7.
• [196] A Clinical scoring model to predict mortality in HIV/TB co-infected patients at end stage of AIDS in China: An observational cohort study.Biosci Trends. 2019 May 12;13(2):136-144. doi: 10.5582/bst.2018.01309. Epub 2019 Mar 29.
• [197] Dietary Balance Index-07 and the Risk of Anemia in Middle Aged and Elderly People in Southwest China: A Cross Sectional Study.Nutrients. 2018 Jan 31;10(2):162. doi: 10.3390/nu10020162.
• [198] Anemia in patients with diabetic foot ulcer and its impact on disease outcome among Nigerians: Results from the MEDFUN study.PLoS One. 2019 Dec 17;14(12):e0226226. doi: 10.1371/journal.pone.0226226. eCollection 2019.
• [199] A phase II/III randomized study to compare the efficacy and safety of rigosertib plus gemcitabine versus gemcitabine alone in patients with previously untreated metastatic pancreatic cancer.Ann Oncol. 2015 Sep;26(9):1923-1929. doi: 10.1093/annonc/mdv264. Epub 2015 Jun 19.
• [200] Headpiece domain of dematin is required for the stability of the erythrocyte membrane.Proc Natl Acad Sci U S A. 2002 May 14;99(10):6637-42. doi: 10.1073/pnas.052155999.
• [201] Dnases in health and disease.Dev Biol. 2017 Sep 1;429(1):1-11. doi: 10.1016/j.ydbio.2017.06.028. Epub 2017 Jun 28.
• [202] A novel mechanism in suppression of erythropoiesis during inflammation: a crucial role of RCAS1.Eur J Haematol. 2005 May;74(5):365-73. doi: 10.1111/j.1600-0609.2004.00389.x.
• [203] Retrovirus-induced feline pure red blood cell aplasia: pathogenesis and response to suramin.Blood. 1991 Apr 1;77(7):1442-51.
• [204] A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily.J Virol. 1999 Aug;73(8):6500-5. doi: 10.1128/JVI.73.8.6500-6505.1999.
• [205] Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver.Stem Cell Reports. 2019 Dec 10;13(6):992-1005. doi: 10.1016/j.stemcr.2019.11.002.
• [206] Association of FCgamma receptor IIA (CD32) polymorphism with malarial anemia and high-density parasitemia in infants and young children.Am J Trop Med Hyg. 2006 Apr;74(4):573-7.
• [207] Trends in anemia care in non-dialysis-dependent chronic kidney disease (CKD) patients in the United States (2006-2015).BMC Nephrol. 2018 Nov 9;19(1):318. doi: 10.1186/s12882-018-1119-7.
• [208] Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts.Br J Haematol. 2015 Nov;171(4):478-90. doi: 10.1111/bjh.13610. Epub 2015 Aug 10.
• [209] Single-cell analyses demonstrate that a heme-GATA1 feedback loop regulates red cell differentiation.Blood. 2019 Jan 31;133(5):457-469. doi: 10.1182/blood-2018-05-850412. Epub 2018 Dec 10.
• [210] Melanoma-Induced Anemia Could be Rescued by Sca-1(+) Mesenchymal Stromal Cells in Mice.Stem Cells Dev. 2017 Apr 1;26(7):495-502. doi: 10.1089/scd.2016.0139. Epub 2017 Feb 7.
• [211] GDF11 is increased in patients with aplastic anemia.Hematology. 2019 Dec;24(1):331-336. doi: 10.1080/16078454.2019.1574386.
• [212] T cell and monocyte/macrophage activation markers associate with adverse outcome, but give limited prognostic value in anemic patients with heart failure: results from RED-HF.Clin Res Cardiol. 2019 Feb;108(2):133-141. doi: 10.1007/s00392-018-1331-2. Epub 2018 Jul 26.
• [213] Large scale expression and purification of secreted mouse hephaestin.PLoS One. 2017 Sep 7;12(9):e0184366. doi: 10.1371/journal.pone.0184366. eCollection 2017.
• [214] Analysis of hematopathology and alteration of JAK1/STAT3/STAT5 signaling axis in experimental myelodysplastic syndrome.Chem Biol Interact. 2016 Dec 25;260:176-185. doi: 10.1016/j.cbi.2016.10.010. Epub 2016 Oct 8.
• [215] An extremely severe case of Aicardi-Goutires syndrome 7 with a novel variant in IFIH1.Eur J Med Genet. 2020 Feb;63(2):103646. doi: 10.1016/j.ejmg.2019.04.003. Epub 2019 Apr 6.
• [216] Interferon-alpha Treatment for Disease Control in Metastatic Pheochromocytoma/Paraganglioma Patients.Horm Cancer. 2017 Dec;8(5-6):330-337. doi: 10.1007/s12672-017-0303-8. Epub 2017 Jul 26.
• [217] Polymorphisms in genes of interleukin 12 and its receptors and their association with protection against severe malarial anaemia in children in western Kenya.Malar J. 2010 Mar 29;9:87. doi: 10.1186/1475-2875-9-87.
• [218] Methylation status of immune response genes promoters in cell-free DNA differs in hemodialyzed patients with diabetic nephropathy according to the intensity of anemia therapy.Blood Purif. 2013;36(3-4):280-6. doi: 10.1159/000356094. Epub 2013 Dec 20.
• [219] Predictors of Recurrent Hospitalizations and the Importance of These Hospitalizations for Subsequent Mortality After Incident Transient Ischemic Attack.J Stroke Cerebrovasc Dis. 2019 Jan;28(1):167-174. doi: 10.1016/j.jstrokecerebrovasdis.2018.09.028. Epub 2018 Oct 17.
• [220] Screening of LHX2 in patients presenting growth retardation with posterior pituitary and ocular abnormalities.Eur J Endocrinol. 2012 Jul;167(1):85-91. doi: 10.1530/EJE-12-0026. Epub 2012 Apr 24.
• [221] Canine Parvovirus ns1 gene and Chicken Anemia vp3 gene induce partial oncolysis of Canine Transmissible Venereal Tumor.Sci Rep. 2017 Nov 13;7(1):15419. doi: 10.1038/s41598-017-15734-6.
• [222] Disruption of the potassium channel regulatory subunit KCNE2 causes iron-deficient anemia.Exp Hematol. 2014 Dec;42(12):1053-8.e1. doi: 10.1016/j.exphem.2014.07.269. Epub 2014 Aug 12.
• [223] A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2.J Biol Chem. 2009 Oct 23;284(43):29968-78. doi: 10.1074/jbc.M109.023663. Epub 2009 Aug 28.
• [224] Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease.Nat Genet. 2003 Jun;34(2):157-65. doi: 10.1038/ng1157.
• [225] Excessive folic acid intake and relation to adverse health outcome.Biochimie. 2016 Jul;126:71-8. doi: 10.1016/j.biochi.2016.04.010. Epub 2016 Apr 27.
• [226] Clinical and equipment-related factors associated with the adequate peripheral blood stem cell collection in autologous transplant at a tertiary cancer center in Kerala - A retrospective cohort study.Transfus Apher Sci. 2019 Aug;58(4):457-463. doi: 10.1016/j.transci.2019.05.007. Epub 2019 Jun 21.
• [227] Methoxy Polyethylene Glycol-Epoetin Beta as a Novel Erythropoiesis Stimulating Agent with Possible Nephroprotective and Cardiovascular Protective Effects in Non-Dialysis Chronic Kidney Disease Patients.Curr Pharm Biotechnol. 2017;18(4):303-308. doi: 10.2174/1389201018666170127104801.
• [228] A phase I trial investigating pulsatile erlotinib in combination with gemcitabine and oxaliplatin in advanced biliary tract cancers.Invest New Drugs. 2017 Feb;35(1):95-104. doi: 10.1007/s10637-016-0406-z. Epub 2016 Nov 16.
• [229] A role of NF-E2 in chronic inflammation and clonal evolution in essential thrombocythemia, polycythemia vera and myelofibrosis?.Leuk Res. 2014 Feb;38(2):263-6. doi: 10.1016/j.leukres.2013.07.002. Epub 2013 Aug 9.
• [230] Multimorbidity and acute heart failure in internal medicine.Int J Cardiol. 2017 Apr 1;232:208-215. doi: 10.1016/j.ijcard.2017.01.020. Epub 2017 Jan 5.
• [231] Pharmacogenetics of efficacy and safety of HCV treatment in HCV-HIV coinfected patients: significant associations with IL28B and SOCS3 gene variants.PLoS One. 2012;7(11):e47725. doi: 10.1371/journal.pone.0047725. Epub 2012 Nov 2.
• [232] Seasonal childhood anaemia in West Africa is associated with the haptoglobin 2-2 genotype.PLoS Med. 2006 May;3(5):e172. doi: 10.1371/journal.pmed.0030172. Epub 2006 May 2.
• [233] ITPA genetic variants influence efficacy of PEG-IFN/RBV therapy in older patients infected with HCV genotype 1 and favourable IL28B type.J Viral Hepat. 2014 Jul;21(7):466-74. doi: 10.1111/jvh.12171. Epub 2013 Sep 3.
• [234] Hypoxia-inducible factor stabilizers for treating anemia of chronic kidney disease.Curr Opin Nephrol Hypertens. 2018 Sep;27(5):331-338. doi: 10.1097/MNH.0000000000000431.
• [235] The actin-binding protein profilin 2 is a novel regulator of iron homeostasis.Blood. 2017 Oct 26;130(17):1934-1945. doi: 10.1182/blood-2016-11-754382. Epub 2017 Aug 3.
• [236] Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies.Haematologica. 2005 Feb;90(2):257-9.
• [237] Therapeutic Benefit of Blood Transfusion in a Patient With Novel PGK1 Mutation (c.461T>C [p.L154P]).J Pediatr Hematol Oncol. 2020 May;42(4):e228-e230. doi: 10.1097/MPH.0000000000001463.
• [238] A phase Ib study of BGJ398, a pan-FGFR kinase inhibitor in combination with imatinib in patients with advanced gastrointestinal stromal tumor.Invest New Drugs. 2019 Apr;37(2):282-290. doi: 10.1007/s10637-018-0648-z. Epub 2018 Aug 13.
• [239] Alpha-thalassaemia.Orphanet J Rare Dis. 2010 May 28;5:13. doi: 10.1186/1750-1172-5-13.
• [240] Luspatercept for the treatment of anemia in myelodysplastic syndromes and primary myelofibrosis.Blood. 2019 Feb 21;133(8):790-794. doi: 10.1182/blood-2018-11-876888. Epub 2019 Jan 2.
• [241] Association mapping reveals candidate loci for resistance and anaemic response to an emerging temperature-driven parasitic disease in a wild salmonid fish.Mol Ecol. 2018 Mar;27(6):1385-1401. doi: 10.1111/mec.14509. Epub 2018 Mar 6.
• [242] Severe malaria: update on pathophysiology and treatment.Curr Opin Infect Dis. 2019 Oct;32(5):413-418. doi: 10.1097/QCO.0000000000000584.
• [243] Improvement of the hematologic toxicities of ruxolitinib in patients with MPN-associated myelofibrosis using a combination of thalidomide, stanozolol and prednisone.Hematology. 2019 Dec;24(1):516-520. doi: 10.1080/16078454.2019.1631509.
• [244] Abnormal development of zebrafish after knockout and knockdown of ribosomal protein L10a.Sci Rep. 2019 Dec 2;9(1):18130. doi: 10.1038/s41598-019-54544-w.
• [245] The molecular pathogenesis of the myelodysplastic syndromes.Eur J Haematol. 2015 Jul;95(1):3-15. doi: 10.1111/ejh.12515. Epub 2015 Feb 20.
• [246] Mutation of the diamond-blackfan anemia gene Rps7 in mouse results in morphological and neuroanatomical phenotypes.PLoS Genet. 2013;9(1):e1003094. doi: 10.1371/journal.pgen.1003094. Epub 2013 Jan 31.
• [247] GATA Factor-Regulated Samd14 Enhancer Confers Red Blood Cell Regeneration and Survival in Severe Anemia.Dev Cell. 2017 Aug 7;42(3):213-225.e4. doi: 10.1016/j.devcel.2017.07.009.
• [248] Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.Virology. 2014 Jul;460-461:34-44. doi: 10.1016/j.virol.2014.04.023. Epub 2014 May 29.
• [249] The BMP-SMAD pathway mediates the impaired hepatic iron metabolism associated with the ERFE-A260S variant.Am J Hematol. 2019 Nov;94(11):1227-1235. doi: 10.1002/ajh.25613. Epub 2019 Aug 30.
• [250] Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice.Cancer Cell. 2003 Jul;4(1):55-65. doi: 10.1016/s1535-6108(03)00163-6.
• [251] Disruption of the mouse Shmt2 gene confers embryonic anaemia via foetal liver-specific metabolomic disorders.Sci Rep. 2019 Nov 5;9(1):16054. doi: 10.1038/s41598-019-52372-6.
• [252] A Shift in Myeloid Cell Phenotype via Down Regulation of Siglec-1 in Island Macrophages of Bone Marrow Is Associated With Decreased Late Erythroblasts Seen in Anemia of Critical Illness.Front Med (Lausanne). 2019 Nov 20;6:260. doi: 10.3389/fmed.2019.00260. eCollection 2019.
• [253] The ISWI ATPase Smarca5 (Snf2h) Is Required for Proliferation and Differentiation of Hematopoietic Stem and Progenitor Cells.Stem Cells. 2017 Jun;35(6):1614-1623. doi: 10.1002/stem.2604. Epub 2017 Apr 15.
• [254] Ledipasvir/sofosbuvir with or without ribavirin for the treatment of chronic hepatitis C genotype 1: A pairwise meta-analysis.J Gastroenterol Hepatol. 2017 Apr;32(4):749-755. doi: 10.1111/jgh.13620.
• [255] Three Novel Spectrin Variants in Jaundiced Neonates.Clin Pediatr (Phila). 2018 Jan;57(1):19-26. doi: 10.1177/0009922816687326. Epub 2017 Jan 15.
• [256] Later puberty onset among chronically undernourished adolescents living in a Karachi slum, Pakistan.Acta Paediatr. 2020 May;109(5):1019-1025. doi: 10.1111/apa.15053. Epub 2019 Oct 30.
• [257] Deletion of Stk40 impairs definitive erythropoiesis in the mouse fetal liver.Cell Death Dis. 2017 Mar 30;8(3):e2722. doi: 10.1038/cddis.2017.148.
• [258] Anemia and hematinic deficiencies in anti-gastric parietal cell antibody-positive and -negative recurrent aphthous stomatitis patients with anti-thyroid antibody positivity.J Formos Med Assoc. 2017 Mar;116(3):145-152. doi: 10.1016/j.jfma.2016.10.008. Epub 2016 Nov 5.
• [259] Colla corii asini might upregulate ZNF471 and THOC5 by KRAB domain-containing zinc-finger protein pathway and THO complex subunit 5 pathway to improve anemia of pregnant women with -thalassemia.Ann Hematol. 2019 Aug;98(8):1813-1826. doi: 10.1007/s00277-019-03710-1. Epub 2019 May 16.
• [260] Enzyme-linked immunosorbent assay and agar gel immunodiffusion assay for diagnosis of equine infectious anemia employing p26 protein fused to the maltose-binding protein.Arch Virol. 2018 Oct;163(10):2871-2875. doi: 10.1007/s00705-018-3923-6. Epub 2018 Jul 7.
• [261] TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis.Autoimmunity. 2018 Nov;51(7):333-344. doi: 10.1080/08916934.2018.1522305. Epub 2018 Nov 13.
• [262] Cost-effectiveness of malaria preventive treatment for HIV-infected pregnant women in sub-Saharan Africa.Malar J. 2017 Oct 6;16(1):403. doi: 10.1186/s12936-017-2047-x.
• [263] The Tetratricopeptide repeat domain 7 gene is mutated in flaky skin mice: a model for psoriasis, autoimmunity, and anemia.Exp Biol Med (Maywood). 2005 Oct;230(9):659-67. doi: 10.1177/153537020523000908.
• [264] Association of cytokine and Toll-like receptor gene polymorphisms with severe malaria in three regions of Cameroon.PLoS One. 2013 Nov 27;8(11):e81071. doi: 10.1371/journal.pone.0081071. eCollection 2013.
• [265] Increased Reactive Oxygen Species and Cell Cycle Defects Contribute to Anemia in the RASA3 Mutant Mouse Model scat.Front Physiol. 2018 Jun 5;9:689. doi: 10.3389/fphys.2018.00689. eCollection 2018.