Details of the Drug Excipient

General Information of Drug Inactive Ingredient (DIG) (ID: E00420)

DIG Name
Fumaric acid
Synonyms
fumaric acid; 110-17-8; 2-Butenedioic acid; trans-Butenedioic acid; Allomaleic acid; Boletic acid; fumarate; (2E)-but-2-enedioic acid; Lichenic acid; Tumaric acid; trans-2-Butenedioic acid; trans-1,2-Ethylenedicarboxylic acid; Allomalenic acid; (E)-2-Butenedioic acid; But-2-enedioic acid; 2-Butenedioic acid (2E)-; 2-Butenedioic acid (E)-; Kyselina fumarova; USAF EK-P-583; Butenedioic acid; Butenedioic acid, (E)-; (2E)-2-butenedioic acid; 2-Butenedioic acid, (E)-; Caswell No. 465E; FEMA No. 2488; FEMA Number 2488; 2-(E)-Butenedioic acid; (E)-but-2-enedioic acid; NSC-2752; 1,2-Ethylenedicarboxylic acid, (E); CCRIS 1039; HSDB 710; U-1149; trans-but-2-enedioic acid; 1,2-Ethenedicarboxylic acid, trans-; EPA Pesticide Chemical Code 051201; Fumaric acid (NF); Fumaric acid [NF]; UNII-88XHZ13131; AI3-24236; MFCD00002700; CHEBI:18012; NSC2752; FC 33; 88XHZ13131; 6915-18-0; fum; E297; Fumaric acid, 99+%; Lichenic acid (VAN); DSSTox_CID_1518; Futrans-2-Butenedioic Acid; (E)-2-Butenedioate; (E)-Butenedioic acid; DSSTox_RID_76195; DSSTox_GSID_21518; Kyselina fumarova [Czech]; (2E)-but-2-enedioate; Malezid CM; H2male; Fumarsaeure; Fumaricum acidum; CAS-110-17-8; fumarate, 10; cis-but-2-enedioic acid; E-2-Butenedioic acid; Fumaric acid (8CI); EINECS 203-743-0; FC 33 (acid); Scotchbond Multipurpose Etchant; (2Z)-but-2-enedioate; BRN 0605763; Allomaleate; Boletate; Lichenate; fumeric acid; Cis-butenedioate; 2-Butenedioate; Modified Gumrosin; (z)-butenedioate; trans-Butenedioate; fumaric acid group; NCGC00091192-02; cis-2-Butenedioate; Fumaric Acid,(S); Maleic Acid (MA); cis-but-2-enedioate; Fumaric acid solution; trans-2-Butenedioate; Fumaric Acid (FA); 2-(E)-Butenedioate; Fumaric acid, 99%; (2Z)-2-Butenedioate; (Trans)-butenedioic acid; (2Z)-Butene-2-dioate; F0067; Fumaric acid, >=99%; bmse000083; (2Z)-2-Butenedioic acid; EC 203-743-0; Maleic acid [NA2215]; WLN: QV1U1VQ-T; SCHEMBL1177; (2Z)-Butene-2-dioic acid; (E)-but-2-enedioate;hydron; 4-02-00-02202 (Beilstein Handbook Reference); MLS002454406; 2-butenedioic acid, (2E)-; (2E)-2-Butenedioic acid #; CHEMBL503160; INS NO.297; Fumaric Acid (Fragrance Grade); trans-1,2-Ethylenedicarboxylate; DTXSID3021518; BDBM26122; CHEBI:22958; INS-297; HMS2270C12; Pharmakon1600-01301022; Fumaric acid, >=99.0% (T); AMY30339; MAE; STR02646; ZINC3860193; Tox21_201769; Tox21_302826; 2-Butenedioic acid (2E)- (9CI); BBL022974; Fumaric acid, >=99%, FCC, FG; NSC760395; s4952; AKOS000118896; Fumaric acid, qNMR Standard for DMSO; CCG-266065; CS-W016599; DB01677; HY-W015883; NE10214; NSC-760395; NCGC00091192-01; NCGC00091192-03; NCGC00256360-01; NCGC00259318-01; AK113080; BP-13087; Fumaric acid, tested according to USP/NF; LS-12976; SMR000112117; Fumaric acid, puriss., >=99.5% (T); 746-EP2269610A2; 746-EP2269983A1; 746-EP2269984A1; 746-EP2269988A2; 746-EP2269989A1; 746-EP2269990A1; 746-EP2270002A1; 746-EP2270006A1; 746-EP2270008A1; 746-EP2270011A1; 746-EP2270505A1; 746-EP2272516A2; 746-EP2272822A1; 746-EP2272827A1; 746-EP2275401A1; 746-EP2275404A1; 746-EP2275411A2; 746-EP2275413A1; 746-EP2275424A1; 746-EP2277507A1; 746-EP2277848A1; 746-EP2277858A1; 746-EP2277866A1; 746-EP2277867A2; 746-EP2280003A2; 746-EP2280009A1; 746-EP2280010A2; 746-EP2281559A1; 746-EP2281563A1; 746-EP2284149A1; 746-EP2284160A1; 746-EP2284169A1; 746-EP2284170A1; 746-EP2284174A1; 746-EP2284178A2; 746-EP2284179A2; 746-EP2286795A1; 746-EP2287147A2; 746-EP2287153A1; 746-EP2287155A1; 746-EP2287156A1; 746-EP2287160A1; 746-EP2287161A1; 746-EP2287162A1; 746-EP2289510A1; 746-EP2289518A1; 746-EP2289879A1; 746-EP2289883A1; 746-EP2289890A1; 746-EP2292231A1; 746-EP2292234A1; 746-EP2292592A1; 746-EP2292611A1; 746-EP2292617A1; 746-EP2295401A2; 746-EP2295402A2; 746-EP2295406A1; 746-EP2295416A2; 746-EP2295423A1; 746-EP2295424A1; 746-EP2295426A1; 746-EP2295427A1; 746-EP2295433A2; 746-EP2295437A1; 746-EP2298731A1; 746-EP2298735A1; 746-EP2298746A1; 746-EP2298747A1; 746-EP2298748A2; 746-EP2298755A1; 746-EP2298757A2; 746-EP2298758A1; 746-EP2298759A1; 746-EP2298767A1; 746-EP2298768A1; 746-EP2298772A1; 746-EP2298775A1; 746-EP2298779A1; 746-EP2301544A1; 746-EP2301922A1; 746-EP2301923A1; 746-EP2301931A1; 746-EP2301937A1; 746-EP2301940A1; 746-EP2305219A1; 746-EP2305257A1; 746-EP2305633A1; 746-EP2305636A1; 746-EP2305641A1; 746-EP2305646A1; 746-EP2305651A1; 746-EP2305653A1; 746-EP2305655A2; 746-EP2305657A2; 746-EP2305660A1; 746-EP2305664A1; 746-EP2305669A1; 746-EP2305672A1; 746-EP2305673A1; 746-EP2305675A1; 746-EP2305679A1; 746-EP2305683A1; 746-EP2308839A1; 746-EP2308849A1; 746-EP2308850A1; 746-EP2308851A1; 746-EP2308854A1; 746-EP2308857A1; 746-EP2308869A1; 746-EP2308871A1; 746-EP2308875A1; 746-EP2308877A1; 746-EP2309584A1; 746-EP2311801A1; 746-EP2311802A1; 746-EP2311803A1; 746-EP2311804A2; 746-EP2311807A1; 746-EP2311809A1; 746-EP2311810A1; 746-EP2311811A1; 746-EP2311814A1; 746-EP2311821A1; 746-EP2311822A1; 746-EP2311824A1; 746-EP2311834A1; 746-EP2311839A1; 746-EP2311842A2; 746-EP2314295A1; 746-EP2314575A1; 746-EP2314585A1; 746-EP2314586A1; 746-EP2314587A1; 746-EP2314589A1; 746-EP2314593A1; 746-EP2316457A1; 746-EP2316458A1; 746-EP2316459A1; 746-EP2316825A1; 746-EP2316826A1; 746-EP2316827A1; 746-EP2316828A1; 746-EP2316831A1; 746-EP2316836A1; 746-EP2316837A1; 746-EP2371802A1; 746-EP2371814A1; 746-EP2374780A1; 746-EP2374781A1; 746-EP2380874A2; E-297; Fumaric acid, Vetec(TM) reagent grade, 99%; 1, (E); C00122; D02308; Q139857; Fumaric acid 1000 microg/mL in Acetonitrile:Water; Fumaric acid, BioReagent, suitable for cell culture; J-002389; F8886-8257; Fumaric acid, certified reference material, TraceCERT(R); 26B3632D-E93F-4655-90B0-3C17855294BA; Fumaric acid, anhydrous, free-flowing, Redi-Dri(TM), >=99%; Fumaric acid, European Pharmacopoeia (EP) Reference Standard; Fumaric acid, United States Pharmacopeia (USP) Reference Standard; Fumaric acid solution, TraceCERT(R), 1H-qNMR Standard, 1 mg/g in D2O; Fumaric Acid, Pharmaceutical Secondary Standard; Certified Reference Material; Fumaric acid, PharmaGrade, USP/NF, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production.
DIG Function
Acidulant; Antioxidant; Complexing agent; Flavoring agent; Solubilizing agent
Formula
C4H4O4
Canonical SMILES
C(=C/C(=O)O)\\C(=O)O
InChI
1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
InChIKey
VZCYOOQTPOCHFL-OWOJBTEDSA-N
Physicochemical Properties Molecular Weight 116.07 Topological Polar Surface Area 74.6
XlogP -0.3 Complexity 119
Heavy Atom Count 8 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 4

Full List of Drug(s) Co-administrated with This DIG

12 Approved Drug(s) Co-administrated with This DIG
Drug Name Drug ID Indication Formulation Name Formulation ID
Avanafil DM75CXN Erectile dysfunction [HA01.1] Avanafil 100 mg tablet F02102
Bupropion DM5PCS7 Depression [6A70-6A7Z] Bupropion 75 mg tablet F03006
Cetirizine DMOMP9U Allergic rhinitis [CA08.0] Cetirizine 10 mg tablet F03870
Diltiazem DMAI7ZV Angina pectoris [BA40] Diltiazem 180 mg capsule F06040
Donepezil DMIYG7Z Advanced cancer [2A00-2F9Z] Donepezil 23 mg tablet F06667
Ibuprofen DM8VCBE Dysmenorrhea [GA34.3] Ibuprofen 100 mg tablet F10471
Morphine DMRMS0L Advanced cancer [2A00-2F9Z] Morphine 120 mg capsule F14512
Naproxen DMZ5RGV Bursitis [] Naproxen 375 mg tablet F14891
Nateglinide DMLK2QH Diabetic complication [5A2Y] Nateglinide 120 mg tablet F15113
Quetiapine DM1N62C Anorexia nervosa cachexia [6B80] Quetiapine 25 mg tablet F18411
Quinine DMSWYF5 Malaria [1F40-1F45] Quinine 300 mg tablet F18648
Verapamil DMA7PEW Angina pectoris [BA40] Verapamil 240 mg capsule F22403
------------------
⏷ Show the Full List of 12 Approved Drug(s)
1 Clinical Trial Drug(s) Co-administrated with This DIG
Drug Name Drug ID Indication Formulation Name Formulation ID
TAK-491 DMCF6SX Hypertension [BA00-BA04] Azilsartan medoxomil 40 mg tablet F02126
------------------