Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DME (ID: DER7TA0)

• DME Name: N-acetyltransferase 2 (NAT2) DME Info
• Gene Name: NAT2

Molecule-Related Drug & Molecule List

5 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amifampridine	DMK08L3	LambertEaton myasthenic syndrome	8C62	Approved	[1]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[2]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[3]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[4]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[5]

1 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Asacolitin	DM3WVPJ	N. A.	N. A.	Investigative	[6]

References

• [1] Genetic variation in aryl N-acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4-diaminopyridine) phosphate. Pharmacol Res Perspect. 2015 Feb;3(1):e00099.
• [2] Importance of the evaluation of N-acetyltransferase enzyme activity prior to 5-aminosalicylic acid medication for ulcerative colitis. Inflamm Bowel Dis. 2016 Aug;22(8):1793-802.
• [3] Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. Allergy Asthma Immunol Res. 2011 Oct;3(4):273-6.
• [4] N-acetyltransferase 2 genotype-dependent N-acetylation of hydralazine in human hepatocytes. Drug Metab Dispos. 2017 Dec;45(12):1276-1281.
• [5] Substrate-dependent regulation of human arylamine N-acetyltransferase-1 in cultured cells. Mol Pharmacol. 2000 Mar;57(3):468-73.
• [6] Identification and functional characterization of arylamine N-acetyltransferases in eubacteria: evidence for highly selective acetylation of 5-aminosalicylic acid. J Bacteriol. 2001 Jun;183(11):3417-27.