Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTCM4B3)

• DTT Name: Nitric-oxide synthase endothelial (NOS3) DTT Info
• Gene Name: NOS3

Molecule-Related Drug & Molecule List

6 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tilarginine acetate	DMZBGI8	Myocardial infarction	BA41-BA43	Phase 3	[1]
ACCLAIM	DM0FGDO	Angina pectoris	BA40	Phase 2	[2]
L-NAME	DM01SR6	Hypertension	BA00-BA04	Phase 2	[3]
MTR105	DMT0K4F	Hypotension	BA20-BA21	Phase 2	[4]
VAS-203	DMKU93J	Brain injury	NA07.Z	Phase 2	[5]
Autologous cell based gene therapy	DMQA1VT	Pulmonary hypertension	BB01	Phase 1	[6]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-NIL	DM6Y49D	N. A.	N. A.	Terminated	[7]

81 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(5-Imino-[1,4]thiazepan-3-yl)-methanol	DMBKZDJ	Discovery agent	N.A.	Investigative	[8]
(5S,6R)-[Octahydro-quinolin-(2E)-ylidene]amine	DMT9CXD	Discovery agent	N.A.	Investigative	[9]
(5S,6S)-[Octahydro-quinolin-(2E)-ylidene]amine	DMP4UC1	Discovery agent	N.A.	Investigative	[9]
(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin	DMOD9R7	Discovery agent	N.A.	Investigative	[10]
(S)-2-Amino-5-(N-methyl-guanidino)-pentanoic acid	DMZSWDM	Discovery agent	N.A.	Investigative	[11]
(S)-3-Propyl-[1,4]thiazepan-(5E)-ylideneamine	DMIG9H3	Discovery agent	N.A.	Investigative	[8]
(S)-6-Amino-2-(2-imino-ethylamino)-hexanoic acid	DMG58HM	Discovery agent	N.A.	Investigative	[8]
1,2,4-Triazole-Carboxamidine	DMOXLHT	Discovery agent	N.A.	Investigative	[10]
1-(2-amino-benzothiazol-5-yl)-2-ethyl-isothiourea	DMAE8BF	Discovery agent	N.A.	Investigative	[12]
1-(2-amino-benzothiazol-6-yl)-2-ethyl-isothiourea	DMCSHRL	Discovery agent	N.A.	Investigative	[12]
1400W	DMLZT64	Discovery agent	N.A.	Investigative	[13]
2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine	DMQPKWM	Discovery agent	N.A.	Investigative	[13]
2-amino-4-methylpyridine	DM1OED2	Discovery agent	N.A.	Investigative	[14]
2-Amino-5-(N-nitro-guanidino)-pentanoic acid	DMDUZ2H	Discovery agent	N.A.	Investigative	[11]
2-Aminothiazoline	DM9YCAH	Discovery agent	N.A.	Investigative	[10]
2-Methyl-2,4-Pentanediol	DMD45CU	Discovery agent	N.A.	Investigative	[10]
2-Methyl-[1,4]thiazepan-(5E)-ylideneamine	DMX1IC4	Discovery agent	N.A.	Investigative	[8]
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[10]
3,4-Dimethyl-pyrrolidin-(2Z)-ylideneamine	DMMO6QI	Discovery agent	N.A.	Investigative	[15]
3-Bromo-1H-indazole-7-carbonitrile	DMZGWL2	Discovery agent	N.A.	Investigative	[16]
3-bromo-7-nitro-1H-indazole	DMM7DHB	Discovery agent	N.A.	Investigative	[10]
3-Ethyl-[1,4]thiazepan-(5E)-ylideneamine	DMX2JKQ	Discovery agent	N.A.	Investigative	[8]
3-Methyl-pyrrolidin-(2Z)-ylideneamine	DMHVUF8	Discovery agent	N.A.	Investigative	[15]
3-Methyl-[1,4]thiazepan-(5E)-ylideneamine	DMCOH46	Discovery agent	N.A.	Investigative	[8]
4,5-Dimethyl-pyrrolidin-(2Z)-ylideneamine	DMB9CJM	Discovery agent	N.A.	Investigative	[15]
4-Ethyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneamine	DMTM1VD	Discovery agent	N.A.	Investigative	[17]
4-Ethyl-5-methyl-pyrrolidin-(2Z)-ylideneamine	DMOAQ1E	Discovery agent	N.A.	Investigative	[15]
4-Ethyl-pyrrolidin-(2Z)-ylideneamine	DMYIWAH	Discovery agent	N.A.	Investigative	[15]
4-Methyl-3,6-dihydro-1H-pyridin-(2Z)-ylideneamine	DM5FWYG	Discovery agent	N.A.	Investigative	[17]
4-Methyl-5,6-dihydro-1H-pyridin-(2Z)-ylideneamine	DMUP8NS	Discovery agent	N.A.	Investigative	[17]
4-methyl-6-propylpyridin-2-amine	DMY04D1	Discovery agent	N.A.	Investigative	[14]
4-Methyl-piperidin-(2E)-ylideneamine	DMNMXCE	Discovery agent	N.A.	Investigative	[9]
4-Methyl-pyrrolidin-(2Z)-ylideneamine	DM0YS36	Discovery agent	N.A.	Investigative	[15]
5,6-Cyclic-Tetrahydropteridine	DMDE7XJ	Discovery agent	N.A.	Investigative	[18]
5-Ethyl-3-methyl-pyrrolidin-(2Z)-ylideneamine	DMS9TFC	Discovery agent	N.A.	Investigative	[15]
5-Ethyl-4-methyl-pyrrolidin-(2Z)-ylideneamine	DMQWOIG	Discovery agent	N.A.	Investigative	[15]
5-Methyl-pyrrolidin-(2Z)-ylideneamine	DM4QB3G	Discovery agent	N.A.	Investigative	[15]
5-Nitroindazole	DMH7SIX	Discovery agent	N.A.	Investigative	[10]
6-(2-Fluoropropyl)-4-methylpyridin-2-amine	DME1JLM	Discovery agent	N.A.	Investigative	[19]
6-(3-Fluoropropyl)-4-methylpyridin-2-amine	DMTJPZU	Discovery agent	N.A.	Investigative	[19]
6-isobutyl-4-methylpyridin-2-amine	DM2XB68	Discovery agent	N.A.	Investigative	[19]
6-Nitroindazole	DM2WZCX	Discovery agent	N.A.	Investigative	[10]
6s-5,6,7,8-Tetrahydrobiopterin	DMIA7ND	Discovery agent	N.A.	Investigative	[10]
7-(2-Nitro-ethyl)-azepan-(2Z)-ylideneamine	DMK28IS	Discovery agent	N.A.	Investigative	[20]
7-Methyl-[1,4]thiazepan-(5E)-ylideneamine	DMUCJA6	Discovery agent	N.A.	Investigative	[8]
7-nitro-1H-indazole	DMW4XKQ	Discovery agent	N.A.	Investigative	[10]
7-Nitroindazole-2-Carboxamidine	DMGLWOM	Discovery agent	N.A.	Investigative	[13]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[10]
AP-Cav	DMT9Z5A	Discovery agent	N.A.	Investigative	[21]
Azepan-(2Z)-ylideneamine	DMZHV39	Discovery agent	N.A.	Investigative	[20]
Cacodylate Ion	DMK4XLD	Discovery agent	N.A.	Investigative	[10]
Ethylisothiourea	DMV9OCU	N. A.	N. A.	Investigative	[10]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[13]
Hexahydro-cyclopenta[c]pyrrol-(1Z)-ylideneamine	DMG0UVT	Discovery agent	N.A.	Investigative	[15]
Hydroxydimethylarsine Oxide	DMPS2B1	Discovery agent	N.A.	Investigative	[10]
L-2-Amino-4-(Guanidinooxy)Butyric Acid	DMWQCRD	Discovery agent	N.A.	Investigative	[10]
L-Homoarginine	DML83XP	Discovery agent	N.A.	Investigative	[10]
L-NIO	DME9FAV	Discovery agent	N.A.	Investigative	[18]
N,N-dimethylarginine	DM0Y8OW	Discovery agent	N.A.	Investigative	[22]
N-(5-Amino-6-oxo-heptyl)-acetamidine	DM47XR8	Discovery agent	N.A.	Investigative	[15]
N-(Chlorophenyl)-N'-Hydroxyguanidine	DMFGSLO	Discovery agent	N.A.	Investigative	[13]
N-omega-allyl-L-arginine	DM0BPCT	Discovery agent	N.A.	Investigative	[23]
N-Omega-Hydroxy-L-Arginine	DMOXQ3N	Discovery agent	N.A.	Investigative	[10]
N-omega-propargyl-L-arginine	DM9X3B7	Discovery agent	N.A.	Investigative	[23]
N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane	DMVIGCJ	Discovery agent	N.A.	Investigative	[10]
N5-(1-iminobut-3-enyl)-L-ornithine	DMB62OI	Discovery agent	N.A.	Investigative	[23]
N5-(1-iminobutyl)-L-ornithine	DMT893N	Discovery agent	N.A.	Investigative	[23]
N5-(1-iminopropyl)-L-ornithine	DM05O7J	Discovery agent	N.A.	Investigative	[23]
Nitroarginine	DM7T80N	N. A.	N. A.	Investigative	[24]
Piperidin-(2E)-ylideneamine	DMN8OR2	Discovery agent	N.A.	Investigative	[9]
Pyrrolidin-(2Z)-ylideneamine	DMS4ZFU	Discovery agent	N.A.	Investigative	[15]
S-(Dimethylarsenic)Cysteine	DMSCHL0	Discovery agent	N.A.	Investigative	[10]
S-Ethyl-N-Phenyl-Isothiourea	DM6DT9Z	Discovery agent	N.A.	Investigative	[13]
S-Isopropyl-Isothiourea	DMZ30AM	Discovery agent	N.A.	Investigative	[10]
Se-Ethyl-Isoselenourea	DM9BJ27	Discovery agent	N.A.	Investigative	[10]
THIOCITRULLINE	DM7X8MH	Discovery agent	N.A.	Investigative	[25]
[1,3]Oxazinan-(2E)-ylideneamine	DMDX6W4	Discovery agent	N.A.	Investigative	[11]
[1,3]Thiazinan-(2E)-ylideneamine	DMOEIHC	Discovery agent	N.A.	Investigative	[11]
[1,4]Oxazepan-(3E)-ylideneamine	DMX58NK	Discovery agent	N.A.	Investigative	[8]
[1,4]Thiazepan-(3E)-ylideneamine	DMCBFJQ	Discovery agent	N.A.	Investigative	[8]
[1,4]Thiazepan-(5E)-ylideneamine	DMFQ0Z4	Discovery agent	N.A.	Investigative	[8]

References

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