General Information of DTT (ID: TTELIN2)

DTT Name PTPN1 messenger RNA (PTPN1 mRNA) DTT Info
Gene Name PTPN1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
2 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1]
TRYPAN BLUE DM4NTMO Ophthalmic surgery injury PK97 Approved [2]
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3 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
ISIS 113715 DMUPD4G Type-2 diabetes 5A11 Phase 2 [3]
ISIS-PTP1Brx DMJGVXT Type-2 diabetes 5A11 Phase 2 [4]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [5]
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1 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
ERTIPROTAFIB DMJXEV7 Type-2 diabetes 5A11 Terminated [6]
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105 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
1,2,3,4,6-penta-O-galloyl-D-glucopyranose DM9ICSA Discovery agent N.A. Investigative [7]
1,2,5-THIADIAZOLIDIN-3-ONE-1,1-DIOXIDE DM9VYOI Discovery agent N.A. Investigative [8]
1,2-NAPHTHOQUINONE DMYXELH Discovery agent N.A. Investigative [9]
1-Iodyl-3-nitro-benzene DMYIQDE Discovery agent N.A. Investigative [1]
1-Iodyl-4-nitro-benzene DMF1WA6 Discovery agent N.A. Investigative [1]
1-METHYL-3-PHENYL-1H-PYRAZOL-5-YLSULFAMIC ACID DMICQWN Discovery agent N.A. Investigative [10]
16-alphaH,17-isovaleryloxy-ent-kauran-19-oic acid DMI49D0 Discovery agent N.A. Investigative [11]
18alpha-Glycyrrhetic acid DMYS6DB Discovery agent N.A. Investigative [12]
18beta-Glycyrrhetic acid DMFMRN8 Discovery agent N.A. Investigative [12]
19alpha,24-dihydroxyurs-12-en-3-on-28-oic acid DMP168O Discovery agent N.A. Investigative [13]
2-(Oxalyl-Amino)-Benzoic Acid DM7LOHK Discovery agent N.A. Investigative [14]
2-Methyl-2,4-Pentanediol DMD45CU Discovery agent N.A. Investigative [14]
24-hydroxyursolic acid DMVY271 Discovery agent N.A. Investigative [13]
3,9-Dihydroxy-4-prenyl-[6aR,11aR]pterocarpan DMK53AT Discovery agent N.A. Investigative [5]
3-(4,5-Bis-biphenyl-4-yl-1H-imidazol-2-yl)-phenol DMGXPJV Discovery agent N.A. Investigative [15]
3-(Oxalyl-Amino)-Naphthalene-2-Carboxylic Acid DMMRV1N Discovery agent N.A. Investigative [14]
3-epi-masilinic acid DM1UOWB Discovery agent N.A. Investigative [16]
3-Iodyl-benzoic acid DMJSLVT Discovery agent N.A. Investigative [1]
3-isopropyl-4-(phenylthio)naphthalene-1,2-dione DMJZEMB Discovery agent N.A. Investigative [17]
3-oxoolean-12-en-27-oic acid DM6JYWQ Discovery agent N.A. Investigative [12]
3alpha,24-dihydroxyolean-12-en-27-oic acid DM3ZR7A Discovery agent N.A. Investigative [12]
3beta,6beta-dihydroxyolean-12-en-27-oic acid DMLEXWC Discovery agent N.A. Investigative [12]
3beta-acetoxyolean-12-en-27-oic acid DMOZAHB Discovery agent N.A. Investigative [12]
3beta-hydroxyolean-12-en-27-oic acid DMF6VGK Discovery agent N.A. Investigative [12]
3beta-hydroxyurs-12-en-27-oic acid DM6NFO0 Discovery agent N.A. Investigative [12]
4'-((2-butylbenzofuran-3-yl)methyl)biphenyl-4-ol DMCRWTH Discovery agent N.A. Investigative [18]
4'-(2-butylbenzofuran-3-yl)biphenyl-4-ol DM2MSEF Discovery agent N.A. Investigative [18]
4-(p-toluidino)-3-isopropylnaphthalene-1,2-dione DMQA0EJ Discovery agent N.A. Investigative [17]
4-Iodyl-benzoic acid DMQ95EG Discovery agent N.A. Investigative [1]
5-deoxyabyssinin II DM1Q0BF Discovery agent N.A. Investigative [19]
6-(Oxalyl-Amino)-1h-Indole-5-Carboxylic Acid DM1LY0S Discovery agent N.A. Investigative [14]
Abyssinin I DMC02FP Discovery agent N.A. Investigative [19]
Abyssinin II DMR7IGZ Discovery agent N.A. Investigative [19]
Abyssinoflavanone VI DMEYQF9 Discovery agent N.A. Investigative [19]
Abyssinoflavanone VII DMTVQSL Discovery agent N.A. Investigative [19]
Abyssinone-IV DM9YAVX Discovery agent N.A. Investigative [20]
Abyssinone-VI-4-O-methyl ether DMZUY93 Discovery agent N.A. Investigative [20]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [14]
ALBAFURAN A DMO1ZC2 Discovery agent N.A. Investigative [21]
Augustic acid DMKVDAN Discovery agent N.A. Investigative [16]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [14]
BURTTINONE DMJP0QT Discovery agent N.A. Investigative [22]
CAULERPIN DM4QKVN Discovery agent N.A. Investigative [23]
CHROMOTROPATE DM5JHUN Discovery agent N.A. Investigative [2]
Cysteine Sulfenic Acid DM4GZUJ N. A. N. A. Investigative [10]
Cysteinesulfonic Acid DMXI8FP Discovery agent N.A. Investigative [14]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [14]
DYSIDINE DMNYQL9 Discovery agent N.A. Investigative [24]
Erybreadin b DM27FRY Discovery agent N.A. Investigative [5]
Erybreadin C DMNS976 Discovery agent N.A. Investigative [5]
Erybreadin D DMYG7BM Discovery agent N.A. Investigative [5]
Erysubin E DMXWK1A Discovery agent N.A. Investigative [5]
ERYTHRIBYSSIN A DM5GEUN Discovery agent N.A. Investigative [5]
FOLITENOL DMSBQL0 Discovery agent N.A. Investigative [5]
FORMYLCHROMONE DMFOU92 Discovery agent N.A. Investigative [25]
Iodyl-benzene DMO73M9 Discovery agent N.A. Investigative [1]
ISIS 107772 DM37VYR Discovery agent N.A. Investigative [26]
ISIS 107773 DMA3ZGH Discovery agent N.A. Investigative [26]
ISIS 107774 DMFOTQY Discovery agent N.A. Investigative [26]
ISIS 107775 DMLBX9Z Discovery agent N.A. Investigative [26]
ISIS 107776 DMNHBGJ Discovery agent N.A. Investigative [26]
ISIS 107791 DMVTU63 Discovery agent N.A. Investigative [26]
ISIS 107792 DMV87MP Discovery agent N.A. Investigative [26]
Isochroman mono-carboxylic acid DMUB187 Discovery agent N.A. Investigative [25]
ISOTHIAZOLIDINONE ANALOG DMKTBEH Discovery agent N.A. Investigative [8]
Isoxazolecarboxylic acid DMPZURH Discovery agent N.A. Investigative [25]
KR61639 DMIEKJ4 Discovery agent N.A. Investigative [27]
Kuwanon J DMFSUJB Discovery agent N.A. Investigative [21]
Kuwanon L DMX4D1Q Discovery agent N.A. Investigative [28]
Kuwanon R DMEZOT9 Discovery agent N.A. Investigative [21]
Kuwanon V DM84M20 Discovery agent N.A. Investigative [21]
LICOAGROCHACONE A DMWY0TN Discovery agent N.A. Investigative [29]
LICOAGROCHALCONE A DMY65ZP Discovery agent N.A. Investigative [19]
MASLINIC ACID DMN9UX3 Discovery agent N.A. Investigative [16]
Methyl 3beta-hydroxyolean-12-en-28-oate DMWG9BE Discovery agent N.A. Investigative [12]
Methyl3beta-hydroxyolean-12-en-27-oate DMOA54M Discovery agent N.A. Investigative [12]
Mulberrofuran C DMYV49C Discovery agent N.A. Investigative [28]
Mulberrofuran D DMMKH72 Discovery agent N.A. Investigative [21]
Mulberrofuran W DMTV9P3 Discovery agent N.A. Investigative [21]
NEORAUTENOL DM5GMOJ Discovery agent N.A. Investigative [5]
Novo Nordisk a/S Compound DM3C2VA Discovery agent N.A. Investigative [14]
OHIOENSIN A DMZMTLB Discovery agent N.A. Investigative [30]
Ohioensin C DMNUGTL Discovery agent N.A. Investigative [30]
Ohioensin F DMCT348 Discovery agent N.A. Investigative [30]
Ohioensin G DMLJBVP Discovery agent N.A. Investigative [30]
OLEANOLIC_ACID DMWDMJ3 Discovery agent N.A. Investigative [31]
Oleanonic acid DMYPJC3 Discovery agent N.A. Investigative [13]
Oxalylaminobenzoic acid DMT7XYE Discovery agent N.A. Investigative [25]
PARA-(BENZOYL)-PHENYLALANINE DM2JUTB Discovery agent N.A. Investigative [8]
PHELLIGRIDIN I DMAP04X Discovery agent N.A. Investigative [32]
PNU177836 DMM0EYR Discovery agent N.A. Investigative [14]
Pomolic acid DM1GV7K Discovery agent N.A. Investigative [13]
RK-682 DM5CI2P Discovery agent N.A. Investigative [33]
Rotungenic acid DM751OH Discovery agent N.A. Investigative [13]
Sanggenon C DMSF5DW Discovery agent N.A. Investigative [28]
Sanggenon G DMNHUOD Discovery agent N.A. Investigative [28]
SIGMOIDIN A DMB70NK Discovery agent N.A. Investigative [19]
SIGMOIDIN B DMVH5WK Discovery agent N.A. Investigative [19]
Sigmoidin F DM8E62L Discovery agent N.A. Investigative [19]
Sp7343-Sp7964 DML2V1I Discovery agent N.A. Investigative [14]
Spathodic acid DMJ6WNK Discovery agent N.A. Investigative [13]
USIMINE A DMCQ8AL Discovery agent N.A. Investigative [34]
USNIC ACID DMGOURX Discovery agent N.A. Investigative [34]
UVAOL DMAFQE1 Discovery agent N.A. Investigative [13]
[[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid, DMU9F2P Discovery agent N.A. Investigative [14]
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⏷ Show the Full List of 105 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6.
2 Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6.
3 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
4 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
5 Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9.
6 2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5357-60.
7 Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor. J Nat Prod. 2010 Sep 24;73(9):1578-81.
8 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
9 Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents. Bioorg Med Chem Lett. 2002 Aug 5;12(15):1941-6.
10 DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
11 Inhibition of protein tyrosine phosphatase 1B by diterpenoids isolated from Acanthopanax koreanum. Bioorg Med Chem Lett. 2006 Jun 1;16(11):3061-4.
12 Protein tyrosine phosphatase 1B inhibitory activity of triterpenes isolated from Astilbe koreana. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3273-6.
13 Triterpenoids from the leaves of Diospyros kaki (persimmon) and their inhibitory effects on protein tyrosine phosphatase 1B. J Nat Prod. 2008 Oct;71(10):1775-8.
14 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
15 Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B. J Med Chem. 2002 May 23;45(11):2213-21.
16 Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6618-22.
17 Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1905-8.
18 Synthesis, activity and molecular modeling of a new series of chromones as low molecular weight protein tyrosine phosphatase inhibitors. Bioorg Med Chem. 2009 Apr 1;17(7):2658-72.
19 Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. J Nat Prod. 2007 Jun;70(6):1039-42.
20 Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii. J Nat Prod. 2006 Nov;69(11):1572-6.
21 Protein tyrosine phosphatase 1B inhibitors isolated from Morus bombycis. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6759-61.
22 Flavanones from the stem bark of Erythrina abyssinica. Bioorg Med Chem. 2008 Dec 15;16(24):10356-62.
23 Two novel aromatic valerenane-type sesquiterpenes from the Chinese green alga Caulerpa taxifolia. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2947-50.
24 A novel sesquiterpene quinone from Hainan sponge Dysidea villosa. Bioorg Med Chem Lett. 2009 Jan 15;19(2):390-2.
25 Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents. Eur J Med Chem. 2010 Sep;45(9):3709-18.
26 US patent application no. 6,261,840, Antisense modulation of PTP1B expression.
27 Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent. Eur J Pharmacol. 2004 Feb 6;485(1-3):333-9.
28 Protein tyrosine phosphatase 1B inhibitors from Morus root bark. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1426-9.
29 Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5155-7.
30 Ohioensins F and G: protein tyrosine phosphatase 1B inhibitory benzonaphthoxanthenones from the Antarctic moss Polytrichastrum alpinum. Bioorg Med Chem Lett. 2008 Jan 15;18(2):772-5.
31 Chemical Constituents of the Roots of Euphorbia micractina. J Nat Prod. 2009 Sep;72(9):1620-6.
32 Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius. J Nat Prod. 2007 Feb;70(2):296-9.
33 Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5398-401.
34 Usimines A-C, bioactive usnic acid derivatives from the Antarctic lichen Stereocaulon alpinum. J Nat Prod. 2008 Apr;71(4):710-2.