Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTFBNVI)

• DTT Name: Aldose reductase (AKR1B1) DTT Info
• Gene Name: AKR1B1

Molecule-Related Drug & Molecule List

2 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epalrestat	DM5OGK0	Diabetic neuropathy	8C0Z	Approved	[1]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[2]

11 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fidarestat	DMZL1I8	Diabetic complication	5A2Y	Phase 3	[3]
Ranirestat	DMD5QRS	Diabetic neuropathy	8C0Z	Phase 3	[4]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[4]
CONTIGOSIDE B	DMX9V8K	Thrombosis	DB61-GB90	Phase 2/3	[5]
ADMVA	DM819CO	Diabetic complication	5A2Y	Phase 2	[4]
LIDORESTAT	DMA0RI9	Diabetic complication	5A2Y	Phase 2	[6]
M-16209	DMZ7YX3	Diabetic complication	5A2Y	Phase 2	[7]
QR-333	DMKVIWM	Diabetic neuropathy	8C0Z	Phase 2	[8]
T2c-003	DMWIH59	Diabetic neuropathy	8C0Z	Phase 1/2	[4]
ALO-1567	DMGFVYL	Glaucoma/ocular hypertension	9C61	Phase 1	[9]
SSR-125047	DMSUFW6	Schizophrenia	6A20	Phase 1	[10]

14 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IMIRESTAT	DM8KSMX	Diabetic complication	5A2Y	Discontinued in Phase 3	[11]
MINALRESTAT	DM86XJG	Diabetic complication	5A2Y	Discontinued in Phase 3	[12]
Ponalrestat	DM04ZUW	Gout	FA25	Discontinued in Phase 3	[13]
AD-5467	DMM02XV	Diabetic complication	5A2Y	Discontinued in Phase 2	[14]
Alrestatin	DMIAXCZ	N. A.	N. A.	Discontinued in Phase 2	[15]
CTL-102-GDEPT	DM09CUO	Head and neck cancer	2D42	Discontinued in Phase 2	[16]
JTT-811	DMJ1ZTB	Diabetic complication	5A2Y	Discontinued in Phase 2	[4]
ZOPOLRESTAT	DMWOT92	Diabetic complication	5A2Y	Discontinued in Phase 2	[17]
E-0722	DM2PVMZ	Diabetic cataract	9B10.21	Terminated	[19]
FR-62765	DMJS9YB	Diabetic complication	5A2Y	Terminated	[20]
Sorbinil	DM31VE4	Diabetic cataract	9B10.21	Terminated	[21]
SPR-210	DMTGIUV	Diabetic complication	5A2Y	Terminated	[22]
WF-2421	DMBMOI6	Diabetic complication	5A2Y	Terminated	[23]
Zenarestat	DMQUSG9	Diabetic neuropathy	8C0Z	Terminated	[24]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARI-809	DM61TDB	Diabetic complication	5A2Y	Preclinical	[18]

73 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(4-Methyl-2-oxo-2H-quinolin-1-yl)-acetic acid	DMPU7KE	Discovery agent	N.A.	Investigative	[25]
(6-Hydroxy-2-oxo-2H-quinolin-1-yl)-acetic acid	DMQJ5RU	Discovery agent	N.A.	Investigative	[25]
(6-Methoxy-2-oxo-2H-quinolin-1-yl)-acetic acid	DMTYXFU	Discovery agent	N.A.	Investigative	[25]
(8-Hydroxy-2-oxo-2H-quinolin-1-yl)-acetic acid	DMRU0IB	Discovery agent	N.A.	Investigative	[25]
2'-Monophosphoadenosine 5'-Diphosphoribose	DME9S8M	Discovery agent	N.A.	Investigative	[15]
2,3-dihydroxypropanal	DMOWNB4	Discovery agent	N.A.	Investigative	[26]
2-(3,4-Dihydroxy-benzyl)-7-hydroxy-chromen-4-one	DMAOD0K	Discovery agent	N.A.	Investigative	[27]
2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one	DM5MKEI	Discovery agent	N.A.	Investigative	[27]
2-(3-benzoyl-1H-pyrrol-1-yl)acetic acid	DMDB4LZ	Discovery agent	N.A.	Investigative	[28]
2-(4-aminophenylsulfonamido)acetic acid	DMMU2BZ	Discovery agent	N.A.	Investigative	[29]
2-(Phenylsulfonamido)acetic Acid	DMMSI67	Discovery agent	N.A.	Investigative	[30]
2-Benzhydryl-7-hydroxy-chromen-4-one	DMXZ1HL	Discovery agent	N.A.	Investigative	[27]
2-Benzyl-7-hydroxy-chromen-4-one	DMAX5TC	Discovery agent	N.A.	Investigative	[27]
3,5-dichlorosalicylic acid	DMQ45WH	Discovery agent	N.A.	Investigative	[31]
3-(3-Benzoyl-1H-pyrrol-1-yl)propanoic acid	DMXKL75	Discovery agent	N.A.	Investigative	[28]
3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid	DM1QKNU	Discovery agent	N.A.	Investigative	[32]
4-(3-Benzoyl-1H-pyrrol-1-yl)butanoic acid	DMT0EK8	Discovery agent	N.A.	Investigative	[28]
4-(3-Methoxy-phenyl)-isoxazolidine-3,5-dione	DMSUFJZ	Discovery agent	N.A.	Investigative	[33]
6,7-Dihydroxy-2-phenyl-chromen-4-one	DMF08UT	Discovery agent	N.A.	Investigative	[27]
6-(1H-Indole-2-sulfonyl)-2H-pyridazin-3-one	DM1TOFD	Discovery agent	N.A.	Investigative	[34]
6-(2-Bromo-benzenesulfonyl)-2H-pyridazin-3-one	DMYDHLN	Discovery agent	N.A.	Investigative	[34]
6-(2-Chloro-benzenesulfonyl)-2H-pyridazin-3-one	DM2Y9O4	Discovery agent	N.A.	Investigative	[34]
6-(2-Fluoro-benzenesulfonyl)-2H-pyridazin-3-one	DMQKR2W	Discovery agent	N.A.	Investigative	[34]
6-(3-Chloro-benzenesulfonyl)-2H-pyridazin-3-one	DMJO4I7	Discovery agent	N.A.	Investigative	[34]
6-(4-Bromo-benzenesulfonyl)-2H-pyridazin-3-one	DM9K8DY	Discovery agent	N.A.	Investigative	[34]
6-(4-Chloro-benzenesulfonyl)-2H-pyridazin-3-one	DMNAHVB	Discovery agent	N.A.	Investigative	[34]
6-(4-Fluoro-benzenesulfonyl)-2H-pyridazin-3-one	DM7WYNT	Discovery agent	N.A.	Investigative	[34]
6-(4-Methoxy-benzenesulfonyl)-2H-pyridazin-3-one	DM5LBCH	Discovery agent	N.A.	Investigative	[34]
6-(Benzofuran-2-sulfonyl)-2H-pyridazin-3-one	DM2GFI3	Discovery agent	N.A.	Investigative	[34]
6-(Benzothiazole-2-sulfonyl)-2H-pyridazin-3-one	DMXLDHR	Discovery agent	N.A.	Investigative	[34]
6-(Biphenyl-2-sulfonyl)-2H-pyridazin-3-one	DM4KMDB	Discovery agent	N.A.	Investigative	[34]
6-(Naphthalene-1-sulfonyl)-2H-pyridazin-3-one	DMXSCQE	Discovery agent	N.A.	Investigative	[34]
6-(Naphthalene-2-sulfonyl)-2H-pyridazin-3-one	DMCIA63	Discovery agent	N.A.	Investigative	[34]
6-(Toluene-4-sulfonyl)-2H-pyridazin-3-one	DMV3MF4	Discovery agent	N.A.	Investigative	[34]
6-Benzenesulfonyl-2H-pyridazin-3-one	DM81DTC	Discovery agent	N.A.	Investigative	[34]
6-Hydroxy-2-(4-hydroxy-benzyl)-chromen-4-one	DMU1CGD	Discovery agent	N.A.	Investigative	[27]
6-methoxykaempferol 3-O-beta-D-robinobioside	DM5JB9D	Discovery agent	N.A.	Investigative	[35]
6-Phenylmethanesulfonyl-2H-pyridazin-3-one	DMPA534	Discovery agent	N.A.	Investigative	[34]
7-Hydroxy-2-(4-hydroxy-benzyl)-chromen-4-one	DMCB2IM	Discovery agent	N.A.	Investigative	[27]
7-Hydroxy-2-(4-methoxy-benzyl)-chromen-4-one	DM2BV6P	Discovery agent	N.A.	Investigative	[27]
7-Hydroxy-4-phenylcoumarin	DM3T612	Discovery agent	N.A.	Investigative	[36]
7-Hydroxy-6-nitro-2-phenyl-chromen-4-one	DM49RWY	Discovery agent	N.A.	Investigative	[27]
AK198	DMWKPJH	Discovery agent	N.A.	Investigative	[37]
Alpha-D-Glucose-6-Phosphate	DMR0EVN	Discovery agent	N.A.	Investigative	[15]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[38]
Apigenin-7-O-beta-D-glucuronide	DMIQOXH	Discovery agent	N.A.	Investigative	[38]
Apigenin-7-O-beta-D-glucuronide methyl ester	DMP7J0I	Discovery agent	N.A.	Investigative	[38]
ASTRAGALIN	DMZHWPG	Discovery agent	N.A.	Investigative	[38]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[39]
daidzein	DMRFTJX	Discovery agent	N.A.	Investigative	[27]
EPALRESTATE	DM01MW7	Discovery agent	N.A.	Investigative	[38]
Fidarestat(Stereoisomer)	DMETVLB	Discovery agent	N.A.	Investigative	[15]
Hydroxydimethylarsine Oxide	DMPS2B1	Discovery agent	N.A.	Investigative	[15]
IDD552	DM3P7W5	Discovery agent	N.A.	Investigative	[15]
IDD594	DMDHLG3	Discovery agent	N.A.	Investigative	[32]
Inhibitor Idd 384	DMBQY3C	Discovery agent	N.A.	Investigative	[15]
Isorhamnetin 3,7-disulfate	DMFKQ0B	Discovery agent	N.A.	Investigative	[5]
Isorhamnetin 3-O-rhamnoside	DMZQUY4	Discovery agent	N.A.	Investigative	[40]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[38]
MANGIFERIN	DMWAF5Z	Discovery agent	N.A.	Investigative	[41]
N-Acetylalanine	DMZW9AC	Discovery agent	N.A.	Investigative	[15]
NSC-94258	DM6VY3P	Discovery agent	N.A.	Investigative	[27]
O5-Acetyl-O7-nitrooxyethyl chrysin	DMKMH2X	Discovery agent	N.A.	Investigative	[39]
O7-Nitrooxyethyl chrysin	DMAUDCW	Discovery agent	N.A.	Investigative	[39]
PALBINONE	DMN97BF	Discovery agent	N.A.	Investigative	[42]
Patuletin 3-O-beta-D-galactoside	DMOXNYQ	Discovery agent	N.A.	Investigative	[35]
Patuletin 3-O-beta-D-robinobioside	DMZ5Q7J	Discovery agent	N.A.	Investigative	[35]
Quercetin 3-O-neohesperidoside	DMXIU6W	Discovery agent	N.A.	Investigative	[40]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[38]
Tamarixetin 3-glucoside-7-sulfate	DM17JFO	Discovery agent	N.A.	Investigative	[5]
TINGENIN B	DMEV7FY	Discovery agent	N.A.	Investigative	[41]
TINGENONE	DMH3NTP	Discovery agent	N.A.	Investigative	[41]
TRIPTOCALLINE A	DMBYV3M	Discovery agent	N.A.	Investigative	[41]

References

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