Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTKPW01)

• DTT Name: Androgen receptor messenger RNA (AR mRNA) DTT Info
• UniProt ID: ANDR_HUMAN
• Gene Name: AR

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[1]

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BAY 86-5044	DMRZLU4	Breast cancer	2C60-2C65	Phase 2	[2]
TRC-253	DMXI8CD	Prostate cancer	2C82.0	Phase 1/2	[3]
EZN-4176	DMNPS59	Prostate cancer	2C82.0	Phase 1	[4]
ISIS-AR	DM8P3N5	Prostate cancer	2C82.0	Phase 1	[5]

1 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eugenol	DM7US1H	Discovery agent	N.A.	Patented	[6]

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RU-58841	DMMEAZ2	Acne vulgaris	ED80	Discontinued in Phase 1	[7]

57 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1,2-dibromo-4-(1,2-dibromoethyl)cyclohexane	DMDJYHK	Discovery agent	N.A.	Investigative	[8]
2'-Hydroxy-3-methoxy-biphenyl-4-carbonitrile	DM5QV19	Discovery agent	N.A.	Investigative	[7]
2-chloro-4-(o-tolyloxy)benzonitrile	DMTPKU8	Discovery agent	N.A.	Investigative	[9]
2-methoxy-4-(2-methoxyphenylthio)benzonitrile	DMF8E5L	Discovery agent	N.A.	Investigative	[10]
2-methoxy-4-(m-tolyloxy)benzonitrile	DM1MGQ6	Discovery agent	N.A.	Investigative	[10]
2-methoxy-4-(o-tolyloxy)benzonitrile	DMT7YR3	Discovery agent	N.A.	Investigative	[10]
2-methoxy-4-(p-tolyloxy)benzonitrile	DMR5YZG	Discovery agent	N.A.	Investigative	[10]
2-methoxy-4-(propylthio)benzonitrile	DMXGP2I	Discovery agent	N.A.	Investigative	[10]
3,2'-bis-trifluoromethyl-biphenyl-4-carbonitrile	DMD0Z3U	Discovery agent	N.A.	Investigative	[11]
3-chloro-4-(o-tolyloxy)benzonitrile	DMNQF03	Discovery agent	N.A.	Investigative	[9]
3-chloro-4-(o-tolylthio)benzonitrile	DM6Z3I8	Discovery agent	N.A.	Investigative	[10]
3-methoxy-4-(m-tolyloxy)benzonitrile	DM2QD45	Discovery agent	N.A.	Investigative	[10]
3-methoxy-4-(o-tolyloxy)benzonitrile	DMEGF58	Discovery agent	N.A.	Investigative	[10]
3-methoxy-4-(p-tolyloxy)benzonitrile	DM37QE8	Discovery agent	N.A.	Investigative	[10]
4-(2,6-dimethylphenylthio)-2-methoxybenzonitrile	DMPLG9Q	Discovery agent	N.A.	Investigative	[10]
4-(butylthio)-2-(trifluoromethyl)benzonitrile	DM6SIA4	Discovery agent	N.A.	Investigative	[10]
4-(butylthio)-2-methoxybenzonitrile	DMH1AZV	Discovery agent	N.A.	Investigative	[10]
4-(cyclobutylmethylthio)-2-methoxybenzonitrile	DMR69K2	Discovery agent	N.A.	Investigative	[10]
4-(cyclopropylmethylthio)-2-methoxybenzonitrile	DM43Z2J	Discovery agent	N.A.	Investigative	[10]
4-(isopentylthio)-2-(trifluoromethyl)benzonitrile	DMGSZB2	Discovery agent	N.A.	Investigative	[10]
4-(isopentylthio)-2-methoxybenzonitrile	DML1G9S	Discovery agent	N.A.	Investigative	[10]
4-(isopropylthio)-2-(trifluoromethyl)benzonitrile	DMVDHX1	Discovery agent	N.A.	Investigative	[10]
4-(isopropylthio)-2-methoxybenzonitrile	DMR5HNI	Discovery agent	N.A.	Investigative	[10]
4-(m-tolyloxy)-2-(trifluoromethyl)benzonitrile	DM8BWZO	Discovery agent	N.A.	Investigative	[9]
4-(mesityloxy)-2-(trifluoromethyl)benzonitrile	DMQG57D	Discovery agent	N.A.	Investigative	[9]
4-(mesitylthio)-2-(trifluoromethyl)benzonitrile	DMAI3NZ	Discovery agent	N.A.	Investigative	[10]
4-(mesitylthio)-2-methoxybenzonitrile	DM1XK68	Discovery agent	N.A.	Investigative	[10]
4-(o-tolyloxy)-2-(trifluoromethyl)benzonitrile	DM8I4B9	Discovery agent	N.A.	Investigative	[9]
4-(o-tolylthio)-2-(trifluoromethyl)benzonitrile	DM85XP6	Discovery agent	N.A.	Investigative	[10]
4-(p-tolyloxy)-2-(trifluoromethyl)benzonitrile	DMXK56P	Discovery agent	N.A.	Investigative	[9]
4-(propylthio)-2-(trifluoromethyl)benzonitrile	DM8BZQ3	Discovery agent	N.A.	Investigative	[10]
5-Methoxyflavone	DMQX3V9	Discovery agent	N.A.	Investigative	[12]
6-amino-4-trifluoromethylquinolin-2(1H)-one	DMC5M76	Discovery agent	N.A.	Investigative	[13]
6-Hydroxyflavanone	DM6FNVC	Discovery agent	N.A.	Investigative	[12]
6-N-propyl -4-trifluoromethylquinolin-2(1H)-one	DMDPA2T	Discovery agent	N.A.	Investigative	[13]
AL-43	DMLEDHR	Discovery agent	N.A.	Investigative	[14]
andarine	DMX4P5A	Discovery agent	N.A.	Investigative	[15]
Apigenin	DMI3491	Discovery agent	N.A.	Investigative	[12]
Bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[16]
BMS-564929	DMILMHZ	Discovery agent	N.A.	Investigative	[17]
CP-394531	DMDPH3W	Discovery agent	N.A.	Investigative	[18]
CP-409069	DM1U6P7	Discovery agent	N.A.	Investigative	[18]
Epierenone	DMVZW92	Discovery agent	N.A.	Investigative	[19]
Flavone	DMEQH6J	Discovery agent	N.A.	Investigative	[12]
Kaempferol	DMHEMUB	Discovery agent	N.A.	Investigative	[12]
LG-120838	DMG1UOR	Discovery agent	N.A.	Investigative	[20]
LG-121071	DMMHYQ4	Discovery agent	N.A.	Investigative	[21]
LGD-2226	DMKRSZY	Discovery agent	N.A.	Investigative	[22]
LGD-5552	DM67KWM	Discovery agent	N.A.	Investigative	[23]
NSC-26745	DMNX245	Discovery agent	N.A.	Investigative	[12]
PF-0998425	DMBM7LU	Discovery agent	N.A.	Investigative	[7]
RU-43044	DMY9P85	Discovery agent	N.A.	Investigative	[18]
RU-56187	DMO3WEG	Discovery agent	N.A.	Investigative	[24]
WAY-255348	DMSLNWA	Solid tumour/cancer	2A00-2F9Z	Investigative	[25]
YM-175735	DMMW3L1	Discovery agent	N.A.	Investigative	[26]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[1]
[3H]mibolerone	DM6HDKQ	Discovery agent	N.A.	Investigative	[1]

References

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• [17] N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation. J Med Chem. 2009 May 14;52(9):2794-8.
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• [20] 5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists. J Med Chem. 1998 Oct 22;41(22):4354-9.
• [21] Novel series of potent, nonsteroidal, selective androgen receptor modulators based on 7H-[1,4]oxazino[3,2-g]quinolin-7-ones. J Med Chem. 2007 May 17;50(10):2486-96.
• [22] Novel selective androgen receptor modulators: SAR studies on 6-bisalkylamino-2-quinolinones. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1527-31.
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