General Information of DTT (ID: TTSJ6Q4)

DTT Name LOX-5 messenger RNA (ALOX5 mRNA) DTT Info
Gene Name ALOX5

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Investigative Drug(s)
3 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
TEBUFELONE DMMUE8P Pain MG30-MG3Z Discontinued in Phase 2 [1]
ZD-2138 DMVFCX7 Asthma CA23 Discontinued in Phase 2 [2]
BW A4C DMNUMDG Arthritis FA20 Terminated [3]
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48 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(+)-3,3'-bisdemethyltanegool DMNUWVB Discovery agent N.A. Investigative [4]
(-)-3,3'-bisdemethylpinoresinol DMGC7F5 Discovery agent N.A. Investigative [4]
(-)-pinoresinol DM4INSG Discovery agent N.A. Investigative [4]
(N-(3-phenoxycinnamyl)-acetohydroxamic acid DM9ATZ8 Discovery agent N.A. Investigative [5]
1-(4-methoxyphenyl)-3-(1,3,4-thiadiazol-2-yl)urea DMNJ2CS Discovery agent N.A. Investigative [6]
1-(4-methoxyphenyl)-3-(4-methylthiazol-2-yl)urea DMYPC0W Discovery agent N.A. Investigative [6]
1-(4-methoxyphenyl)-3-(5-methylthiazol-2-yl)urea DMVWIE5 Discovery agent N.A. Investigative [6]
2,4'-Diacetoxy-5,3'-di-(2-propenyl)-biphenyl DMVPWML Discovery agent N.A. Investigative [7]
2,4'-Dimethoxy-5,3'-di-(2-propenyl)-biphenyl DMWNJ84 Discovery agent N.A. Investigative [7]
2,4,5-Triarylimidazole analogue DMSJBEH Discovery agent N.A. Investigative [8]
2-(4-methoxyphenyl)-N-(thiazol-2-yl)acetamide DM1N08O Discovery agent N.A. Investigative [6]
2-(benzyloxy)naphthalene DME50RZ Discovery agent N.A. Investigative [9]
2-phenyl-N-(1,3,4-thiadiazol-2-yl)acetamide DMFC3B5 Discovery agent N.A. Investigative [6]
2-phenyl-N-(thiazol-2-yl)acetamide DMP0NW3 Discovery agent N.A. Investigative [6]
3,4,5-trimethoxy-N-(thiazol-2-yl)benzamide DMU5NRA Discovery agent N.A. Investigative [6]
3-methoxy-N-(1,3,4-thiadiazol-2-yl)benzamide DMFEL39 Discovery agent N.A. Investigative [6]
3-methoxy-N-(4-methylthiazol-2-yl)benzamide DM4WJX3 Discovery agent N.A. Investigative [6]
4'-Methoxy-5,3'-dipropyl-biphenyl-2ol DM5FRV2 Discovery agent N.A. Investigative [7]
4-(dimethylamino)-N-(thiazol-2-yl)benzamide DMJP5YH Discovery agent N.A. Investigative [6]
4-methoxy-N-(thiazol-2-yl)benzamide DMPQKGY Discovery agent N.A. Investigative [6]
5,3'-Dipropyl-biphenyl-2,4'-diol DMJRXLD Discovery agent N.A. Investigative [7]
HONOKIOL DMJWT3X Discovery agent N.A. Investigative [7]
ISAINDIGOTONE DMD6U4F Discovery agent N.A. Investigative [10]
ISIS 1820 DMQ5A4Y Discovery agent N.A. Investigative [11]
ISIS 1821 DMUG2PN Discovery agent N.A. Investigative [11]
ISIS 1822 DMLJBU8 Discovery agent N.A. Investigative [11]
ISIS 1827 DMPHWMO Discovery agent N.A. Investigative [11]
ISIS 1831 DM1LWGI Discovery agent N.A. Investigative [11]
ISIS 2177 DM4VZPU Discovery agent N.A. Investigative [11]
Isojaspic acid DMHTBDN Discovery agent N.A. Investigative [12]
JASPAQUINOL DMJAEMT Discovery agent N.A. Investigative [12]
KAEMPFEROL DMHEMUB Discovery agent N.A. Investigative [4]
L-689065 DM42BGX Discovery agent N.A. Investigative [13]
L-702-539 DM92X5T Discovery agent N.A. Investigative [14]
L-746530 DMUY8MP Discovery agent N.A. Investigative [15]
Methyl 2-(Benzylamino)-1H-indole-3-carboxylate DMB1PXR Discovery agent N.A. Investigative [5]
Methyl 2-(Diallylamino)-1H-indole-3-carboxylate DMB74WP Discovery agent N.A. Investigative [5]
METHYLHONOKIOL DM9YE6K Discovery agent N.A. Investigative [7]
N-(1,3,4-thiadiazol-2-yl)benzamide DMWP6OZ Discovery agent N.A. Investigative [6]
N-(4-methylthiazol-2-yl)-2-phenylacetamide DM03VXN Discovery agent N.A. Investigative [6]
N-(4-methylthiazol-2-yl)benzamide DMTCA2Z Discovery agent N.A. Investigative [6]
N-(5-methylthiazol-2-yl)-2-phenylacetamide DM8PNKC Discovery agent N.A. Investigative [6]
N-(5-methylthiazol-2-yl)benzamide DMFI057 Discovery agent N.A. Investigative [6]
N-(thiazol-2-yl)benzamide DM1N7AG Discovery agent N.A. Investigative [6]
N-hydroxy-N-[1-(4-isobutylphenyl)ethyl]urea DM4E8NJ Discovery agent N.A. Investigative [16]
PD-169316 DM1Z3D7 Discovery agent N.A. Investigative [8]
PUUPEHEDIONE DMF28IU Discovery agent N.A. Investigative [12]
PUUPEHENONE DMF3BCK Discovery agent N.A. Investigative [12]
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⏷ Show the Full List of 48 Investigative Drug(s)
Molecule Interaction Atlas

References

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2 Synthesis and biological activity of N-aroyl-tetrahydro-gamma-carbolines. Bioorg Med Chem. 2010 Jun 1;18(11):3910-24.
3 Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid. J Med Chem. 2008 Sep 11;51(17):5449-53.
4 Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti. J Nat Prod. 2007 May;70(5):859-62.
5 Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. J Med Chem. 2009 Jun 11;52(11):3474-83.
6 Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening. J Med Chem. 2007 May 31;50(11):2640-6.
7 Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxyge... Bioorg Med Chem. 2009 Jul 1;17(13):4459-65.
8 2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis, Bioorg. Med. Chem. Lett. 5(11):1171-1176 (1995).
9 Bioactivity-guided mapping and navigation of chemical space. Nat Chem Biol. 2009 Aug;5(8):585-92.
10 Inhibition of leukocyte functions by the alkaloid isaindigotone from Isatis indigotica and some new synthetic derivatives. J Nat Prod. 2001 Oct;64(10):1297-300.
11 US patent application no. 5,530,114, Oligonucleotide modulation of arachidonic acid metabolism.
12 Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes. J Nat Prod. 2009 Oct;72(10):1857-63.
13 Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation ... J Med Chem. 1993 Sep 17;36(19):2771-87.
14 Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics... J Med Chem. 1997 Aug 29;40(18):2866-75.
15 Substituted coumarins as potent 5-lipoxygenase inhibitors. Bioorg Med Chem Lett. 2006 May 1;16(9):2528-31.
16 Nonsteroidal anti-inflammatory drugs as scaffolds for the design of 5-lipoxygenase inhibitors. J Med Chem. 1997 Feb 28;40(5):819-24.