Details of Disease

General Information of Disease (ID: DIS3MADM)

Disease Name	Common cold
Synonyms	nasopharyngitis, acute; acute rhinitis; rhino-sinusitis; acute viral rhinopharyngitis; nasopharyngitis - acute; acute coryza; acute nasopharyngitis [common cold]; acute nasopharyngitis
Disease Class	CA00: Nasopharyngitis
Definition	An inflammatory process affecting the nasal mucosa, usually caused by viruses (e.g., rhinovirus, adenovirus, parainfluenza virus, and coronavirus). It is characterized by chills, headaches, mucopurulent nasal discharge, coughing, and facial pain.
Disease Hierarchy	DISVLL0V: Nasopharyngitis DIS3MADM: Common cold
ICD Code	ICD-11 ICD-11: CA00 ICD-10 ICD-10: J00 Expand ICD-10 J00,T78 Expand ICD-9 460995.3
Disease Identifiers	MONDO ID MONDO_0005709 MESH ID D003139 UMLS CUI C0009443 MedGen ID 3179 SNOMED CT ID 82272006

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 35 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Acetaminophen	DMUIE76	Approved	Small molecular drug	[1]
Acrivastine	DMTIGA0	Approved	Small molecular drug	[2]
Ammonium chloride	DMPJCXG	Approved	Small molecular drug	[3]
Aspirin	DM672AH	Approved	Small molecular drug	[4]
Azatadine	DMZ80SB	Approved	Small molecular drug	[5]
Bromodiphenhydramine	DMNDJT5	Approved	Small molecular drug	[6]
Caffeine	DMKBJWP	Approved	Small molecular drug	[7]
Carbinoxamine	DMCT31R	Approved	Small molecular drug	[8]
Cetirizine	DMOMP9U	Approved	Small molecular drug	[9]
Chlophedianol	DMXGJEI	Approved	Small molecular drug	[10]
Codeine	DMJX6ZG	Approved	Small molecular drug	[11]
Cyclizine	DM9G7BS	Approved	Small molecular drug	[12]
Desloratadine	DM56YN7	Approved	Small molecular drug	[13]
Dextromethorphan	DMUDJZM	Approved	Small molecular drug	[14]
Doxylamine	DMKOXFE	Approved	Small molecular drug	[15]
Ephedrine	DMMV0KW	Approved	Small molecular drug	[16]
Epoprostenol	DMUTYR2	Approved	Small molecular drug	[17]
Glycine	DMIOZ29	Approved	Small molecular drug	[18]
Hydrocodone	DMQ2JO5	Approved	Small molecular drug	[19]
Hydromorphone	DMHP21E	Approved	Small molecular drug	[20]
Isoproterenol	DMK7MEY	Approved	Small molecular drug	[21]
Loratadine	DMF3AN7	Approved	Small molecular drug	[22]
Mepyramine	DMB4SFH	Approved	Small molecular drug	[23]
Phenindamine	DMDTC7R	Approved	Small molecular drug	[24]
Pheniramine	DMCH7RU	Approved	Small molecular drug	[25]
Phenylephrine	DMZHUO5	Approved	Small molecular drug	[21]
Potassium iodide	DMPO7S1	Approved	Small molecular drug	[26]
Pseudoephedrine	DMIVJ0D	Approved	Small molecular drug	[16]
Salicyclic acid	DM2F8XZ	Approved	Small molecular drug	[27]
Scopolamine	DMOM8AL	Approved	Small molecular drug	[28]
Triprolidine	DM7SWIA	Approved	Small molecular drug	[16]
TRN-124	DMVAPTC	Approved	NA	[29]
Zinc Chloride	DMU7KK5	Approved	Small molecular drug	[30]
Chlorphenamine	DM6C4YJ	Phase 4	NA	[31]
Dihydrocodeine	DMB0FWL	Phase 4	Small molecular drug	[7]
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⏷ Show the Full List of 35 Drug(s)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Chlorcyclizine	DM3L52Q	Phase 1	Small molecular drug	[32]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Phenylpropanolamine	DMTFK3O	Withdrawn from market	Small molecular drug	[33]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SODIUM CITRATE	DMHPD2Y	Investigative	Small molecular drug	[34]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
DUSP10	TTF3RJ0	Limited	Biomarker	[35]
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This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
NANOS2	OTFM2IDJ	Limited	Altered Expression	[36]
PLAAT3	OTVXXJ5K	Limited	Biomarker	[37]
SARS1	OTFKXQ1O	Strong	Genetic Variation	[38]
SARS2	OTU4T99W	Strong	Genetic Variation	[38]
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References

1	Acetaminophen FDA Label
2	Acrivastine FDA Label
3	Ammonium chloride FDA Label
4	Aspirin FDA Label
5	Azatadine FDA Label
6	Bromodiphenhydramine FDA Label
7	Caffeine FDA Label
8	Carbinoxamine FDA Label
9	Cetirizine FDA Label
10	Chlophedianol FDA Label
11	Codeine FDA Label
12	Cyclizine FDA Label
13	Desloratadine FDA Label
14	Dextromethorphan FDA Label
15	Doxylamine FDA Label
16	Ephedrine FDA Label
17	Epoprostenol FDA Label
18	Glycine FDA Label
19	Hydrocodone FDA Label
20	Hydromorphone FDA Label
21	Isoproterenol FDA Label
22	Loratadine FDA Label
23	Determination of amine ingredients in cough-cold liquids by reversed-phase ion-pair high-performance liquid chromatography. J Pharm Sci. 1982 Oct;71(10):1108-12.
24	Drug information of Phenindamine, 2008. eduDrugs.
25	Pheniramine FDA Label
26	Potassium iodide FDA Label
27	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
28	Scopolamine FDA Label
29	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
30	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
31	Symptomatic treatment of the common cold with a fixed-dose combination of paracetamol, chlorphenamine and phenylephrine: a randomized, placebo-controlled trial. BMC Infect Dis. 2013 Nov 22;13:556.
32	Chlorcyclizine hydrochloride poisoning in an infant. Br Med J. 1954 Mar 20;1(4863):687-8.
33	Phenylpropanolamine FDA Label
34	SODIUM CITRATE FDA Label
35	DUSP10 Negatively Regulates the Inflammatory Response to Rhinovirus through Interleukin-1 Signaling.J Virol. 2019 Jan 4;93(2):e01659-18. doi: 10.1128/JVI.01659-18. Print 2019 Jan 15.
36	Rhinovirus infection induces expression of type 2 nitric oxide synthase in human respiratory epithelial cells in vitro and in vivo.J Allergy Clin Immunol. 2001 Feb;107(2):235-43. doi: 10.1067/mai.2001.112028.
37	A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.Nature. 2017 Oct 5;550(7674):114-118. doi: 10.1038/nature24027. Epub 2017 Sep 27.
38	Structural model of the SARS coronavirus E channel in LMPG micelles.Biochim Biophys Acta Biomembr. 2018 Jun;1860(6):1309-1317. doi: 10.1016/j.bbamem.2018.02.017. Epub 2018 Feb 21.