Details of the Drug

General Information of Drug (ID: DMOMP9U)

• Drug Name: Cetirizine
• Synonyms: Cetiderm; Cetirizin; Cetirizina; Cetirizinum; Cetryn; Setir; Virlix; Ziptek; Zirtek; Zyrlex; Cetirizina [Spanish]; Cetirizinum [Latin]; Cetrizine Hcl; Hitrizin Film Tablet; Cetiderm (TN); Cetirizine (INN); Cetirizine [INN:BAN]; P-071; Reactine (TN); Zyrtec (TN); [(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethyl)oxy]acetic acid; (2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)acetic acid; (2-{4-[(4-Chloro-phenyl)-phenyl-methyl]-piperazin-1-yl}-ethoxy)-acetic acid; (2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid; 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid; 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid

Indication

Disease Entry	ICD 11	Status	REF
Allergic rhinitis	CA08.0	Approved	[1]
Common cold	CA00	Approved	[2]
Seasonal allergic rhinitis	CA08.01	Approved	[2]
Vasomotor/allergic rhinitis	CA08	Approved	[2]

• Therapeutic Class: Antiallergic Agents
• Affected Organisms: Humans and other mammals
• ATC Code:
  R06AE07: Cetirizine
  R06AE: Piperazine derivatives
  R06A: ANTIHISTAMINES FOR SYSTEMIC USE
  R06: ANTIHISTAMINES FOR SYSTEMIC USE
  R: RESPIRATORY SYSTEM
  S01GX12: Cetirizine
  S01GX: Other antiallergics
  S01G: DECONGESTANTS AND ANTIALLERGICS
  S01: OPHTHALMOLOGICALS
  S: SENSORY ORGANS
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 388.9
  Logarithm of the Partition Coefficient (xlogp); 1.7
  Rotatable Bond Count (rotbonds); 8
  Hydrogen Bond Donor Count (hbonddonor); 1
  Hydrogen Bond Acceptor Count (hbondacc); 5
• ADMET Property:
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 1 h []
  BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [3]
  Bioavailability: 90% of drug becomes completely available to its intended biological destination(s) [4]
  Clearance: The total body clearance of drug is 53 mL/min [5]
  Elimination: 70 C 85% of an orally administered dose can be found in the urine and 10 C 13% in the feces [5]
  Half-life: The concentration or amount of drug in body reduced by one-half in 8.3 hours []
  Metabolism: The drug is metabolized via the hepatic [5]
  MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.3673 micromolar/kg/day [6]
  Vd: The volume of distribution (Vd) of drug is 0.44 +/- 0.19 L/kg [7]
  Water Solubility: The ability of drug to dissolve in water is measured as 0.101 mg/mL [3]
• Chemical Identifiers:
  Formula: C21H25ClN2O3
  IUPAC Name: 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]acetic acid
  Canonical SMILES: C1CN(CCN1CCOCC(=O)O)C(C2=CC=CC=C2)C3=CC=C(C=C3)Cl
  InChI: InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)
  InChIKey: ZKLPARSLTMPFCP-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 2678
  ChEBI ID: CHEBI:3561
  CAS Number: 83881-51-0
  UNII: YO7261ME24
  DrugBank ID: DB00341
  TTD ID: D0DK8V
  VARIDT ID: DR00177
  INTEDE ID: DR2269
  ACDINA ID: D00116
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Histamine H1 receptor (H1R)	TTTIBOJ	HRH1_HUMAN	Antagonist	[8]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[9]

Molecular Expression Atlas of This Drug

• The Studied Disease: Allergic rhinitis
• ICD Disease Classification: CA08.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Histamine H1 receptor (H1R)	DTT	HRH1	6.74E-01	0.13	0.43
P-glycoprotein 1 (ABCB1)	DTP	P-GP	6.54E-01	1.95E-01	4.04E-01

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Cetirizine

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Chlorpheniramine	DM5URA2	Moderate	Additive CNS depression effects by the combination of Cetirizine and Chlorpheniramine.	Vasomotor/allergic rhinitis [CA08]	[10]
Triprolidine	DM7SWIA	Moderate	Additive CNS depression effects by the combination of Cetirizine and Triprolidine.	Vasomotor/allergic rhinitis [CA08]	[10]
Methdilazine	DMAUHQX	Moderate	Additive CNS depression effects by the combination of Cetirizine and Methdilazine.	Vasomotor/allergic rhinitis [CA08]	[10]
Carbinoxamine	DMCT31R	Moderate	Additive CNS depression effects by the combination of Cetirizine and Carbinoxamine.	Vasomotor/allergic rhinitis [CA08]	[10]
Trimeprazine	DMEMV9D	Moderate	Additive CNS depression effects by the combination of Cetirizine and Trimeprazine.	Vasomotor/allergic rhinitis [CA08]	[10]
Brompheniramine	DMFOVSD	Moderate	Additive CNS depression effects by the combination of Cetirizine and Brompheniramine.	Vasomotor/allergic rhinitis [CA08]	[10]
Dexbrompheniramine	DMKVWGE	Moderate	Additive CNS depression effects by the combination of Cetirizine and Dexbrompheniramine.	Vasomotor/allergic rhinitis [CA08]	[10]
Azatadine	DMZ80SB	Moderate	Additive CNS depression effects by the combination of Cetirizine and Azatadine.	Vasomotor/allergic rhinitis [CA08]	[10]

Coadministration of a Drug Treating the Disease Different from Cetirizine (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Oliceridine	DM6MDCF	Moderate	Additive CNS depression effects by the combination of Cetirizine and Oliceridine.	Acute pain [MG31]	[10]
Chlorzoxazone	DMCYVDT	Moderate	Additive CNS depression effects by the combination of Cetirizine and Chlorzoxazone.	Acute pain [MG31]	[10]
Mepyramine	DMB4SFH	Moderate	Additive CNS depression effects by the combination of Cetirizine and Mepyramine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[10]
Tripelennamine	DMZBU15	Moderate	Additive CNS depression effects by the combination of Cetirizine and Tripelennamine.	Allergic/hypersensitivity disorder [4A80-4A8Z]	[10]
Marinol	DM70IK5	Moderate	Additive CNS depression effects by the combination of Cetirizine and Marinol.	Anorexia nervosa [6B80]	[10]
Buspirone	DMBS632	Moderate	Additive CNS depression effects by the combination of Cetirizine and Buspirone.	Anxiety disorder [6B00-6B0Z]	[10]
Clorazepate	DMC3JST	Moderate	Additive CNS depression effects by the combination of Cetirizine and Clorazepate.	Anxiety disorder [6B00-6B0Z]	[10]
Alprazolam	DMC7XDN	Moderate	Additive CNS depression effects by the combination of Cetirizine and Alprazolam.	Anxiety disorder [6B00-6B0Z]	[10]
Methylphenobarbital	DMDSWAG	Moderate	Additive CNS depression effects by the combination of Cetirizine and Methylphenobarbital.	Anxiety disorder [6B00-6B0Z]	[11]
Hydroxyzine	DMF8Y74	Moderate	Additive CNS depression effects by the combination of Cetirizine and Hydroxyzine.	Anxiety disorder [6B00-6B0Z]	[10]
Halazepam	DMPFWO6	Moderate	Additive CNS depression effects by the combination of Cetirizine and Halazepam.	Anxiety disorder [6B00-6B0Z]	[10]
Chlordiazepoxide	DMTN5XI	Moderate	Additive CNS depression effects by the combination of Cetirizine and Chlordiazepoxide.	Anxiety disorder [6B00-6B0Z]	[10]
Chlormezanone	DMTWUXR	Moderate	Additive CNS depression effects by the combination of Cetirizine and Chlormezanone.	Anxiety disorder [6B00-6B0Z]	[10]
Clobazam - Lundbeck	DMW1OQ0	Moderate	Additive CNS depression effects by the combination of Cetirizine and Clobazam - Lundbeck.	Anxiety disorder [6B00-6B0Z]	[10]
Oxazepam	DMXNZM4	Moderate	Additive CNS depression effects by the combination of Cetirizine and Oxazepam.	Anxiety disorder [6B00-6B0Z]	[10]
Promazine	DMZAL7W	Moderate	Additive CNS depression effects by the combination of Cetirizine and Promazine.	Appearance/behaviour symptom [MB23]	[10]
Desipramine	DMT2FDC	Moderate	Additive CNS depression effects by the combination of Cetirizine and Desipramine.	Attention deficit hyperactivity disorder [6A05]	[10]
Retigabine	DMGNYIH	Moderate	Additive CNS depression effects by the combination of Cetirizine and Retigabine.	Behcet disease [4A62]	[10]
Lamotrigine	DM8SXYG	Moderate	Additive CNS depression effects by the combination of Cetirizine and Lamotrigine.	Bipolar disorder [6A60]	[10]
Cariprazine	DMJYDVK	Moderate	Additive CNS depression effects by the combination of Cetirizine and Cariprazine.	Bipolar disorder [6A60]	[10]
Diphenoxylate	DMO5SZX	Moderate	Additive CNS depression effects by the combination of Cetirizine and Diphenoxylate.	Bowel habit change [ME05]	[10]
Loperamide	DMOJZQ9	Moderate	Additive CNS depression effects by the combination of Cetirizine and Loperamide.	Bowel habit change [ME05]	[10]
Secobarbital	DM14RF5	Moderate	Additive CNS depression effects by the combination of Cetirizine and Secobarbital.	Chronic insomnia [7A00]	[10]
Dihydrocodeine	DMB0FWL	Moderate	Additive CNS depression effects by the combination of Cetirizine and Dihydrocodeine.	Chronic pain [MG30]	[10]
Levetiracetam	DMTGDN8	Moderate	Additive CNS depression effects by the combination of Cetirizine and Levetiracetam.	Chronic pain [MG30]	[10]
Olopatadine	DMKMWQG	Moderate	Additive CNS depression effects by the combination of Cetirizine and Olopatadine.	Conjunctiva disorder [9A60]	[11]
Azelastine	DMXTMBJ	Moderate	Additive CNS depression effects by the combination of Cetirizine and Azelastine.	Conjunctiva disorder [9A60]	[10]
Propofol	DMB4OLE	Moderate	Additive CNS depression effects by the combination of Cetirizine and Propofol.	Corneal disease [9A76-9A78]	[10]
Thiopental	DMGP8AX	Moderate	Additive CNS depression effects by the combination of Cetirizine and Thiopental.	Corneal disease [9A76-9A78]	[10]
Ketamine	DMT5HA4	Moderate	Additive CNS depression effects by the combination of Cetirizine and Ketamine.	Corneal disease [9A76-9A78]	[10]
Alfentanil	DMVO0UB	Moderate	Additive CNS depression effects by the combination of Cetirizine and Alfentanil.	Corneal disease [9A76-9A78]	[10]
Remifentanil	DMZTXCH	Moderate	Additive CNS depression effects by the combination of Cetirizine and Remifentanil.	Corneal disease [9A76-9A78]	[10]
Chlophedianol	DMXGJEI	Moderate	Additive CNS depression effects by the combination of Cetirizine and Chlophedianol.	Cough [MD12]	[10]
Ethanol	DMDRQZU	Moderate	Additive CNS depression effects by the combination of Cetirizine and Ethanol.	Cystitis [GC00]	[11]
Sertraline	DM0FB1J	Moderate	Additive CNS depression effects by the combination of Cetirizine and Sertraline.	Depression [6A70-6A7Z]	[10]
Trimipramine	DM1SC8M	Moderate	Additive CNS depression effects by the combination of Cetirizine and Trimipramine.	Depression [6A70-6A7Z]	[10]
Cyclobenzaprine	DM1YBRM	Moderate	Additive CNS depression effects by the combination of Cetirizine and Cyclobenzaprine.	Depression [6A70-6A7Z]	[10]
Imipramine	DM2NUH3	Moderate	Additive CNS depression effects by the combination of Cetirizine and Imipramine.	Depression [6A70-6A7Z]	[10]
Fluoxetine	DM3PD2C	Moderate	Additive CNS depression effects by the combination of Cetirizine and Fluoxetine.	Depression [6A70-6A7Z]	[10]
Nefazodone	DM4ZS8M	Moderate	Additive CNS depression effects by the combination of Cetirizine and Nefazodone.	Depression [6A70-6A7Z]	[10]
Paroxetine	DM5PVQE	Moderate	Additive CNS depression effects by the combination of Cetirizine and Paroxetine.	Depression [6A70-6A7Z]	[10]
Duloxetine	DM9BI7M	Moderate	Additive CNS depression effects by the combination of Cetirizine and Duloxetine.	Depression [6A70-6A7Z]	[10]
Isocarboxazid	DMAF1NB	Moderate	Additive CNS depression effects by the combination of Cetirizine and Isocarboxazid.	Depression [6A70-6A7Z]	[10]
Escitalopram	DMFK9HG	Moderate	Additive CNS depression effects by the combination of Cetirizine and Escitalopram.	Depression [6A70-6A7Z]	[10]
Tranylcypromine	DMGB5RE	Moderate	Additive CNS depression effects by the combination of Cetirizine and Tranylcypromine.	Depression [6A70-6A7Z]	[10]
Desvenlafaxine	DMHD4PE	Moderate	Additive CNS depression effects by the combination of Cetirizine and Desvenlafaxine.	Depression [6A70-6A7Z]	[10]
OPC-34712	DMHG57U	Moderate	Additive CNS depression effects by the combination of Cetirizine and OPC-34712.	Depression [6A70-6A7Z]	[10]
Phenelzine	DMHIDUE	Moderate	Additive CNS depression effects by the combination of Cetirizine and Phenelzine.	Depression [6A70-6A7Z]	[10]
Clomipramine	DMINRKW	Moderate	Additive CNS depression effects by the combination of Cetirizine and Clomipramine.	Depression [6A70-6A7Z]	[10]
Trazodone	DMK1GBJ	Moderate	Additive CNS depression effects by the combination of Cetirizine and Trazodone.	Depression [6A70-6A7Z]	[10]
Amoxapine	DMKITQE	Moderate	Additive CNS depression effects by the combination of Cetirizine and Amoxapine.	Depression [6A70-6A7Z]	[10]
Mirtazapine	DML53ZJ	Moderate	Additive CNS depression effects by the combination of Cetirizine and Mirtazapine.	Depression [6A70-6A7Z]	[10]
Protriptyline	DMNHTZI	Moderate	Additive CNS depression effects by the combination of Cetirizine and Protriptyline.	Depression [6A70-6A7Z]	[10]
Doxepin	DMPI98T	Moderate	Additive CNS depression effects by the combination of Cetirizine and Doxepin.	Depression [6A70-6A7Z]	[10]
Maprotiline	DMPWB7T	Moderate	Additive CNS depression effects by the combination of Cetirizine and Maprotiline.	Depression [6A70-6A7Z]	[10]
Esketamine	DMVU687	Moderate	Additive CNS depression effects by the combination of Cetirizine and Esketamine.	Depression [6A70-6A7Z]	[12]
Heroin diacetylmorphine	DMDBWHY	Moderate	Additive CNS depression effects by the combination of Cetirizine and Heroin diacetylmorphine.	Dissociative neurological symptom disorder [6B60]	[10]
Tetrabenazine	DMYWQ0O	Moderate	Additive CNS depression effects by the combination of Cetirizine and Tetrabenazine.	Dissociative neurological symptom disorder [6B60]	[10]
Meclizine	DMS7T13	Moderate	Additive CNS depression effects by the combination of Cetirizine and Meclizine.	Dizziness and giddiness [MB48]	[10]
Trihexyphenidyl	DMB19L8	Moderate	Additive CNS depression effects by the combination of Cetirizine and Trihexyphenidyl.	Dystonic disorder [8A02]	[10]
Deutetrabenazine	DMUPFLI	Moderate	Additive CNS depression effects by the combination of Cetirizine and Deutetrabenazine.	Dystonic disorder [8A02]	[10]
Ingrezza	DMVPLNC	Moderate	Additive CNS depression effects by the combination of Cetirizine and Ingrezza.	Dystonic disorder [8A02]	[10]
Diazepam	DM08E9O	Moderate	Additive CNS depression effects by the combination of Cetirizine and Diazepam.	Epilepsy/seizure [8A61-8A6Z]	[10]
Zonisamide	DM0DTF7	Moderate	Additive CNS depression effects by the combination of Cetirizine and Zonisamide.	Epilepsy/seizure [8A61-8A6Z]	[10]
Primidone	DM0WX6I	Moderate	Additive CNS depression effects by the combination of Cetirizine and Primidone.	Epilepsy/seizure [8A61-8A6Z]	[10]
Felbamate	DM1V5ZS	Moderate	Additive CNS depression effects by the combination of Cetirizine and Felbamate.	Epilepsy/seizure [8A61-8A6Z]	[10]
Oxcarbazepine	DM5PU6O	Moderate	Additive CNS depression effects by the combination of Cetirizine and Oxcarbazepine.	Epilepsy/seizure [8A61-8A6Z]	[10]
Mephenytoin	DM5UGDK	Moderate	Additive CNS depression effects by the combination of Cetirizine and Mephenytoin.	Epilepsy/seizure [8A61-8A6Z]	[10]
Ethosuximide	DMDZ9LT	Moderate	Additive CNS depression effects by the combination of Cetirizine and Ethosuximide.	Epilepsy/seizure [8A61-8A6Z]	[10]
Cenobamate	DM8KLU9	Moderate	Additive CNS depression effects by the combination of Cetirizine and Cenobamate.	Epilepsy/seizure [8A61-8A6Z]	[10]
Tiagabine	DMKSQG0	Moderate	Additive CNS depression effects by the combination of Cetirizine and Tiagabine.	Epilepsy/seizure [8A61-8A6Z]	[10]
Phenacemide	DMOHS9P	Moderate	Additive CNS depression effects by the combination of Cetirizine and Phenacemide.	Epilepsy/seizure [8A61-8A6Z]	[10]
Paramethadione	DMR5ZUP	Moderate	Additive CNS depression effects by the combination of Cetirizine and Paramethadione.	Epilepsy/seizure [8A61-8A6Z]	[10]
Brivaracetam	DMSEPK8	Moderate	Additive CNS depression effects by the combination of Cetirizine and Brivaracetam.	Epilepsy/seizure [8A61-8A6Z]	[10]
Clonazepam	DMTO13J	Moderate	Additive CNS depression effects by the combination of Cetirizine and Clonazepam.	Epilepsy/seizure [8A61-8A6Z]	[10]
Rufinamide	DMWE60C	Moderate	Additive CNS depression effects by the combination of Cetirizine and Rufinamide.	Epilepsy/seizure [8A61-8A6Z]	[10]
Ethotoin	DMXWOCP	Moderate	Additive CNS depression effects by the combination of Cetirizine and Ethotoin.	Epilepsy/seizure [8A61-8A6Z]	[10]
Phenobarbital	DMXZOCG	Moderate	Additive CNS depression effects by the combination of Cetirizine and Phenobarbital.	Epilepsy/seizure [8A61-8A6Z]	[10]
Vigabatrin	DMYT0OG	Moderate	Additive CNS depression effects by the combination of Cetirizine and Vigabatrin.	Epilepsy/seizure [8A61-8A6Z]	[10]
Carbamazepine	DMZOLBI	Moderate	Additive CNS depression effects by the combination of Cetirizine and Carbamazepine.	Epilepsy/seizure [8A61-8A6Z]	[10]
Cannabidiol	DM0659E	Moderate	Additive CNS depression effects by the combination of Cetirizine and Cannabidiol.	Epileptic encephalopathy [8A62]	[10]
Diphenhydramine	DMKQTBA	Moderate	Additive CNS depression effects by the combination of Cetirizine and Diphenhydramine.	Episodic vestibular syndrome [AB31]	[10]
Brimonidine	DMQLT4N	Moderate	Additive CNS depression effects by the combination of Cetirizine and Brimonidine.	Glaucoma [9C61]	[13]
Procarbazine	DMIK367	Moderate	Additive CNS depression effects by the combination of Cetirizine and Procarbazine.	Hodgkin lymphoma [2B30]	[10]
Clonidine	DM6RZ9Q	Moderate	Additive CNS depression effects by the combination of Cetirizine and Clonidine.	Hypertension [BA00-BA04]	[10]
Suvorexant	DM0E6S3	Moderate	Additive CNS depression effects by the combination of Cetirizine and Suvorexant.	Insomnia [7A00-7A0Z]	[10]
Amobarbital	DM0GQ8N	Moderate	Additive CNS depression effects by the combination of Cetirizine and Amobarbital.	Insomnia [7A00-7A0Z]	[10]
Eszopiclone	DM8RZ9H	Moderate	Additive CNS depression effects by the combination of Cetirizine and Eszopiclone.	Insomnia [7A00-7A0Z]	[10]
Flurazepam	DMAL4G0	Moderate	Additive CNS depression effects by the combination of Cetirizine and Flurazepam.	Insomnia [7A00-7A0Z]	[10]
Triazolam	DMETYK5	Moderate	Additive CNS depression effects by the combination of Cetirizine and Triazolam.	Insomnia [7A00-7A0Z]	[10]
Zaleplon	DMGFWSM	Moderate	Additive CNS depression effects by the combination of Cetirizine and Zaleplon.	Insomnia [7A00-7A0Z]	[10]
Propiomazine	DMKY8V1	Moderate	Additive CNS depression effects by the combination of Cetirizine and Propiomazine.	Insomnia [7A00-7A0Z]	[10]
Tasimelteon	DMLOQ1V	Moderate	Additive CNS depression effects by the combination of Cetirizine and Tasimelteon.	Insomnia [7A00-7A0Z]	[10]
Paraldehyde	DMOC1BX	Moderate	Additive CNS depression effects by the combination of Cetirizine and Paraldehyde.	Insomnia [7A00-7A0Z]	[10]
ITI-007	DMUQ1DO	Moderate	Additive CNS depression effects by the combination of Cetirizine and ITI-007.	Insomnia [7A00-7A0Z]	[10]
Nabilone	DMVRYT2	Moderate	Additive CNS depression effects by the combination of Cetirizine and Nabilone.	Insomnia [7A00-7A0Z]	[10]
Zolpidem	DMWOSKJ	Moderate	Additive CNS depression effects by the combination of Cetirizine and Zolpidem.	Insomnia [7A00-7A0Z]	[10]
Quazepam	DMY4D87	Moderate	Additive CNS depression effects by the combination of Cetirizine and Quazepam.	Insomnia [7A00-7A0Z]	[10]
Estazolam	DMZGXUM	Moderate	Additive CNS depression effects by the combination of Cetirizine and Estazolam.	Insomnia [7A00-7A0Z]	[10]
Remimazolam	DMLVSYX	Moderate	Additive CNS depression effects by the combination of Cetirizine and Remimazolam.	Labour/delivery anaesthesia complication [JB0C]	[10]
Meprobamate	DMHM93Y	Moderate	Additive CNS depression effects by the combination of Cetirizine and Meprobamate.	Malaria [1F40-1F45]	[10]
Allopregnanolone	DMNLHAC	Moderate	Additive CNS depression effects by the combination of Cetirizine and Allopregnanolone.	Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z]	[14]
Lasmiditan	DMXLVDT	Moderate	Additive CNS depression effects by the combination of Cetirizine and Lasmiditan.	Migraine [8A80]	[15]
Flibanserin	DM70DTN	Moderate	Additive CNS depression effects by the combination of Cetirizine and Flibanserin.	Mood disorder [6A60-6E23]	[16]
Dexmedetomidine	DM93L4X	Moderate	Additive CNS depression effects by the combination of Cetirizine and Dexmedetomidine.	Mood/affect symptom [MB24]	[10]
Midazolam	DMXOELT	Moderate	Additive CNS depression effects by the combination of Cetirizine and Midazolam.	Mood/affect symptom [MB24]	[10]
Doxylamine	DMKOXFE	Moderate	Additive CNS depression effects by the combination of Cetirizine and Doxylamine.	Morning sickness disorder [SC00]	[10]
Thalidomide	DM70BU5	Moderate	Additive CNS depression effects by the combination of Cetirizine and Thalidomide.	Multiple myeloma [2A83]	[17]
Carisoprodol	DMWR1JC	Moderate	Additive CNS depression effects by the combination of Cetirizine and Carisoprodol.	Musculoskeletal disorder [FA00-FC0Z]	[10]
Phenindamine	DMDTC7R	Moderate	Additive CNS depression effects by the combination of Cetirizine and Phenindamine.	Nasopharyngitis [CA00]	[10]
Droperidol	DM0DXA8	Moderate	Additive CNS depression effects by the combination of Cetirizine and Droperidol.	Nausea/vomiting [MD90]	[10]
Dimenhydrinate	DM264B3	Moderate	Additive CNS depression effects by the combination of Cetirizine and Dimenhydrinate.	Nausea/vomiting [MD90]	[10]
Prochlorperazine	DM53SRA	Moderate	Additive CNS depression effects by the combination of Cetirizine and Prochlorperazine.	Nausea/vomiting [MD90]	[10]
Promethazine	DM6I5GR	Moderate	Additive CNS depression effects by the combination of Cetirizine and Promethazine.	Nausea/vomiting [MD90]	[10]
Cyclizine	DM9G7BS	Moderate	Additive CNS depression effects by the combination of Cetirizine and Cyclizine.	Nausea/vomiting [MD90]	[10]
Metoclopramide	DMFA5MY	Moderate	Additive CNS depression effects by the combination of Cetirizine and Metoclopramide.	Nausea/vomiting [MD90]	[10]
Thiethylperazine	DMU3IET	Moderate	Additive CNS depression effects by the combination of Cetirizine and Thiethylperazine.	Nausea/vomiting [MD90]	[10]
Sibutramine	DMFJTDI	Moderate	Additive CNS depression effects by the combination of Cetirizine and Sibutramine.	Obesity [5B80-5B81]	[10]
Levomethadyl Acetate	DM06HG5	Moderate	Additive CNS depression effects by the combination of Cetirizine and Levomethadyl Acetate.	Opioid use disorder [6C43]	[10]
Lofexidine	DM1WXA6	Moderate	Additive CNS depression effects by the combination of Cetirizine and Lofexidine.	Opioid use disorder [6C43]	[10]
Apraclonidine	DMO4PVE	Moderate	Additive CNS depression effects by the combination of Cetirizine and Apraclonidine.	Optic nerve disorder [9C40]	[13]
Pentazocine	DM1XBHS	Moderate	Additive CNS depression effects by the combination of Cetirizine and Pentazocine.	Pain [MG30-MG3Z]	[10]
Butorphanol	DM5KYPJ	Moderate	Additive CNS depression effects by the combination of Cetirizine and Butorphanol.	Pain [MG30-MG3Z]	[10]
Oxymorphone	DM65AGJ	Moderate	Additive CNS depression effects by the combination of Cetirizine and Oxymorphone.	Pain [MG30-MG3Z]	[10]
Levorphanol	DMGS80V	Moderate	Additive CNS depression effects by the combination of Cetirizine and Levorphanol.	Pain [MG30-MG3Z]	[10]
Dezocine	DMJDB0Y	Moderate	Additive CNS depression effects by the combination of Cetirizine and Dezocine.	Pain [MG30-MG3Z]	[10]
Flavoxate	DMKV4NL	Moderate	Additive CNS depression effects by the combination of Cetirizine and Flavoxate.	Pain [MG30-MG3Z]	[10]
Nalbuphine	DMOSQGU	Moderate	Additive CNS depression effects by the combination of Cetirizine and Nalbuphine.	Pain [MG30-MG3Z]	[10]
Buprenorphine	DMPRI8G	Moderate	Additive CNS depression effects by the combination of Cetirizine and Buprenorphine.	Pain [MG30-MG3Z]	[10]
Hydrocodone	DMQ2JO5	Moderate	Additive CNS depression effects by the combination of Cetirizine and Hydrocodone.	Pain [MG30-MG3Z]	[10]
Meperidine	DMX4GND	Moderate	Additive CNS depression effects by the combination of Cetirizine and Meperidine.	Pain [MG30-MG3Z]	[10]
Oxycodone	DMXLKHV	Moderate	Additive CNS depression effects by the combination of Cetirizine and Oxycodone.	Pain [MG30-MG3Z]	[10]
Trimethadione	DM0Q8MZ	Moderate	Additive CNS depression effects by the combination of Cetirizine and Trimethadione.	Pancreatic cancer [2C10]	[10]
Opicapone	DM1BKA6	Moderate	Additive CNS depression effects by the combination of Cetirizine and Opicapone.	Parkinsonism [8A00]	[10]
Biperiden	DME78OA	Moderate	Additive CNS depression effects by the combination of Cetirizine and Biperiden.	Parkinsonism [8A00]	[10]
Procyclidine	DMHFJDT	Moderate	Additive CNS depression effects by the combination of Cetirizine and Procyclidine.	Parkinsonism [8A00]	[10]
Entacapone	DMLBVKQ	Moderate	Additive CNS depression effects by the combination of Cetirizine and Entacapone.	Parkinsonism [8A00]	[10]
Pramipexole	DMNMW9R	Moderate	Additive CNS depression effects by the combination of Cetirizine and Pramipexole.	Parkinsonism [8A00]	[10]
Levomepromazine	DMIKFEL	Moderate	Additive CNS depression effects by the combination of Cetirizine and Levomepromazine.	Psychotic disorder [6A20-6A25]	[10]
Fluphenazine	DMIT8LX	Moderate	Additive CNS depression effects by the combination of Cetirizine and Fluphenazine.	Psychotic disorder [6A20-6A25]	[10]
Triflupromazine	DMKFQJP	Moderate	Additive CNS depression effects by the combination of Cetirizine and Triflupromazine.	Psychotic disorder [6A20-6A25]	[10]
Neupro	DMHEAB1	Moderate	Additive CNS depression effects by the combination of Cetirizine and Neupro.	Restless legs syndrome [7A80]	[10]
Cyproheptadine	DM92AH3	Moderate	Additive CNS depression effects by the combination of Cetirizine and Cyproheptadine.	Rheumatoid arthritis [FA20]	[10]
Mesoridazine	DM2ZGAN	Moderate	Additive CNS depression effects by the combination of Cetirizine and Mesoridazine.	Schizophrenia [6A20]	[10]
Thioridazine	DM35M8J	Moderate	Additive CNS depression effects by the combination of Cetirizine and Thioridazine.	Schizophrenia [6A20]	[10]
Aripiprazole	DM3NUMH	Moderate	Additive CNS depression effects by the combination of Cetirizine and Aripiprazole.	Schizophrenia [6A20]	[10]
Iloperidone	DM6AUFY	Moderate	Additive CNS depression effects by the combination of Cetirizine and Iloperidone.	Schizophrenia [6A20]	[10]
Paliperidone	DM7NPJS	Moderate	Additive CNS depression effects by the combination of Cetirizine and Paliperidone.	Schizophrenia [6A20]	[10]
Loxapine	DM8AI9U	Moderate	Additive CNS depression effects by the combination of Cetirizine and Loxapine.	Schizophrenia [6A20]	[10]
Haloperidol	DM96SE0	Moderate	Additive CNS depression effects by the combination of Cetirizine and Haloperidol.	Schizophrenia [6A20]	[10]
Perphenazine	DMA4MRX	Moderate	Additive CNS depression effects by the combination of Cetirizine and Perphenazine.	Schizophrenia [6A20]	[10]
Molindone	DMAH70G	Moderate	Additive CNS depression effects by the combination of Cetirizine and Molindone.	Schizophrenia [6A20]	[10]
Chlorpromazine	DMBGZI3	Moderate	Additive CNS depression effects by the combination of Cetirizine and Chlorpromazine.	Schizophrenia [6A20]	[10]
Thiothixene	DMDINC4	Moderate	Additive CNS depression effects by the combination of Cetirizine and Thiothixene.	Schizophrenia [6A20]	[10]
Clozapine	DMFC71L	Moderate	Additive CNS depression effects by the combination of Cetirizine and Clozapine.	Schizophrenia [6A20]	[10]
Risperidone	DMN6DXL	Moderate	Additive CNS depression effects by the combination of Cetirizine and Risperidone.	Schizophrenia [6A20]	[10]
Asenapine	DMSQZE2	Moderate	Additive CNS depression effects by the combination of Cetirizine and Asenapine.	Schizophrenia [6A20]	[10]
Pimozide	DMW83TP	Moderate	Additive CNS depression effects by the combination of Cetirizine and Pimozide.	Schizophrenia [6A20]	[10]
Fentanyl	DM8WAHT	Moderate	Additive CNS depression effects by the combination of Cetirizine and Fentanyl.	Sensation disturbance [MB40]	[10]

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Acesulfame	E00341	36573	Flavoring agent
Allura red AC dye	E00338	33258	Colorant
Aspartame	E00402	134601	Flavoring agent
Benzyl alcohol	E00010	244	Antimicrobial preservative; Solvent
Butylated hydroxytoluene	E00336	31404	Antioxidant
DL-alpha-tocopherol	E00052	2116	Antioxidant
FD&C blue no. 1	E00263	19700	Colorant
FD&C blue no. 2	E00446	2723854	Colorant
Fumaric acid	E00420	444972	Acidulant; Antioxidant; Complexing agent; Flavoring agent; Solubilizing agent
Isopropyl alcohol	E00070	3776	Antimicrobial preservative; Solvent
Kyselina citronova	E00014	311	Acidulant; Antioxidant; Buffering agent; Complexing agent; Flavoring agent
Mannitol	E00103	6251	Diluent; Flavoring agent; Lyophilization aid; Plasticizing agent; Tonicity agent
Quinoline yellow WS	E00309	24671	Colorant
Sodium lauryl sulfate	E00464	3423265	Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Sucralose	E00370	71485	Flavoring agent
Sunset yellow FCF	E00255	17730	Colorant
Tocopherol nicotinate	E00325	27990	Antioxidant
Tocopheryl acetate	E00053	86472	Antioxidant
Ammonia	E00007	222	Alkalizing agent
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Butyl alcohol	E00011	263	Flavoring agent; Solvent
Carmellose sodium	E00625	Not Available	Disintegrant
Crospovidone	E00626	Not Available	Disintegrant
Dextrin	E00359	62698	Binding agent; Diluent; Microencapsulating agent; Stiffening agent; Suspending agent; Viscosity-controlling agent
Eisenoxyd	E00585	56841934	Colorant
Ferric hydroxide oxide yellow	E00539	23320441	Colorant
Glycerin	E00026	753	Antimicrobial preservative; Emollient; Flavoring agent; Humectant; Lubricant; Plasticizing agent; Solvent; Suppository base; Tonicity agent; Viscosity-controlling agent
Hexahydric alcohol	E00083	5780	Diluent; Flavoring agent; Humectant; Plasticizing agent
Hydroxypropyl cellulose	E00632	Not Available	Binding agent; Coating agent; Emulsifying agent; Film/Membrane-forming agent; Modified-release agent; Suspending agent; Viscosity-controlling agent
Hypromellose	E00634	Not Available	Coating agent
Lactose monohydrate	E00393	104938	Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium oxide	E00232	14792	Anticaking agent; Diluent; Emulsifying agent; Glidant; Tonicity agent
Magnesium stearate	E00208	11177	lubricant
Medium-chain triglyceride	E00640	Not Available	Emollient; Lubricant; Surfactant
Polyethylene glycol 1000	E00647	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 3350	E00652	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polyethylene glycol 400	E00653	Not Available	Coating agent; Diluent; Ointment base; Plasticizing agent; Solvent; Suppository base; lubricant
Polysorbate 80	E00665	Not Available	Dispersing agent; Emollient; Emulsifying agent; Plasticizing agent; Solubilizing agent; Surfactant; Suspending agent
Polyvinyl alcohol	E00666	Not Available	Coating agent; Emulsion stabilizing agent; Film/Membrane-forming agent
Povidone	E00667	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Propylene glycol	E00040	1030	Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Saccharose	E00091	5988	Binding agent; Coating agent; Cryoprotectant; Diluent; Flavoring agent; Suspending agent; Viscosity-controlling agent
Silicon dioxide	E00670	Not Available	Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium bicarbonate	E00424	516892	Alkalizing agent; Diluent
Sodium hydroxide	E00234	14798	Alkalizing agent
Talc	E00520	16211421	Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide	E00322	26042	Coating agent; Colorant; Opacifying agent
Triacetin	E00080	5541	Humectant; Plasticizing agent; Solvent
Vinylpyrrolidone	E00668	Not Available	Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Water	E00035	962	Solvent

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Cetirizine 5 mg tablet	5 mg	Chewable Tablet	Oral
Cetirizine 10 mg tablet	10 mg	Disintegrating Oral Tablet	Oral
Cetirizine 10 mg capsule	10 mg	Oral Capsule	Oral
Cetirizine 10 mg tablet	10 mg	Chewable Tablet	Oral
Cetirizine 10 mg tablet	10 mg	Oral Tablet	Oral
Cetirizine 5 mg tablet	5 mg	Oral Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1222).
• [2] Cetirizine FDA Label
• [3] BDDCS applied to over 900 drugs
• [4] Critical Evaluation of Human Oral Bioavailability for Pharmaceutical Drugs by Using Various Cheminformatics Approaches
• [5] Morrison RA, Singhvi SM, Creasey WA, Willard DA: Dose proportionality of nadolol pharmacokinetics after intravenous administration to healthy subjects. Eur J Clin Pharmacol. 1988;33(6):625-8.
• [6] Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
• [7] Spicak V, Dab I, Hulhoven R, Desager JP, Klanova M, de Longueville M, Harvengt C: Pharmacokinetics and pharmacodynamics of cetirizine in infants and toddlers. Clin Pharmacol Ther. 1997 Mar;61(3):325-30. doi: 10.1016/S0009-9236(97)90165-X.
• [8] Design, synthesis and histamine H1-receptor antagonistic activity of some novel 4-amino-2-(substituted)-5-(substituted) aryl-6-[(substituted aryl) amino] pyrimidines. Arzneimittelforschung. 2009;59(5):243-7.
• [9] Stereoselective and multiple carrier-mediated transport of cetirizine across Caco-2 cell monolayers with potential drug interaction. Chirality. 2010 Jul;22(7):684-92.
• [10] Product Information. Zyrtec (cetirizine). Pfizer US Pharmaceuticals, New York, NY.
• [11] Warrington SJ, Ankier SI, Turner P "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology 15 (1986): 31-7. [PMID: 3725002]
• [12] Cerner Multum, Inc. "Australian Product Information.".
• [13] Product Information. Alphagan (brimonidine ophthalmic). Allergan Inc, Irvine, CA.
• [14] Product Information. Zulresso (brexanolone). Sage Therapeutics, Inc., Cambridge, MA.
• [15] Product Information. Reyvow (lasmiditan). Lilly, Eli and Company, Indianapolis, IN.
• [16] Product Information. Addyi (flibanserin). Sprout Pharmaceuticals, Raleigh, NC.
• [17] Product Information. Thalomid (thalidomide). Celgene Corporation, Warren, NJ.