Details of Disease

General Information of Disease (ID: DIS4L94Y)

• Disease Name: Ovarian hyperstimulation syndrome
• Synonyms: ovarian hyperstimulation syndrome, familial gestational spontaneous; secondary Meig's syndrome; ovarian hyperstimulation syndrome; OHSS
• Definition: A complication of ovulation induction in infertility treatment. It is graded by the severity of symptoms which include ovary enlargement, multiple ovarian follicles; ovarian cysts; ascites; and generalized edema. The full-blown syndrome may lead to renal failure, respiratory distress, and even death. Increased capillary permeability is caused by the vasoactive substances, such as vascular endothelial growth factors, secreted by the overly-stimulated ovaries.
• Disease Hierarchy:
  DISYKSRF: Genetic disease
  DISHZX9D: Ovarian disorder
  DIS4L94Y: Ovarian hyperstimulation syndrome
• Disease Identifiers:
  MONDO ID: MONDO_0011972
  MESH ID: D016471
  UMLS CUI: C0085083
  OMIM ID: 608115
  MedGen ID: 38966
  Orphanet ID: 64739
  SNOMED CT ID: 129635004

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 8 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
DRD2	TTEX248	Limited	Therapeutic	[1]
NR1H3	TTECBXN	Limited	Biomarker	[2]
CGA	TTFC29G	moderate	Altered Expression	[3]
CGB3	TTUH273	moderate	Altered Expression	[3]
LHCGR	TT2O4W9	moderate	Genetic Variation	[4]
AMHR2	TTZDCPK	Strong	Genetic Variation	[4]
FSHR	TTZFDBT	Strong	Autosomal dominant	[5]
ZNF217	TTY3BRA	Strong	Biomarker	[6]

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BMP15	OT2G3YR1	moderate	Biomarker	[7]
AMH	OT5FH4BD	Strong	Altered Expression	[8]
FSHR	OT9MVMLI	Strong	Autosomal dominant	[5]
PROK1	OT8S7RUG	Strong	Biomarker	[9]

References

• [1] Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in an ovarian hyperstimulation syndrome (OHSS) animal model: implications for treatment of OHSS with dopamine receptor 2 agonists.Fertil Steril. 2014 Nov;102(5):1468-1476.e1. doi: 10.1016/j.fertnstert.2014.07.1240. Epub 2014 Sep 11.
• [2] Nogo-B receptor deficiency increases liver X receptor alpha nuclear translocation and hepatic lipogenesis through an adenosine monophosphate-activated protein kinase alpha-dependent pathway.Hepatology. 2016 Nov;64(5):1559-1576. doi: 10.1002/hep.28747. Epub 2016 Aug 23.
• [3] Vascular endothelial growth factor antagonist reduces the early onset and the severity of ovarian hyperstimulation syndrome.J Gynecol Obstet Hum Reprod. 2017 Jan;46(1):87-91. doi: 10.1016/j.jgyn.2016.04.002. Epub 2016 May 27.
• [4] The implication of single-nucleotide polymorphisms in ovarian hyperstimulation syndrome.Mol Reprod Dev. 2019 Aug;86(8):964-971. doi: 10.1002/mrd.23171. Epub 2019 May 22.
• [5] Follicle-stimulating-hormone receptor and twinning. Lancet. 2001 Jan 20;357(9251):230; author reply 231-2. doi: 10.1016/S0140-6736(05)71328-3.
• [6] Zinc finger gene 217 (ZNF217) Promoted Ovarian Hyperstimulation Syndrome (OHSS) through Regulating E(2) Synthesis and Inhibiting Thrombospondin-1 (TSP-1).Sci Rep. 2017 Jun 12;7(1):3245. doi: 10.1038/s41598-017-03555-6.
• [7] A single nucleotide polymorphism in BMP15 is associated with high response to ovarian stimulation.Reprod Biomed Online. 2011 Jul;23(1):97-104. doi: 10.1016/j.rbmo.2011.02.015. Epub 2011 Mar 3.
• [8] Intrafollicular melatonin concentration is elevated in patients with ovarian hyperstimulation syndrome (OHSS) and can serve as an important predictor of OHSS.Arch Gynecol Obstet. 2019 Apr;299(4):1151-1158. doi: 10.1007/s00404-018-4994-z. Epub 2019 Feb 6.
• [9] High levels of soluble vascular endothelial growth factor receptor 1/sFlt1 and low levels of vascular endothelial growth factor in follicular fluid on the day of oocyte retrieval correlate with ovarian hyperstimulation syndrom regardless of the stimulation protocol.J Physiol Pharmacol. 2017 Jun;68(3):477-484.