Details of Disease

General Information of Disease (ID: DIS9WQAI)

Disease Name	Urticaria
Synonyms	Urticarias; urticaria; hives; urticaria (disease)
Disease Class	EB00-EB05: Urticaria
Definition	A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.
Disease Hierarchy	DISY5SZC: Dermatitis DIS9WQAI: Urticaria
ICD Code	ICD-11 ICD-11: EB00-EB05 ICD-10 ICD-10: L50 Expand ICD-10 'L50
Disease Identifiers	MONDO ID MONDO_0005492 MESH ID D014581 UMLS CUI C0042109 MedGen ID 22587 HPO ID HP:0001025 SNOMED CT ID 126485001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 24 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Antazoline	DMA04JS	Approved	Small molecular drug	[1]
Azatadine	DMZ80SB	Approved	Small molecular drug	[2]
Brompheniramine	DMFOVSD	Approved	Small molecular drug	[3]
Canakinumab	DM8HLO5	Approved	Antibody	[4]
Carbinoxamine	DMCT31R	Approved	Small molecular drug	[5]
Clemastine	DMBZWQL	Approved	Small molecular drug	[6]
Cyproheptadine	DM92AH3	Approved	Small molecular drug	[7]
Dexbrompheniramine	DMKVWGE	Approved	Small molecular drug	[8]
Dexchlorpheniramine Maleate	DMA8DPN	Approved	Small molecular drug	[9]
Diphenylpyraline	DMW4X37	Approved	Small molecular drug	[10]
Doxylamine	DMKOXFE	Approved	Small molecular drug	[11]
Emedastine	DM36LAJ	Approved	Small molecular drug	[12]
Hydroxyzine	DMF8Y74	Approved	Small molecular drug	[13]
Mepyramine	DMB4SFH	Approved	Small molecular drug	[14]
Methdilazine	DMAUHQX	Approved	Small molecular drug	[15]
Methotrexate	DM2TEOL	Approved	Small molecular drug	[16]
Phenindamine	DMDTC7R	Approved	Small molecular drug	[17]
Pheniramine	DMCH7RU	Approved	Small molecular drug	[18]
Promazine	DMZAL7W	Approved	Small molecular drug	[19]
Promethazine	DM6I5GR	Approved	Small molecular drug	[20]
Trimeprazine	DMEMV9D	Approved	Small molecular drug	[21]
Tripelennamine	DMZBU15	Approved	Small molecular drug	[22]
Triprolidine	DM7SWIA	Approved	Small molecular drug	[23]
Chlorphenamine	DM6C4YJ	Phase 4	NA	[24]
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⏷ Show the Full List of 24 Drug(s)

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AK002	DM8H3ZH	Phase 2	NA	[25]
GSK2646264	DMQOM5V	Phase 1	NA	[25]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
V-0096	DMLXILY	Discontinued in Phase 2	NA	[26]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 22 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
HLA-DRB1	TTUXSTW	Limited	Genetic Variation	[27]
SERPING1	TTVQ6R9	Limited	Altered Expression	[28]
NLRP3	TT4EN8X	moderate	Genetic Variation	[29]
AGXT	TTF5NVW	Strong	Biomarker	[30]
ALB	TTFNGC9	Strong	Altered Expression	[31]
CASP6	TTKW4ML	Strong	Biomarker	[32]
CD9	TTZEIBV	Strong	Altered Expression	[33]
FOXP3	TT1X3QF	Strong	Altered Expression	[34]
HDC	TTV9GOF	Strong	Altered Expression	[35]
HNMT	TT2B6EV	Strong	Biomarker	[36]
ICAM1	TTA1L39	Strong	Biomarker	[37]
IL31	TT1RJXK	Strong	Biomarker	[38]
LTC4S	TTW7OTG	Strong	Genetic Variation	[39]
LY96	TT8S9AV	Strong	Altered Expression	[40]
MAPKAPK3	TTFS4VU	Strong	Biomarker	[40]
METAP2	TTZL0OI	Strong	Altered Expression	[41]
MPO	TTVCZPI	Strong	Biomarker	[42]
OPRD1	TT27RFC	Strong	Biomarker	[43]
PTGER1	TTG1QMU	Strong	Genetic Variation	[44]
SELE	TT1PL7M	Strong	Biomarker	[37]
VCAM1	TTHCEF6	Strong	Biomarker	[37]
ALOX5	TTSJ6Q4	Definitive	Genetic Variation	[44]
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⏷ Show the Full List of 22 DTT(s)

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
GSTM1	DEYZEJA	Strong	Biomarker	[45]
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This Disease Is Related to 20 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ABI3BP	OTW8DN50	Limited	Genetic Variation	[46]
CAPS	OTC9GZ2M	Limited	Altered Expression	[47]
IFT43	OTKWYQ5C	Limited	Genetic Variation	[46]
FCER1A	OTIRUOHF	moderate	Biomarker	[36]
ADD2	OTRCPCD2	Strong	Altered Expression	[41]
CD63	OT2UGZA9	Strong	Biomarker	[48]
CHP1	OTHTXN1A	Strong	Altered Expression	[33]
CREB5	OTJDUJPI	Strong	Biomarker	[40]
DGKG	OTBL32T3	Strong	Altered Expression	[40]
HLA-DPB1	OTW8JHU2	Strong	Biomarker	[49]
HLA-DQB1	OTVVI3UI	Strong	Biomarker	[49]
IL18BP	OTW0LRYZ	Strong	Altered Expression	[50]
INA	OT1D33T4	Strong	Altered Expression	[51]
ITIH4	OT460OO1	Strong	Biomarker	[52]
NRSN1	OT1KKXC8	Strong	Altered Expression	[33]
RDX	OTNSYUN6	Strong	Biomarker	[40]
SMOC1	OTJG2JQY	Strong	Altered Expression	[53]
SYN2	OTK0DEGH	Strong	Biomarker	[41]
TMED2	OTBLO7RW	Strong	Altered Expression	[33]
TPPP	OTCFMSUF	Strong	Altered Expression	[33]
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⏷ Show the Full List of 20 DOT(s)

References

1	Antazoline FDA Label
2	Azatadine FDA Label
3	Brompheniramine FDA Label
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6773).
5	Carbinoxamine FDA Label
6	Clemastine FDA Label
7	Cyproheptadine FDA Label
8	Dexbrompheniramine FDA Label
9	Dexchlorpheniramine maleate FDA Label
10	Diphenylpyraline FDA Label
11	Doxylamine FDA Label
12	Emedastine FDA Label
13	Hydroxyzine FDA Label
14	The widely used antihistamine mepyramine causes topical pain relief through direct blockade of nociceptor sodium channels. FASEB J. 2021 Dec;35(12):e22025.
15	Methdilazine FDA Label
16	Methotrexate FDA Label
17	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
18	Pheniramine FDA Label
19	Promazine FDA Label
20	Promethazine FDA Label
21	Trimeprazine FDA Label
22	Tripelennamine FDA Label
23	Ephedrine FDA Label
24	Chlorpheniramine, an Old Drug with New Potential Clinical Applications: A Comprehensive Review of the Literature. Curr Rev Clin Exp Pharmacol. 2024;19(2):137-145.
25	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
26	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040649)
27	HLA status in patients with chronic spontaneous urticaria.Int Arch Allergy Immunol. 2010;153(4):419-23. doi: 10.1159/000316354. Epub 2010 Jun 18.
28	Review of the Manitoba cohort of patients with hereditary angioedema with normal C1 inhibitor.Allergy Asthma Clin Immunol. 2019 Nov 12;15:66. doi: 10.1186/s13223-019-0381-y. eCollection 2019.
29	Neurology of the cryopyrin-associated periodic fever syndrome.Eur J Neurol. 2016 Jul;23(7):1145-51. doi: 10.1111/ene.12965. Epub 2016 Mar 2.
30	Do helminth infections underpin urban-rural differences in risk factors for allergy-related outcomes?.Clin Exp Allergy. 2019 May;49(5):663-676. doi: 10.1111/cea.13335. Epub 2019 Jan 25.
31	CRP relevance in clinical assessment of chronic spontaneous urticaria Tunisian patients.Cutan Ocul Toxicol. 2017 Dec;36(4):387-392. doi: 10.1080/15569527.2017.1311338. Epub 2017 Apr 25.
32	MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase-6 regulates astrocyte survival.FASEB J. 2010 Jun;24(6):1799-812. doi: 10.1096/fj.09-147819. Epub 2010 Jan 22.
33	Molecular and pathologic insights from latent HIV-1 infection in the human brain.Neurology. 2013 Apr 9;80(15):1415-23. doi: 10.1212/WNL.0b013e31828c2e9e. Epub 2013 Mar 13.
34	Defective functions of circulating CD4+CD25+ and CD4+CD25- T cells in patients with chronic ordinary urticaria.J Dermatol Sci. 2008 Aug;51(2):121-30. doi: 10.1016/j.jdermsci.2008.02.012. Epub 2008 Apr 28.
35	Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria.J Invest Dermatol. 2005 Nov;125(5):952-5. doi: 10.1111/j.0022-202X.2005.23913.x.
36	Genetic and ethnic risk factors associated with drug hypersensitivity. Curr Opin Allergy Clin Immunol. 2010 Aug;10(4):280-90. doi: 10.1097/ACI.0b013e32833b1eb3.
37	Evaluation of inflammatory parameters in physical urticarias and effects of an anti-inflammatory/antiallergic treatment.Int J Dermatol. 2002 Jul;41(7):431-8. doi: 10.1046/j.1365-4362.2002.01441.x.
38	Role of the Pruritic Cytokine IL-31 in Autoimmune Skin Diseases.Front Immunol. 2019 Jun 21;10:1383. doi: 10.3389/fimmu.2019.01383. eCollection 2019.
39	The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria. J Investig Allergol Clin Immunol. 2009;19(5):375-82.
40	CREB5 computational regulation network construction and analysis between frontal cortex of HIV encephalitis (HIVE) and HIVE-control patients.Cell Biochem Biophys. 2011 Jul;60(3):199-207. doi: 10.1007/s12013-010-9140-x.
41	Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis.J Neuroimmunol. 2004 Dec;157(1-2):163-75. doi: 10.1016/j.jneuroim.2004.08.026.
42	Neutrophil activation in patients with ASA-induced urticaria.J Clin Immunol. 2008 May;28(3):244-9. doi: 10.1007/s10875-007-9165-0.
43	The association between serum vitamin D levels and urticaria: a meta-analysis of observational studies.G Ital Dermatol Venereol. 2018 Jun;153(3):389-395. doi: 10.23736/S0392-0488.17.05774-1. Epub 2017 Oct 23.
44	Copy number variation in ALOX5 and PTGER1 is associated with NSAIDs-induced urticaria and/or angioedema.Pharmacogenet Genomics. 2016 Jun;26(6):280-7. doi: 10.1097/FPC.0000000000000216.
45	Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant. Br J Dermatol. 2006 Feb;154(2):256-60. doi: 10.1111/j.1365-2133.2005.06851.x.
46	Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.Pharmacogenomics. 2013 Nov;14(15):1857-69. doi: 10.2217/pgs.13.166.
47	Guidelines for the management and treatment of periodic fever syndromes: Cryopyrin-associated periodic syndromes (cryopyrinopathies - CAPS).Rev Bras Reumatol Engl Ed. 2016 Jan-Feb;56(1):44-51. doi: 10.1016/j.rbre.2015.08.020. Epub 2015 Oct 20.
48	Basophil CD63 expression in chronic spontaneous urticaria: correlation with allergic sensitization, serum autoreactivity and basophil reactivity.J Eur Acad Dermatol Venereol. 2017 Mar;31(3):463-468. doi: 10.1111/jdv.13912. Epub 2016 Sep 5.
49	Genetic markers for differentiating aspirin-hypersensitivity.Yonsei Med J. 2006 Feb 28;47(1):15-21. doi: 10.3349/ymj.2006.47.1.15.
50	Level of interleukin-18 binding protein is significantly different in patients with anaphylaxis than urticaria.Asian Pac J Allergy Immunol. 2022 Dec;40(4):368-373. doi: 10.12932/AP-270619-0588.
51	Interaction between C1-INA, coagulation, fibrinolysis and kinin system in hereditary angioneurotic edema (HANE) and urticaria.Arch Dermatol Res. 1984;276(6):375-80. doi: 10.1007/BF00413358.
52	The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons.Neurotox Res. 2016 May;29(4):583-593. doi: 10.1007/s12640-016-9608-6. Epub 2016 Mar 2.
53	OAS Gene Family Expression Is Associated with HIV-Related Neurocognitive Disorders.Mol Neurobiol. 2018 Mar;55(3):1905-1914. doi: 10.1007/s12035-017-0460-3. Epub 2017 Feb 24.