Details of Disease

Disease Name

Prostate cancer, hereditary, 1

Prca1; HPC1; RNASEL familial prostate cancer; prostate cancer 1; prostate cancer, hereditary, type 1; familial prostate cancer caused by mutation in RNASEL; prostate cancer, hereditary, 1

Definition

Any familial prostate cancer in which the cause of the disease is a mutation in the RNASEL gene.

Disease Hierarchy

DISL9KNO: Familial prostate carcinoma

DISE2P4L: Prostate cancer, hereditary, 1

Disease Identifiers

MONDO ID

MONDO_0011098

UMLS CUI

C4722327

OMIM ID

601518

MedGen ID

1648436

General Information of Disease (ID: DISE2P4L)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 18 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
RNASEL	TT7V0K4	Limited	Autosomal dominant	[1]
ATAT1	TTWUHQ1	Strong	Biomarker	[2]
ATM	TTKBM7V	Strong	Biomarker	[2]
CASP8	TT6SZNG	Strong	Biomarker	[2]
CDH1	TTLAWO6	Strong	Biomarker	[3]
CDKN1B	TTLGFVW	Strong	Biomarker	[2]
CHEK2	TT9ABMF	Strong	Biomarker	[4]
DNMT3B	TT6VZ78	Strong	Biomarker	[2]
HOXB13	TTZ6I58	Strong	Biomarker	[5]
ITGB8	TTIF29E	Strong	Biomarker	[2]
KDM2A	TT8XTY2	Strong	Biomarker	[2]
MAD1L1	TTNE9U7	Strong	Biomarker	[2]
MAP2K1	TTIDAPM	Strong	Biomarker	[2]
MMP14	TTJ4QE7	Strong	Biomarker	[2]
RGS8	TTWME23	Strong	Genetic Variation	[6]
RNF43	TTD91BL	Strong	Biomarker	[2]
TCF7L2	TT80QAL	Strong	Biomarker	[2]
TOR1A	TTF85KW	Strong	Biomarker	[2]
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⏷ Show the Full List of 18 DTT(s)

This Disease Is Related to 33 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
RNASEL	OTP6UQUP	Limited	Autosomal dominant	[1]
ADGRG1	OTQBB8NT	Strong	Biomarker	[2]
ARHGAP6	OTNVXXFX	Strong	Biomarker	[2]
B3GAT1	OTXFP98E	Strong	Biomarker	[2]
BCAS1	OTQKJR81	Strong	Biomarker	[2]
BCL2L11	OTNQQWFJ	Strong	Biomarker	[2]
CDCA7	OT12HDZY	Strong	Biomarker	[2]
CHD3	OTDBU4F3	Strong	Biomarker	[2]
COL23A1	OTYE0N3I	Strong	Biomarker	[2]
DENND4B	OTFEO8KG	Strong	Biomarker	[2]
DOCK2	OTZTS3PA	Strong	Biomarker	[2]
EMSY	OTBQ3KQE	Strong	Biomarker	[2]
FBRSL1	OT4BPXGG	Strong	Biomarker	[2]
HAUS6	OT7ZVR57	Strong	Biomarker	[2]
HLA-DOA	OTZE5Q7R	Strong	Biomarker	[2]
INCENP	OT9HFRYK	Strong	Biomarker	[2]
KNL1	OT4Q3LHV	Strong	Biomarker	[2]
LARP4B	OT2HI0QE	Strong	Biomarker	[2]
MBD2	OTUQPP0R	Strong	Biomarker	[2]
MBNL1	OTOV7J85	Strong	Biomarker	[2]
MECOM	OTP983W8	Strong	Biomarker	[2]
MOB2	OTMBE0NS	Strong	Biomarker	[2]
MYO9B	OTQ94R5K	Strong	Biomarker	[2]
PAX9	OT25J0F7	Strong	Biomarker	[2]
POU2F2	OTPV0J0C	Strong	Biomarker	[2]
PPFIBP2	OTXQO55Y	Strong	Biomarker	[2]
RASSF3	OT4V9SRK	Strong	Biomarker	[2]
RFX7	OTKFNW3A	Strong	Biomarker	[2]
RNLS	OTVP2WJM	Strong	Biomarker	[2]
SUGCT	OTA8L0TN	Strong	Biomarker	[2]
TCF4	OTB9ASTK	Strong	Biomarker	[2]
TSHZ1	OTYQ9ECW	Strong	Biomarker	[2]
TTC28	OTFOOYC3	Strong	Biomarker	[2]
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⏷ Show the Full List of 33 DOT(s)

References

1	Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.
2	Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.Nat Genet. 2018 Jul;50(7):928-936. doi: 10.1038/s41588-018-0142-8. Epub 2018 Jun 11.
3	Comprehensive genetic evaluation of common E-cadherin sequence variants and prostate cancer risk: strong confirmation of functional promoter SNP.Hum Genet. 2005 Dec;118(3-4):339-47. doi: 10.1007/s00439-005-0060-6. Epub 2005 Sep 28.
4	Mutations in CHEK2 associated with prostate cancer risk.Am J Hum Genet. 2003 Feb;72(2):270-80. doi: 10.1086/346094. Epub 2003 Jan 17.
5	Germline mutations in HOXB13 and prostate-cancer risk. N Engl J Med. 2012 Jan 12;366(2):141-9. doi: 10.1056/NEJMoa1110000.
6	Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus.Genomics. 2001 Apr 15;73(2):211-22. doi: 10.1006/geno.2001.6500.