Details of Disease

General Information of Disease (ID: DISHNU25)

• Disease Name: Hypertension, pregnancy-induced
• Synonyms: pregnancy induced hypertension; hypertension, pregnancy transient; induced Hypertensions, pregnancy; hypertension, gestational; hypertension complicating pregnancy; induced hypertension, pregnancy; hypertensions, pregnancy induced; transient hypertension, pregnancy; gestational hypertension; hypertension, pregnancy induced; pregnancy transient hypertension; hypertension induced by pregnancy; hypertension associated disorders of pregnancy; hypertension-associated pregnancy disorder; pregnancy-induced hypertension
• Definition: A hypertensive disorder that develops during pregnancy.
• Disease Hierarchy:
  DISR4QMU: Increase blood pressure
  DIS5V7J6: Pregnancy disorder
  DISHNU25: Hypertension, pregnancy-induced
• Disease Identifiers:
  MONDO ID: MONDO_0024664
  MESH ID: D046110
  UMLS CUI: C0852036
  MedGen ID: 852894
  SNOMED CT ID: 48194001

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Labetalol	DMK8U72	Approved	Small molecular drug	[1]
Magnesium Sulfate	DMVEK07	Approved	Small molecular drug	[2]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 13 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
REN	TTB2MXP	Limited	Genetic Variation	[3]
ADRB1	TTR6W5O	moderate	Biomarker	[4]
CYP11B2	TT9MNE2	moderate	Genetic Variation	[5]
AGTR1	TT8DBY3	Strong	Biomarker	[6]
CA13	TTQPHSR	Strong	Genetic Variation	[7]
CALCRL	TTY6O0Q	Strong	Altered Expression	[8]
F5	TT1O264	Strong	Genetic Variation	[9]
GPR182	TTT23CG	Strong	Altered Expression	[8]
HP	TTLC8E1	Strong	Biomarker	[10]
HSD11B2	TT9H85R	Strong	Biomarker	[11]
LIPE	TTLUQ8E	Strong	Genetic Variation	[12]
PGF	TT48I1Y	Strong	Biomarker	[13]
TFPI	TT068JH	Strong	Biomarker	[14]

This Disease Is Related to 2 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
HSD3B1	DERDQWN	moderate	Genetic Variation	[15]
HSD3B2	DEN0GVQ	moderate	Genetic Variation	[15]

This Disease Is Related to 20 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ERVFRD-1	OT3064D7	Limited	Biomarker	[16]
ERVH48-1	OT303JGE	Limited	Biomarker	[16]
ADD1	OTTF68DC	moderate	Genetic Variation	[17]
BCAR3	OTPJ17M8	moderate	Genetic Variation	[18]
CENPJ	OTZCQZN5	moderate	Biomarker	[19]
ENHO	OT91QASK	moderate	Altered Expression	[20]
GCM1	OT5CPAUT	moderate	Biomarker	[21]
HTRA3	OTXJ0H4X	moderate	Altered Expression	[22]
PROK1	OT8S7RUG	moderate	Biomarker	[23]
ROM1	OTE7H0YV	moderate	Biomarker	[24]
RRS1	OTTNCZN6	moderate	Biomarker	[25]
CCHCR1	OT22C116	Strong	Altered Expression	[26]
DBP	OTE0W7LN	Strong	Altered Expression	[26]
GLS2	OT08MSHL	Strong	Genetic Variation	[27]
ISYNA1	OT49ONSE	Strong	Altered Expression	[28]
LIPC	OTZY5SC9	Strong	Genetic Variation	[12]
PAPPA	OTTTG9PG	Strong	Biomarker	[29]
RAMP2	OTGQXLH5	Strong	Altered Expression	[8]
SELENBP1	OT3NZNTR	Strong	Altered Expression	[26]
SHBG	OTPWU5IW	Strong	Altered Expression	[26]

References

• [1] Labetalol FDA Label
• [2] Magnesium Sulfate FDA Label
• [3] Chronic hypertension in pregnancy: impact of ethnicity and superimposed preeclampsia on placental, endothelial, and renal biomarkers.Am J Physiol Regul Integr Comp Physiol. 2018 Jul 1;315(1):R36-R47. doi: 10.1152/ajpregu.00139.2017. Epub 2018 Mar 7.
• [4] ADRB1 as a potential target for gene therapy of pregnancy induced hypertension and gestational diabetes mellitus.Clin Exp Hypertens. 2011;33(6):422-6. doi: 10.3109/10641963.2010.532265. Epub 2011 Aug 1.
• [5] Relationship of aldosterone synthase gene (C-344T) and mineralocorticoid receptor (S810L) polymorphisms with gestational hypertension.J Hum Hypertens. 2011 May;25(5):320-6. doi: 10.1038/jhh.2010.58. Epub 2010 Jun 10.
• [6] The agonistic autoantibodies to the angiotensin II type 1 receptor in pregnancies complicated by hypertensive disorders.J Matern Fetal Neonatal Med. 2019 Apr;32(7):1219-1223. doi: 10.1080/14767058.2017.1400006. Epub 2017 Nov 13.
• [7] Matrix metalloproteinase-9 polymorphisms affect plasma MMP-9 levels and antihypertensive therapy responsiveness in hypertensive disorders of pregnancy.Pharmacogenomics J. 2012 Dec;12(6):489-98. doi: 10.1038/tpj.2011.31. Epub 2011 Jul 19.
• [8] Alteration of the adrenomedullin receptor components gene expression associated with the blood pressure in pregnancy-induced hypertension.J Clin Endocrinol Metab. 2001 Oct;86(10):5079-82. doi: 10.1210/jcem.86.10.8099.
• [9] Genetic thromobophilia in pregnancy: a case-control study among North Indian women.J Thromb Thrombolysis. 2013 Feb;35(2):250-6. doi: 10.1007/s11239-012-0797-4.
• [10] Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMP1 (SLC11A1) on host-pathogen interactions in tuberculosis and HIV.Clin Sci (Lond). 2006 May;110(5):503-24. doi: 10.1042/CS20050273.
• [11] Increased cortisol metabolism in women with pregnancy-related hypertension.Endocrine. 2018 Jul;61(1):125-133. doi: 10.1007/s12020-018-1586-4. Epub 2018 Apr 2.
• [12] The combination of ApoCIII, hepatic lipase and hormono sensitive lipase gene polymorphisms suggests an association with susceptibility to gestational hypertension.J Hum Genet. 2007;52(3):244-254. doi: 10.1007/s10038-006-0106-1. Epub 2007 Feb 15.
• [13] Placental growth factor reverses decreased vascular and uteroplacental MMP-2 and MMP-9 and increased MMP-1 and MMP-7 and collagen types I and IV in hypertensive pregnancy.Am J Physiol Heart Circ Physiol. 2018 Jul 1;315(1):H33-H47. doi: 10.1152/ajpheart.00045.2018. Epub 2018 Mar 23.
• [14] Effect of nitric oxide deficiency on tissue-type plasminogen activator expression in the umbilical cord in a pregnancy-induced hypertension rat model.Pregnancy Hypertens. 2012 Jan;2(1):53-8. doi: 10.1016/j.preghy.2011.10.002. Epub 2011 Oct 21.
• [15] Estrogen synthesis genes CYP19A1, HSD3B1, and HSD3B2 in hypertensive disorders of pregnancy.Endocrine. 2012 Dec;42(3):700-7. doi: 10.1007/s12020-012-9699-7. Epub 2012 May 26.
• [16] Cellular localization of placenta-specific human endogenous retrovirus (HERV) transcripts and their possible implication in pregnancy-induced hypertension.Placenta. 2008 Mar;29(3):282-9. doi: 10.1016/j.placenta.2007.11.009. Epub 2007 Dec 26.
• [17] Angiotensin-converting enzyme and adducin-1 polymorphisms in women with preeclampsia and gestational hypertension.Reprod Sci. 2009 Sep;16(9):819-26. doi: 10.1177/1933719109336612. Epub 2009 May 14.
• [18] Maternal Venous Hemodynamic Dysfunction in Proteinuric Gestational Hypertension: Evidence and Implications.J Clin Med. 2019 Mar 11;8(3):335. doi: 10.3390/jcm8030335.
• [19] Maternal Sleep-Disordered Breathing.Chest. 2018 Apr;153(4):1052-1066. doi: 10.1016/j.chest.2017.10.011. Epub 2017 Oct 21.
• [20] Negative association between serum adropin and hypertensive disorders complicating pregnancy.Hypertens Pregnancy. 2019 Nov;38(4):237-244. doi: 10.1080/10641955.2019.1657887. Epub 2019 Aug 23.
• [21] Effects of reduced Gcm1 expression on trophoblast morphology, fetoplacental vascularity, and pregnancy outcomes in mice.Hypertension. 2012 Mar;59(3):732-9. doi: 10.1161/HYPERTENSIONAHA.111.183939. Epub 2012 Jan 23.
• [22] Low Serum Levels of HtrA3 at 15 Weeks of Gestation Are Associated with Late-Onset Preeclampsia Development and Small for Gestational Age Birth.Fetal Diagn Ther. 2019;46(6):392-401. doi: 10.1159/000497144. Epub 2019 Apr 23.
• [23] EG-VEGF Maintenance Over Early Gestation to Develop a Pregnancy-Induced Hypertensive Animal Model.Methods Mol Biol. 2018;1710:317-324. doi: 10.1007/978-1-4939-7498-6_25.
• [24] Placental hypoplasia and maternal organic vascular disorder in pregnant women with gestational hypertension and preeclampsia.J Matern Fetal Neonatal Med. 2021 Feb;34(3):353-359. doi: 10.1080/14767058.2019.1608175. Epub 2019 May 2.
• [25] The Spectrum of Adverse Pregnancy Outcomes Based on Kidney Disease Diagnoses: A 20-Year Population Study.Am J Nephrol. 2019;49(5):400-409. doi: 10.1159/000499965. Epub 2019 Apr 12.
• [26] Feature of trajectory of blood pressure among pregnant women with gestational hypertension.J Hypertens. 2020 Jan;38(1):127-132. doi: 10.1097/HJH.0000000000002197.
• [27] Obstetric and perinatal outcomes of singleton pregnancies conceived via assisted reproductive technology complicated by gestational diabetes mellitus: a prospective cohort study.BMC Pregnancy Childbirth. 2018 Dec 14;18(1):495. doi: 10.1186/s12884-018-2115-4.
• [28] Placental expression of endothelial and inducible nitric oxide synthase and NO metabolism in gestational hypertension: a case-control study.J Matern Fetal Neonatal Med. 2016;29(4):576-81. doi: 10.3109/14767058.2015.1011615. Epub 2015 Feb 18.
• [29] Association of pregnancy-associated plasma protein A and vascular endothelial growth factor with pregnancy-induced hypertension.Exp Ther Med. 2019 Sep;18(3):1761-1767. doi: 10.3892/etm.2019.7724. Epub 2019 Jul 2.