Details of Disease

General Information of Disease (ID: DISKYC7V)

Disease Name Metastatic sarcoma
Synonyms metastatic carcinoma
Disease Class 2D50-2E2Z: Metastatic tumour
Definition
A carcinoma which has spread from the original site of growth to another anatomic site.|Note that we currently treat secondary neoplasms as being neoplastic diseases that are derived from neoplasm; classes such as 'neoplasm', 'carcinoma' are implicitly primary. This may change in future.
Disease Hierarchy
DIS86UK6: Metastatic malignant neoplasm
DISDZHBX: Secondary carcinoma
DISKYC7V: Metastatic sarcoma
ICD Code
ICD-11
ICD-11: 2D50-2E2Z
ICD-10
ICD-10: C49
Disease Identifiers
MONDO ID
MONDO_0024879
UMLS CUI
C1384494
MedGen ID
235141
SNOMED CT ID
79282002

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Ganglioside vaccine DMH8BUZ Phase 2 NA [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
SCGB2A2 TT1W3RE moderate Altered Expression [2]
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This Disease Is Related to 9 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
BRMS1 OTV5A6LL Limited Biomarker [3]
AHSP OTTHBSUS moderate Biomarker [4]
NUTM1 OTONYC08 moderate Biomarker [5]
PIP OTH719AH moderate Altered Expression [6]
TFCP2 OTA246TE moderate Biomarker [7]
TNFRSF10D OTOSRDJT moderate Biomarker [8]
ING5 OTRNNSFM Strong Altered Expression [9]
TTF1 OT4K90WD Strong Altered Expression [10]
ATP2A3 OTFYDEES Definitive Altered Expression [11]
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⏷ Show the Full List of 9 DOT(s)

References

1 Clinical pipeline report, company report or official report of Mabvax therapeutics.
2 Mammaglobin expression in lymph nodes is an important marker of metastatic breast carcinoma.Arch Pathol Lab Med. 2003 Oct;127(10):1330-4. doi: 10.5858/2003-127-1330-MEILNI.
3 Multiple forms of BRMS1 are differentially expressed in the MCF10 isogenic breast cancer progression model.Clin Exp Metastasis. 2009;26(2):89-96. doi: 10.1007/s10585-008-9216-9. Epub 2008 Oct 8.
4 -Hemoglobin-stabilizing Protein: An Effective Marker for Erythroid Precursors in Bone Marrow Biopsy Specimens.Appl Immunohistochem Mol Morphol. 2016 Jan;24(1):51-6. doi: 10.1097/PAI.0000000000000139.
5 First evidence of treatment efficacy in metastatic carcinoma of the parotid gland with BRD4/NUT translocation.J Chemother. 2016 Jun;28(3):242-6. doi: 10.1179/1973947815Y.0000000046.
6 Hormone-regulated genes (pS2, PIP, FAS) in breast cancer and nontumoral mammary tissue.Pathobiology. 1994;62(2):82-9. doi: 10.1159/000163882.
7 Spindle cell rhabdomyosarcoma in a lumbar vertebra with FUS-TFCP2 fusion.Pathol Res Pract. 2019 Aug;215(8):152399. doi: 10.1016/j.prp.2019.03.027. Epub 2019 Mar 27.
8 Expression of TNF-related apoptosis-inducing ligand (TRAIL) and its receptors in gastric carcinoma and tumor-infiltrating lymphocytes: a possible mechanism of immune evasion of the tumor.J Cancer Res Clin Oncol. 2002 Feb;128(2):73-9. doi: 10.1007/s004320100292. Epub 2001 Dec 12.
9 The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression.Hum Pathol. 2011 Jan;42(1):25-35. doi: 10.1016/j.humpath.2010.05.024. Epub 2010 Nov 9.
10 TTF-1-positive Metastatic Endometrioid Carcinoma: A Case Report and Review of Literature of a Potential Diagnostic Pitfall.Appl Immunohistochem Mol Morphol. 2020 Jan;28(1):e6-e9. doi: 10.1097/PAI.0000000000000539.
11 Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence.Oncol Rep. 2014 Jan;31(1):232-40. doi: 10.3892/or.2013.2837. Epub 2013 Nov 7.