Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTPHOC22)

• DOT Name: Cell cycle exit and neuronal differentiation protein 1 (CEND1)
• Synonyms: BM88 antigen
• Gene Name: CEND1
• Related Disease:
  Beckwith-Wiedemann syndrome
  Joubert syndrome
  Neuroblastoma
• UniProt ID: CEND_HUMAN
• Pfam ID: PF15677
• Sequence:
  MESRGKSASSPKPDTKVPQVTTEAKVPPAADGKAPLTKPSKKEAPAEKQQPPAAPTTAPA
  KKTSAKADPALLNNHSNLKPAPTVPSSPDATPEPKGPGDGAEEDEAASGGPGGRGPWSCE
  NFNPLLVAGGVAVAAIALILGVAFLVRKK
• Function: Involved in neuronal differentiation.
• Tissue Specificity: Neuron specific.

Molecular Interaction Atlas (MIA) of This DOT

3 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Beckwith-Wiedemann syndrome	DISH15GR	Strong	Genetic Variation	[1]
Joubert syndrome	DIS7P5CO	Strong	Biomarker	[2]
Neuroblastoma	DISVZBI4	Strong	Biomarker	[1]

2 Drug(s) Affected the Post-Translational Modifications of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Valproate	DMCFE9I	Approved	Valproate increases the methylation of Cell cycle exit and neuronal differentiation protein 1 (CEND1).	[3]
Benzo(a)pyrene	DMN7J43	Phase 1	Benzo(a)pyrene increases the methylation of Cell cycle exit and neuronal differentiation protein 1 (CEND1).	[9]

9 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Tretinoin	DM49DUI	Approved	Tretinoin increases the expression of Cell cycle exit and neuronal differentiation protein 1 (CEND1).	[4]
Cisplatin	DMRHGI9	Approved	Cisplatin decreases the expression of Cell cycle exit and neuronal differentiation protein 1 (CEND1).	[5]
Temozolomide	DMKECZD	Approved	Temozolomide decreases the expression of Cell cycle exit and neuronal differentiation protein 1 (CEND1).	[6]
Triclosan	DMZUR4N	Approved	Triclosan decreases the expression of Cell cycle exit and neuronal differentiation protein 1 (CEND1).	[7]
Dexamethasone	DMMWZET	Approved	Dexamethasone increases the expression of Cell cycle exit and neuronal differentiation protein 1 (CEND1).	[8]
(+)-JQ1	DM1CZSJ	Phase 1	(+)-JQ1 increases the expression of Cell cycle exit and neuronal differentiation protein 1 (CEND1).	[10]
PMID28460551-Compound-2	DM4DOUB	Patented	PMID28460551-Compound-2 increases the expression of Cell cycle exit and neuronal differentiation protein 1 (CEND1).	[11]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A decreases the expression of Cell cycle exit and neuronal differentiation protein 1 (CEND1).	[12]
Acetaldehyde	DMJFKG4	Investigative	Acetaldehyde increases the expression of Cell cycle exit and neuronal differentiation protein 1 (CEND1).	[13]

References

• [1] Cloning, expression and localization of human BM88 shows that it maps to chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and tumorigenesis.Biochem J. 2001 May 1;355(Pt 3):715-24. doi: 10.1042/bj3550715.
• [2] Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.J Neurosci. 2013 May 8;33(19):8172-84. doi: 10.1523/JNEUROSCI.0119-13.2013.
• [3] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [4] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [5] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [6] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [7] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [8] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [9] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [10] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [11] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [12] Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
• [13] Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.