General Information of Drug Combination (ID: DC1DU43)

Drug Combination Name
Omeprazole Amoxicillin
Indication
Disease Entry Status REF
Helicobacter Pylori Infection Phase 4 [1]
Component Drugs Omeprazole   DM471KJ Amoxicillin   DMUYNEI
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Omeprazole
Disease Entry ICD 11 Status REF
Cystic fibrosis CA25 Approved [2]
Gastric ulcer DA60 Approved [2]
Gastrinoma 2C10.1 Approved [2]
Gastroesophageal reflux disease DA22.Z Approved [3]
Laryngeal disorder N.A. Approved [2]
Nausea MD90 Approved [2]
Peptic esophagitis N.A. Approved [2]
Peptic ulcer DA61 Approved [2]
Congenital laryngomalacia N.A. Investigative [2]
Omeprazole Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Gastric H(+)/K(+) ATPase (Proton pump) TTLOKXP ATP4A_HUMAN; ATP4B_HUMAN Modulator [7]
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Omeprazole Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [8]
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Omeprazole Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [9]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [10]
Cytochrome P450 2C18 (CYP2C18) DEZMWRE CP2CI_HUMAN Metabolism [11]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [11]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [12]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [9]
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⏷ Show the Full List of 6 DME(s)
Omeprazole Interacts with 14 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Alcohol dehydrogenase 1C (ADH1C) OTO1DV7F ADH1G_HUMAN Decreases Expression [13]
Phosphatidylcholine translocator ABCB4 (ABCB4) OTE6PY83 MDR3_HUMAN Decreases Expression [13]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1) OTAYZZE6 AL3A1_HUMAN Increases Expression [13]
Retinaldehyde dehydrogenase 3 (ALDH1A3) OT1C9NKQ AL1A3_HUMAN Increases Expression [13]
Solute carrier organic anion transporter family member 1A2 (SLCO1A2) OTO70C5O SO1A2_HUMAN Increases Expression [6]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Increases Expression [14]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Activity [15]
Aryl hydrocarbon receptor nuclear translocator (ARNT) OTMSIEZY ARNT_HUMAN Affects Localization [16]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [17]
Phospholipid-transporting ATPase ABCA1 (ABCA1) OT94G6BQ ABCA1_HUMAN Increases Expression [18]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [19]
HLA class I histocompatibility antigen, alpha chain G (HLA-G) OTMLK1KN HLAG_HUMAN Affects Expression [20]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [21]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [21]
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⏷ Show the Full List of 14 DOT(s)
Indication(s) of Amoxicillin
Disease Entry ICD 11 Status REF
Acute otitis media AB00 Approved [4]
Bacterial infection 1A00-1C4Z Approved [5]
Staphylococcus aureus infection N.A. Approved [4]
Streptococcal pneumonia N.A. Approved [4]
Urinary tract infection GC08 Approved [4]
Pneumonia due to Klebsiella pneumoniae CA40.03 Investigative [4]
Sinusitis CA0A.Z Investigative [4]
Amoxicillin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bacterial Cell membrane (Bact CM) TTXT4D5 NOUNIPROTAC Modulator [7]
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Amoxicillin Interacts with 4 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [22]
Peptide transporter 1 (SLC15A1) DT9G7XN S15A1_HUMAN Substrate [23]
Peptide transporter 2 (SLC15A2) DT8QKNP S15A2_HUMAN Substrate [23]
Organic anion transporter 1 (SLC22A6) DTQ23VB S22A6_HUMAN Substrate [24]
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Amoxicillin Interacts with 46 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [25]
Beta-lactamase (blaB) DED0TBR A0A414M273_9BACE Metabolism [26]
Beta-lactamase (blaB) DEX8KJO A6NX15_9FIRM Metabolism [27]
Beta-lactamase (blaB) DEAYSTX C0W968_9FIRM Metabolism [28]
Beta-lactamase (blaB) DERGEVU C3WC84_FUSMR Metabolism [29]
Beta-lactamase (blaB) DEV0KWQ Q8KT52_9BACT Metabolism [30]
Beta-lactamase (blaB) DEQMISO F9Z530_ODOSD Metabolism [29]
Beta-lactamase (blaB) DEHFJ4G Q8KT51_9BACT Metabolism [29]
Beta-lactamase (blaB) DEHPJRC Q8KT60_9BACT Metabolism [29]
Beta-lactamase (blaB) DEITMS0 Q9XBM2_ACIFE Metabolism [31]
N-acylhomoserine lactone acylase (lacA) DEIU0XN A0A0A1VBK6_9BURK Metabolism [32]
Beta-lactamase (blaB) DET9I1W BLAC_BACUN Metabolism [33]
Beta-lactamase (blaB) DE7IH52 AMPC_CITFR Metabolism [30]
Beta-lactamase (blaB) DENJ2SQ BLAB_BACFG Metabolism [33]
Beta-lactamase (blaB) DE5HV8P A0A4Q5I6I2_9BACE Metabolism [33]
Beta-lactamase (blaB) DE47ARF B5WXV2_9BACT Metabolism [34]
Beta-lactamase (blaB) DEG2PK9 B5WXV3_BACOV Metabolism [33]
Beta-lactamase (blaB) DEWHJ7A B5WXV7_BACT4 Metabolism [33]
Beta-lactamase (blaB) DEU1RXB BLAC_BACVU Metabolism [33]
Beta-lactamase (blaB) DETDS7E A0A2S0LB67_9FLAO Metabolism [30]
Beta-lactamase (blaB) DE37FJH C6JIU1_FUSVA Metabolism [29]
Beta-lactamase (blaB) DEC7JEF A0A1S1G219_9NEIS Metabolism [30]
Beta-lactamase (blaB) DEP7MN1 Q9X4S7_PREIN Metabolism [35]
Beta-lactamase (blaB) DEAILCM A0A246EJV2_9BACT Metabolism [35]
Beta-lactamase (blaB) DET4XFN Q8KT59_9BACT Metabolism [30]
Metallo-beta-lactamase (blaM) DEPCQ12 Q68K11_ALCXX Metabolism [36]
Beta-lactamase (blaB) DEACNTL Q2F4C6_SHISO Metabolism [37]
Beta-lactamase (blaB) DEE8742 O32372_CAPOC Metabolism [38]
Beta-lactamase (blaB) DEY09SU C9MN73_9BACT Metabolism [30]
Beta-lactamase (blaB) DEQLVCA C9LD75_9BACT Metabolism [35]
Beta-lactamase (blaB) DE2IL34 C2M7J0_CAPGI Metabolism [38]
Beta-lactamase (blaB) DE1NJIW B6VMJ3_PHOAA Metabolism [39]
Beta-lactamase (blaB) DEDIMN9 A0A413GBG0_9BACE Metabolism [33]
Beta-lactamase (blaB) DEJ8X2W A0A412YFL9_9BACE Metabolism [33]
Beta-lactamase (blaB) DEFEVNH A0A381DV31_9FLAO Metabolism [38]
Beta-lactamase (blaB) DEAPGXV A0A347B2J2_9BACT Metabolism [30]
Beta-lactamase (blaB) DE0PDVC A0A2A3N1K0_CAPSP Metabolism [38]
Beta-lactamase (blaB) DEQL32N A0A250F962_9FLAO Metabolism [38]
Beta-lactamase (blaB) DE9HF0I A0A120A1C6_BACSE Metabolism [33]
Beta-lactamase (blaB) DESHI6O A0A108T9G3_9BACE Metabolism [33]
Beta-lactamase (blaB) DEZS3N4 A0A069QS91_PRELO Metabolism [30]
Beta-lactamase (blaB) DE5NSUX A0A095XPV0_9FIRM Metabolism [30]
New delhi metallo-beta-lactamase NDM-1 (blaNDM) DEBGCYQ A0A345N7K5_SALET Metabolism [40]
Beta-lactamase (blaB) DEW193R BLA1_KLEPN Metabolism [36]
Metallo-beta-lactamase (blaM) DEK9VG2 BLAN1_KLEPN Metabolism [36]
Beta-lactamase (blaB) DEQ1CTE A0A2T4TNV5_9BACT Metabolism [41]
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⏷ Show the Full List of 46 DME(s)
Amoxicillin Interacts with 5 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1) OTVVI3UI DQB1_HUMAN Affects Expression [20]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Increases Expression [42]
Sulfiredoxin-1 (SRXN1) OTYDBO4L SRXN1_HUMAN Increases Expression [42]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [43]
Organic solute transporter subunit alpha (SLC51A) OTDJRZ0P OSTA_HUMAN Increases Expression [44]
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