Details of the Drug Combination

General Information of Drug Combination (ID: DCWFG8C)

Drug Combination Name
Testosterone undecanoate Testosterone undecanoate
Indication
Disease Entry Status REF
Hypogonadism Phase 2 [1]
Component Drugs Testosterone undecanoate   DMZO10Y Testosterone undecanoate   DMZO10Y
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Testosterone undecanoate
Disease Entry ICD 11 Status REF
Hypogonadism 5A61.0 Approved [2]
Testosterone undecanoate Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [4]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [5]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [6]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [7]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [8]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [9]
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⏷ Show the Full List of 6 DME(s)
Testosterone undecanoate Interacts with 72 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Decreases Expression [3]
Calcineurin B homologous protein 2 (CHP2) OT4UMKUR CHP2_HUMAN Decreases Expression [3]
Ribonuclease H1 (RNASEH1) OTT7L25X RNH1_HUMAN Decreases Expression [3]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Increases Expression [3]
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6) OTDFQV81 FKBP6_HUMAN Increases Expression [3]
Immunoglobulin superfamily member 6 (IGSF6) OT5TUH02 IGSF6_HUMAN Increases Expression [3]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Decreases Expression [3]
C-X-C motif chemokine 10 (CXCL10) OTTLQ6S0 CXL10_HUMAN Increases Expression [3]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Decreases Expression [3]
Inhibin alpha chain (INHA) OT7HWCO3 INHA_HUMAN Decreases Expression [3]
Homeobox protein Hox-C6 (HOXC6) OTBCRAZV HXC6_HUMAN Increases Expression [3]
Serglycin (SRGN) OTFAVSX0 SRGN_HUMAN Decreases Expression [3]
Gamma-interferon-inducible lysosomal thiol reductase (IFI30) OT9DERT1 GILT_HUMAN Increases Expression [3]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Increases Expression [3]
Protein kinase C alpha type (PRKCA) OT5UWNRD KPCA_HUMAN Increases Expression [3]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Increases Expression [3]
Galactoside alpha-(1,2)-fucosyltransferase 1 (FUT1) OTODG57A FUT1_HUMAN Decreases Expression [3]
Zinc-alpha-2-glycoprotein (AZGP1) OTPD9TDR ZA2G_HUMAN Decreases Expression [3]
Ciliary neurotrophic factor (CNTF) OTNEEWRN CNTF_HUMAN Increases Expression [3]
Olfactory receptor 10J1 (OR10J1) OTS7B2ZB O10J1_HUMAN Increases Expression [3]
Protein EVI2B (EVI2B) OT98X1OE EVI2B_HUMAN Increases Expression [3]
Thrombopoietin (THPO) OTO73DZ2 TPO_HUMAN Increases Expression [3]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Increases Expression [3]
CCN family member 3 (CCN3) OTOW5YL4 CCN3_HUMAN Decreases Expression [3]
Granzyme K (GZMK) OT6O7PCT GRAK_HUMAN Increases Expression [3]
Insulin-like 3 (INSL3) OT7KUNTE INSL3_HUMAN Decreases Expression [3]
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) OT4O4NFS ROA3_HUMAN Decreases Expression [3]
Growth/differentiation factor 10 (GDF10) OTEVXGJ7 GDF10_HUMAN Decreases Expression [3]
C-C motif chemokine 18 (CCL18) OT7JYSK9 CCL18_HUMAN Increases Expression [3]
Ras-related protein Rab-1A (RAB1A) OTKPHRD0 RAB1A_HUMAN Increases Expression [3]
Cdc42 effector protein 1 (CDC42EP1) OTT525WA BORG5_HUMAN Decreases Expression [3]
AMP deaminase 3 (AMPD3) OT5SP1KJ AMPD3_HUMAN Increases Expression [3]
Desmoglein-1 (DSG1) OT11HC3A DSG1_HUMAN Increases Expression [3]
Pappalysin-1 (PAPPA) OTTTG9PG PAPP1_HUMAN Decreases Expression [3]
Transformer-2 protein homolog alpha (TRA2A) OT5NHOO3 TRA2A_HUMAN Decreases Expression [3]
Deoxyribonuclease gamma (DNASE1L3) OTEUIMC2 DNSL3_HUMAN Decreases Expression [3]
Transcription factor Dp-2 (TFDP2) OTKQFX5H TFDP2_HUMAN Decreases Expression [3]
Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) OT460OO1 ITIH4_HUMAN Increases Expression [3]
Protein GREB1 (GREB1) OTU6ZA26 GREB1_HUMAN Decreases Expression [3]
Novel acetylcholine receptor chaperone (TMEM35A) OTBFC7X1 NACHO_HUMAN Decreases Expression [3]
Probable E3 ubiquitin-protein ligase HERC4 (HERC4) OTU4DSDE HERC4_HUMAN Decreases Expression [3]
ADP-ribosylation factor-like protein 9 (ARL9) OTCP868V ARL9_HUMAN Increases Expression [3]
Lysophospholipase D GDPD3 (GDPD3) OTOHM9QM GDPD3_HUMAN Increases Expression [3]
Monocarboxylate transporter 9 (SLC16A9) OTVCLKQQ MOT9_HUMAN Decreases Expression [3]
Alpha-protein kinase 2 (ALPK2) OTWZZDQ9 ALPK2_HUMAN Increases Expression [3]
Immunoglobulin superfamily member 1 (IGSF1) OT3XD6U2 IGSF1_HUMAN Decreases Expression [3]
Collagen alpha-1(XXII) chain (COL22A1) OTSWGZRD COMA1_HUMAN Increases Expression [3]
Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) OTA1STFZ LIRB1_HUMAN Increases Expression [3]
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1) OTDCBTBS LIGO1_HUMAN Increases Expression [3]
F-box/LRR-repeat protein 20 (FBXL20) OTVTR1KY FXL20_HUMAN Decreases Expression [3]
Fc receptor-like protein 5 (FCRL5) OTA7VHNE FCRL5_HUMAN Increases Expression [3]
Heat shock protein beta-9 (HSPB9) OTB97F1J HSPB9_HUMAN Increases Expression [3]
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) OTBUZ7KA KATL1_HUMAN Increases Expression [3]
Oxysterol-binding protein-related protein 10 (OSBPL10) OT0TFMBE OSB10_HUMAN Increases Expression [3]
Protein maestro (MRO) OT5U38CP MSTRO_HUMAN Decreases Expression [3]
Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14) OT87E7HW B2L14_HUMAN Increases Expression [3]
Kelch-like protein 4 (KLHL4) OTEFI623 KLHL4_HUMAN Decreases Expression [3]
Chondrolectin (CHODL) OTVCNOUQ CHODL_HUMAN Decreases Expression [3]
Reticulon-4 (RTN4) OTIH85O3 RTN4_HUMAN Decreases Expression [3]
Olfactomedin-like protein 3 (OLFML3) OTDN45FN OLFL3_HUMAN Decreases Expression [3]
Kelch-like protein 11 (KLHL11) OTX7VZKT KLH11_HUMAN Increases Expression [3]
E3 ubiquitin-protein ligase RNF216 (RNF216) OTR1XEZ3 RN216_HUMAN Increases Expression [3]
Docking protein 5 (DOK5) OT2XWUPN DOK5_HUMAN Increases Expression [3]
Rho GTPase-activating protein 23 (ARHGAP23) OTX1RY0T RHG23_HUMAN Increases Expression [3]
Signal recognition particle subunit SRP68 (SRP68) OTZ7HIID SRP68_HUMAN Increases Expression [3]
Kallikrein-13 (KLK13) OT8LOD2U KLK13_HUMAN Increases Expression [3]
Hippocalcin-like protein 4 (HPCAL4) OT793RNP HPCL4_HUMAN Decreases Expression [3]
Syntaxin-binding protein 5-like (STXBP5L) OTNXAUKD STB5L_HUMAN Increases Expression [3]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C) OTXK0SDM 2ABG_HUMAN Increases Expression [3]
Sodium- and chloride-dependent glycine transporter 2 (SLC6A5) OTKYC433 SC6A5_HUMAN Increases Expression [3]
Nuclear protein AMMECR1 (AMMECR1) OTWMQ67T AMMR1_HUMAN Decreases Expression [3]
Atrial natriuretic peptide-converting enzyme (CORIN) OT4SK7DK CORIN_HUMAN Increases Expression [3]
------------------------------------------------------------------------------------
⏷ Show the Full List of 72 DOT(s)
Indication(s) of Testosterone undecanoate
Disease Entry ICD 11 Status REF
Hypogonadism 5A61.0 Approved [2]
Testosterone undecanoate Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [4]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [5]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [6]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [7]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Metabolism [8]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [9]
------------------------------------------------------------------------------------
⏷ Show the Full List of 6 DME(s)
Testosterone undecanoate Interacts with 72 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Decreases Expression [3]
Calcineurin B homologous protein 2 (CHP2) OT4UMKUR CHP2_HUMAN Decreases Expression [3]
Ribonuclease H1 (RNASEH1) OTT7L25X RNH1_HUMAN Decreases Expression [3]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Increases Expression [3]
Inactive peptidyl-prolyl cis-trans isomerase FKBP6 (FKBP6) OTDFQV81 FKBP6_HUMAN Increases Expression [3]
Immunoglobulin superfamily member 6 (IGSF6) OT5TUH02 IGSF6_HUMAN Increases Expression [3]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Decreases Expression [3]
C-X-C motif chemokine 10 (CXCL10) OTTLQ6S0 CXL10_HUMAN Increases Expression [3]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Decreases Expression [3]
Inhibin alpha chain (INHA) OT7HWCO3 INHA_HUMAN Decreases Expression [3]
Homeobox protein Hox-C6 (HOXC6) OTBCRAZV HXC6_HUMAN Increases Expression [3]
Serglycin (SRGN) OTFAVSX0 SRGN_HUMAN Decreases Expression [3]
Gamma-interferon-inducible lysosomal thiol reductase (IFI30) OT9DERT1 GILT_HUMAN Increases Expression [3]
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Increases Expression [3]
Protein kinase C alpha type (PRKCA) OT5UWNRD KPCA_HUMAN Increases Expression [3]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Increases Expression [3]
Galactoside alpha-(1,2)-fucosyltransferase 1 (FUT1) OTODG57A FUT1_HUMAN Decreases Expression [3]
Zinc-alpha-2-glycoprotein (AZGP1) OTPD9TDR ZA2G_HUMAN Decreases Expression [3]
Ciliary neurotrophic factor (CNTF) OTNEEWRN CNTF_HUMAN Increases Expression [3]
Olfactory receptor 10J1 (OR10J1) OTS7B2ZB O10J1_HUMAN Increases Expression [3]
Protein EVI2B (EVI2B) OT98X1OE EVI2B_HUMAN Increases Expression [3]
Thrombopoietin (THPO) OTO73DZ2 TPO_HUMAN Increases Expression [3]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Increases Expression [3]
CCN family member 3 (CCN3) OTOW5YL4 CCN3_HUMAN Decreases Expression [3]
Granzyme K (GZMK) OT6O7PCT GRAK_HUMAN Increases Expression [3]
Insulin-like 3 (INSL3) OT7KUNTE INSL3_HUMAN Decreases Expression [3]
Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3) OT4O4NFS ROA3_HUMAN Decreases Expression [3]
Growth/differentiation factor 10 (GDF10) OTEVXGJ7 GDF10_HUMAN Decreases Expression [3]
C-C motif chemokine 18 (CCL18) OT7JYSK9 CCL18_HUMAN Increases Expression [3]
Ras-related protein Rab-1A (RAB1A) OTKPHRD0 RAB1A_HUMAN Increases Expression [3]
Cdc42 effector protein 1 (CDC42EP1) OTT525WA BORG5_HUMAN Decreases Expression [3]
AMP deaminase 3 (AMPD3) OT5SP1KJ AMPD3_HUMAN Increases Expression [3]
Desmoglein-1 (DSG1) OT11HC3A DSG1_HUMAN Increases Expression [3]
Pappalysin-1 (PAPPA) OTTTG9PG PAPP1_HUMAN Decreases Expression [3]
Transformer-2 protein homolog alpha (TRA2A) OT5NHOO3 TRA2A_HUMAN Decreases Expression [3]
Deoxyribonuclease gamma (DNASE1L3) OTEUIMC2 DNSL3_HUMAN Decreases Expression [3]
Transcription factor Dp-2 (TFDP2) OTKQFX5H TFDP2_HUMAN Decreases Expression [3]
Inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) OT460OO1 ITIH4_HUMAN Increases Expression [3]
Protein GREB1 (GREB1) OTU6ZA26 GREB1_HUMAN Decreases Expression [3]
Novel acetylcholine receptor chaperone (TMEM35A) OTBFC7X1 NACHO_HUMAN Decreases Expression [3]
Probable E3 ubiquitin-protein ligase HERC4 (HERC4) OTU4DSDE HERC4_HUMAN Decreases Expression [3]
ADP-ribosylation factor-like protein 9 (ARL9) OTCP868V ARL9_HUMAN Increases Expression [3]
Lysophospholipase D GDPD3 (GDPD3) OTOHM9QM GDPD3_HUMAN Increases Expression [3]
Monocarboxylate transporter 9 (SLC16A9) OTVCLKQQ MOT9_HUMAN Decreases Expression [3]
Alpha-protein kinase 2 (ALPK2) OTWZZDQ9 ALPK2_HUMAN Increases Expression [3]
Immunoglobulin superfamily member 1 (IGSF1) OT3XD6U2 IGSF1_HUMAN Decreases Expression [3]
Collagen alpha-1(XXII) chain (COL22A1) OTSWGZRD COMA1_HUMAN Increases Expression [3]
Leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) OTA1STFZ LIRB1_HUMAN Increases Expression [3]
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1) OTDCBTBS LIGO1_HUMAN Increases Expression [3]
F-box/LRR-repeat protein 20 (FBXL20) OTVTR1KY FXL20_HUMAN Decreases Expression [3]
Fc receptor-like protein 5 (FCRL5) OTA7VHNE FCRL5_HUMAN Increases Expression [3]
Heat shock protein beta-9 (HSPB9) OTB97F1J HSPB9_HUMAN Increases Expression [3]
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) OTBUZ7KA KATL1_HUMAN Increases Expression [3]
Oxysterol-binding protein-related protein 10 (OSBPL10) OT0TFMBE OSB10_HUMAN Increases Expression [3]
Protein maestro (MRO) OT5U38CP MSTRO_HUMAN Decreases Expression [3]
Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14) OT87E7HW B2L14_HUMAN Increases Expression [3]
Kelch-like protein 4 (KLHL4) OTEFI623 KLHL4_HUMAN Decreases Expression [3]
Chondrolectin (CHODL) OTVCNOUQ CHODL_HUMAN Decreases Expression [3]
Reticulon-4 (RTN4) OTIH85O3 RTN4_HUMAN Decreases Expression [3]
Olfactomedin-like protein 3 (OLFML3) OTDN45FN OLFL3_HUMAN Decreases Expression [3]
Kelch-like protein 11 (KLHL11) OTX7VZKT KLH11_HUMAN Increases Expression [3]
E3 ubiquitin-protein ligase RNF216 (RNF216) OTR1XEZ3 RN216_HUMAN Increases Expression [3]
Docking protein 5 (DOK5) OT2XWUPN DOK5_HUMAN Increases Expression [3]
Rho GTPase-activating protein 23 (ARHGAP23) OTX1RY0T RHG23_HUMAN Increases Expression [3]
Signal recognition particle subunit SRP68 (SRP68) OTZ7HIID SRP68_HUMAN Increases Expression [3]
Kallikrein-13 (KLK13) OT8LOD2U KLK13_HUMAN Increases Expression [3]
Hippocalcin-like protein 4 (HPCAL4) OT793RNP HPCL4_HUMAN Decreases Expression [3]
Syntaxin-binding protein 5-like (STXBP5L) OTNXAUKD STB5L_HUMAN Increases Expression [3]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C) OTXK0SDM 2ABG_HUMAN Increases Expression [3]
Sodium- and chloride-dependent glycine transporter 2 (SLC6A5) OTKYC433 SC6A5_HUMAN Increases Expression [3]
Nuclear protein AMMECR1 (AMMECR1) OTWMQ67T AMMR1_HUMAN Decreases Expression [3]
Atrial natriuretic peptide-converting enzyme (CORIN) OT4SK7DK CORIN_HUMAN Increases Expression [3]
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⏷ Show the Full List of 72 DOT(s)

References

1 ClinicalTrials.gov (NCT00695110) Pharmacokinetic Study of Oral Testosterone (T) Ester Formulations in Hypogonadal Men
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. Biol Reprod. 2009 Mar;80(3):484-92.
4 In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug Metab Dispos. 2003 Jul;31(7):938-44.
5 Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus. Res Commun Mol Pathol Pharmacol. 1998 Apr;100(1):15-28.
6 Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241.
7 Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos. 2006 May;34(5):734-7.
8 Insights into CYP2B6-mediated drug-drug interactions. Acta Pharm Sin B. 2016 Sep;6(5):413-425.
9 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.