Details of the Drug Combinations

General Information of This Drug (ID: DM1YB0R)

Drug Name
OZ277   DM1YB0R
Synonyms
Arterolane; UNII-3N1TN351VB; 664338-39-0; OZ277; 3N1TN351VB; OZ-277; C22H36N2O4; Arterolane [INN]; RBx11160; OZ 277; SCHEMBL4547841; CHEMBL404431; CHEMBL580910; CHEMBL221773; SCHEMBL12612733; CHEMBL1197433; SCHEMBL13951812; SCHEMBL11379522; SCHEMBL10307589; VXYZBLXGCYNIHP-BBMJWGJISA-N; VXYZBLXGCYNIHP-CAGINOIPSA-N; ZINC14191464; RBX-11160; NCGC00274173-01; HY-10852; Y1261
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

33 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Arbidol + OZ277 DCHNZ8D Arbidol DD2 (Cell Line: DD2) [2]
Arbidol + OZ277 DCCX1P1 Arbidol Hepatoblastoma (Cell Line: HB3) [3]
Artemisinin + OZ277 DCM60H5 Artemisinin Hepatoblastoma (Cell Line: HB3) [2]
Atovaquone + OZ277 DC5HS54 Atovaquone DD2 (Cell Line: DD2) [2]
Atovaquone + OZ277 DC61777 Atovaquone Hepatoblastoma (Cell Line: HB3) [2]
Bifemelane + OZ277 DC7WKOI Bifemelane Hepatoblastoma (Cell Line: HB3) [3]
Curcumin + OZ277 DC558CB Curcumin DD2 (Cell Line: DD2) [2]
Dihydroergotamine + OZ277 DC1L1IY Dihydroergotamine DD2 (Cell Line: DD2) [2]
Docetaxel + OZ277 DCKQD8K Docetaxel DD2 (Cell Line: DD2) [2]
Docetaxel + OZ277 DC24WT2 Docetaxel Hepatoblastoma (Cell Line: HB3) [2]
Epothilone B + OZ277 DCLDM8L Epothilone B Hepatoblastoma (Cell Line: HB3) [3]
Fosmidomycin + OZ277 DCSM80Q Fosmidomycin Hepatoblastoma (Cell Line: HB3) [3]
KN-62 + OZ277 DC4OOIE KN-62 DD2 (Cell Line: DD2) [2]
KN-62 + OZ277 DC15OO8 KN-62 Hepatoblastoma (Cell Line: HB3) [3]
Lumefantrine + OZ277 DC4CUJA Lumefantrine DD2 (Cell Line: DD2) [2]
Lumefantrine + OZ277 DCNJ4ZV Lumefantrine Hepatoblastoma (Cell Line: HB3) [2]
Mefloquine + OZ277 DC3J9D5 Mefloquine DD2 (Cell Line: DD2) [2]
Mefloquine + OZ277 DC37Z5O Mefloquine Hepatoblastoma (Cell Line: HB3) [2]
Menadione + OZ277 DC8H4IT Menadione DD2 (Cell Line: DD2) [2]
NITD609 + OZ277 DCY71Q9 NITD609 DD2 (Cell Line: DD2) [2]
Omacetaxine mepesuccinate + OZ277 DCM6EZX Omacetaxine mepesuccinate DD2 (Cell Line: DD2) [2]
Omacetaxine mepesuccinate + OZ277 DC6MB1T Omacetaxine mepesuccinate Hepatoblastoma (Cell Line: HB3) [3]
Piperaquine + OZ277 DCH9CG0 Piperaquine DD2 (Cell Line: DD2) [2]
Piperaquine + OZ277 DCOZHPF Piperaquine Hepatoblastoma (Cell Line: HB3) [3]
Proguanil + OZ277 DC5JNRC Proguanil Hepatoblastoma (Cell Line: HB3) [2]
Quinine + OZ277 DCLN8X2 Quinine DD2 (Cell Line: DD2) [2]
Quinine + OZ277 DCZQEK6 Quinine Hepatoblastoma (Cell Line: HB3) [2]
Rifampin + OZ277 DC2FP4T Rifampin DD2 (Cell Line: DD2) [2]
Ritonavir + OZ277 DCAEURP Ritonavir DD2 (Cell Line: DD2) [2]
Trimethoprim + OZ277 DCIEIO3 Trimethoprim Hepatoblastoma (Cell Line: HB3) [2]
Verapamil + OZ277 DC134AR Verapamil DD2 (Cell Line: DD2) [3]
Verteporfin + OZ277 DC0VO2B Verteporfin DD2 (Cell Line: DD2) [2]
ZM-447439 + OZ277 DCYHRMA ZM-447439 DD2 (Cell Line: DD2) [2]
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⏷ Show the Full List of 33 DrugCom(s)

References

1 The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.