Details of the Drug Combination

General Information of Drug Combination (ID: DC558CB)

Drug Combination Name
Curcumin OZ277
Indication
Disease Entry Status REF
DD2 Investigative [1]
Component Drugs Curcumin   DMQPH29 OZ277   DM1YB0R
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: DD2
Zero Interaction Potency (ZIP) Score: 3.136
Bliss Independence Score: 2.94
Loewe Additivity Score: 0.349
LHighest Single Agent (HSA) Score: 4.751

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Curcumin
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 3 [2]
Curcumin Interacts with 19 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Nitric-oxide synthase inducible (NOS2) TTF10I9 NOS2_HUMAN Inhibitor [23]
Carbonic anhydrase VI (CA-VI) TTCFSPE CAH6_HUMAN Inhibitor [24]
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [24]
Multidrug resistance protein (MDR) TT0JLSD NOUNIPROTAC Inhibitor [25]
Carbonic anhydrase XII (CA-XII) TTSYM0R CAH12_HUMAN Inhibitor [24]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [24]
Carbonic anhydrase XIV (CA-XIV) TTEYTKG CAH14_HUMAN Inhibitor [24]
Matrix metalloproteinase-13 (MMP-13) TTHY57M MMP13_HUMAN Inhibitor [26]
Albendazole monooxygenase (CYP3A4) TTXV4FI CP3A4_HUMAN Inhibitor [27]
Xanthine dehydrogenase/oxidase (XDH) TT7RJY8 XDH_HUMAN Inhibitor [28]
Carbonic anhydrase (CA) TTUNARX NOUNIPROTAC Inhibitor [24]
Carbonic anhydrase IV (CA-IV) TTZHA0O CAH4_HUMAN Inhibitor [24]
Matrix metalloproteinase-9 (MMP-9) TT6X50U MMP9_HUMAN Inhibitor [29]
Prostaglandin G/H synthase 1 (COX-1) TT8NGED PGH1_HUMAN Inhibitor [30]
Carbonic anhydrase IX (CA-IX) TT2LVK8 CAH9_HUMAN Inhibitor [24]
DNA [cytosine-5]-methyltransferase 3B (DNMT3B) TT6VZ78 DNM3B_HUMAN Inhibitor [31]
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [30]
Amyloid beta A4 protein (APP) TTE4KHA A4_HUMAN Inhibitor [32]
DNA [cytosine-5]-methyltransferase (DNMT) TTHVCUP NOUNIPROTAC Inhibitor [31]
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⏷ Show the Full List of 19 DTT(s)
Curcumin Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [33]
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Curcumin Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [5]
UDP-glucuronosyltransferase 1A9 (UGT1A9) DE85D2P UD19_HUMAN Metabolism [5]
UDP-glucuronosyltransferase 1A8 (UGT1A8) DE2GB8N UD18_HUMAN Metabolism [5]
UDP-glucuronosyltransferase 1A7 (UGT1A7) DEZO4N3 UD17_HUMAN Metabolism [5]
NADPH-dependent curcumin reductase (curA) DEZWDKE CURA_ECOLI Metabolism [34]
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Curcumin Interacts with 262 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Expression [35]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [19]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [36]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Decreases Expression [6]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [6]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Expression [6]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Expression [6]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Decreases Expression [6]
TNF receptor-associated factor 2 (TRAF2) OT1MEZZN TRAF2_HUMAN Increases Expression [6]
TNF receptor-associated factor 3 (TRAF3) OT5TQBGV TRAF3_HUMAN Increases Expression [6]
Septin-7 (SEPTIN7) OTJI08YX SEPT7_HUMAN Increases Expression [6]
Secreted frizzled-related protein 5 (SFRP5) OTLCVVSH SFRP5_HUMAN Decreases Expression [6]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Increases Expression [6]
Death domain-associated protein 6 (DAXX) OTX6O7PL DAXX_HUMAN Increases Expression [6]
Farnesyl pyrophosphate synthase (FDPS) OT6CKWV5 FPPS_HUMAN Increases Expression [37]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG) OTUX45ZF MFNG_HUMAN Increases Expression [7]
Period circadian protein homolog 2 (PER2) OTU2B1DJ PER2_HUMAN Increases Expression [7]
Dual specificity protein phosphatase CDC14B (CDC14B) OTAESVOZ CC14B_HUMAN Increases Expression [7]
Receptor activity-modifying protein 1 (RAMP1) OT7UT2XB RAMP1_HUMAN Decreases Expression [7]
Anterior gradient protein 2 homolog (AGR2) OTRRZT7W AGR2_HUMAN Decreases Expression [7]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [7]
Fructose-bisphosphate aldolase C (ALDOC) OTEC13I5 ALDOC_HUMAN Decreases Expression [7]
B-lymphocyte antigen CD20 (MS4A1) OTZTVUBX CD20_HUMAN Decreases Expression [7]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [7]
Immunoglobulin lambda-like polypeptide 1 (IGLL1) OTRTNVOG IGLL1_HUMAN Decreases Expression [7]
Splicing factor, proline- and glutamine-rich (SFPQ) OTLCIAPJ SFPQ_HUMAN Increases Expression [7]
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) OT33XNZM PTN6_HUMAN Increases Expression [7]
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF) OTRA8ZVE PPIF_HUMAN Increases Expression [7]
Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA) OTOJ8QFF SDHA_HUMAN Decreases Expression [7]
Tyrosine-protein phosphatase non-receptor type 7 (PTPN7) OTXYSIIV PTN7_HUMAN Increases Expression [7]
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1) OTNWEJ5Y PCKGC_HUMAN Decreases Expression [7]
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PPP3CC) OT0AQD93 PP2BC_HUMAN Decreases Expression [7]
Alanine--tRNA ligase, cytoplasmic (AARS1) OTW8D813 SYAC_HUMAN Decreases Expression [7]
Ras association domain-containing protein 2 (RASSF2) OT2JHDO4 RASF2_HUMAN Increases Expression [7]
H(+)/Cl(-) exchange transporter 6 (CLCN6) OT9QW5R4 CLCN6_HUMAN Decreases Expression [7]
Nuclear pore complex protein Nup98-Nup96 (NUP98) OTNT12G2 NUP98_HUMAN Increases Expression [7]
NPC intracellular cholesterol transporter 2 (NPC2) OTE9UEJC NPC2_HUMAN Decreases Expression [7]
Dynein light chain 1, cytoplasmic (DYNLL1) OTR69LHT DYL1_HUMAN Increases Expression [7]
Serine/arginine-rich splicing factor 3 (SRSF3) OTOFT707 SRSF3_HUMAN Increases Expression [7]
Serine/arginine-rich splicing factor 2 (SRSF2) OTVDHO6U SRSF2_HUMAN Increases Expression [7]
Transcription factor Spi-B (SPIB) OTO4YKYI SPIB_HUMAN Increases Expression [7]
Cadherin-17 (CDH17) OT9EV2XK CAD17_HUMAN Decreases Expression [7]
Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2) OTLUTKJQ IRAG2_HUMAN Decreases Expression [7]
Lymphocyte cytosolic protein 2 (LCP2) OT57KE22 LCP2_HUMAN Increases Expression [7]
Serine/arginine-rich splicing factor 6 (SRSF6) OTGLOSYE SRSF6_HUMAN Increases Expression [7]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [7]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) OTQYEXL2 F264_HUMAN Decreases Expression [7]
Heme transporter HRG1 (SLC48A1) OTPFHZLO HRG1_HUMAN Increases Expression [7]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Decreases Expression [7]
BCL-6 corepressor (BCOR) OTG013AX BCOR_HUMAN Increases Expression [7]
Ankyrin repeat domain-containing protein 37 (ANKRD37) OTXSY21F ANR37_HUMAN Decreases Expression [7]
TBC1 domain family member 1 (TBC1D1) OTI9V7B0 TBCD1_HUMAN Decreases Expression [7]
Histone H1.10 (H1-10) OTBWDA4E H1X_HUMAN Decreases Expression [7]
Secernin-2 (SCRN2) OTSG9EUS SCRN2_HUMAN Decreases Expression [7]
Beta-1,3-galactosyltransferase 6 (B3GALT6) OTF4HBAT B3GT6_HUMAN Increases Expression [7]
Dehydrogenase/reductase SDR family member 1 (DHRS1) OT8YRGCM DHRS1_HUMAN Decreases Expression [7]
Junctional sarcoplasmic reticulum protein 1 (JSRP1) OT1AAYWO JSPR1_HUMAN Decreases Expression [7]
Large ribosomal subunit protein uL1m (MRPL1) OT3YIQIA RM01_HUMAN Increases Expression [7]
Leucine-rich repeat neuronal protein 3 (LRRN3) OT7X0AA7 LRRN3_HUMAN Increases Expression [7]
Pancreatic progenitor cell differentiation and proliferation factor (PPDPF) OT4LO2GJ PPDPF_HUMAN Increases Expression [7]
tRNA endonuclease ANKZF1 (ANKZF1) OTFDA384 ANKZ1_HUMAN Decreases Expression [7]
Triggering receptor expressed on myeloid cells 1 (TREM1) OTCVFEE6 TREM1_HUMAN Decreases Expression [7]
Cytohesin-4 (CYTH4) OTOR82ID CYH4_HUMAN Increases Expression [7]
Kelch-like protein 21 (KLHL21) OT28Y2LQ KLH21_HUMAN Increases Expression [7]
Cell cycle progression protein 1 (CCPG1) OT0IHDKL CCPG1_HUMAN Increases Expression [7]
Calcium-activated potassium channel subunit beta-2 (KCNMB2) OTBXUQGK KCMB2_HUMAN Decreases Expression [7]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [38]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [8]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [8]
Baculoviral IAP repeat-containing protein 1 (NAIP) OTLA925F BIRC1_HUMAN Decreases Expression [8]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Decreases Expression [8]
Regulatory factor X-associated protein (RFXAP) OTX46DKQ RFXAP_HUMAN Decreases Expression [9]
Myosin regulatory light chain 12B (MYL12B) OTXMLQOT ML12B_HUMAN Increases Expression [9]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Decreases Expression [9]
Tripartite motif-containing protein 16 (TRIM16) OTLRXYOZ TRI16_HUMAN Increases Expression [9]
TBC1 domain family member 8 (TBC1D8) OT2011SS TBCD8_HUMAN Increases Expression [9]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Decreases Expression [9]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Decreases Expression [9]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) OTIRPN6B ROA1_HUMAN Decreases Expression [9]
RNA-binding protein FUS (FUS) OTPPNGQO FUS_HUMAN Decreases Expression [9]
Eukaryotic translation initiation factor 1 (EIF1) OTB4GZ0V EIF1_HUMAN Decreases Expression [9]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Decreases Expression [9]
Protein farnesyltransferase subunit beta (CHURC1-FNTB) OT34M7E3 FNTB_HUMAN Increases Expression [9]
Regulator of G-protein signaling 7 (RGS7) OTDQA90X RGS7_HUMAN Decreases Expression [9]
Histone H2B type 1-D (H2BC5) OTXDTDHN H2B1D_HUMAN Increases Expression [9]
Large ribosomal subunit protein eL31 (RPL31) OTV9E1OE RL31_HUMAN Increases Expression [9]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [9]
Serine/arginine-rich splicing factor 1 (SRSF1) OTF61HOV SRSF1_HUMAN Increases Expression [9]
Krueppel-like factor 10 (KLF10) OT4F4UGS KLF10_HUMAN Decreases Expression [9]
Serine/arginine-rich splicing factor 5 (SRSF5) OTC5WP98 SRSF5_HUMAN Decreases Expression [9]
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) OT5UO1FA HNRPD_HUMAN Decreases Expression [9]
RNA-binding protein 39 (RBM39) OTCMPTF9 RBM39_HUMAN Increases Expression [9]
NHL repeat-containing protein 2 (NHLRC2) OTY4HPWB NHLC2_HUMAN Decreases Expression [9]
Nanos homolog 1 (NANOS1) OT3UNZZY NANO1_HUMAN Decreases Expression [9]
DNA damage-inducible transcript 4-like protein (DDIT4L) OT26Z2KN DDT4L_HUMAN Decreases Expression [9]
Constitutive coactivator of peroxisome proliferator-activated receptor gamma (FAM120B) OTGYUFOJ F120B_HUMAN Decreases Expression [9]
Keratin-associated protein 2-1 (KRTAP2-1) OTV1SGF2 KRA21_HUMAN Decreases Expression [9]
DnaJ homolog subfamily B member 9 (DNAJB9) OT38EQT6 DNJB9_HUMAN Increases Expression [9]
Ankyrin repeat domain-containing protein 50 (ANKRD50) OTTLA4W2 ANR50_HUMAN Decreases Expression [9]
Regulating synaptic membrane exocytosis protein 2 (RIMS2) OTQASWDH RIMS2_HUMAN Decreases Expression [9]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Increases Expression [9]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Increases Expression [39]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [39]
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) OTG2T749 CP24A_HUMAN Increases Expression [40]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Decreases Expression [41]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [10]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Activity [10]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1) OT1QHOS2 NF2L1_HUMAN Increases Expression [42]
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) OTFBU4GD P3C2A_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase PLK4 (PLK4) OTV8KZDZ PLK4_HUMAN Increases Expression [11]
Poly polymerase tankyrase-1 (TNKS) OTVOUTPX TNKS1_HUMAN Decreases Expression [11]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Decreases Expression [11]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Decreases Expression [11]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) OTNIZPEA ATF2_HUMAN Decreases Expression [11]
Receptor tyrosine-protein kinase erbB-3 (ERBB3) OTRSST0A ERBB3_HUMAN Decreases Expression [11]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) OTTOMI8J PK3CA_HUMAN Decreases Expression [11]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [11]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Decreases Expression [11]
Growth factor receptor-bound protein 2 (GRB2) OTOP7LTE GRB2_HUMAN Decreases Expression [11]
Interferon regulatory factor 5 (IRF5) OT8SIIAP IRF5_HUMAN Increases Expression [11]
Serine/threonine-protein kinase PLK3 (PLK3) OT19CT2Z PLK3_HUMAN Increases Expression [11]
Serine/threonine-protein kinase PLK2 (PLK2) OTKMJXJ8 PLK2_HUMAN Increases Expression [11]
Segment polarity protein dishevelled homolog DVL-1 (DVL1) OTD67RF1 DVL1_HUMAN Decreases Expression [43]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Decreases Activity [44]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [45]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [46]
Zinc finger protein SNAI2 (SNAI2) OT7Y8EJ2 SNAI2_HUMAN Decreases Expression [43]
Glucose-6-phosphate exchanger SLC37A4 (SLC37A4) OTLCYA32 G6PT1_HUMAN Decreases Expression [47]
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3) OTDVVNS0 EDIL3_HUMAN Decreases Expression [21]
Adenylate cyclase type 9 (ADCY9) OT1IZT5K ADCY9_HUMAN Decreases Expression [19]
DNA polymerase zeta catalytic subunit (REV3L) OT0OP8EJ REV3L_HUMAN Increases Expression [48]
Tyrosine-protein kinase JAK2 (JAK2) OTBIDOOR JAK2_HUMAN Decreases Expression [49]
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) OT4CA13K ATS4_HUMAN Increases Expression [50]
Serine/threonine-protein kinase Chk2 (CHEK2) OT8ZPCNS CHK2_HUMAN Increases Phosphorylation [51]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Decreases Expression [52]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [53]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Activity [54]
Collagen alpha-1(II) chain (COL2A1) OT5E59C8 CO2A1_HUMAN Increases Expression [50]
Collagen alpha-1(IV) chain (COL4A1) OTL6D1YE CO4A1_HUMAN Increases Expression [20]
Serotransferrin (TF) OT41PEMS TRFE_HUMAN Increases Expression [19]
Fructose-bisphosphate aldolase A (ALDOA) OTWRFTIB ALDOA_HUMAN Decreases Expression [55]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Expression [56]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Increases Expression [19]
Plasminogen activator inhibitor 1 (SERPINE1) OTT0MPQ3 PAI1_HUMAN Increases Expression [19]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Phosphorylation [57]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Decreases Expression [55]
DNA excision repair protein ERCC-1 (ERCC1) OTNPYQHI ERCC1_HUMAN Decreases Expression [13]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Decreases Expression [22]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Increases Expression [19]
Tyrosine-protein kinase HCK (HCK) OTRL6OSI HCK_HUMAN Decreases Activity [58]
Homeobox protein Hox-B5 (HOXB5) OTU74TB8 HXB5_HUMAN Increases Expression [21]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Increases Expression [19]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) OTA675TJ GTR1_HUMAN Decreases Expression [59]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [43]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Decreases Activity [58]
Metalloproteinase inhibitor 2 (TIMP2) OT8S1RRP TIMP2_HUMAN Decreases Expression [52]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Increases Expression [19]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Phosphorylation [60]
Epithelial cell adhesion molecule (EPCAM) OTHBZK5X EPCAM_HUMAN Decreases Expression [22]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Expression [13]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Increases Ubiquitination [61]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Decreases Expression [59]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) OTAFHAVI ATF6A_HUMAN Increases Expression [15]
ETS domain-containing protein Elk-1 (ELK1) OTH9MXD6 ELK1_HUMAN Increases Phosphorylation [62]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Activity [56]
Kallikrein-2 (KLK2) OT9RE37R KLK2_HUMAN Decreases Expression [63]
Nuclear transcription factor Y subunit alpha (NFYA) OTWFFOVH NFYA_HUMAN Decreases Expression [19]
Adenomatous polyposis coli protein (APC) OTKV0TIK APC_HUMAN Decreases Expression [19]
Atypical chemokine receptor 3 (ACKR3) OTA6GA4F ACKR3_HUMAN Increases Expression [20]
Aryl hydrocarbon receptor nuclear translocator (ARNT) OTMSIEZY ARNT_HUMAN Decreases Expression [64]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Decreases Expression [65]
Collagen alpha-5(IV) chain (COL4A5) OTHG60RE CO4A5_HUMAN Decreases Expression [19]
Protein disulfide-isomerase A3 (PDIA3) OTHPQ0Q3 PDIA3_HUMAN Increases Expression [15]
G1/S-specific cyclin-D3 (CCND3) OTNKPQ22 CCND3_HUMAN Decreases Expression [66]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Increases Phosphorylation [60]
Heat shock 70 kDa protein 4 (HSPA4) OT5HR0AR HSP74_HUMAN Increases Expression [67]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Expression [56]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [68]
Serpin B5 (SERPINB5) OTSMXQRJ SPB5_HUMAN Increases Expression [69]
DNA-binding protein inhibitor ID-1 (ID1) OTKGNZN5 ID1_HUMAN Decreases Expression [20]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Decreases Expression [61]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Increases Phosphorylation [62]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) OTZPZX11 MP2K4_HUMAN Decreases Expression [19]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [19]
Neurogenic locus notch homolog protein 1 (NOTCH1) OTI1WADQ NOTC1_HUMAN Decreases Expression [70]
Solute carrier organic anion transporter family member 1A2 (SLCO1A2) OTO70C5O SO1A2_HUMAN Increases Expression [21]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) OTI2OREX MP2K3_HUMAN Increases Expression [19]
Transcription factor SOX-9 (SOX9) OTVDJFGN SOX9_HUMAN Increases Expression [71]
Nuclear receptor-interacting protein 1 (NRIP1) OTIZOJQV NRIP1_HUMAN Decreases Expression [72]
Tuberin (TSC2) OT47LWI9 TSC2_HUMAN Decreases Phosphorylation [73]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Decreases Expression [19]
Signal transducer and activator of transcription 5B (STAT5B) OTZVPEBT STA5B_HUMAN Decreases Expression [49]
Tyrosine-protein kinase JAK3 (JAK3) OTQ8QW2L JAK3_HUMAN Decreases Activity [74]
Mitogen-activated protein kinase 12 (MAPK12) OTTCKE27 MK12_HUMAN Increases Activity [20]
Cadherin-11 (CDH11) OTIZKPTF CAD11_HUMAN Decreases Expression [75]
Ras-related protein Rab-8A (RAB8A) OTPB54Y3 RAB8A_HUMAN Decreases Expression [20]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [73]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Increases Expression [19]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Affects Localization [76]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Decreases Activity [45]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Decreases Expression [22]
Transcription factor Sp4 (SP4) OTWB30IZ SP4_HUMAN Decreases Expression [77]
Transcription factor Sp3 (SP3) OTYDQZ1T SP3_HUMAN Decreases Expression [77]
DNA-binding protein inhibitor ID-3 (ID3) OTUULW5Z ID3_HUMAN Decreases Expression [20]
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) OT2CF1E6 IF4G1_HUMAN Decreases Phosphorylation [73]
Max dimerization protein 1 (MXD1) OTS5CTHX MAD1_HUMAN Increases Expression [19]
Tyrosine-protein phosphatase non-receptor type 13 (PTPN13) OTESFZSO PTN13_HUMAN Decreases Expression [19]
Forkhead box protein F2 (FOXF2) OTV20NGX FOXF2_HUMAN Decreases Expression [19]
A-kinase anchor protein 6 (AKAP6) OTN59BZS AKAP6_HUMAN Increases Expression [21]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Decreases Expression [44]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Increases Phosphorylation [73]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) OT7TNF0L AAPK1_HUMAN Increases Phosphorylation [73]
Serine/threonine-protein kinase PAK 2 (PAK2) OTLUNCIH PAK2_HUMAN Decreases Cleavage [78]
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) OTS3FVTY M3K1_HUMAN Decreases Expression [19]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Phosphorylation [60]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Decreases Expression [13]
CD166 antigen (ALCAM) OTCO4LP7 CD166_HUMAN Decreases Expression [22]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [46]
Kelch-like ECH-associated protein 1 (KEAP1) OTFHOD0C KEAP1_HUMAN Decreases Expression [79]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Increases Expression [20]
Polycomb protein SUZ12 (SUZ12) OT655XF8 SUZ12_HUMAN Decreases Expression [21]
kinase isozyme 1, mitochondrial (PDK1) OTMABK9Z PDK1_HUMAN Increases Phosphorylation [80]
Receptor-type tyrosine-protein phosphatase R (PTPRR) OT790UA2 PTPRR_HUMAN Decreases Expression [20]
Transcription factor E2F5 (E2F5) OT1XWING E2F5_HUMAN Decreases Expression [19]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Decreases Expression [19]
ETS-related transcription factor Elf-2 (ELF2) OTEI347F ELF2_HUMAN Decreases Expression [19]
Myosin light chain kinase, smooth muscle (MYLK) OT78QB4A MYLK_HUMAN Increases Expression [20]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Decreases Expression [81]
Filamin A-interacting protein 1-like (FILIP1L) OTPY8IMS FIL1L_HUMAN Increases Expression [20]
OTU domain-containing protein 7B (OTUD7B) OTMVM8R7 OTU7B_HUMAN Decreases Expression [21]
Rho GTPase-activating protein 30 (ARHGAP30) OTESZLFG RHG30_HUMAN Decreases Expression [21]
Pleckstrin homology domain-containing family H member 2 (PLEKHH2) OT3TK3NN PKHH2_HUMAN Increases Expression [21]
Extracellular sulfatase Sulf-1 (SULF1) OTJCNCO0 SULF1_HUMAN Increases Expression [20]
Cell division cycle and apoptosis regulator protein 1 (CCAR1) OTUXLQZZ CCAR1_HUMAN Increases Expression [20]
Histone H2B type 3-B (H2BC26) OT0E1H99 H2B3B_HUMAN Increases Expression [19]
DNA damage-regulated autophagy modulator protein 1 (DRAM1) OTIJTXEN DRAM1_HUMAN Increases Expression [20]
Unconventional myosin-XVIIIa (MYO18A) OT2YPT7O MY18A_HUMAN Increases Expression [21]
DNA repair endonuclease XPF (ERCC4) OTFIOPG1 XPF_HUMAN Decreases Expression [82]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Increases Expression [76]
Protein TMEPAI (PMEPA1) OTY8Z9UF PMEPA_HUMAN Decreases Expression [63]
Baculoviral IAP repeat-containing protein 7 (BIRC7) OTITCGHB BIRC7_HUMAN Increases Expression [53]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [46]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [63]
M-phase phosphoprotein 6 (MPHOSPH6) OT6E2S48 MPH6_HUMAN Decreases Expression [21]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [19]
Max dimerization protein 3 (MXD3) OT4U88UP MAD3_HUMAN Decreases Expression [19]
Synaptonemal complex protein 2 (SYCP2) OTBH622S SYCP2_HUMAN Increases Expression [21]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Decreases Expression [83]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) OTUYHB84 MLP3B_HUMAN Increases Expression [84]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Decreases Expression [59]
Sideroflexin-1 (SFXN1) OTL66767 SFXN1_HUMAN Decreases Expression [21]
N-lysine methyltransferase KMT5A (KMT5A) OTW2A5YY KMT5A_HUMAN Decreases Expression [85]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Increases Expression [86]
NAD-dependent protein deacetylase sirtuin-7 (SIRT7) OT5M4OT4 SIR7_HUMAN Decreases Expression [87]
Fanconi anemia group I protein (FANCI) OTW8E3SC FANCI_HUMAN Decreases Expression [83]
Interferon kappa (IFNK) OTO2WDPX IFNK_HUMAN Decreases Expression [21]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Decreases Expression [22]
Frizzled-1 (FZD1) OTZATHVS FZD1_HUMAN Decreases Expression [19]
HBS1-like protein (HBS1L) OTA3U1N6 HBS1L_HUMAN Decreases Expression [21]
Cysteine protease ATG4B (ATG4B) OTQ4RNRM ATG4B_HUMAN Decreases Expression [59]
DNA (DNMT3A) OTEJP0GH DNM3A_HUMAN Decreases Expression [88]
Serine/threonine-protein kinase Chk1 (CHEK1) OTTTI622 CHK1_HUMAN Decreases Response To Substance [89]
------------------------------------------------------------------------------------
⏷ Show the Full List of 262 DOT(s)
Indication(s) of OZ277
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [3]
OZ277 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Sarcoplasmic/endoplasmic reticulum calcium ATPase (ATP2A) TTZVSJ2 NOUNIPROTAC Inhibitor [3]
------------------------------------------------------------------------------------

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